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763 articles for “drugs”
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Comprehensive Review on Antimicrobial based Hydrogel for Wound Healing
Abstract: Chronic wounds present a significant clinical challenge due to their prolonged healing time, high risk of infection, and frequent recurrence. The development of novel wound dressings with both healing and antimicrobial properties is essential for effective wound management. This study focuses on the formulation and evaluation of an antimicrobial drug-loaded hydrogel designed to promote chronic wound healing. Chronic wounds are a growing concern in healthcare, often taking weeks or even …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 72–88 Read article
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Pharmacovigilance: The Silent Guardian of Patient Safety
Abstract: Pharmacovigilance is critical in protecting the populace health by monitoring, detecting and preventing adverse drug reaction (ADR) post drug approval. Although there is technological advancement and national initiatives such as the Pharmacovigilance Programme of India (PvPI), there is still a great problem of underreporting. Many benefits of effective pharmacovigilance include identification of risks early, better prescriptions and patient confidence. There are historical examples of drugs being withdrawn due to thalidomide, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 01–05 Read article
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Synthesis and Characterization of pH-Sensitive Poly (N-isopropylacrylamide-co-acrylic Acid) Hydrogels for Controlled Release of Doxorubicin
Abstract: pH-responsive polymeric hydrogels have attracted significant attention as intelligent biomaterials for site-specific and controlled drug delivery in cancer therapy due to their ability to respond to the acidic tumor microenvironment. In the present study, poly (N-isopropylacrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] hydrogels were synthesized via free radical copolymerization and systematically characterized to evaluate their suitability for controlled delivery of doxorubicin, a widely used chemotherapeutic agent. The copolymer hydrogels were prepared using N-isopropylacrylamide and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 449–458 Read article
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Formulation and Evaluation of Betel Leaf and Clove Based Herbal Gel
Abstract: This study developed and assessed a herbal gel comprising extracts of betel leaf (Piper betle) and clove (Syzygium aromaticum) for topical use. Herbal extracts were prepared by Soxhlet extraction and analyzed for yield, phytochemical profile and total phenolic content (TPC). The phytochemicals present were alkaloids, flavonoids, tannins and phenols, and glycosides, with a greater phenolic content for clove extract. Herbal gels were prepared using Carbopol 934 and assessed for properties, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 2, 2026 Read article
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Drugs for Alzheimer’s Disease from Salix Alba Discovered Computationally Utilizing Virtual Screening and Docking against 1b41 Protein
Abstract: Objective : The of this research is to evaluate the feasibility of using molecular docking techniques to identify novel acetylcholinesterase, a key enzyme implicated in the pathogenesis of Alzheimer’s disease, a neurodegenerative disorder with a gradual but steady progression to death, due to the gradual accumulation of beta-plaques and neurofibrillary tangles, as well as a decline in acetylcholine levels. Due to its function in converting acetylcholine into acyl and choline …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 07–19 Read article
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Deciphering Th-Related Gene Interactions in Chronic Spontaneous Urticaria: Bioinformatics Insights and Drug Affinity Exploration
Abstract: Objective: There has been a great deal of interest in how inflammatory dermatosis and The cell interact, but the etiopathogenesis of chronic spontaneous urticaria (CSU) is still inadequately comprehended. Through bioinformatics techniques, the purpose of this work is to elucdate the molecular mechanism underlying Th-related genes in CSU and seeks to find the highest affinity drug. Methods: The CSU RNA expression profiling dataset provided the basis for the investigation. The …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 1–15 Read article
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Biopharmaceuticals: A Review of Biopolymeric Drugs and Accessibility Challenges in India
Abstract: Advances in biotechnology have allowed us to produce biosynthesized proteins that have therapeutic benefits. The drug products having biotechnology derived proteins, i.e. Biopharmaceuticals, have evolved the treatment of several diseases. knowledge about biological systems have been explored scientifically, there have been significant efforts to utilize them for improving human lives. These biopharmaceutical products have a rapidly growing market which needs to be closely monitored to avoid any potential risks. This …
Published in Journal of Polymer & Composites · Vol. 12, Issue 5, 2024 · pp. 32–38 Read article
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Personalized Medicines in Pharmaceutics: Drug Delivery System
Abstract: Pharmaceutics personalized medicine is a developing area that seeks to customize medical interventions for specific patients. Instead of a one-size-fits-all approach, personalized medicine focuses on developing treatments that consider a person’s unique characteristics, such as their genetic makeup, environment, and lifestyle. This allows for more effective treatment outcomes, as drugs are specifically designed to work best for each patient, reducing side effects and improving therapeutic results. In pharmaceutics, this involves …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 11–22 Read article
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Drug Repurposing of Anticancer Agents JP-8g and REDX05358 Against the Target Protein Plectin 1a in Epidemolysis Bullosa Simplex with Muscular Dystrophy (EBS-MD)
Abstract: Epidermolysis Bullosa Simplex with Muscle Dystrophy is a genetic disease affecting the skin and muscles which can be seen at birth or start at adulthood due to the mutation in the protein Plectin 1a (PLEC gene) causing skin blisters and muscle weakness. This protein is seen in sarcolemma, Z disks in skeletal muscles, hemidesmosomes in skin and cardiac muscles giving stability to cytoskeleton, playing a crucial role in neuromuscular transmission …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 2, 2025 · pp. 22–34 Read article
