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26 articles for “Replication mechanism”
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Viral Chronicles: The Ever-Evolving Saga of COVID-19
Abstract: Coronaviruses, belonging to the family of RNA viruses, have recently captured global attention owing to their remarkable ability to infect a diverse array of species, ranging from animals to humans. These viral agents, recognized by their characteristic crown-like morphology when observed through electron microscopy, have a historical association with zoonotic diseases. Previous examples include Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The term "Corona" …
Published in International Journal of Virus Studies · Vol. 1, Issue 1, 2024 · pp. 16–25 Read article
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Identifying Origin of Replication (ORI) sites in genomic sequence using Python-based programming and Motif analysis in Bioinformatics
Abstract: ORI sites serve a critical function in DNA replication serving as the beginning point of the process. Identifying the spots appropriately means a lot and is important for the biologists working in the lab. Detecting the ORI is not only vital for the detection of replication sites but is also important in numerous biological processes. In this study, we offer a unique approach employing Python-based motif analysis to discover the …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 3, 2024 · pp. 22–33 Read article
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Polymer Chemistry-Guided Development of Biomimetic Composite Scaffolds
Abstract: Polymer chemistry plays a fundamental role in advancing biomaterials for anatomical tissue engineering, particularly in the design of composite scaffolds that replicate the intrinsic characteristics of native tissues. The regeneration of damaged tissues, especially within anatomically complex structures such as bone, cartilage, and skin, necessitates biomaterials that closely emulate the hierarchical architecture and biological functions of native extracellular matrices (ECMs). The capacity to replicate both mechanical and biochemical cues of …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 7–13 Read article
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Computational Identification of Antigenic Proteins and Epitopes in Hantavirus sp. for Drug Repurposing
Abstract: Hantavirus is an emerging virus that spreads from animals to humans and can cause serious illnesses like hantavirus pulmonary syndrome (HPS) and hemorrhagic fever with renal syndrome (HFRS). there are no FDA-approved treatments available for these diseases. This study explores in-silico drug repurposing as a strategy to identify potential therapeutic candidates. The physicochemical, secondary structure, antigenicity, and post-translational modification analysis of hantavirus proteins – specifically the glycoprotein precursor, N protein, …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 20–26 Read article
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Development of a Novel Therapeutic Approach Using RNA Interference for Targeting Viral Genes
Abstract: RNA interference (RNAi) is a ground breaking therapeutic strategy that holds immense promise for targeting viral genes in the treatment of viral infections. This approach leverages the natural gene-silencing mechanisms of RNAi to inhibit viral replication and expression at the molecular level, providing a precise and adaptable method to counteract viral pathogens, including influenza, HIV, and hepatitis viruses. Recent advancements in RNAi technology have enabled the development of highly specific …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 12–22 Read article
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Integrated Analysis of Stress Patterns in Transparent Polycarbonate Specimens: A Comparative Study between Photoelasticity and FEA Simulation for Compact Circular Testing
Abstract: Photoelasticity stands as a robust experimental technique within the realms of mechanics and materials science, offering a means to visually assess and analyze stress distribution within materials possessing transparency or translucency. This method, a non-destructive testing approach, involves the visualization of stress on a model subjected to a load, leveraging the unique property of materials known as birefringence or double refraction. The procedure entails the careful selection of a suitable …
Published in Journal of Polymer & Composites · Vol. 12, Issue 4, 2024 · pp. 79–87 Read article
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The Role of Natural Products in Antiviral Drug Discovery: Insights into Mechanisms and Therapeutic Potential
Abstract: Drug discovery has always relied heavily on natural sources, especially when it comes to creating antiviral medications. This review explores the therapeutic potential of various natural products, including plant extracts, marine compounds, and microbial metabolites, in the fight against viral infections. We examine the mechanisms of action by which these natural compounds exert their antiviral effects, including direct inhibition of viral replication, modulation of host immune responses, and interference with …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 36–47 Read article
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Enhancing Mechanical Properties by Parameter Optimization in Fiber and Particle Reinforced Composites
Abstract: This research focuses on optimizing the mechanical and thermal properties of hybrid fiber and particle-reinforced composites through systematic parameter optimization using the Taguchi method and Grey Relational Analysis (GRA). Composites were fabricated using varying fiber volume fractions (20%, 30%, and 40%), particle sizes (20 μm, 60 μm, and 100 μm), and curing temperatures (60°C, 80°C, and 100°C) in a 3-factor, 3-level experimental design. Key properties such as tensile strength, impact …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 75–85 Read article
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A Study on Precision Blood Propulsion in Motor-Driven Artificial Hearts
Abstract: The development of biocompatible, energy-efficient pumping mechanisms is pivotal for advancing artificial heart (AH) technology. This study explores a motor-driven centrifugal pump designed to replicate the physiological dynamics of natural ventricles while mitigating complications associated with conventional axial and pulsatile systems. The proposed system employs a brushless DC motor with closed-loop control, integrated with pressure and flow sensors to modulate rotational speed (RPM) and generate biomimetic cardiac output. The suggested …
Published in Trends in Electrical Engineering · Vol. 16, Issue 1, 2025 · pp. 53–59 Read article
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Innovative Approaches to Water Conservation in India: State-wise Case Studies
Abstract: India, a water-stressed country, faces significant challenges in managing its water resources. In response, various states in India have adopted innovative approaches to water conservation. This case study showcases state-wise initiatives, highlighting successes, challenges, and best practices. The study covers eight states: Rajasthan (Jal Bhagirathi Foundation's water harvesting structures), Gujarat (Check Dam initiative), Maharashtra (Jalyukt Shivar Abhiyan's watershed development), Karnataka (Malaprabha Reservoir rejuvenation), Tamil Nadu (Tamil Nadu Water Investment Company's …
