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22 articles for “acetylation”
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An Efficient Synthesis of Some Novel Benzo Coumarin Derivatives Under Solvent Conditions from 2-acetyl-benzo[f]chromen-3-one
Abstract: The synthesis of the target compounds began with the preparation of 2-[3-dimethylamino[acryloyl-3H-benzo[f]chromen-3-one. This intermediate was obtained through the reaction of 2-acetylbenzo[f]coumarin-3-one with N,N-dimethylformamide dimethyl acetal [DMFDMA[ under reflux conditions in xylene. The enaminone thus formed was subsequently reacted with 6-aminothiouracil in acetic acid, leading to the formation of 2-thioxo-2,3-dihydro-1H-pyrido[2,3-d]pyrimidin-4-one. This compound served as a pivotal intermediate for the synthesis of a series of pyridotriazolopyrimidinones. These derivatives were synthesized by reacting …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 33–46 Read article
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Drugs for Alzheimer’s Disease from Salix Alba Discovered Computationally Utilizing Virtual Screening and Docking against 1b41 Protein
Abstract: Objective : The of this research is to evaluate the feasibility of using molecular docking techniques to identify novel acetylcholinesterase, a key enzyme implicated in the pathogenesis of Alzheimer’s disease, a neurodegenerative disorder with a gradual but steady progression to death, due to the gradual accumulation of beta-plaques and neurofibrillary tangles, as well as a decline in acetylcholine levels. Due to its function in converting acetylcholine into acyl and choline …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 07–19 Read article
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Synthesis, Characterization of New Imidazolidin-4-One Containing Azo Compound Derived from Acetylacetone as Antibacterial and Antioxidant Agents
Abstract: In the present study, new derivatives of imidazolidine-4-one was prepared. Which involved reactions to diazonium salt of o-methoxy aniline with acetylacetone in the presence of sodium hydroxide, and isolating the azo compound as a brown precipitate. The azo diketone reacts efficiently with aromatic amine derivatives to produce Schiff bases as a light yellow and dark brown precipitates, and from this Schiff bases three derivatives of imidazolidine-4-one was prepared by reacting …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 1, 2026 · pp. 94–114 Read article
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Effect of Ply Orientation on Thermal Erosion and Conductivity of Silica Phenolic Composites Under Oxy-Acetylene Flame
Abstract: The thermal and erosion performance of fiber-reinforced composites is highly sensitive to fiber architecture, matrix chemistry, and processing techniques, factors that have shaped development of advanced thermal protection systems (TPS) over past two decades. Silica phenolic (SP) composites, in particular, are widely employed in aerospace and defense applications due to their flame resistance, char stability, and ability to withstand severe thermal shock. However, optimizing thermal conductivity while improving erosion resistance …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 273–283 Read article
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Effect of Chemically Treated Plant Cellulose on Mechanical, Fatigue and Fracture Toughness Behaviour of Polyester Composite
Abstract: In this research study, the effect of chemically treated plant cellulose on the mechanical, fatigue, and fracture toughness behaviour of polyester composites was investigated. Ramie plant cellulose fibers were used as the reinforcing material, and polyester resin was used as the matrix material. Three different chemical treatment processes, namely alkalization, acetylation, and etherification, were used to adapt the superficial chemistry of the fibers and advance their compatibility with the polyester …
Published in Journal of Polymer & Composites · Vol. 11, Issue 3, 2023 · pp. 21–29 Read article
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A Short Review on Long-Term Effects of Botox on Neuronal Sprouting: Mechanisms and Its Clinical Implications
Abstract: Botulinum toxin (Botox) is extensively used for its ability to induce temporary muscle paralysis through inhibition of acetylcholine release at neuromuscular junctions. While its short-term effects are well documented, emerging evidence suggests that chronic use of Botox may trigger neuronal sprouting, a process that could have significant long-term implications. This review synthesizes current research on the mechanisms by which Botox induces nerve sprouting and evaluates the clinical outcomes associated with …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 72–87 Read article
