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478 articles for “ADME”
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Heavy Metal Assessment of Rainwater from Owerri Metropolis and Suburbs of Imo State, Nigeria Using GIS, MATLAB and ANN Models.
Abstract: Three hundred and fifty (350) rainwater samples were collected from 35 select locations within Owerri Metropolis, Ehime Mbano and Mbaitoli LGAs and analyzed for Cd, Cu, Fe, Zn, and Pb using standard instrumental methods. The results were compared with the World Health Organization (WHO), National Ambient Air Quality Standards (NAAQS), Federal Environmental Protection Agency (FEPA) and National Agency for Food and Drug Administration and Control (NAFDAC) Standards for drinking water …
Published in Journal of Materials & Metallurgical Engineering · Vol. 14, Issue 1, 2024 · pp. 38–57 Read article
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Revolutionizing Diabetes Management: Nanostructured Biosensors for Real-time Monitoring
Abstract: Chronic metabolic disease known as diabetes mellitus, which is characterized by dysregulated blood glucose levels, is becoming a major global health concern. The implementation of automated insulin administration systems and continuous glucose monitoring (CGM) has shown promise in the management of diabetes. Nanostructured biosensors, leveraging the unique properties of nanomaterials, offer enhanced sensitivity, selectivity, and biocompatibility, making them ideal candidates for real-time monitoring and personalized treatment. This article delves into …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 1, 2024 · pp. 49–70 Read article
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Implementing Quality by Design (QbD): Strategies, Challenges, and Best Practices across Industries
Abstract: The present comprehensive review investigated the dynamic landscape of quality standards within the pharmaceutical sector, with a primary focus on the implementation and impact of Quality by Design principles. It illuminated the multifaceted challenges encountered by pharmaceutical companies in upholding stringent quality standards amidst evolving regulatory requirements and complex manufacturing processes. By embracing Quality by Design principles, the industry aims to foster a proactive and systematic approach to product development …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 28–36 Read article
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Empowering Knowledge: Design and Development of Expert Systems with Shell Programs
Abstract: Even if one never intends to write scripts, mastery of shell scripting is an essential skill for anybody hoping to advance in system administration. For instance, a Linux computer uses the shell scripts to start services and restore system settings when it first boots up. Gaining an in-depth understanding of these starting scripts facilitates the analysis and possible optimization of system behavior. Because scripts may be written in short bursts …
Published in Journal of Advances in Shell Programming · Vol. 11, Issue 2, 2024 · pp. 1–4 Read article
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Secure Framework for Government Tender Allocation
Abstract: Governments and public sector entities worldwide are actively seeking innovative strategies to adapt to rapid technological progress, aiming to enhance governance effectiveness, streamline work processes, and optimize expenditure. Blockchain technology stands out as a prime example, captivating the interest of governments globally in recent years. Its ability to offer heightened security, enhanced traceability, and cost-efficient infrastructure positions blockchain as a versatile solution applicable across diverse sectors. Typically, governments engage third-party …
Published in Current Trends in Information Technology · Vol. 14, Issue 2, 2024 · pp. 23–27 Read article
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Review paper on concrete mix design optimization using machine learning based algorithm
Abstract: Concrete is an essential part of most construction works in civil engineering. The mix design of concrete is usually specified in terms of prescription or performance-based approach. One of the most important procedures is proportioning the concrete mix, which requires taking several safety precautions to get the proper amounts of elements like cement, aggregate, water, and admixtures. The current study offers a thorough analysis of the Artificial Neural Networks (ANN) …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 311–320 Read article
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Change Detection in Aerial Imagery
Abstract: The development of the Multi U-Net engineering marks an essential headway in geospatial question location inside ethereal symbolism investigation. The altered U-Net addresses the complexities of multi-class division in assorted geospatial settings. Leveraging the inalienable growing and contracting pathways inside U-Net plans, the Multi U-Net exceeds expectations in capturing complicated spatial data, in this manner setting up a vigorous establishment for exact division. The extend envelops an advanced picture handling …
Published in Journal of Image Processing & Pattern Recognition Progress · Vol. 11, Issue 2, 2024 · pp. 22–28 Read article
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Sentiment Analysis of X (Formerly Twitter) Using Machine Learning
Abstract: Sentiment analysis is a methodology to determine the nature and behavior of each and every user for the content posted on the social media platform in the form of post and feed. Consumers of the online platform are encouraged to post reviews of the product that they purchase. Little attempt is created by Amazon to confine or limit the content of these reviews. The number of reviews for various merchandise …
Published in Journal of Software Engineering Tools & Technology Trends · Vol. 11, Issue 2, 2024 · pp. 28–37 Read article
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CALMA: A Personalized Android-based Salon Appointment Booking System
Abstract: Amidst the hustle and bustle of modern life, discovering moments of calm and self-nurturing is a precious indulgence. The CALMA salon appointment application is a revolutionary solution designed to bridge the gap between tranquility and the beauty and grooming industry. The research aims to provide users with an intuitive, user-friendly, and informative platform that seamlessly integrates the technologies of Flutter, Figma, Firebase, Spring Boot, and MySQL. CALMA goes beyond being …
