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185 articles for “immune T cells”
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Clinical Significance of Immune Cells and T-cell Subsets in Lung Cancer
Abstract: Objectives: The aim of the study was to determine the clinical usefulness of pretreatment hematological parameters including neutrophils, lymphocytes, monocytes and immune T-cell subsets as well as calculated coefficients such as neutrophils-to-lymphocytes ratio(NLR),monocytes-to-lymphocytes ratio(MLR) and platelets-to-lymphocyte ratio(PLR)in patients with lung cancer. Materials and Methods: A total of 102 patients with lung cancer were prospectively analyzed. T-cell subsets were assessed by flow cytometry method. Peripheral blood was collected from 25 healthy …
Published in Research and Reviews : A Journal of Immunology · Vol. 9, Issue 2, 2019 · pp. 14–29 Read article
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Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature
Abstract: Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 7–26 Read article
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Immunology and Immunotherapy of Pulmonary adenocarcinoma: A Systematic Review
Abstract: Lung cancer is the world's second leading cause of death, with an estimated 9.6 million deaths in 2018. Approximately 80% of all lung cancer is caused by non-small cell lung cancer (NSCLC). Due to lack of early detection and treatment, the incidence rate of lung cancer prognosis remains low. CD4+T-lymphocytes, macrophages, dendritic cells, and natural killer cells are among the immune cells involved in the pathogenesis of lung cancer. The …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 2, 2022 · pp. 15–25 Read article
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An Overview of the Human Immune Response
Abstract: This overview of the immune response provides a glimpse of the complexity of the interactions between the cells and mediators of the immune system. The recognition of the innate immune response by microbes and foreign substances leads to the induction of inflammatory and adaptive immune response. when oxidative stress increases, it affects our vital processes such as glucose homeostasis, cellular life-span and inflammation, which contributes to the pathogenesis of many …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 2, 2021 · pp. 46–62 Read article
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Cell Membrane Immunogens of a Biofilm-producing Staphylococcus aureus Isolate Adjuvanted with Bacterial Chromosomal DNA Are Protective in a Mouse Mastitis Model
Abstract: Biofilm-forming staphylococci have been implicated in persistent bovine udder infections. Prophylactic potential of Staphylococcus aureus biofilm phenotype-associated immunogens in mouse models of systemic, but not intramammary infections has been demonstrated. In the present study, the authors observed protection in a murine model of intramammary infection by two subcutaneous injections at four-week interval of biofilm-forming S. aureus cell membrane antigens mixed with homologous chromosomal DNA as adjuvant, when challenged after eight …
Published in Research and Reviews : A Journal of Immunology · Vol. 3, Issue 3, 2013 · pp. 18–24 Read article
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Immunologic Characteristics of Apparently Healthy Nigerians Exhibiting Abnormal SPE: A Preliminary Study
Abstract: Abnormal serum protein electrophoresis patterns have been discovered in apparently healthy Africans in Britain and Ghanaians living in Accra, Ghana. Conflicting reasons were suggested for this phenomenon. The aim of present study was to determine the prevalence and characteristics of serum protein electrophoresis (SPE) abnormalities in apparently healthy Nigerians living in Ogbomoso. Three hundred (300) apparently healthy subjects aged 20–30 years were selected for the study. SPE was performed on …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 3, 2015 · pp. 1–6 Read article
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An Ayurveda Management of High Level of Fecal Calprotectin – A Single Case Study
Abstract: Calprotectin is protein found in leucocytes. Calprotectin plays a crucial role in various physiological processes, including cell differentiation, immune modulation, tumor development, programmed cell death, and inflammatory responses. Gut inflammation due to various cause like genetic inheritance, changes in microbiota within intestine, defective immune regulation. Also, some infective such as salmonella, E. coli, Cytomegalovirus, Amoebiasis etc., and Non-infective such as Ischaemic colitis, Non-steroidal anti-inflammatory drugs, Colonic carcinoma etc., can mimic …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 11, Issue 3, 2024 · pp. 19–25 Read article
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Nano-Materials in Vaccine Formation and Chemical Formulae’s for Vaccination
Abstract: For centuries, vaccines have been a cornerstone of public health, preventing debilitating and deadly diseases. However, the development and delivery of effective vaccines have always been met with challenges. From stability issues and limited immune response to the need for specific targeting, scientists are constantly seeking innovative approaches to improve vaccine efficacy and accessibility. Enter nanomaterials – minuscule materials with dimensions at the nanoscale – offering a powerful toolkit to …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 15, Issue 3, 2025 · pp. 27–39 Read article
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Immunological Biomarkers and Epidemiological Evaluation of Lymphatic Filariasis Elimination Efforts in Osun State, Nigeria
Abstract: Lymphatic filariasis (LF) remains a neglected tropical disease affecting millions globally, despite extensive elimination efforts. While the interruption of transmission is a key goal, the long-term immunological effects on individuals with existing complications like elephantiasis remain poorly understood. This study assessed the current transmission status of LF and the haematological profiles of infected individuals across selected Local Government Areas (LGAs) in Osun State, Nigeria. A total of 7,388 individuals from …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 22–30 Read article
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Current Tumour Immunotherapy strategies and their molecular basis
