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837 articles for “Clinical”
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The Function of Diuretics in Current Medical Practice and Prospective Advancements
Abstract: Diuretics have a rich history that spans several centuries, and this review aims to highlight their progression and clinical uses. We start by exploring kidney physiology, followed by a description of how diuretics function through symporters in the renal tubules. Different categories of diuretics are outlined, along with details of their specific actions. Next, we investigate the clinical use of diuretics in conditions, such as congestive heart failure and hypertension, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 1, 2025 · pp. 70–75 Read article
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Tribological Characteristics of Dental Crowns
Abstract: Dental tribology is an emerging field that focuses on improving the design and material choices for artificial dental systems. This paper looks at different dental crown materials, their clinical efficacy and the consequences of tribological wear on teeth due to interfacial movement. Ceramics are commonly utilized in fixed dental restorations because of their superior mechanical and cosmetic qualities, which include exceptional fracture resistance and clinical endurance. Ceramic crowns, often used …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 550–559 Read article
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Extraction of Impacted Lower 3rd Molars immediately after the Single Visit Endodontic treatment of 2nd Molar - A Case Series
Abstract: Patients who visit a dental clinic often anticipate fewer appointments and quicker recovery times. This expectation is particularly relevant when discussing impacted lower third molars in conjunction with decayed second molars. Dentists often struggle with the decision of whether to start endodontic treatment on the second molar or to proceed with extracting the third molar. This dilemma arises due to the absence of sufficient research or documentation specifically addressing the …
Published in Research and Reviews: A Journal of Dentistry · Vol. 16, Issue 2, 2025 · pp. 6–11 Read article
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Neuro-Rehabilitation Reimagined: A Cross-Cultural Paradigm Integrating Immunotherapeutics and Multidimensional Analytics in Pediatric Cerebral Palsy
Abstract: Researchers performed multidimensional data analysis on the clinical records of 1,586 cerebral palsy pediatric patients to investigate the rehabilitative benefits of immunotherapy and the advantages of blending Traditional Chinese Medicine with Western treatments. A multi-center, prospective cohort study established a standardized system for data gathering that included clinical baseline databases along with treatment protocols and follow-up information. Baseline data analysis showed substantial patient diversity across clinical types and TCM syndromes …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 67–84 Read article
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Brain Tumor Detection Using RestNet50 Architecture
Abstract: This paper presents a novel deep learning model for brain tumor diagnosis from MRI scans on the basis of ResNet50 with some modifications. Optimizing the modified layers and pre-trained ResNet50 for improved diagnostic accuracy and reliability in real-world clinical settings is one of the key contributions of this paper. The model was trained on an extremely well-balanced data of 2,577 MRI scans, which were split equally among the tumor and …
Published in Current Trends in Signal Processing · Vol. 15, Issue 2, 2025 · pp. 1–13 Read article
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Multimodal Disease Detection Using Deep Learning
Abstract: Artificial Intelligence (AI) is playing an increasingly pivotal role in modern healthcare, particularly in improving the speed and accuracy of disease detection. With the evolution of Machine Learning (ML), Deep Learning (DL), and high-performance computing, AI-based solutions are now capable of processing extensive medical datasets, ranging from patient records to diagnostic images, with remarkable efficiency. These systems offer immense potential for early intervention, improved clinical decision-making, and alleviating pressure on …
Published in Journal of Computer Technology & Applications · Vol. 16, Issue 2, 2025 · pp. 129–139 Read article
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A Review on Unmasking Merkel Cell Polyomavirus: From Discovery to Cancer Driver
Abstract: Merkel cell polyomavirus (MCPyV) is a small, non-enveloped, circular double-stranded DNA virus belonging to the Polyomaviridae family, first characterized in 2008. Epidemiological data suggest widespread exposure, with seroprevalence rates approaching 80% in adults. While primary infection is typically asymptomatic, rare integration events in Merkel cells can initiate oncogenesis, yielding Merkel cell carcinoma (MCC), a neuroendocrine skin cancer with a five-year survival rate under 60%. This review integrates findings from six …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 6–11 Read article
