Nano Trends – A Journal of Nano Technology & Its Applications Original Research

Histological Effects of Nano-Synthesized Particles of Nagilla Sativa Seeds Extract on Digestive System of Male Albino Mice

  1. Noor M. Hasnawi Department of Forensic Techniques, Al-Furat Al-Awsat Technical University, Najaf, Najaf Governorate
  2. Zahraa Hussein Abdulateef Ali Department of Dental Industry, Al-Furat Al-Awsat Technical University, Najaf, Najaf Governorate

Abstract

This revision considers the belongings of Tartrazine and black seed nanoparticles on body mass and cardiac histology in male albino mice. Group of male mice were separated into 4 clusters: a regulator cluster getting physiological saline, other cluster preserved with Tartrazine (20 mg/kg), another cluster getting equally Tartrazine with N. sativa nanoparticles (100 mg/kg), while last cluster preserved solely besides to N. sativa nanoparticles (100 mg/kg). The assumptions confirmed an important escalation in body mass in the Tartrazine cluster associated with the regulator, portentous that Tartrazine could inspire metabolic lanes. Co-administration of N. sativa nanoparticles with Tartrazine occasioned in a straight more proliferation in body mass, representing a potential synergistic consequence. However, N. sativa nanoparticles on their own showed no notable effect on body weight. Histological analysis of cardiac tissues revealed no structural alterations across all treatment groups, suggesting that the administered doses did not cause cardiotoxic effects. These fallouts propose that although Tartrazine significantly disturbs body mass, it does not alter cardiac histology below the disorders calculated., The revision targeted to reveal the bearing of lately synthesized nanoparticles on hemolytic anemia finished the behind specific intentions: Synthesis of iron nanoparticles., Planning of N. sativa quotation nanoparticles at capricious meditations., Analysis of the possessions of N. sativa seed nanoparticles on minor intestine healthiness.

Keywords

References (20)

  1. Kumar R, DuMond JF, Khan SH, Thompson EB, He Y, Burg MB, et al. NFAT5, which protects against hypertonicity, is activated by that stress via structuring of its intrinsically disordered domain. Proceedings of the National Academy of Sciences. 2020;117(33):20292-20297. doi:10.1073/pnas.1911680117
  2. Essawy A, Matar S, Mohamed N, Abdel-Wahab W, Abdou H. Ginkgo biloba extract protects against tartrazine-induced testicular toxicity in rats: involvement of antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. Environmental Science and Pollution Research. 2024;31(10):15065-15077. doi:10.1007/s11356-024-32047-0
  3. Al Asoom LI. Is Nigella sativa an Effective Bodyweight Lowering Agent and a Mitigator of Obesity Risk? A Literature Review. Vascular Health and Risk Management. 2022;Volume18:495-505. doi:10.2147/vhrm.s373702
  4. Kabir Y, Akasaka-Hashimoto Y, Kubota K, Komai M. Volatile compounds of black cumin (Nigella sativa) seeds cultivated in Bangladesh and India. Heliyon. 2020;6(10):e05343. doi:10.1016/j.
  5. Al Ardhil JAM, Aziz Alshemkhi MA. The histological structure of thyroid gland and the relationship between the hyperthyroidism and total protein, albumin, globulin, liver enzymes and some minerals deficiency. Int J Pharmtech Res. 2016;9(8):189–196.
  6. Sensoy I. A review on the food digestion in the digestive tract and the used in vitro models. Current Research in Food Science. 2021;4:308-319. doi:10.1016/j.crfs.2021.04.004
  7. Rawan Hasan Abdul Aal, Siham Jasem Alkaabi. Inhibition activity of silver nanoparticles (AgNPs) biosynthesized by Ziziphus spina-christi leaf extract against local pathogenic bacterial isolates. Al-Harf Journal. 2024;22.
  8. Gieryńska M, Szulc-Dąbrowska L, Struzik J, Mielcarska MB, Gregorczyk-Zboroch KP. Integrity of the intestinal barrier: The involvement of epithelial cells and microbiota—a mutual relationship. Animals. 2022;12(2):145.‏
  9. Kastl AJ, Terry NA, Wu GD, Albenberg LG. The Structure and Function of the Human Small Intestinal Microbiota: Current Understanding and Future Directions. Cellular and Molecular Gastroenterology and Hepatology. 2020;9(1):33-45. doi:10.1016/j.jcmgh.2019.07.006
  10. Bernal A, Zafra MA, Simón MJ, Mahía J. Sodium Homeostasis, a Balance Necessary for Life. Nutrients. 2023;15(2):395. doi:10.3390/nu15020395
  11. Madhavan Unny N, Zarina A, Beena V. Fluid and Electrolyte Balance. In: Textbook of Veterinary Physiology. Singapore: Springer Nature Singapore; 2023. pp. 193–211.
  12. Mushattat SJ, Alaridi JA. Effect addition of the extract Nigella sativa on the histological and physiological changes of the domestic chicken experimental infected with Eimeria maxima. J Pharm Sci Res. 2018;10(8):1934–1938.
  13. Bankir L, Crambert G, Vargas-Poussou R. The SLC6A18 Transporter Is Most Likely a Na-Dependent Glycine/Urea Antiporter Responsible for Urea Secretion in the Proximal Straight Tubule: Influence of This Urea Secretion on Glomerular Filtration Rate. Nephron. 2024:1-27. doi:10.1159/000539602
  14. Abbood D, Mohammed Z, عنوز دصباح عباس. Silver biosynthesis, characterization, antioxidant, and antihemolysis activity of nanoparticles (AgNPs) produced using Cynophyta alga extract (Spirulina platensis). Al-Harf Journal. 2023;19.
  15. Amchova P, Siska F, Ruda-Kucerova J. Safety of tartrazine in the food industry and potential protective factors. Heliyon. 2024;10(18):e38111. doi:10.1016/j.heliyon.2024.e38111
  16. Ravichandran G, Lakshmanan DK, Arunachalam A, Thilagar S. Food obesogens as emerging metabolic disruptors; A toxicological insight. The Journal of Steroid Biochemistry and Molecular Biology. 2022;217:106042. doi:10.1016/j.jsbmb.2021.106042
  17. Ethaeb AM, Al-Shaeli SJJ, Ahmed TH. Histopathological and Hormonal Evaluation of Interaction effects of Ethidium Bromide, Nigella sativa, and Silver Nanoparticle on Male Rat Fertility. Research Journal of Pharmacy and Technology. 2021:3184-3190. doi:10.52711/0974-360x.2021.00555
  18. Liu H, Dong X, Tan B, Du T, Zhang S, Yang Y, et al. Effects of fish meal replacement by low‐gossypol cottonseed meal on growth performance, digestive enzyme activity, intestine histology and inflammatory gene expression of silver sillago ( Sillago sihama Forsskál) (1775). Aquaculture Nutrition. 2020;26(5):1724-1735. doi:10.1111/anu.13123
  19. Wu L, Lv X, Zhang Y, Xin Q, Zou Y, Li X. Tartrazine exposure results in histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in juvenile crucian carp (Carassius carassius). Aquatic Toxicology. 2021;241:105998. doi:10.1016/j.aquatox.2021.105998
  20. Elekima I, Horsfall OL, Adimefe IG, Ayaugbokor SI, Waribo HA, Nwachuku EON. Assessment of Ovarian Integrity, Reproductive Hormones, and Oxidative Stress in Albino Rats Exposed to Tartrazine Azo Dye. Asian Journal of Biochemistry, Genetics and Molecular Biology. 2020:9-19. doi:10.9734/ajbgmb/2020/v5i430136
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