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1340 articles for “Target”
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Generative Design of Bioactive Orthopedic Composites for Fracture Repair Using an Integrated Conditional GAN–Transformer Framework: A Multi-Objective Approach
Abstract: Orthopedic composite implants for fracture repair must simultaneously satisfy conflicting mechanical and biological demands: high fracture toughness, sufficient compressive stiffness, and bioactive surface chemistry enabling osteoblast adhesion and mineralization. Existing design approaches rely on trial-and-error experimentation, yielding sub-optimal trade-offs between these objectives. This paper presents an integrated conditional Generative Adversarial Network–Transformer (cGAN-T) framework for fully computational, multi-objective generative design of hydroxyapatite (HA)-reinforced polymer composite microstructures targeting Orthopedic fracture repair. A …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 21–35 Read article
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Cancer Prevention Activity in Vitro and the Mechanism of Action Bioactive Ingredients
Abstract: Natural substances that can treat a variety of ailments, including cancer, can be found in the Solanaceae plant family. There is still uncertainty regarding the location and mode of action of these substances in cells. Several of the cellular targets can now be studied and identified thanks to increasing advances in biological science research. The relevant studies that describe how some of these substances may fight cancer are found in …
Published in Journal of Catalyst & Catalysis · Vol. 9, Issue 2, 2022 · pp. 20–25 Read article
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Design of Photonic Sensor for Driver Assistance
Abstract: AbstractA report from National Highway Traffic Safety Association, USA, states that 100000 police reported crashes are a result of driver fatigue. This figure would be quite mind boggling for developing nations, where work periods are usually extended without conducting detailed scrutiny. Sophisticated vehicles are equipped with sensors for assisting drivers and providing them with time-critical accident alerts. However, there is a need to develop cheap and reliable sensors for 24x7 …
Published in Journal of Electronic Design Technology · Vol. 9, Issue 2, 2018 · pp. 14–23 Read article
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Cancer Treatment by Radionuclide Therapy
Abstract: Recently, pretargeted nuclear imaging and radiotherapy have gained tremendous attention for diagnosis and treatment of cancer with nanomedicines. Radionuclide therapy (RNT) is one of the rapidly growing fields of nuclear medicine which works on the mechanism of delivery of cytotoxic levels of radiation to the disease sites, sparing the normal cells. RNT targets diseases at the cellular level rather than on a topographic anatomical level when compared to conventional external …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 2, 2018 · pp. 4–7 Read article
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The Application of Python Programming Language in the Automation of a Mathematical Model for Well Trajectory Selection Optimisation for a Given Field
Abstract: Directional drilling plays a major role in the exploration and recovery of hydrocarbons. There are three basic trajectories that a well may follow. They include; Build-and-Hold, Build-Hold-andDrop and Continuous-Build Trajectories. The selection of a trajectory is usually based on experience/trial and error approach and may be associated with errors. This work has therefore developed a mathematical model that optimised the automatic selection of a well trajectory type for a given …
Published in Journal of Petroleum Engineering & Technology · Vol. 12, Issue 3, 2022 · pp. 1–9 Read article
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Soursop Phytocompounds as Potential Anticancer Agents: A Molecular Docking Study
Abstract: Objective: According to tumor statistics, there will be a total of approximately 1,958,310 new malignancy cases, that balances to nearly 5,370 cases day by day. Without any questions its clearly evident that cancer is considered as one of the deadliest diseases of mankind. The course of this study emphasizes on computational approach for finding new drug for potential target proteins Bcl-2 (4MAN) and Mcl-1(5FDO) by docking against soursop (Annona Muricata …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 3, 2023 · pp. 18–39 Read article
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Emerging Engineered Nanoweapons for Tumors
Abstract: Cancer is a type of disease characterized by abnormal growth of cells which tend to proliferate in uncontrolled manner. It occurs at molecular level when genes undergo genetic alterations. The malignant growth of tumor cells results in non-functioning of the concerned organ. Over the years, cancer targeting technique has greatly improved by new approaches based on nanotechnology. Nanotechnology is helpful in development of new therapies against cancer. Nanotechnology is a …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 2, 2012 · pp. 1–6 Read article
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Current Tumour Immunotherapy strategies and their molecular basis
Abstract: AbstractStudying cancer and devising techniques to combat the deadly disease has witnessed a paradigm shift, from conventional toxic treatments of radiation and chemotherapy, to a more specific, and biologically significant immunotherapy and molecular targeted therapy. This can be seen in the global immunotherapy market, which is dominated by North America region valued about $45.9 billion in 2017 that is estimated to reach about $115.9 billion by 2025, and is closely …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 1–18 Read article
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Extrapolations of Periwinkle Secondary Metabolites as Multitarget Inhibitor of Breast Cancer Proteins
Abstract: Objective: Breast cancer is considered as one of the most common and dangerous forms of cancer. It is a significant public health issue on a global scale. The study estimates that 10.0 million people will die from cancer this year, and 19.3 million people will develop the disease overall (BC). In this computation approach nowadays emphasises for new drug discovery, the target protein EGFR (5UGB), ER (2QGT), and PI3KA (4OYS) …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 3, 2022 · pp. 22–36 Read article
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Optimized Test Suites with Small Code Coverage in Software Testing
Abstract: A common scenario in software testing is to test the data is to be generated and tester manually adds test oracles.It meausured using code coverage and fundamental problemwith common apporach is coverage the goals and how an of them are feasible. In this whole test suites are evovled covering all goals at same time.Its effectiveness not added by number of infeasible targets in code.It has a novel approach in approach …