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Advancing Gene Therapy: Next-Generation Viral Vector Engineering for Precision, Safety, and Scalability
Abstract: Gene therapy has emerged as a paradigm-shifting modality for the treatment of genetic disorders, malignancies, and rare diseases through the delivery of therapeutic nucleic acids aimed at correcting or modulating dysfunctional gene expression. Among the various delivery systems, viral vectors including adeno-associated viruses (AAVs), lentiviruses, adenoviruses, retroviruses, and herpes simplex viruses have proven indispensable owing to their high transduction efficiencies and adaptability. This review offers a comprehensive assessment of viral …
Published in International Journal of Virus Studies · Vol. 2, Issue 2, 2025 · pp. 37–55 Read article
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Early Disease Detection Using Artificial Intelligence
Abstract: Growth in artificial intelligence and machine learning now make it possible for the healthcare sector to be totally transformed by a new chapter, particularly in the era of medical image analysis. This study focuses on harnessing these advancements to develop a sophisticated model for early disease detection across diverse medical domains, majorly in skin disease. By integrating diverse datasets and leveraging advanced algorithms, our methodology aims to identify subtle disease …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 14, Issue 3, 2024 · pp. 11–19 Read article
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A Cross-Sectional Study to Find Out the Incidence and Associated Risk Factors of Pressure Injury Acquired in the ICU Unit at Pt. B.D. PGIMS, Rohtak
Abstract: Pressure injuries, also known as pressure ulcers or bedsores, remain a major concern in intensive care units (ICUs) due to their adverse impact on patient outcomes and healthcare quality. This study aimed to assess the incidence and associated risk factors of pressure injuries among patients admitted to the ICU at Pt. B.D. Sharma Post Graduate Institute of Medical Sciences (PGIMS), Rohtak. A descriptive cross-sectional design was adopted, and data were …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 7–41 Read article
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Polymers In Low-Resource Biomedical Innovation: Maker Labs, DIY Devices and Ethics
Abstract: The low-cost biomedical devices have been prototyped and sometimes put into practice by maker laboratories and community "DIY" (Do-It-Yourself maker) innovators due to the fast-growing availability of polymer-based fabrication (desktop 3D printing, laser cutting, and simple molding). Nowadays, polymers such as PLA, PETG, TPU, and PEEK are used in a wide range of applications, including surgical guides and anatomical models, as well as assistive technology and diagnostic housings. Such innovations …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 108–119 Read article
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Modernizing Pharmacovigilance: Leveraging AI, Automation, and Real-World Data for Drug Safety
Abstract: Pharmacovigilance, or PV, is “the pharmacological science relating to the detection, assessment, understanding, and prevention of adverse effects, mainly long term and short-term adverse effects of medicines.” PV’s specific objectives are to increase patient care and safety when using medications and all medical and paramedical therapies; assist in evaluating the benefits, drawbacks, efficacy, and risks of medications, ensuring their safe, prudent, and more effective use; and promote clinical training, education, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 · pp. 12–21 Read article
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Management of Kosthasakhashrita Kamala W.S.R. to Hepatocellular Jaundice – A Case Study
Abstract: Kosthasakhāśrit Kamala is a well-recognized clinical entity in Ayurveda and is widely correlated with modern hepatocellular jaundice. The condition arises primarily due to the vitiation of Pitta dosha within the Kostha (gastrointestinal tract), which subsequently spreads to the Sakha (peripheral tissues). Classical texts describe hallmark features such as Haridra Netra (yellowish discoloration of the eyes), yellowish hue of twak and nakha, pitta varṇa of mutra and sakrit (yellow urine and …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 15, Issue 1, 2026 · pp. 1–8 Read article
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Quorum Sensing and Biofilm Dynamics in Pathogens: An Evolving Frontier in Infectious Disease
Abstract: Bacterial and fungal pathogens rarely act as solitary invaders. Instead, they engage in sophisticated chemical communication known as quorum sensing (QS) to coordinate population-wide behaviours and construct structured, multicellular biofilm communities. These biofilms, composed of extracellular polymeric substances, not only facilitate microbial persistence on biotic and abiotic surfaces but also confer remarkable protection against host immune defenses and antimicrobial therapies. QS systems act as central regulators of biofilm dynamics, orchestrating …
