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80 articles for “Formulation Development”
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Formulation Development and Evaluation Technique for Immediate and Modified Release Capsule
Abstract: The development and evaluation of formulations for immediate-release (IR) and modified-release (MR) capsules represent a critical aspect of pharmaceutical dosage form design, offering distinct advantages in terms of drug release profiles and therapeutic outcomes. This study focuses on the formulation strategies, techniques, and evaluation methods used to develop both IR and MR capsules. Immediate-release capsules are designed to disintegrate quickly in the gastrointestinal tract, ensuring rapid drug absorption, while modified-release …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 1–9 Read article
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Development of Formulation for Dry Powder Inhalation of Amino Acids Aimed at Smoking Cessation: A Biomedical Perspective
Abstract: This study aims to develop an effective and compliant therapy targeting the lungs through the strategic utilization of amino acids, which play a crucial role in modulating mood and behavior during activities like smoking. L-Tryptophan and L-Tyrosine were finely micronized within the 2–4 µm range, with lactose serving as a carrier, to create a dry powder inhalation formulation. The combination of these amino acids is anticipated to elicit a synergistic …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 18–36 Read article
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Development and Formulation of Chocolate-coated Seeds Bar
Abstract: Vitamins E, D, and B6 minerals like zinc and selenium and amino acids like glutamine all play a role in the body's immune system development. Edible seeds are a great source of protein, healthy fats, fiber, and important minerals like magnesium, potassium, calcium, iron, and zinc in addition to vitamins B1, B2, B3, and E. Examples of edible seeds include pumpkin, flax, sesame, sunflower, mustard, amaranth, oat, barley, black rice, …
Published in International Journal of Nutritions · Vol. 1, Issue 1, 2024 · pp. 1–12 Read article
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Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
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Exploring Biomedical Innovations in the Formulation and Assessment of Medicated Hard Candy Lozenges Containing Metoclopramide Hydrochloride
Abstract: The objective of this study was to formulate and evaluate metoclopramide hydrochloride medicated lozenges for antiemetic action through buccal absorption by incorporating a polymer. All formulations were developed and assessed for in-vitro drug release, physical appearance, weight variation, thickness, hardness, moisture content, mouth-dissolving time, and drug content. The prepared lozenges exhibited uniformity in weight and thickness. The hardness of all formulations ranged between 7.3–15.50 kg/cm², falling within standard limits. The …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 50–62 Read article
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Development of an Innovative Nanotransdermal Formulation Utilizing an Optimal Combination of Acyclovir and Omeprazole to Improve Antiviral Efficacy
Abstract: The study effectively created nanogel formulations of Acyclovir and Omeprazole using the solvent diffusion technique. Among the various formulations (F1–F9), F9 was identified as the most suitable for gel preparation based on its pH evaluation. Drug content analysis, performed using UV-spectroscopy, confirmed the homogeneity of the prepared nanogels, which appeared opaque, free of lumps, particles, or aggregates. The spreadability assessment of F9 demonstrated excellent spreadability, while viscosity values for all …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 19–35 Read article
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Photochemically Assisted LC–MS Method Development and Validation for Stability-Indicating Determination of Glasdegib in Rat Plasma
Abstract: A simple, precise, and cost-effective LC–MS method was successfully developed for the determination of Glasdegib in rat plasma. The method optimization was carried out by systematically varying key chromatographic parameters, including flow rate, injection volume, analyte concentration, and mobile phase composition, to achieve optimal sensitivity and resolution. A C18 Hypersil BDS column (150 mm × 4.6 mm, 3.5 µm particle size) was used for chromatographic separation, offering effective peak shape …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
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Development and Evaluation of a Cost-Effective UV-Protective Cream Containing Para-Aminobenzoic Acid and Aloe Vera for Indian Climatic Conditions.