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Chemical Profile and Toxicity of Fresh and Dry leaves of the Essential Oils of Vetiveria zizanioides (L.) Nash. From Southwest Nigeria
Abstract: The fresh and dry leaves of Vetiveria zizanioides (L.) Nash (Gramineae) plant was collected, air dried and authenticated at the University of Ibadan Herbarium with voucher number: UIH-23237. The plant's dried, fresh leaves were hydro distilled in a Clevenger device to extract the essential oils. The oils were characterized by Gas Chromatography-Mass Spectrometry (GC – MS) while the toxicity of the essential oils was tested using brine shrimps’ lethality assay. …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 44–49 Read article
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Impact of Chemical Conditioning on the Mechanical Performance of Pine Fibre-Reinforced Composites
Abstract: The study examines the effects of treatments like alkaline, silane, and acetylation on enhancing the mechanical strength and reducing water absorption in pine fiber-reinforced composites. Natural fibres, while eco-friendly and sustainable, present challenges in fibre-matrix adhesion due to their hydrophilic nature, impacting composite performance. Chemical treatments were employed to modify fibre surface characteristics, enhance interfacial bonding, and thereby improve mechanical properties. Silane-treated composites exhibited the highest tensile and flexural strengths, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 140–150 Read article
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Garcinia cambogia Use of Weight Loss and Hepatotoxicity: A Review
Abstract: A complex disorder of hunger control and energy metabolism driven by certain biological variables is obesity. This study aims to evaluate the applications of Garcinia cambogia products for appetite suppression and fat burning. This little fruit, which looks a lot like a pumpkin, is marketed and used most frequently these days as a weight-loss supplement. Research has demonstrated that the fruit rind's main organic acid component, (−)-hydroxycitric acid (HCA), and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 08–14 Read article
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Reactivity of Monochlorotetrakis2-Isopropylphenoxoniobium(V), [NbCl(OC6H4CH(CH3)2-2)4] towards Chelating Ligands
Abstract: The niobium(V) complexes with the formula [NbCl(OC₆H₄CH(CH₃)₂-2)₄] were successfully synthesized in high yields through the reaction of niobium pentachloride with four equivalent amounts of 2-isopropylphenol in carbon tetrachloride. The synthesized complexes were characterized and confirmed by elemental analysis, molar conductance measurements, infrared (IR) spectroscopy, ^1H and ^13C NMR spectroscopy, as well as mass spectrometric analysis. The spectroscopic studies have shown these to exhibit dimeric structures bridging through isopropylphenoxo groups. The …
Published in International Journal of Minerals · Vol. 3, Issue 1, 2026 · pp. 37–45 Read article
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An Integrated Study to Extrapolate the Interaction of NMDAR with Potential Ligands for the Treatment of Alzheimer’s Disease Symptoms
Abstract: Objective: Alzheimer’s disease (AD) is the most common neurodegenerative disease affecting the health status of older adults especially those above the age of 60 years. As an outcome, two types of medications have been developed for the treatment of its symptoms which are acetylcholinesterase (AChE) and N-methyl-D-aspartate receptor (NMDAR) antagonist. This paper uses the computational approach to understand the interaction of NMDAR with four major phytocompounds (curcumin, L-epicatechin, ginsenosides, and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 1, 2023 · pp. 15–27 Read article
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Multiple Sclerosis: A Brief Overview of the Disease, Its Pharmacotherapy
Abstract: Multiple Sclerosis is an autoimmune disorder mostly affecting individuals aged between 20-40. In this disorder, the optic, vertebral, and central nervous system nerves are primarily impacted. It is a neurological condition that worsens over time and is characterized by inflammation and the breakdown of the sheath that surrounds and shields the nerve fiber. Common symptoms may include muscle weakness, numbness, tingling, fatigue, vertigo, tremor, vision complications, pain, Lhermitte sign, sexual …
Published in International Journal of Brain Sciences · Vol. 1, Issue 1, 2024 · pp. 13–18 Read article
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Phytochemical Profile & Therapeutic Potential of Clematis Terniflora: A Comprehensive Review