Published in International Journal of Pathogens · Vol. 3, Issue 1, 2026 · pp. 18–23 Read article
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Advances in Simulation and Surgical Skill Training Evolution: Narrative Integrative Review
Abstract: Simulation-based education has emerged as a cornerstone of contemporary general surgery training, driven by increasing emphasis on patient safety, competency-based education, and rapid technological innovation. Traditional apprenticeship models, while foundational, are constrained by reduced operative exposure, work-hour limitations, and variability in clinical case mix. In this context, simulation provides a structured, reproducible, and safe environment for acquisition, assessment, and refinement of surgical skills across the training continuum. This narrative review …
Published in Research and Reviews : Journal of Surgery · Vol. 15, Issue 1, 2026 · pp. 7–13 Read article
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Pain Management Through Ayurvedic Tablets and Capsules
Abstract: Triphala Guggulu is a classical formulation widely used in Ayurveda for the management of metabolic and inflammatory disorders. It represents a synergistic combination of Triphala – composed of Emblica officinalis, Terminalia bellirica, and Terminalia chebula – along with the oleo-gum resin of Commiphora mukul. In traditional Ayurvedic practice, this formulation has been prescribed for conditions, such as arthritis, obesity, hyperlipidemia, and chronic constipation, primarily due to its reputed ability to …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 1, 2026 · pp. 23–28 Read article
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STRUCTURAL–EPIGENOMIC ATLAS: CNV/SV- DRIVEN PROGNOSTIC REFINEMENT ACROSS CANCERS
Abstract: Structural genomic alterations, including copy number variations (CNVs) and structural variants (SVs), play a central role in cancer initiation and progression. These alterations extend beyond gene dosage effects and interact dynamically with epigenomic mechanisms such as DNA methylation, histone modifications, and three-dimensional chromatin organization. Recent pan-cancer studies have demonstrated that CNV burden and SV signatures reflect key oncogenic processes including chromothripsis, homologous recombination deficiency, enhancer hijacking, and extrachromosomal DNA (ecDNA) …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 1, 2026 Read article
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Demodex spp. (Acari: Demodicidae) Infestation in Humans: Diagnostic Clues and Therapeutic Approaches to Primary and Secondary Demodicosis.
Abstract: Demodicosis represents an inflammatory dermatosis and adnexal disorder arising from pathologic overgrowth of Demodex mites, primarily Demodex folliculorum and Demodex brevis, which are ubiquitous human ectoparasites residing in pilosebaceous units and eyelid margins. Once regarded as benign commensals, these mites are now recognized as primary drivers or key cofactors in diverse clinical phenotypes, including papulopustular eruptions, pityriasis folliculorum, rosacea-like disorders, blepharitis, meibomian gland dysfunction, and exacerbations of comorbid dermatoses such …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 12–20 Read article
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Medically Important Hemiptera: Bed Bugs and Kissing Bugs in Human Health.
Abstract: Bed bugs (family Cimicidae) and kissing bugs (subfamily Triatominae) are hematophagous Hemiptera of major medical importance, yet they differ markedly in their public health impact. Bed bugs have resurged globally over the past three decades, with infestations reported from homes, multi-unit housing, hotels, transportation, and healthcare facilities in both high and low-income settings. They are not established biological vectors of human pathogens, but their bites cause pruritic papules, urticarial, and …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 41–49 Read article
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Engineering Anti-Tau Monoclonal Antibodies for Alzheimer’s Disease and Parkinsonian Tauopathies: A Biotechnological Perspective
Abstract: Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are characterized by progressive neuronal loss associated with abnormal protein aggregation. Among these, tauopathies are defined by the accumulation of hyperphosphorylated tau protein, which plays a central role in disease progression. Advances in biotechnology have enabled the development of anti-tau monoclonal antibodies (mAbs) as promising therapeutic agents aimed at neutralizing pathological tau species and inhibiting their propagation. This review provides a …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 16, Issue 1, 2026 Read article