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550 articles for “HIV-1 Integrase” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Exploring Phytochemicals from Ricinus Communis for Potential Therapeutic Applications in Rheumatoid Arthritis: An in-Silico Approach
Abstract: Aim: Rheumatoid arthritis (RA) is a long-term autoimmune condition characterized by the immune system mistakenly attacking the joints, leading to swelling, discomfort, and joint deformities. Current management strategies include anti-rheumatic drugs and biologics, which have limitations. This study aims to explore the therapeutic potential of Ricinus communis (castor bean plant) phytochemicals as plant-based therapies for autoimmune conditions, like RA. Methods: Phytochemicals from Ricinus communis were retrieved using the IMPPAT database, …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 32–41 Read article
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Synthesis and Characterization of a Naphthalene-Derived Schiff Base for Fe³⁺ Sensing Applications
Abstract: The development of chemosensors for metal ions has gained significant attention due to their crucial role in industrial, environmental, and biological applications. Metal ion detection is essential for monitoring environmental pollution, industrial processes, and biological systems where metal homeostasis plays a vital role. In this study, we focus on the synthesis, characterization, and application of a novel naphthalene-based Schiff base ligand, derived from the condensation reaction between 1,8-diaminonaphthalene and 3-nitrobenzaldehyde. …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 1–8 Read article
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Effective Strategies for Sustainable Soil and Water Management: Enhancing Agricultural Productivity and Environmental Conservation
Abstract: Soil and water are essential natural resources, and their degradation due to erosion, overgrazing and other factors is ongoing. Water erosion is influenced by climate, topography, vegetation and soil, while wind erosion is affected by wind characteristics, surface features, topography and soil properties. Unsustainable land and water management practices lead to reduced soil fertility, soil loss, lower crop yields, water depletion, deforestation, and diminished biomass. Of the 1386 million cubic …
Published in International Journal of Land · Vol. 1, Issue 1, 2024 · pp. 11–36 Read article
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Effect of 4-Week Protocol of Kegel Exercise on Pelvic Floor Strength on a Patient with Ovarian Endometriosis—A Case Report
Abstract: Purpose: The purpose of this case study was to describe the effects of Kegel exercise in a 4-week protocol for a patient with endometriosis associated with urinary incontinence. Case description: A 23-year-old female patient presented with chronic low back pain and also complained of difficulty in holding urine and leakage while doing forceful activities like lifting heavy objects, coughing, and sneezing in the past 6 months. She also complained of …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 9–14 Read article
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A Study to Assess the Effectiveness of Self-Instructional Module on Knowledge of Electrocardiogram Among Staff Nurse in a Selected Hospital in Mahagaon
Abstract: Objectives: This study aimed to evaluate the staff nurses' knowledge of electrocardiograms (ECG) and to determine the impact of a structured teaching program in improving their understanding of the subject. Methodology: An evaluative research design was employed for this study. The study involved 22 staff nurses chosen through simple random sampling and was carried out at Sant Gajanan Maharaj Rural Hospital, Mahagaon. A structured knowledge questionnaire was used to gather …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 7–27 Read article
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Exploring Sustainable Fuel Production from Waste: A Feasibility Study in Zimbabwe
Abstract: Some organisms are in danger of going extinct, and environmental pollution from waste plastics, tires, and used lubricating oils has significantly contributed to the decline of biodiversity. Tires, plastics, and spent oil all contribute significantly to environmental deterioration, and this issue has been linked to improper treatment and disposal of these materials. Only 15% of the 200 auto technicians surveyed for this study acknowledged that they reuse spent oil, 5% …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 3, Issue 1, 2025 · pp. 30–38 Read article
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Live Epidemiological Tracking of COVID-19 in Senegalese Participants of the Hajj
Abstract: Background: Since the COVID-19 outbreak, global efforts have focused on controlling the disease. However, intense cross border movements pose a risk for the emergence of new SARS-CoV-2 strains. A recent example is the detection of cases among the 2024 Senegalese pilgrims returning from Mecca, Saudi Arabia. Investigations of these cases have revealed genomic evolution of the virus. The lack of surveillance may lead to the emergence of high-threat strains. This …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 2, 2025 · pp. 8–16 Read article
