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412 articles for “Gene targeting”
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Next-Generation Biorepositories: Accelerating Infectious Disease Research and Vaccine Innovation
Abstract: Next-generation biorepositories have emerged as critical infrastructure for advancing infectious disease research and accelerating vaccine development. By integrating cellular, genomic, and clinical data within harmonized frameworks, these repositories overcome traditional limitations of fragmented datasets and limited interoperability. The evolution from conventional biobanks to digitally enabled, multi-omics platforms has enabled comprehensive analysis of pathogen–host interactions, facilitating the identification of novel vaccine targets and correlates of protection. The COVID-19 pandemic underscored the …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 Read article
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Aurora Kinase: A Target for Cancer Therapy
Abstract: Aurora kinases are the enzymes that belong to the family of serine/threonine kinases. It consists of Aurora-A (AURK-A), Aurora-B (AURK-B) and Aurora-C (AURK-C), which are the essential kinases for cell division through mitosis regulation especially for the process of chromosomal segregation. Aurora kinases are involved in meiosis regulation along with the regulation of mitosis. Inhibition of Aurora kinase leads to neglected cell division. Various cancer studies generally deal with gene …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 3, 2019 · pp. 10–17 Read article
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Next-Generation mRNA Therapeutics: Self-Amplifying, Thermostable and Personalized mRNA Vaccines in the Era of Precision Medicine
Abstract: Messenger RNA (mRNA) technology has brought a major change in modern medicine, especially after its successful use in COVID-19 vaccines. However, early mRNA vaccines faced several problems such as low stability, strict cold storage requirements, and lack of personalized treatment. To overcome these challenges, next-generation mRNA technologies have been developed, including self-amplifying mRNA (saRNA), thermostable mRNA vaccines, and personalized mRNA vaccines. This article discusses the development of mRNA therapeutics, the …
Published in International Journal of Vaccines · Vol. 3, Issue 1, 2026 · pp. 38–54 Read article
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Plant-Derived Antimicrobials as Next-Generation Solutions to Multidrug Resistance
Abstract: The steady rise of multidrug-resistant (MDR) pathogens is reshaping how clinicians, researchers, and policymakers think about infection control. When bacteria acquire the ability to survive exposure to three or more antibiotic classes at once—whether through efflux pumps, enzyme-mediated drug destruction, target modifications, or reduced membrane permeability—treatment options narrow dramatically, hospital stays lengthen, and mortality climbs. Conventional pharmaceutical pipelines have struggled to keep pace with this biological arms race, pushing the …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 · pp. 27–40 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Enhancing Puberty in Dairy Heifers: Targeted Management Practices For Sustainable Development.
Abstract: Early attainment of puberty in dairy heifers is critical for improving reproductive efficiency and ensuring sustainable dairy production systems. This study explores targeted management practices that can accelerate puberty onset, contributing to enhanced productivity and economic viability in dairy farming. Key factors influencing puberty in heifers include nutritional management, genetic potential, health care, environmental factors, and behavioral interventions. Adequate nutrient supply, especially energy and protein, along with balanced mineral and …
Published in Research & Reviews : Journal of Ecology · Vol. 14, Issue 2, 2025 · pp. 28–35 Read article
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Novel Strategic Framework for AI-Driven Discovery and Development of Smart and Sustainable Polymers in Healthcare
Abstract: The development of new smart and sustainable polymers is emerging as a priority of new health care innovative development, but event before it may be actualized, the usual culprit is the delay and unproductive execution of the old-fashioned R&D efforts. The current paper proposes a strategic plan which will solve all these shortcomings and speed up the material discovery process by using Artificial Intelligence (AI) and Machine Learning (ML). The …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1535–1550 Read article
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Optimization of Pesticide Requirement Calculations for IoT-Operated Hexacopter Delivery Systems
Abstract: The integration of Internet of Things (IoT) technology into precision agriculture has transformed pesticide application strategies, enabling resource-efficient and environmentally sustainable practices. This study presents a computational methodology for optimizing pesticide requirements in an IoT-operated hexacopter system, designed for dynamic, data-driven pesticide delivery. Leveraging a fusion of real-time telemetric data from onboard LiDAR, multispectral imaging sensors, and environmental monitoring modules, the system employs predictive analytics and edge computing to calculate …
Published in International Journal on Drones · Vol. 2, Issue 1, 2026 · pp. 08–14 Read article
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Integrated Hybrid Design for Irrigation Control with Intelligent Feeder System
Abstract: Developed agriculture needs to find new ways to improve efficiency. One approach is to utilize the available information technologies in the form of more intelligent machines to reduce and target energy inputs in more effective ways than in the past. Precision farming has shown benefits of this approach but we can now move towards a new generation of equipment. The advent of autonomous system architectures gives us the opportunity to …
Published in Journal of Microcontroller Engineering and Applications · Vol. 3, Issue 1, 2016 · pp. 7–9 Read article
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Performance Evaluation and Yield Stability Test of Released Food Barely (Hordeum Vulgare L.) Varieties in Highland Areas of Siltie and Gurage Zones
Abstract: Improved barley varieties under barley production were limited in study areas. Therefore, testing of food barley varieties including check over locations for their performance is of paramount important in identification of superior varieties for production. The experiments were conducted to identify high yielding and to determine the stability of the varieties, and specifically and widely adapted food barley varieties for the target areas. Combined analysis of variance showed highly significant …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 12, Issue 1, 2022 · pp. 1–10 Read article
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Microsphere-Based Drug Delivery: A Critical Review of Innovations and Applications
Abstract: Microspheres have emerged as a revolutionary approach in pharmaceutical sciences, offering controlled and targeted drug delivery with improved bioavailability, stability, and patient compliance. These spherical carriers, ranging from nanometers to micrometers in size, can encapsulate both hydrophilic and hydrophobic drugs, enabling sustained and site-specific release. The development of microspheres has been significantly driven by the need to enhance drug efficacy while minimizing systemic side effects. This review provides a comprehensive …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 52–59 Read article
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Pharmacogenetics: A Marvel!
