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30 articles for “cell line studies”
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Iota carrageenan, a Sustainable polymer transformed into a nanogel formulation, by using environment friendly method for antitumor action
Abstract: In the pharmaceutical field, the utilization of polymers, both in their natural form and through chemical modifications, holds immense importance. In this context, a novel and eco-friendly method for the synthesis of nano carrageenan-based polymers has been developed. The efficacy of carrageenan in this domain is attributed to its crosslinking and biological properties, which are largely influenced by its sulfate ion content. This study aims to formulate nanogels via a …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 881–889 Read article
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Phytochemical Screening and Biological Activity of Pomegranate Extracts
Abstract: Pomegranates are renowned for their abundance of bioactive compounds that exhibit potent antioxidant, anti-inflammatory, and antimicrobial properties, making them a subject of growing interest in natural medicine. This study aimed to compare the biological activities of ethanolic extracts derived from different parts of the pomegranate plant—specifically, the bark, peel, and leaves. A comprehensive investigation was conducted to evaluate their phytochemical composition and assess their antimicrobial, antioxidant, and anticancer properties. The …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 64–79 Read article
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Comparative Proteomics: From Cell Lines to Clinical Samples
Abstract: Comparative proteomics is a powerful tool for understanding the molecular differences between various biological samples. It entails identifying and measuring proteins in complex biological samples to assess their abundance, modifications, and interactions under various conditions. This approach plays a crucial role in advancing biomedical research, especially in disease understanding, biomarker discovery, and therapeutic development. While cell lines are widely used for proteomic studies due to their controlled environments and reproducibility, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 30–34 Read article
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Study Review: Molecular Mechanisms of Nanoparticle-Cell Interaction – Implications for Drug Delivery and Toxicity
Abstract: The application of nanoparticles in drug delivery and biomedical therapies holds great promise, yet their interaction with cells and the underlying molecular mechanisms remains areas of active research. This study explores the molecular mechanisms of nanoparticle-cell interactions, focusing on the effects of gold nanoparticles (AuNPs) and silica nanoparticles (SiNPs) in human cancer cell lines (HeLa and MCF-7). The study examines how nanoparticles are internalized by cells, their impact on cellular …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 2, 2025 · pp. 31–40 Read article
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Factors Affecting Shear Stress on Tablet Hardness and Disintegration
Abstract: The quality and effectiveness of pharmaceutical tablets depend heavily on several factors influencing shear stress on tablet hardness and disintegration. These factors include formulation composition, wherein the selection and concentration of excipients and active ingredients affect how the tablet material responds to shear stress. Additionally, the compression force, speed, and duration during tablet compression are critical, impacting tablet hardness and disintegration properties. Tablet geometry and design, along with tablet press …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 1–19 Read article
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Drug Screening Using Stem Cell Technology
Abstract: Stem cell technology in drug screening has transformed the research and development sector of pharmaceuticals. Although stem cells imitate their human counterparts in terms of both safety and potential, it is a new paradigm for mimicking diseases of humans and scale measuring for toxicity. These tissues will, therefore, be more predictive of what will happen in humans during clinical situations, compared to conventional cell lines or animal models, since they …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 3, 2025 · pp. 42–51 Read article
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The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases
Abstract: The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 46–52 Read article
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Practical studies in Vero cell and Human amnion cells for viral and stem cell applications
Abstract: Vero cells are one of the most popular mammalian continuous cells in molecular, cellular, and microbiological research. African green monkey kidneys are used to make these.One continuous cell line is the Vero cell line. This cell line is dependent on anchorage. Vero cells can be cultured in suspension because they are anchorage independent. Thought to be non-tumorigenic cells that came from a female Chlorocebus sabaeus Numerous viruses can infect vero …
Published in International Journal of Vaccines · Vol. 2, Issue 1, 2025 · pp. 1–8 Read article
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An Overview of Artificially Generated Neural Networks Inside the Brain’s Structure in an Alzheimer’s Disease Patient
Abstract: Alzheimer’s disease produces significant neuronal loss, while the precise mechanisms and timing are yet unknown. Other types of cell death, such necroptosis, parthanatosis, ferroptosis, and cuproptosis, need further investigation. Based on brain images of people with mild cognitive impairment, this study assesses artificial neural networks (ANNs) used to diagnose and predict Alzheimer’s disease (AD). This research was conducted considering growing recognition among researchers and medical professionals regarding the importance of …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 2, 2025 Read article
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Comparison of a Human Papillomavirus Test with the Hybrid Capture 2 and a Real-Time PCR Method for 18 High-Risk and Low-Risk Human Papillomavirus Infections in Women
Abstract: Squamous intraepithelial lesions (SILs), which are a kind of cancer, and HUMAN papillomavirus (HPV) viral load have frequently been investigated as a risk factor in findings that were in dispute. These studies made use of several HPV viral quantitation assays [including the commercially available hybrid capture 2 (HC2) assays], which vary in their capacity to consider variations in cervical cell collection, linear dynamic range of viral load quantitation, and identified …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 10–16 Read article
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Expression Profiling of Immunomodulatory Genes in Canine Adipose Tissue–Derived Mesenchymal Stem Cells
