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52 articles for “Multi-drug Resistance.”
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Evaluating the Role of Pharmacists in Managing Antibiotic Use and Combating Multi-Drug Resistance in Hospital Settings
Abstract: Antibiotic resistance is now one of the crucial health issues of the world, especially in hospitals where high usage of antimicrobials is increasing the rate at which multi-drug resistant (MDR) organisms appear. Misprescription, extended treatment, and over-use of broad spectrum antibiotics play a large role in the development of resistance resulting in the growth of morbidity, mortality and health care expenditure. This review analyses the essentiality of pharmacists in controlling …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 12–19 Read article
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Antibiotic Resistance in the Bacterial Isolates of Bengaluru Lakes
Abstract: Increased urbanization in Bengaluru has resulted in excessive drainage of antibiotic-resistant bacteria into its pristine lakes via sewage and seepage. This pollution of the resistant bacteria is a direct result of the unregulated use and abuse of antibiotics which has only increased over the years and become a global health threat. Regarding this issue, we conducted a study to confirm the presence of antibiotic-resistant bacteria in Bengaluru lakes. For this, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 3, 2023 · pp. 22–28 Read article
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A Pilot Study on β-lactamase Producing Escherichia coli from Bovine Milk, West Bengal
Abstract: Drug resistant bacteria have become a significant global healthcare issue that requires close attention. With regards to antibiotic resistance, E.coli and its Enterobacteriaceae family are highly notorious for their ability to swiftly spread antibiotic resistance genes, thereby posing a major concern. In order to effectively address the spread of multi drug resistant bacteria, ongoing monitoring of the microflora in milk for the presence of drug resistant genes is essential. This …
Published in International Journal of Toxins and Toxics · Vol. 1, Issue 1, 2024 · pp. 01–05 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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First Insights into Whole Genome Sequencing of the Mycobacterium tuberculosis Complex: Molecular Diversity and Drug Susceptibility Patterns in Senegal
Abstract: Background: We conducted a bibliographic analysis of the Mycobacterium tuberculosis complex (MTBC) in sub-Saharan Africa, which included the analysis of 8,139 genomic sequences from 34 of the 49 sub-Saharan African countries. Notably, only one complete sequence from Senegal was identified, which had been generated in the United States. Our primary objective was to utilize whole genome sequencing (WGS) to detect resistance in anti-tuberculous strains of the MTBC in Senegal. This …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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Colorimetric Redox Indicator assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region
Abstract: Tuberculosis (TB) has affected humans since antiquity. The burden of TB particularly with multi-drug-resistance (MDR) is increasing worldwide and has become a major public health concern. This study aims to perform Colorimetric Redox Indicator (CRI) assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region. Total 234 samples were collected from South Gujarat region and were subjected for microscopy examination, culturing on Lowenstein-Jensen (LJ) medium and drug susceptibility …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 65–70 Read article
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Melanoma Skin Cancer Detection Using Deep Learning
Abstract: Cancer as one of the major diseases rank in the World is still very challenging to diagnose and treat hence need for the technological advancements. Chemotherapy, radiation, as well as surgery therapies have several drawbacks including non-selective action, damage to healthy tissues, and multi-drug resistance. Smart nano-theranostics, an advanced integration of nanotechnology with diagnostic and therapeutic modalities, offers a next-generation approach for precision oncology. Thus, the development of multifunctional nanoparticles …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 2, 2025 Read article
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Fabrics and medical devices (catheters) coated with Zn doped CuO nanoparticles kills micro-oganisms and provide healthy environment
Abstract: These days, drug resistance by microorganisms is a major challenge in the field of medicinal chemistry. Most of the familiar antibiotics turnout to be of no impact in curbing the proliferation of microorganism (bacteria, virus and fungus). To address the issue of multi-drug resistance (MDR) and extremely drug resistance (EDR) in microorganisms that cause various health complications, like the dental decay, biofilm formation, foul smell, delayed wound healing, aggravation of …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 1, 2025 · pp. 1–9 Read article
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Antibiotic Resistance: Molecular Mechanisms of Resistance
Abstract: Antibiotics are called as ‘Wonder Drugs’, the miracles of modern sciences. They help combat bacteria and prevent their growth. But due to unmonitored and uncontrolled consumption of these antibiotics, there is an emergence of antibiotic resistance. This has led to a series of downfall in the therapeutic potency and efficacy of many drugs. More and more bacteria are becoming Multi-Drug Resistant (MDR); such highly resistant strains of certain bacteria are …
Published in Research and Reviews: A Journal of Microbiology and Virology Read article
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Antibiotic Resistance: Molecular Mechanisms of Resistance
Abstract: Antibiotics are called as ‘Wonder Drugs’, the miracles of modern sciences. They help combat bacteria and prevent their growth. But due to unmonitored and uncontrolled consumption of these antibiotics, there is an emergence of antibiotic resistance. This has led to a series of downfall in the therapeutic potency and efficacy of many drugs. More and more bacteria are becoming Multi-Drug Resistant (MDR); such highly resistant strains of certain bacteria are …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 11, Issue 1, 2021 · pp. 1–8 Read article