Abstract: AbstractStudying cancer and devising techniques to combat the deadly disease has witnessed a paradigm shift, from conventional toxic treatments of radiation and chemotherapy, to a more specific, and biologically significant immunotherapy and molecular targeted therapy. This can be seen in the global immunotherapy market, which is dominated by North America region valued about $45.9 billion in 2017 that is estimated to reach about $115.9 billion by 2025, and is closely …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 1–18 Read article
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Mucosal Defense Mechanism in Fish: An Overview
Abstract: Mucosal surfaces are important physical barriers whose main function is to protect the systemic environment of the body against microbial invasion. It is the first line of defense to protect the animal and also functioning as an active immune tissue. Four mucosal-associated lymphoid tissues (MALTs), which start the immune responses are skin, gills, gut, and nose, have been reported in fish. Humoral and cellular immunity, their regulation and the factors …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 3, 2017 · pp. 1–5 Read article
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Mathematical Modeling of Tumor Growth and Immune System Interaction Incorporating Time Delays and Suppression Effects for Tumor Control
Abstract: Cancer growth is a complex biological process influenced by various factors, including the dynamic interaction between tumor cells and the host immune system. Mathematical modeling serves as a powerful tool to understand these interactions and predict the outcomes of different therapeutic strategies. This study presents a mathematical framework that captures the essential dynamics of tumor-immune interactions, specifically incorporating the effects of time delay and immune suppression mechanisms. Time delay accounts …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 3, 2025 · pp. 25–34 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Biopolymer-Based 3D Composite Scaffolds for Bone Tissue Engineering: Photothermal-Responsive Systems with Controlled Pt (IV) Prodrug Release
Abstract: Biopolymer-based composite scaffolds have attracted significant attention as multifunctional platforms at the intersection of polymer science, regenerative medicine, and cancer nanotherapy. In this study, a dual-functional scaffold was developed for simultaneous osteosarcoma treatment and bone regeneration using poly (L-lactic acid) (PLLA) reinforced with bioactive glass (BG) and integrated with a glutathione-responsive platinum (IV) prodrug system (PDA@Pt). To improve interfacial adhesion, photothermal conversion efficiency, and tumor-specific activation, the Pt (IV) prodrug …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 351–361 Read article
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Recent Advancement in Understanding the Aetiopathogenesis of Psoriasis: A Review
Abstract: Psoriasis is an immune-mediated inflammatory skin disease with periods of recurrence and remission. Various researches have globally explored the aetiopathogenesis of psoriasis but still it is not crystal clear. Abundant evidence suggest that dysregulation of immune cells in the skin, particularly keratinocytes, T cells, dendritic cells, natural killer cells, neutrophils, and macrophages play a vital role in the development of psoriasis. The combined effects of these cells explain most of …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 9–21 Read article
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Expression Profiling of Immunomodulatory Genes in Canine Adipose Tissue–Derived Mesenchymal Stem Cells
Abstract: Adipose tissue–derived mesenchymal stem cells (AT-MSC) represent a heterogeneous population of self-renewing, multipotent progenitor cells residing in the stromal compartment of adipose tissue. Canine adipose tissue-derived mesenchymal stem cells have attracted significant interest in regenerative medicine due to their therapeutic potential in naturally occurring canine diseases and their translational relevance to human medicine. In the present study, canine adipose tissue–derived MSCs (cAT-MSCs) were isolated and differentiated into osteogenic, chondrogenic and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 Read article
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Decoding Innate Immunity: Mechanisms, Components, and Clinical Implication
Abstract: Innate immunology represents the body's first line of defense against pathogens, acting as a rapid, non-specific response to a wide array of microbial invaders. This part of the immune system depends on pattern recognition receptors (PRRs) to identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), leading to the activation of immune cells such as macrophages, dendritic cells, and neutrophils. The innate immune system also plays a crucial role …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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Gossypetin Inhibits ROS Generation in HeLa and HepG2 Cell Lines
Abstract: Antioxidants are known for their ability to neutralize the reactive oxygen species present within the living system. These antioxidants are mainly secondary metabolites present in plant products and are generally known as nutraceuticals or bioactive compounds. Antioxidant can be categorized into many categories based upon their structure and activities like flavonoids, anthrocyanins and carotenoids. Flavonoids are heterogeneous polyphenolic compounds having beneficiary effect on human body and are also known to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 1, 2017 · pp. 25–31 Read article
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Anthrax Toxin Time-Resolved Absorption and Resonance FT-IR and Raman Biospectroscopy and Density Functional Theory (DFT) Investigation of Vibronic-Mode Coupling Structure in Vibrational Spectra Analysis
Abstract: Anthrax toxin is a three-protein exotoxin that is secreted by the bacterium's virulent strains, the anthrax causative agent Bacillus anthracis. Harry Smith first found the toxin in 1954. Anthrax toxin consists of a protein called a protective antigen (PA) binding cell protein and two enzyme parts called an edema factor (EF) and a deadly factor (LF). These three protein components act together to impart their physiological effects. Assembled complexes containing …
Published in Research and Reviews : Journal of Computational Biology · Vol. 8, Issue 2, 2019 · pp. 23–51 Read article