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Innovations in Targeted Drug Discovery for Personalized Medicine
Abstract: Personalized medicine is revolutionizing modern healthcare by custoizing treatment plans to match an individual’s genetic makeup, protein expression, and metabomlic characteristics. Also referred to as precision medicine, this approach seeks to improve therapeutic outcomes, reduce adverse effects, and make efficient use of healthcare resources. The incorporation of various omics technologies—including genomics, proteomics, transcriptomics, metabolomics, and epigenomics—has greatly advanced our ability to understand disease biology and molecular variations specific to each …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 19–41 Read article
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Scientific Appraisal of Unani Drugs Used in Neurological Disorders
Abstract: Background: Neurological disorders are prevalent and are increasing. The Unani system of medicine provides insights into the pathogenesis, prevention, and treatment of these diseases. Objective: This study explores the Unani perspective on neurological disorders, focusing on therapies and the pharmacodynamics of related medicines. Methods: A comprehensive review of Unani literature was conducted using digital and traditional sources. Unani texts, like “Al Qanoon Fil Tib” by Ibn Sina and “Al Jami …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 13, Issue 1, 2026 · pp. 34–44 Read article
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Evaluating the Role of Pharmacists in Managing Antibiotic Use and Combating Multi-Drug Resistance in Hospital Settings
Abstract: Antibiotic resistance is now one of the crucial health issues of the world, especially in hospitals where high usage of antimicrobials is increasing the rate at which multi-drug resistant (MDR) organisms appear. Misprescription, extended treatment, and over-use of broad spectrum antibiotics play a large role in the development of resistance resulting in the growth of morbidity, mortality and health care expenditure. This review analyses the essentiality of pharmacists in controlling …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 12–19 Read article
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Child Friendly Innovation: A New Era in Pediatrics Drug Delivery Systems
Abstract: Pediatric formulations are becoming more and more popular as a result of advancements in pharmaceutical delivery technology. For young patients, there isn't a safe and effective drug delivery system in place. Since children's pharmacokinetics and pathophysiologic profiles differ from those of adults, it is imperative to design and develop an innovative and appropriate delivery system to provide accurate and dependable medicine administration to pediatric patients. Discussions will be held under …
Published in Trends in Drug Delivery · Vol. 13, Issue 2, 2026 Read article
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Development and Fabrication of Biohydrogel for Targeted Delivery of Delafloxacin for Bacterial Skin Infections
Abstract: The escalating challenge of bacterial resistance necessitates innovative drug delivery systems to enhance the efficacy of antibiotics. This study focuses on the development and optimization of a biohydrogel formulation for the targeted delivery of Delafloxacin, aiming to improve its therapeutic outcomes against resistant bacterial strains. Utilizing a 3² factorial design, biohydrogel formulations incorporating Poly(N-isopropylacrylamide) (PNIPAM) and Genipin were synthesized. The optimization process was guided by Design Expert software, focusing on …
Published in Research & Reviews: A Journal of Drug Design & Discovery Read article
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A Brief Review On Nanoparticles Drug Delivery System Used In Cervical Cancer
Abstract: Among cervical tumor-related deaths worldwide, cervical cancer is a major cause. The limitations of traditional methods, such as chemotherapy and radiation therapy, stem from their adverse effects and increased susceptibility to medications. Despite being seen as innovative options, immune checkpoint inhibitors (ICIs) have rather low clinical response rates. Reliable treatments for patients with metastatic or recurring cervical cancer are currently lacking. Lately, nanomaterials including polymers, liposomes, and dendrimers have been …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 15, Issue 1, 2025 · pp. 30–40 Read article
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An Insightful Study on SMEDDS Challenges and Potential Strategies
Abstract: Self-microemulsifying drug delivery systems (SMEDDS) have gained attention as an effective approach to enhance the bioavailability of poorly water-soluble drugs. They are innovative lipid-based formulations designed to enhance the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs. The development of SMEDDS involves systematic selection of components based on solubility and emulsification efficiency, followed by optimization of ratios using pseudo-ternary phase diagrams. The resulting formulations are evaluated for droplet size, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 311–334 Read article
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Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article
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Drug Utilisation and Cost Analysis in End-Stage Renal Disease Patients: A Prospective Observational Study
Abstract: Chronic Kidney Disease (CKD) is a condition in which the kidneys are damaged and unable to efficiently remove waste and excess fluid from the blood. Dialysis serves as a treatment for CKD by artificially carrying out the kidney’s filtering functions. This prospective observational cross-sectional study was conducted to evaluate drug utilization patterns, economic burden, and health-related quality of life (HRQoL) among patients with end-stage renal disease (ESRD) undergoing dialysis. Over …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 2, 2025 · pp. 1–12 Read article
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Advances in Polymer Chemistry for Coronary Artery Disease
Abstract: Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide, driving ongoing innovation in therapeutic materials and device design. Polymer chemistry has emerged as a cornerstone in the development of advanced cardiovascular interventions, offering versatile platforms to improve the safety, efficacy, and functionality of implantable devices. This review explores recent advances in the synthesis and application of biodegradable and biostable polymers, focusing on their roles in drug-eluting …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 710–716 Read article