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Antibacterial Activity of Pongamia pinnata Leaf and Callus Extracts against Microorganisms Causing Periodontal Diseases
Abstract: Some specific microorganisms have been identified as etiologic agents of periodontitis. The main goal of treatment is to control the spread of infection. Depending on the extent of the gum disease, treatment varies. Therapeutic antibiotic along with surgery are the most opted form of treatment. But, due to high costs of antibiotics, the disastrous side effects and emergence of multi drug resistant strains of these pathogenic bacteria, a safe alternative …
Published in Research and Reviews: A Journal of Dentistry · Vol. 3, Issue 2, 2012 · pp. 1–7 Read article
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Incidence of Community acquired MRSA in the nasal swabs of general population of Gulbarga region
Abstract: Background: Methicillin resistant S. aureus (MRSA) has emerged as a major pathogen in both community and hospital settings. Nasal carriage of S. aureus represents a major risk factor for the development of infection with this bacterium. Objective: The aim was to study community acquired MRSA incidence among nasal swabs of general population of Gulbarga. Methods: Nasal swabs from anterior nares were collected for the isolation of S. aureus from 224 …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 3, 2017 · pp. 8–13 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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Zn Doped CuO Nanoparticles for Increasing the Longevity of The Agricultural Products †
Abstract: Nanotechnology is an enabling technology at the service of mankind. Indeed, enhancing the long-term storage of agricultural products (post-harvest during transportation and storage) in general and apples and tomatoes, in particular, is a challenge. Zn-doped CuO is a proven nanomaterial with special ability to kill plant pathogens as well as a variety of microorganisms (bacteria, virus, and fungus). Much of the review is focused on the landmark papers published by …
Published in International Journal of Crystalline Materials · Vol. 1, Issue 1, 2024 · pp. 14–29 Read article
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An Update on HIV-2 Infection
Abstract: Human immunodeficiency virus type 2 (HIV–2) infection is an important cause of disease in a number of regions of the world. But the knowledge about this infection is sparse. Prevalence data on HIV-2 is heterogeneous. HIV-2 has a lower infectivity than HIV-1 which can be related to the lower RNA levels in this virus. The rate of progression to Acquired Immunodeficiency Syndrome (AIDS) in HIV-2-infected patients is highly variable making …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 2, 2018 · pp. 34–42 Read article
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Whispers of the Microbial World: Unveiling Bacterial Dialogues through Quorum Sensing
Abstract: Quorum sensing is a special way of bacteria by which they can regulate their own gene expression as per the population density of the bacteria. It is basically a type of cell-to-cell communication pathway used by the microbes. The signal molecule which helps in this mechanism are called auto inducer(AI). As the mechanism depends by changes in the cell density, so when the cell density reaches to the threshold cell …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 14, Issue 3, 2024 · pp. 1–8 Read article
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Drug-Resistant TB—Problem and Management: a Review
Abstract: Tuberculosis (TB) is one of the oldest diseases known to affect humans. TB is a major cause of death worldwide. The bacteria Mycobacterium tuberculosis is the causative agent of TB. It usually affects the lungs and causes pulmonary TB. The intestine, meninges, bones, joints, lymph glands, skin and other tissues of the body are also affected. TB caused by drug-susceptible strains is curable in virtually all the cases after proper …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 6, Issue 3, 2019 · pp. 30–34 Read article
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Biodegradable and Natural Fiber-Reinforced Polymer Composites for Co-Delivery of Multiple Therapeutic Agents
Abstract: The co-delivery of multiple drugs using advanced nanocarriers has revolutionized targeted therapy in various diseases, particularly in cancer, infectious diseases, and neurological disorders. Multi-layered polymeric nanocarriers (MLPNs) offer a sophisticated platform to encapsulate multiple therapeutic agents with precise control over drug release, bioavailability, and synergistic effects. These nanocarriers are designed with distinct polymer layers that enable sequential or simultaneous drug release based on stimuli-responsive mechanisms such as pH, temperature, and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 406–419 Read article
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Innovations in Tuberculosis Management: Advancements in Drug-Resistant TB Treatment and Rapid Diagnostics
Abstract: Tuberculosis (TB) remains one of the deadliest infectious diseases worldwide, exacerbated by the increasing prevalence of drug-resistant strains, such as multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB). Despite advancements in first-line and second-line treatments, resistance to conventional antibiotics has complicated therapeutic strategies, necessitating novel approaches. This mini review explores emerging advancements in TB treatment, including gene editing technologies, such as CRISPR, which offer potential for precise targeting of drug-resistant bacterial …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–7 Read article
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AI in Healthcare: Drug Delivery in Tuberculosis
Abstract: Tuberculosis (TB) , mainly caused by Mycobacterium tuberculosis, remains a major global health burden, accounting for millions of new infections and deaths each year. Although progress has been made in diagnosis and treatment, the growing threat of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes disease control increasingly difficult. Conventional diagnostic approaches such as chest X-rays, sputum smear microscopy, and culture methods continue to play an important role, but they …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 9–17 Read article