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311 articles for “Metabolic”
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Strategy to Accelerate the Biopharmaceuticals Production Using Komogataella phaffii (Pichia pastoris)
Abstract: Revenue generation has been the primary goals for nations as well as the industries worldwide. Biopharmaceutical verticals have become potential revenue generators as they are the industrial workhorses and the economic engines that drive the upcoming biopharmaceutical industries with advances in DNA recombinant technology. A breakthrough in the indusrial biotechnology for the production of biopharmaceuticals using Pichia pastoris is awaited. Ablynx NV, Recombinant proteins (RP), HSA-pFSH beta, antibodies, borosin, N-glycoprotein, …
Published in International Journal of Advance in Molecular Engineering · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Targeting Vasopressin 2 Receptor (V2R) in Renal Cystogenesis by Exploring the Nephroprotective Potential of “Terminalia arjuna”
Abstract: Objectives: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, leading to the formation of multiple cysts in the kidneys. It is a major cause of end-stage renal disease (ESRD), which often requires dialysis or a kidney transplant for survival. This research focuses on identifying potential bioactive compounds derived from natural sources that show promise for drug development targeting the V2R gene. Methods: The naturally occurred …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 14–24 Read article
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Exploring the Potential of Allium sativum Phytocompounds as B-Cell Leukemia 2 Inhibitors in Acute Lymphoblastic Leukemia: Molecular Docking Study
Abstract: Objective: Acute lymphoblastic leukemia (ALL) is a lymphoid progenitor cell malignancy that could be treated with plant-based drugs, thus alleviating the off-target effects caused by conventional chemotherapy. Since ancient days, Allium sativum has been an integral part of traditional medicine and an excellent antimicrobial, antioxidant, and antiproliferative agent. Hence, this study aims to assess the anti-leukemic potential of A. sativum phytoconstituents as the B-cell leukemia 2 protein (Bcl-2) natural inhibitor …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 2, 2024 · pp. 53–80 Read article
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Role of Genetics in Improving Fitness and Sports Performance
Abstract: Research indicates that variations in specific genes affects sports performance, comparing athletes with nonathletes. The genes that have been examined the most in relation to athletic performance are ACE and ACTN3. Strength and endurance have been associated with these genes, which also affect the type of fiber that makes up muscles. Sports performance factors primarily affected by genes are intrinsic motivation to exercise, power and endurance potential, training response to …
Published in Recent Trends in Sports · Vol. 1, Issue 2, 2024 · pp. 28–34 Read article
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Human Milk and Infant Growth: A Systematic Review of Nutritional Outcomes
Abstract: Human milk is recognized as the optimal source of nutrition for infants, playing a critical role in their growth and development. This systematic review explores the evidence linking human milk consumption to various growth parameters in infants, including weight gain, length, and head circumference while considering the influencing factors of prematurity and health status. The composition of human milk, rich in essential macronutrients (proteins, fats, carbohydrates) and micronutrients (vitamins and …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–6 Read article
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Stingless Honeybee’s Rare Sugar and PCSK 9 - LDLR Interaction, A New Hope for Hormone Dependent Breast Cancer Patients – An In-silico Study
Abstract: Hypercholesterolemia is a lipid disorder characterized by elevated levels of low-density lipoprotein (LDL), commonly known as "bad" cholesterol. This condition is a significant risk factor in the development and progression of hormone-dependent breast cancer, as well as in the emergence of resistance to hormonal therapy. One of the key regulators of cholesterol metabolism is the proprotein convertase subtilisin/kexin type-9 (PCSK9) protein, which facilitates the degradation of the LDL receptor (LDLR) …
Published in International Journal of Cheminformatics · Vol. 3, Issue 1, 2025 · pp. 1–6 Read article
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Investigating the Impact of Viral Infections on Pharmacokinetics and Pharmacodynamics of Antiviral Drugs
Abstract: The emergence and re-emergence of viral infections pose significant challenges to public health, necessitating a comprehensive understanding of how these infections impact the pharmacokinetics and pharmacodynamics of antiviral drugs. This review explores the intricate interactions between viral pathophysiology and the pharmacological effects of antiviral agents. Factors such as viral replication dynamics, host immune responses, and the genetic variability of both viruses and hosts significantly influence drug absorption, distribution, metabolism, and …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 23–30 Read article
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Effect of Nano-Prepared N. sativa Seed Extract on Cardiac Tissue Structure in Tartrazine-Treated Male Albino Mice
Abstract: This study investigates the effects of Tartrazine and N. sativa nanoparticles on body weight and cardiac histology in male albino mice. Thirty-six male mice were divided into four groups: a control group receiving physiological saline, a group treated with Tartrazine (20 mg/kg), a group receiving both Tartrazine and N. sativa nanoparticles (100 mg/kg), and a group treated solely with N. sativa nanoparticles (100 mg/kg). The body weights were chronicled before …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 119–124 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Pharmacovigilance And Drug-Induced Toxicities: A Clinical Perspective
Abstract: Pharmacovigilance, which aims to detect, assess, and prevent medication-induced toxicities and adverse drug reactions (ADRs), is a crucial part of healthcare. This study examines the several kinds of drug-induced toxicities, such as idiosyncratic, dose-dependent, and allergic reactions, and emphasizes the function of clinical pharmacists in the tracking and treatment of these illnesses. Pharmacovigilance systems are crucial because they can identify and handle drug-related safety issues that might not surface during …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 17–30 Read article
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Assessment of Vitamin D Levels Among Hashimoto and Hypothyroidism Disease in Iraq, A Comparative Study