Published in Journal of Web Engineering & Technology · Vol. 1, Issue 1, 2014 · pp. 24–27 Read article
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Extending the Mind Share Model by Measuring Media Share of Voice
Abstract: In this study, the author extends Mind Share model construction to use media Share of Voice to measure Mind Share of customer in a particular brand. The logit regression is used to find the impact factors which can predict the media Share of Voice. The empirical data is obtained from the Google search engine, and the cumulative volume of keyword searches is used to make model application. The volume of …
Published in Journal of Multimedia Technology & Recent Advancements · Vol. 9, Issue 1, 2022 · pp. 18–22 Read article
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Review Paper on Experimental Investigation of the Impingement Cooling for Single Stationary Flat Plate in Case of Laminar Flow
Abstract: In this paper, impingement cooling on single stationary flat stainless steel plate in which we illustrate the effects of cooling rate, heat transfer rate, and heat transfer coefficient of plate when jet hole diameter changes from 5 to 8 mm; it means that there are changes in Re and Nu number and corresponding changes in air velocity. Select the jet to target plate distance as 9D, where D=diameter of the …
Published in Recent Trends in Fluid Mechanics · Vol. 3, Issue 2, 2016 · pp. 36–43 Read article
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The Impingement Cooling for Single Stationary Flat Plate in Case of Laminar Flow
Abstract: In this paper, impingement cooling on single stationary flat stainless steel plate is performed to illustrate the effects of cooling rate, heat transfer rate, heat transfer coefficient of the plate when the jet hole diameter is changed from 5 to 8 mm. It means that changes in Reynolds number (Re) and Nusselt number (Nu) show corresponding changes in air velocity. Select the jet to target plate distance nine times diameter …
Published in Recent Trends in Fluid Mechanics · Vol. 3, Issue 2, 2016 · pp. 44–52 Read article
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Lipid Drug Conjugates: A Novel Approach for Drug Delivery A Systematic Review
Abstract: The lipid drug conjugates (LDCS) a novel lipid based nanoparticles which has been extensively employed for the delivery and targeting of drugs. These have been exploited for many features in the field of pharmaceutical technology. The lipid drug conjugates have a 33% drug loading capacity more than the solid lipid nanoparticles (SLNs). The lipid drug conjugates have the potential to act as a delivery system for hydrophilic and lipophilic drugs, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 3, 2012 · pp. 1–8 Read article
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A Contribution to the Study of Geographical Displacement of Crime using GIS–Kings Cross, London
Abstract: Displacement of crime is the specter that haunts crime prevention studies, in that, the crime problem does not go away but shifts from one location to another. The fact that crime is not reduced in an area but rather moves around means that trying to change the situation and circumstances surrounding the targeted area may not fully reduce crime. Research that has been previously carried out into the study of …
Published in Journal of Remote Sensing & GIS · Vol. 4, Issue 3, 2013 · pp. 12–25 Read article
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Pathogenesis, Treatment and Molecular Mechanisms for Development of Multidrug-resistant (MDR) TB as well as Identification of MDR Mycobacterium Tuberculosis
Abstract: Normal 0 false false false EN-US X-NONE X-NONE Tuberculosis (TB) is a medical, social, and economic disaster of huge magnitude in the world. Prevalence of TB has increased due to poverty, population growth, migration and a high number of TB cases in HIV positive individuals. High prevalence rate of M. tuberculosis strains with multidrug resistance (MDR) is a serious problem as global emergency. Strains of M. tuberculosis resistant to both …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 1, 2013 · pp. 16–38 Read article
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Path, Trajectory, and Deviation Calculator for Bullets
Abstract: The topic of path, trajectory, and deviation calculators for bullets is of great importance in the field of ballistics and marksmanship. Accurately estimating the flight of a bullet and its deviation from the intended target is crucial for marksmen and ballistics enthusiasts. This thesis aims to design and implement a calculator that considers various factors that influence the flight of a bullet, such as its initial velocity, air resistance, gravitational …
Published in Journal of Aerospace Engineering & Technology · Vol. 13, Issue 1, 2023 · pp. 23–36 Read article
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Biochemical and Structural Characterization of Helicobacter pylori Peptide deformylase by Computational Methods
Abstract: Helicobacter pylorus is classified as class one carcinogen in causing gastric cancer. Peptide deformylases (PDFs) present in bacteria removes the formyl group from the N-terminal Methionine of newly synthesized proteins which is necessary in protein maturation. These enzymes have shown as new targets in antibacterial, antimalarial and anticancer drug discovery. Here an insilico technique was initiated to characterize structural and biochemical properties of this protein. Pair wise sequence alignment with …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 4, Issue 3, 2017 · pp. 22–28 Read article
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Auditory Tone Monitoring in Adults with Stuttering
Abstract: Introduction: Stuttering is portrayed by involuntary disruptions in the flow and rhythm of speaking despite the fact that the individual knows precisely what he/she needs to state [1]. Over the past decades, many studies have examined neural mechanisms of stuttering in adults who stutter and have proposed that stuttering may be associated with deficits in the sensorimotor system. Many neuroimaging studies investigating underlying neural deficits of stuttering have reported abnormal …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 6, Issue 2, 2019 · pp. 16–25 Read article
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Bioinformatics role in Drug discovery
Abstract: Drug discovery is a strenuous, time devouring and costly prepare requiring a few a long time and a colossal sum of financing. Distinguishing a potential medicate target and appropriate lead atom for medicate improvement are basic steps within the medicate disclosure handle. Among the different strategies accessible for the recognizable proof of unused lead molecules, basic bioinformatics features an uncommon put. Basic bioinformatics plays an imperative part in target approval, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 2, 2022 · pp. 31–35 Read article