Abstract: Clematis terniflora is a plant comes under the family Ranunculaceae, which is folk medicinal plant which is found widely in China, according to the Chinese medical system, Clematis terniflora is a widely distributed folk remedy that is used to cure rheumatoid arthritis, asthma, syphilis, gout, malaria, dysentery and used as analgesic, antitumor, anti-inflammatory, diuretic, antibacterial, antioxidants and anti-inflammatory etc. It is distributed around the world like China, Japan, Korea, Mongolia, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 11, Issue 2, 2024 · pp. 16–24 Read article
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Risk Assessment of Batch Sulfonation Process using Fault Tree and Bowtie
Abstract: The current study looks into the batch reactor's sulfonation reaction's safety features. Acetanilide, thionyl chloride, and chlorosulphonic acid are used in the sulfonation reaction under consideration to generate acetyl sulphonyl chloride as well as by-products such HCl and SOx. Steam starts the process, which is exothermic in nature. Water is then chilled to maintain a temperature of 50°C and a pressure of one atmosphere. The Hazard and Operability (HAZOP) analysis …
Published in Emerging Trends in Chemical Engineering · Vol. 11, Issue 3, 2024 · pp. 50–56 Read article
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Role of Centella asiatica in Alzheimer’s Disease: A Comprehensive Review
Abstract: Alzheimer's disease (AD) is a progressive neurological illness that causes cognitive decline and memory loss and affects millions of people worldwide. As synthetic medications often prove ineffective or cause severe side effects, natural remedies are gaining attention. This review explores the potential of Centella asiatica, a herb traditionally used in oriental medicine, in the treatment of Alzheimer's disease. Triterpenoids, asiaticoside, and madecassoside are among the bioactive substances found in Centella …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 1–7 Read article
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Treatment of Hepatotoxicity
Abstract: An instantaneous or prolonged response to a synthetic or natural substance is known as drug-induced liver injury, or drug-induced hepatotoxicity (DILI). There are two distinct pathways that lead to hepatotoxicity: the more unpredictable idiosyncratic mechanism and the dose-dependent intrinsic mechanism. Several pathways, some known and others speculated, may be involved in the emergence of drug-induced damage. Drug-induced liver impairment can have several causes, and elevated liver tests are one of …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 1, 2025 · pp. 31–37 Read article
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Samelisant, an H3 Receptor Agonist as an Anti-Alzheimer Potential – A Pilot Study on Molecular Docking
Abstract: Neurodegenerative diseases have become more prevalent and about 55 million of the population are affected by dementia globally. One of the most important neurodegenerative diseases is Alzheimer’s disease which is known for its effect on memory and cognitive impairment. Alzheimer’s disease (AD) is an area of intense scientific investigation due to its high prevalence and the lack of a definitive cure. Amyloid precursor protein plays a central role in Alzheimer’s …
Published in International Journal of Brain Sciences · Vol. 3, Issue 1, 2026 · pp. 15–26 Read article
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Exploring Chicken Sternal Cartilage as an Alternative Source of Bioactive Protein Hydrolysates
Abstract: There is a growing concern on the correct use and dispose of the by-products of the food industry, and chicken slaughterhouse, such as cartilage, combs, and wattles may be strong candidates as a protein source for bioactive peptides, however it is crucial to understand how the proteolysis process may affect the peptide profile and their bioactivity. The objective of this work was to obtain protein hydrolysates from chicken sternal cartilage …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 14, Issue 3, 2025 · pp. 15–28 Read article
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Drug-Induced Liver Injury: Hepatotoxicity and Treatment - A Literature Review
Abstract: Drug-induced liver injury (DILI) is a major clinical and regulatory challenge, posing risks to patient safety and drug development worldwide. As the primary organ responsible for xenobiotic metabolism, the liver is particularly susceptible to toxic injury from prescription drugs, over-the-counter medications, herbal products, and dietary supplements. Drug-induced liver injury (DILI) accounts for a substantial proportion of acute liver failure cases and remains a leading cause of post-marketing drug withdrawal. Its …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 1, 2026 · pp. 1–17 Read article