Abstract: Adipose tissue–derived mesenchymal stem cells (AT-MSC) represent a heterogeneous population of self-renewing, multipotent progenitor cells residing in the stromal compartment of adipose tissue. Canine adipose tissue-derived mesenchymal stem cells have attracted significant interest in regenerative medicine due to their therapeutic potential in naturally occurring canine diseases and their translational relevance to human medicine. In the present study, canine adipose tissue–derived MSCs (cAT-MSCs) were isolated and differentiated into osteogenic, chondrogenic and …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 15, Issue 1, 2026 Read article
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Integration of Modular Multilevel Converter Topology in the Design and Control of Hybrid Electric Vehicles
Abstract: A back-to-back modular multilevel converter (BMMC) based plug-in hybrid electric vehicle power conversion system is proposed to solve the problems of traditional MMC-EV. The local AC harmonics generated by the operation of MMC-EV accelerate the battery degradation and reduce the battery life. Currently, electric vehicles are in great demand due to the rising oil prices and environmental pollution concerns. Since the backbone of electric vehicles is the energy storage system, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1195–1205 Read article
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Corrosion Testing and Evaluation of Inhibitors Performance
Abstract: Choosing test methods that will analyze specific needs, like film barrier strength that real field settings is essential for the proper evaluation and development of inhibitors. The flowing loop and the bubble test are two examples of the first and second, respectively. Corrosion is measured by gravimetric, electrical noise, alternating-current impedance, potentiodynamic measurement, linear polarization and gravimetric. The inhibitors action can be analyzed in different corrosive environments. Their performance is …
Published in Journal of Materials & Metallurgical Engineering · Vol. 16, Issue 1, 2026 · pp. 82–88 Read article
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Evaluation of Antioxidant and Cytotoxic activities of Mycelia Biomass and Culture broth of three Edible Mushrooms, Morchella conica, Hericium erinaceus and Pleurotus florida Grown in Submerged Culture
Abstract: Mycelia biomass of three edible mushrooms namely, Morchella conica, Pleurotus florida and Hericium erinaceus were grown as submerged culture in potato dextrose broth supplemented with yeast extract, potassium dihydrogen orthophosphate and magnesium sulphate. The mycelia biomass was extracted with 70% ethanol and culture broth with ethyl acetate. The solvents were evaporated to dryness at low temperature using a rotary vacuum evaporator and the residues thus obtained were used for the …
Published in International Journal of Fungi · Vol. 1, Issue 1, 2024 · pp. 37–50 Read article
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Drive Line for Plug-in Electric Vehicle with PMSM Motor and Hydrogen Fuel Cell
Abstract: In the era of transportation, the best effort will be to replace conventional fossil fuels. Instead, the usage of fossil fuels will give way to renewable energy sources and other clean energies. Many institutions promote the developments and research in the area of hydrogen fuel cell development. This paper passes through the hydrogen fuel cell area as the primary source considered here is a hydrogen fuel cell. Since electric motors …
Published in Journal of Nuclear Engineering & Technology · Vol. 14, Issue 1, 2024 · pp. 32–49 Read article
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An Evaluative Comparison of CD123 and CD66c as Biomarkers to Detect Minimal Residual Disease in B-Cell Acute Lymphoblastic Leukemia
Abstract: Background: B-cell Acute Lymphoblastic Leukemia (B-ALL) often shows lineage heterogeneity with lymphoid cells expressing myeloid markers. Minimal Residual Disease (MRD) refers to the small number of cancer cells that may remain in a patient's body after treatment and that are undetectable by standard diagnostic methods. In diseases like B-cell Acute Lymphoblastic Leukemia (B-ALL), MRD is a critical prognostic indicator, as its presence can signal a higher risk of relapse. In …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 7–12 Read article
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Decoding Innate Immunity: Mechanisms, Components, and Clinical Implication
Abstract: Innate immunology represents the body's first line of defense against pathogens, acting as a rapid, non-specific response to a wide array of microbial invaders. This part of the immune system depends on pattern recognition receptors (PRRs) to identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), leading to the activation of immune cells such as macrophages, dendritic cells, and neutrophils. The innate immune system also plays a crucial role …
Published in Research and Reviews : A Journal of Immunology · Vol. 15, Issue 2, 2025 Read article
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Genetic Authentication of Acacia Senegal (L.) Wild
Abstract: A study was carried out to ascertain the taxonomic identity and phylogenetic lineage of three presumed Acacia senegalensis using molecular markers. Three (3) varieties of seeds presumed to belong to Acacia spp. were collected from the Rubber Research Institute of Nigeria (RRIN) Benin City and three BP haplotypes (A, B, and C) was used as control for the analysis. These seeds were processed at the Applied Biotech International Laboratory Nigeria …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 2, 2024 · pp. 33–39 Read article
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Construction and Development of pSB111 Bar Plasmid Vector for Activation Tagging
Abstract: To get desired traits and to know the precise expression patterns of genes in the plant, Agrobacterium tumefaciens has been widely employed in the generation of transgenic plants using plasmid vectors. Many methods are come forward to establish the gene expression of unknown genes but in these techniques gene alteration isthe main drawback orsometimesit islethal to organisms also, to overcome these problems activator tag method developed to know the specific …
Published in Research & Reviews : Journal of Botany Read article
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Preparation, Categorization and Anticancer Study of Novel Bicyclic Compounds from Various Types for (Five and Six)- Membered Ring
Abstract: The characteristics of ring systems change in the presence of functional groups, but in some cases, elements that are considered functional groups can be classified within the same ring. Compounds that contain only carbon and hydrogen are called homogeneous rings, while those that contain other elements are called heterogeneous rings. The atom substituted in place of the carbon atom is referred to as a heteroatom. Generally, the heterocyclic atom is …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 3, 2025 · pp. 18–30 Read article