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In-Silico Docking of Rubia cordifolia Phytocompounds as Potential MMP-2 Inhibitors for Varicose Vein Management
Abstract: Varicose veins are one of the most common disorders, affecting the vein structure and function of lower limbs, yet there has been no absolute cure found yet. One of the underlying causes for worsening of the condition is the proteolytic activity of MMPs which are a group of enzymes that affect the extracellular matrix (ECM) surrounding the affected veins. Phytocompounds of Rubia cordifolia (Manjishta) were docked against the MMP-2 protein …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 2, 2025 · pp. 31–42 Read article
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Enhancing Glaucoma Diagnosis with Deep Learning: A Study Using ResNet-50 and DenseNet-121
Abstract: Glaucoma is a leading cause of irreversible blindness worldwide, mainly resulting from progressive optic nerve damage, often related to elevated intraocular pressure. Early detection is essential to prevent vision loss, but traditional diagnostic methods rely on specialized equipment and trained professionals, making large-scale screening difficult. This study uses a publicly available fundus imaging dataset to explore the effectiveness of deep learning models for glaucoma detection. These datasets provide medical images, …
Published in International Journal of Brain Sciences · Vol. 2, Issue 2, 2025 · pp. 9–18 Read article
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A Study to Evaluate Nurse Led Intervention Regarding Home Care Management Among Tuberculosis Patients Attending Chest and TB OPD at PGIMS Rohtak
Abstract: Introduction: Tuberculosis is an infectious bacterial pathogen caused by the bacillus called Mycobacteriumtuberculosis, an acid-fast rode shaped bacillus 0.8–5 μm in length and 0.2–0.6 μm in thickness. Tuberculosis (TB) primarily impacts the lungs (pulmonary TB), but it can also affect other parts of the body (extra-pulmonary TB). It spreads through the air and causes damage to the lungs and various other organs. TB is a significant public health issue in …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 31–36 Read article
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A Study to Evaluate the Impact of a Self-instructional Module on Knowledge Enhancement Regarding the Management of Common Pregnancy Discomforts Among Primigravida Mothers in Selected Hospitals of Mysuru
Abstract: Gestation is a time of physical, emotional and hormonal changes in a woman. It is one of the important phases in a woman’s life from the time of be. It is accompanied by discomforts that are generally known as minor ailments. These common discomforts occur generally among primigravida mothers. Symptoms of discomfort due to gestation vary from woman to woman; they are nausea and vomiting, fatigue, backache, heartburn and indigestion, …
Published in International Journal of Midwifery Nursing And Practices · Vol. 3, Issue 1, 2025 · pp. 21–34 Read article
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In-Silico Screening of Phytochemicals for Identification of Alternative Therapy for Thyroid Cancer
Abstract: Thyroid cancer remains a significant health concern globally, necessitating the exploration of novel therapeutic alternatives to improve treatment outcomes. This study targets COT kinase (Cancer Osaka Thyroid Kinase), a protein implicated in the progression of thyroid cancer, using molecular docking methods with various phytochemicals to identify potential therapeutic compounds. PyRx and Discovery Studio were employed to evaluate the interactions and binding affinities of a diverse set of natural compounds with …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 31–55 Read article
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Assessment of Noise Pollution Level in Port Harcourt City: a Location Based Comparative Study
Abstract: Noise pollution has emerged as a significant environmental health concern in urban centers, particularly in rapidly developing cities like Port Harcourt, Nigeria. This study presents a comprehensive, location-based comparative assessment of ambient noise levels across selected zones within Port Harcourt metropolis, including residential, commercial, industrial, and traffic-dense areas. Sound level measurements were conducted in the different areas of Port-Harcourt metropolis. High-density and low-density residential neighborhoods, busy roadways, business centers, road …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 3, Issue 2, 2025 · pp. 7–17 Read article
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The Effect of Nature Connectedness on Cognitive Functions and Perceived Stress: A Gender-Based Analysis