Abstract: The thyroid gland is a small gland that regulates the body’s metabolism. It secretes the hormones that the body needs to maintain this process. People of different ages may be afflicted with thyroid diseases, including Hashimoto disease and hypothyroidism. The current study aimed to compare the levels of vitamin D among patients with Hashimoto’s disease and hypothyroidism coming to the Diabetes and Endocrinology Center in Al-Sadr Medical City in Najaf …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 77–83 Read article
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Role of Ginger (Zingiber officinale Roscoe) in Sustainable Health
Abstract: Attaining sustainable health involves a comprehensive blend of multiple factors, including structural, physiological, metabolic, and psychological aspects, alongside the cultivation of self-awareness and a sense of fulfillment. The World Health Organization (WHO) underscores in its 2030 Agenda for Sustainable Development that lifestyle-related illnesses, especially non-communicable diseases (NCDs), present considerable hurdles to sustainable progress, stressing the importance of mitigating their risk factors. Nutrition is acknowledged as a cornerstone of health preservation, …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 3, 2024 · pp. 72–76 Read article
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Environmental Pollutants and Biodiversity Loss: Analyzing the Role of Persistent Organic Pollutants in Ecosystem Decline
Abstract: Persistent Organic Pollutants (POPs) significantly impact biodiversity, with various factors influencing their effects on species and ecosystems. Species in poor body condition, like carnivores and predators, are more vulnerable to POPs due to weakened immune systems and reduced detoxification abilities. Dietary habits also affect the accumulation of POPs, as chemicals biomagnify up the food chain. Carnivores accumulate higher concentrations, leading to reproductive failures, hormonal imbalances, and death, while herbivores face …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 1, 2025 · pp. 9–20 Read article
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Histological Effects of Nano-Synthesized Particles of Nagilla Sativa Seeds Extract on Digestive System of Male Albino Mice
Abstract: This revision considers the belongings of Tartrazine and black seed nanoparticles on body mass and cardiac histology in male albino mice. Group of male mice were separated into 4 clusters: a regulator cluster getting physiological saline, other cluster preserved with Tartrazine (20 mg/kg), another cluster getting equally Tartrazine with N. sativa nanoparticles (100 mg/kg), while last cluster preserved solely besides to N. sativa nanoparticles (100 mg/kg). The assumptions confirmed an …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 1–6 Read article
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Data Integration and Visualization in Bioinformatics: Techniques and Challenges
Abstract: Data integration and visualization play essential roles in bioinformatics, facilitating the thorough analysis, and interpretation of intricate biological datasets. In the field of bioinformatics, vast amounts of data are generated from various experimental platforms, such as genomic sequencing, proteomics, transcriptomics, and metabolomics. However, the heterogeneity of these datasets, coupled with their large scale and complexity, presents significant challenges in terms of integration, analysis, and visualization. Data integration techniques aim to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 1–8 Read article
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Exploring Azadirachta indica’s Potential to Combat Visceral Leishmaniasis Through GP63 Inhibition
Abstract: Objectives: Millions of people worldwide suffer from the parasite disease visceral leishmaniasis. Determine the naturally occurring active ingredients in Azadirachta indica, which are employed as a disease-prevention agent and have several uses in medicine. To choose the best ligand to use as a medication, absorption, distribution, metabolism, and excretion (ADME) studies and molecular docking are employed. Methods: To obtain the GP63 protein, the Protein Data Bank (PDB) database was accessed. …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 1–12 Read article
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The Intersection of Bioinformatics and Cellular Function in Disease Modeling
Abstract: The integration of bioinformatics and cellular biology has revolutionized our understanding of disease mechanisms, offering unprecedented opportunities to model complex biological systems. Bioinformatics is an interdisciplinary field that merges biology, computer science, and statistics, offering advanced tools to analyze vast biological datasets. Cellular functions, including gene expression, protein interactions, and metabolic pathways, form the foundation of physiological and pathological states. Disruptions in these processes can result in diseases like cancer, …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Computational Approaches to Understanding Cellular Signaling Pathways
Abstract: Cellular signaling pathways are fundamental in regulating vital processes, such as cell growth, differentiation, and apoptosis. The intricate and interconnected nature of these signaling networks requires sophisticated methods for their analysis. Computational approaches, including mathematical modeling, network analysis, and machine learning, have revolutionized the way researchers analyze and simulate cellular signaling. This article provides a comprehensive overview of computational strategies employed to model signaling pathways, with a focus on integrating …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 8–13 Read article
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Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications
Abstract: A well established strategy is to introduce a biologically relevant organic molecule in coordination sphere of transition metal complexes to increase the selectivity and biocompatibility. Phenylacetic acid (PAA), an organic molecule with a phenyl functional group and a carboxylic acid functional group, is a phenylalanine that is generated from the naturally occurring auxin, which is extensively present in plants. The most promising outcomes in the battle against cancer and microbes …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 68–78 Read article
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Multi-Target Molecular Docking of Anantmul (Hemidesmus indicus) Compounds for Tay-Sachs Disease Treatment
Abstract: This research aimed to study the effects of the plant Anantmul (Hemidesmus indicus) in the treatment of Tay-Sachs disease using molecular docking studies. Tay-Sachs disease is a neurodegenerative autosomal recessive disorder caused due to accumulation of the molecule GM2 ganglioside which is caused due to lack of enzyme Beta Hexosaminidase which breaks down GM2 Ganglioside. Anantmul (Hemidesmus indicus) is a an ayurvedic plant used in the Indian subcontinent that has …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 2, 2024 · pp. 61–69 Read article