Abstract: Normal 0 MicrosoftInternetExplorer4 Pharmacogenetics is a new paradigm in the field of medical research and therapeutics which is set to revolutionize the current scenario of drug prescribing in health care. It can identify the genetic variations responsible for differences in drug efficacy and safety among individuals by employing pharmacogenomic tools and hence result in lowering of the chances of therapeutic failures and adverse effects. Clinical practitioners will also need to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 2, Issue 2, 2012 · pp. 12–20 Read article
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Patellar Mobility in Elite Swimmers of Jorhat Swimming Society: A Cross-Sectional Study
Abstract: Background: Patellar mobility is vital for swimmers, affecting leg propulsion and injury risk. Understanding its role in swimming biomechanics enhances insights into knee stability and performance across different strokes. Aim: To assess patellar mobility in elite swimmers of Jorhat Swimming Society, Jorhat, Assam. Purpose: To explore the relationship between patellar mobility and swimming stroke styles, specifically focusing on knee biomechanics during the stroke. Methodology: A cross-sectional study involving 27 elite …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
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Computer-aided Drug Design Method for Anti-hepatitis C Drug Design
Abstract: Hepatitis C is a disease caused by the hepatitis C virus and can cause serious liver damage. There is currently no vaccine for this disease and the number of infections continues to increase worldwide. Currently used antiviral drugs are interferon alfa-2a and ribavirin, but about half of patients do not respond to therapy. Therefore, new drugs that protect against hepatitis C need to be investigated. Computational drug methods have been …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 1–8 Read article
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Industrial Prognostics via Ensemble Machine Learning: An Uncertainty Aware Framework for RUL Estimation on NASA FD004 Telemetry
Abstract: Estimating the Remaining Useful Life (RUL) of industrial machinery in real-time is now vital for both operational safety and smart resource management. In the aviation industry, turbofan engines deal with constantly shifting flight conditions, making traditional, scheduled maintenance both expensive and prone to error. This paper addresses the flaws in common “point-prediction” AI models, which offer a single failure date without any margin for error, by introducing a new, uncertainty-aware …
Published in Journal of Aerospace Engineering & Technology · Vol. 16, Issue 2, 2026 Read article
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Research on Overall Design of VTOL UAV
Abstract: A VTOL (vertical takeoff and landing) UAV (unmanned aerial vehicle) is an aircraft that flies without a human crew on board of the aircraft. It uses microprocessors and microsensors to navigate and track targets. The design mainly comprises of two sections (i) the mechanical design and (ii) electronic design. This paper describes the onboard processing technique commonly used in UAV. The next-generation UAVs like the micro-UAV play a vital role …
Published in Research & Reviews: A Journal of Embedded System & Applications · Vol. 3, Issue 1, 2015 · pp. 6–10 Read article
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Target Tracking Mobile Sensor Network Using Mobile AdHoc Networks (MANET)
Abstract: Target trailing mobile device network could be a major challenge in mobile unintended networks due partly to the dynamically dynamic network topologies. For mobile device networks that square measure developed for police investigation applications, it's vital to use a quality management theme empower nodes to create higher choices concerning their positions specified strategic tasks like target trailing can like node movement to explain a distributed quality management theme for mobile …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 5, Issue 3, 2018 · pp. 23–26 Read article
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Bacteriophages- A New Frontier in Medicine
Abstract: Bacteriophages, or phages, are viruses that specifically target and infect bacteria, offering an innovative alternative to traditional antibiotic treatments, especially in the face of rising antibiotic resistance. The resurgence of phage therapy has been driven by the increasing prevalence of multidrug-resistant bacterial strains and the slowdown in the development of new antibiotics. Phages, unlike antibiotics, target specific bacterial strains, reducing the impact on the natural microbiota and potentially offering a …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 31–35 Read article
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Formulation And Evaluation of Paper Soap
Abstract: People are more likely to get bacterial skin infections, which need careful attention to both treat and preserve healthy skin. This article’s frequently used hand wash preparation calls for making paper soap with almond and peppermint and assessing its parameters. According to the study, the tested paper soaps may have antimicrobial qualities and can help treat and manage bacterial skin infections if they are properly prepared using the right plant …
Published in Research & Reviews : Journal of Herbal Science · Vol. 13, Issue 2, 2024 · pp. 1–6 Read article