Published in Journal of Water Resource Engineering and Management · Vol. 13, Issue 1, 2026 · pp. 6–12 Read article
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Sensors based Human Visual System: e-Retina
Abstract: This study explores the potential of bio-inspired sensor design to replicate the adaptive and highly efficient nature of the human visual system and e-retina. This study presents a novel sensor array incorporating foveated vision principles and dynamic range adaptation mechanisms. Our study demonstrates the improved performance of this system in complex visual scenes, particularly in low illumination and high-contrast scenarios. This study highlights the advantages of mimicking biological principles in …
Published in Trends in Opto-electro & Optical Communication · Vol. 15, Issue 1, 2025 · pp. 14–22 Read article
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A Comprehensive Study of Quantum Cryptography
Abstract: Quantum cryptography has emerged as one of the most promising fields in modern information security, offering innovative solutions that have the potential to transform the future of global cyber-defense. Unlike classical cryptographic systems, which depend primarily on the computational difficulty of solving complex mathematical problems, quantum cryptography is grounded in the fundamental and unbreakable laws of quantum mechanics. Core principles such as superposition, entanglement, and the uncertainty principle form the …
Published in Journal of Advanced Database Management & Systems · Vol. 12, Issue 3, 2025 · pp. 12–26 Read article
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Polymer-Inspired Underwater Friction Stir Welding of Aluminum–Copper Composite Joints
Abstract: The problem of high-performance dissimilar joints and their compatibility with polymer and composite engineering applications is the impetus to the current work. This paper seeks to investigate the possibility of applying the polymer-based composite ideas with underwater friction stir welding (UWFSW) to improve the performance of AA5083 aluminumcopper joints. To achieve this a systematic experimental method was followed by varying the tool rotational speed, traverse speed and tilt angle and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 372–383 Read article
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ISGylation: A Key Host Cellular Defense Mechanism
Abstract: ISGylation, a crucial process of the innate immune response, has garnered increasing attention for its involvement in host's defense against pathogenic infections as well in cancer progression. The key player of ISGylation, ISG15, is stimulated by type I interferons (IFNs). ISG15 covalently binds with viral (influenza NS1A and nucleoproteins) and host (Nedd4, filamin B and CHMP5) target proteins and this interaction inhibits the viral replication process and release of viral …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 14, Issue 2, 2024 · pp. 68–80 Read article
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Electrospun Nanofibers for Biomedical and Pharmacological Applications
Abstract: In biological and pharmaceutical sectors, nanofibers which have unique properties including a lot of surface area, tunable porosity, and high mechanical strength are very fascinating and may be made flexibly and effectively by electrospinning. More and more in biosensors, tissue engineering, drug delivery, wound healing, and medication delivery are these electrospun nanofibers being used. They may fundamentally alter the way healthcare is administered. Advanced medical applications benefit from fibres' ability …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 375–387 Read article
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Zebra Fish Embryo Assay: A Wonderful Tool for Ecotoxicological Risk Assessment with Special Reference to Heavy Metals - An Overview
Abstract: In recent years, environmental pollution has become a pressing concern, prompting extensive research in aquatic ecotoxicology. With environmental degradation getting worse day by day, ecotoxicology research has gained a lot of attention. This area of study examines how biological communities in aquatic environments are affected by environmental contaminants. To unravel the toxicological mechanisms of these exogenous compounds, scientists turn to biological models. Several aquatic species, including zebrafish, toads, and big …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 2, 2025 · pp. 56–70 Read article
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Computational Simulations in Drug Discovery: Modeling Protein Folding and Drug Binding
Abstract: Computational simulations have become essential tools in drug discovery, offering unprecedented insights into molecular behavior at the atomic level. These simulations, particularly in the domains of protein folding and drug binding, allow for the exploration of complex biological systems that are often difficult to study experimentally. Protein folding, a critical aspect of drug discovery, involves the transition of a polypeptide chain from an unfolded to a biologically active structure. Understanding …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 1, 2025 · pp. 23–29 Read article
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Harnessing Bacteria for Next-Generation Data Storage Technologies – A Review
Abstract: The exponential increase in global digital information has created a pressing need for storage technologies that are more durable, compact, and sustainable than conventional electronic media. While hard drives, solid-state drives, and cloud-based systems have transformed information management, they face severe limitations related to storage density, energy consumption, maintenance costs, and long-term preservation. Researchers have, therefore, begun exploring biological systems as alternative information storage platforms. Among these, bacteria have emerged …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Biomedical Coatings: Surface Engineering for Enhanced Biocompatibility and Performance
Abstract: Biomedical coatings have become essential in modern healthcare, significantly improving the performance, durability, and biocompatibility of medical implants and devices. These coatings serve multiple functions, including reducing infection risks, enhancing osseointegration, promoting tissue integration, and enabling localized drug delivery. Advances in surface engineering have led to the development of innovative coatings with superior properties such as antimicrobial resistance, bioactivity, and controlled biodegradation. Various materials are employed in biomedical coatings, including …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 1, 2025 · pp. 8–15 Read article
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Hydrological Modeling and Classification of Various Models: A Review
Abstract: Hydrology is the science which deals with the existence, movement and distribution of water of the earth, below the earth and earth’s atmosphere. As one of the branches of earth science, hydrology deals with the water in waterways and lakes, precipitation and snow, snow on the terrestrial and water underneath the earth and rocks. Hydrology has its links with meteorology, geography, measurements, science, material science and liquid mechanics. Engineers and …
Published in Journal of Water Resource Engineering and Management · Vol. 13, Issue 1, 2026 · pp. 1–5 Read article