Abstract: In today’s fast-paced world, young adults face increasing cognitive demands and heightened stress levels due to academic, professional, and social pressures. At the same time, modern lifestyles have ledto a decline in meaningful interactions with nature, which may impact both cognitive function and stressmanagement. The present study, entitled "The Effect of Nature Connectedness on Cognitive Functions and Perceived Stress: A Gender-Based Analysis," aimed to explore the effects of nature connectedness …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 1–9 Read article
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Histological Effects of the Antibiotic Gentamicin on the Ovarian Tissue of Female White Laboratory Rats
Abstract: This study aimed to evaluate the histological alterations induced by Gentamicin in the ovarian tissue of white laboratory rats. A total of 12 adult female rats were used and randomly divided into two groups, with each group consisting of six animals. The experimental group received Gentamicin at a dose of 120 mg/kg body weight administered as an injection once daily, while the control group received an equivalent volume of normal …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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Fabrication and Multi scale Characterization of Functionally Graded Composites Reinforced with Hybrid Ceramic–Metallic Phases
Abstract: Using composite materials as functionally graded composites (FGM) can improve its excellent material properties. In this work, magnesium peroxide, silicon carbide, and aluminum are used to create four-layer FGMs. The sintering process, which blends the particles of each material using a powder methodology, has been used to complete the fabrication process. Three factors, including sintering time, sintering temperature, and compacting pressure, are taken into account when fabricating FGM. The FGM …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 3, Issue 2, 2025 · pp. 1–11 Read article
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Development and Evaluation of a Cost-Effective UV-Protective Cream Containing Para-Aminobenzoic Acid and Aloe Vera for Indian Climatic Conditions.
Abstract: The increasing incidence of ultraviolet (UV) radiation-induced skin disorders has heightened the demand for effective, affordable photoprotective agents, especially in countries with high sun exposure such as India. This study aimed to develop a cost-effective and efficient UV-B protective cream formulation suitable for populations in Indian latitudes. Para-aminobenzoic acid (PABA) was selected as the primary sunscreening agent due to its high UV-B absorption efficiency, low toxicity, and affordability compared with …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 7–18 Read article
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Knowledge, Attitude, and Practice Regarding Breast Cancer and Its Prevention Among Adolescent School-Going Girls
Abstract: Introduction: Breast cancer claims the lives of over 500,000 women globally each year. In low-resource settings, most women are diagnosed at an advanced stage of the disease, resulting in low 5-year survival rates, typically ranging between 10 and 40%. However, in regions where early detection and basic treatment are both available and accessible, the 5-year survival rate for early-stage localized breast cancer can exceed 80%. Objectives of the Study: The …
Published in International Journal of Community Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 1–9 Read article
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A Study to Assess the Effectiveness of Structured Teaching Program on Knowledge Regarding Menstrual Hygiene Among the Adolescent Girls in Kanpur
Abstract: Background: Adolescent girls are less aware or unaware about menstrual hygiene and diseases occurring from unhygienic menstrual practice. Therefore, the present study aims to assess the effectiveness of a structured teaching program in improving menstrual hygiene knowledge. Method: The study utilized a quasi-experimental, one-group pretest-posttest design, with 40 adolescent girls chosen as participants using a simple random sampling method. Result: The mean pretest knowledge score was 1.90, while the mean …
Published in International Journal of Midwifery Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 7–12 Read article
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A Retrospective Study to Assess the Incidence of Anaemia Among Pregnant Women Admitted in a Tertiary Care Centre, Jalandhar, Punjab
Abstract: Background: Anemia during pregnancy is a common and preventable condition that contributes significantly to adverse maternal and neonatal outcomes, including preterm delivery, low birth weight, and increased maternal morbidity. Despite the implementation of various national health programs in India, the burden of anemia among pregnant women remains high, particularly in rural regions. Objective: To assess the incidence and severity of anemia among pregnant women admitted to a tertiary care center …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 38–42 Read article