Published in Journal of Artificial Intelligence Research & Advances · Vol. 11, Issue 2, 2024 · pp. 109–121 Read article
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Fluidic Engineering: Investigating Cutting Fluids’ Effect on Machined Surface Roughness
Abstract: The primary goal of this experimental study project is to determine the optimal cutting fluid by experimenting with two distinct oil kinds and compositions. Thirty-six compositions of cutting oil are obtained by mixing three distinct oil compositions, such as mineral oil and paraffin oil, with six different additive and anti-foaming agent compositions. Then, using a trial-and-error methodology, we employed these 36 cutting oil compositions for drilling operations with constant pressure …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 2, Issue 1, 2024 · pp. 27–42 Read article
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Practical approach for Type 2 Diabetes: Role of DPP4 Inhibitors
Abstract: Dipeptidyl peptidase-4 inhibitors (DPP-4Is) have become essential in managing type 2 diabetes mellitus (T2DM) due to their ability to enhance incretin hormone activity, which promotes insulin secretion and inhibits glucagon release. These agents effectively lower HbA1c levels by 0.5–1.0%, are weight-neutral, and have a low risk of hypoglycemia, making them suitable for a broad patient population, including the elderly. The antidiabetic market in India is vast. Gliptin as group row …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 2, 2024 · pp. 20–26 Read article
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An Effective & Novel Approach as Gastro-retentive Drug Delivery Systems
Abstract: Researcher’s curiosity about gastro-retentive drug delivery system increased so high in recent years because of its excellent drug releasing properties to the target site. The delivery system's residence time in the stomach can be extended with the usage of gastro-retentive drug delivery system by using a number of natural and synthetic polymers such as guar gum, hydoxy propyl methyl cellulose which can be used to improve the bioavailability of a …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 47–54 Read article
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Role of Low Level Laser Therapy (LLLT) in Healing of Electric Burns
Abstract: The objective of this case study is to evaluate the effectiveness of low-level laser therapy (LLLT) in treating scalp wounds caused by electric burns. A thorough examination of the scalp wound was conducted both before and after administering LLLT. The findings suggest that LLLT plays a beneficial role in the healing process of superficial ulcers. Specifically, the application of LLLT (as depicted in Figure 1) demonstrated promising results in facilitating …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 39–44 Read article
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Evaluating the Benefits of Lift Procedure for Fistula in Ano: A Peripheral Centre Experience
Abstract: Introduction: Surgery is considered the only definitive treatment for anal fistula. Many surgical techniques have been described. The aim of this study was to communicate the authors’ preliminary experience in the use of a very recent, simplified technique, at a peripheral surgical centre. Patients And Methods: This was a retrospective study of 10 patients of Fistula-in-ano admitted from October 2021 through September 2023. Patients were managed with the ligation of …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 2, 2024 · pp. 17–20 Read article
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Case Study on Snake Bite
Abstract: Snakebites are a major public health concern in India, with the World Health Organization (WHO) estimating approximately 5 million cases annually. Out of these, around 2.7 million involve envenomation, where venom is injected through the snake's bite. These venomous bites pose significant medical emergencies and can lead to severe complications, including permanent physical impairments if not treated promptly. Immediate medical intervention is crucial to mitigating the adverse effects of snakebites. …
Published in Research and Reviews : Journal of Surgery · Vol. 13, Issue 2, 2024 · pp. 21–25 Read article
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A Novel Categorization System for Pressure Ulcers Reframed in the Context of Bioinformatics
Abstract: Pressure sores are a serious complication of multi morbidity and lack of mobility. Pressure injuries are commonly encountered in geriatric patients. Certain well-recognized risk factors, such as immobility and incontinence, may predispose to the development of pressure injury (PI); consequently, risk factor modification is an important aspect of prevention and treatment. One of the fundamental documentation details when describing a wound is the use of the appropriate staging system. Each …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 2, 2024 · pp. 1–5 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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The Evolution of Student Monitoring Systems in School Buses: A Detailed Review
Abstract: In modern educational institutions, ensuring the safety and well-being of students during transportation is paramount. To address this, we propose a comprehensive Student Monitoring System for buses, designed to enhance safety, efficiency, and communication between stakeholders. The system utilizes advanced technologies such as GPS tracking, RFID tags, and real-time data processing to monitor students' location, track bus routes, and provide instant notifications to parents and school administrators. By integrating these …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 2, Issue 1, 2024 · pp. 1–6 Read article
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Evaluation Tumor Necrosis Factor-α (TNF- α) Levels in Patients with Rheumatoid Arthritis
Abstract: Background: RA is an inflammatory, long-term autoimmune illness, that is impacted by external variables, according to a report from the World Health Organization. Women are 2-3 times more likely than men to develop RA, though this difference diminishes with older age at onset. Aim: The purpose of this study is to assess the significance of TNF-α concentrations in the predisposition to rheumatoid arthritis. Methods: The research project enrolled 100 patients …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article