Abstract: The increasing incidence of ultraviolet (UV) radiation-induced skin disorders has heightened the demand for effective, affordable photoprotective agents, especially in countries with high sun exposure such as India. This study aimed to develop a cost-effective and efficient UV-B protective cream formulation suitable for populations in Indian latitudes. Para-aminobenzoic acid (PABA) was selected as the primary sunscreening agent due to its high UV-B absorption efficiency, low toxicity, and affordability compared with …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 7–18 Read article
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Development, Optimization and Evaluation of Polyherbal Gel Comprising of Azadirachta Indica, Calendula Officenalis, Turmeric and Aloe-vera for Treatment of Wound
Abstract: Azadirachta indica, Calendula officinalis, Turmeric (Curcuma longa), and Aloe-vera are known to possess numerous medicinal properties. These herbs have been traditionally used across various cultures for the treatment of a wide range of ailments due to their potent therapeutic effects. Individually, they have demonstrated efficacy in addressing conditions such as acne, diabetes, wound healing, gastric ulcers, first-degree burns, psoriasis, arthritis, and pneumonia. Additionally, they are known for their antimicrobial, anti-inflammatory, …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 41–53 Read article
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Innovative Approaches in Pediatric Drug Formulation Catering to Specialized Need: Review Article
Abstract: This detailed article review examines innovations in pediatric drug formulation, highlighting developments that cater to children’s specific healthcare needs. It covers pediatric pharmacology and advanced solutions like nanoparticle drug delivery and taste-making techniques, focusing on improving the safety, effectiveness, and acceptability of medications for young patients. The review highlights the benefits for patients, including improved adherence to treatment, fewer side effects, and better overall treatment outcomes. It also addresses regulatory …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 35–43 Read article
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A Sustainable EOQ Model for Declining Products Incorporating Cubic Demand, Variable Deterioration, Partial Backlogging, and Carbon Emission Optimization
Abstract: In this paper proposes a sustainable Economic Order Quantity (EOQ) model for inventory systems involving decaying items under cubic time-dependent demand, variable decaying rates, and partial backlogging while absolutely considering carbon emission costs. The model reflects practical market actions where demand initially increases and afterwards declines over time, and decay depends on the age of the item. To demonstrate the current model's applicability as well as evaluate the trade-off between …
Published in International Journal of Industrial and Product Design Engineering · Vol. 4, Issue 1, 2026 · pp. 20–28 Read article
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Hydrogel Membranes for Skin Moisturization and Hydration: A Comparative Study
Abstract: Hydrogel membranes have emerged as a revolutionary technology in skin care, particularly for moisturizing and hydration applications. These water-swellable polymers mimic the extracellular matrix, providing an ideal environment for skin nourishment and moisture retention. This review comprehensively explores the various types of hydrogel membranes, including natural, synthetic, and hybrid formulations, highlighting their physicochemical properties, mechanisms of action, and applications in skin care. We examine how factors such as crosslinking density, …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 13–22 Read article
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A Study on Relationship of Sustainable Development Goals with the Usage of Cosmetic Skin Care Products- A Study
Abstract: Sustainable Development Goals is nothing but making addressing the conflicts worldwide and giving better lives for people in the globe. The main aim is to tackle the challenges along with others to make the globe more sustainable for future generations. There are seventeen goals defined in SDGs which are focused on sustainable development. They are exclusively designed for eradication of poverty, protection of the environment, and the promotion of our …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 2, 2025 · pp. 36–40 Read article
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Assessing the Socioeconomic Impacts of Land Tenure Systems Across Different Regions
Abstract: Land tenure systems are fundamental in shaping the socioeconomic structure and dynamics of communities across the globe. These systems, which define the legal and customary relationship between individuals, groups, and the land they own, use, or occupy, hold significant implications for economic development, social equity, and environmental sustainability. They determine how land resources are accessed, managed, and transferred, thereby influencing economic activities, wealth distribution, and community stability. This article provides …
Published in International Journal of Land · Vol. 2, Issue 1, 2025 · pp. 24–27 Read article
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Study on the Method of Calculation of the Additional Mass of Parachute
Abstract: As is well known, the air drag experienced by a parachute when it is open is one of the important parameters that must be taken into account in studying the parachute opening process. If this term is not calculated correctly, it can have a negative effect on the parachute canopy, and may lead to errors in the number of parachute strings, the nominal diameter of the parachute, and the material …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 3, Issue 2, 2025 · pp. 22–31 Read article
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Nutraceuticals Unveiled: Exploring the Science, Benefits, and Future of Functional Food
Abstract: The rapidly developing subject of nutraceuticals is critically examined in this review, with a focus on its scientific basis, proven health advantages, and possible future applications in the functional food industry. Key bioactive ingredients that contribute to the therapeutics effectiveness of functional foods, including flavonoids, polyphenols, carotenoids, probiotics, and essential fatty acids, have been identified and characterized as a result of recent developments in nutritional science. Both experimental and clinical …
Published in International Journal of Nutritions · Vol. 2, Issue 2, 2025 Read article
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A Research on Goat milk and Papaya Face Wash
Abstract: The increasing demand for natural and sustainable skincare products has driven interest in bio-based cosmetic formulations. This study focuses on the development and evaluation of a goat milk and papaya–based face wash aimed at providing gentle cleansing, moisturizing, and exfoliating properties through natural ingredients. Goat milk, rich in lactic acid, proteins, and essential fatty acids, contributes to hydration and mild exfoliation, while papaya (Carica papaya) extract, containing papain enzyme and …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 1, 2026 · pp. 30–38 Read article
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A Concurrent Estimation of Phytoconstituents Piperine, Quercetin and Kaempferol Present in Siddha Polyherbal Formulation Kabasara Kudineer by Rp-Hplc
Abstract: A straightforward, accurate, and precise technique was developed and validated for the simultaneous determination of Quercetin, Kaempferol, and Piperine in the polyherbal formulation Kabasura Kudineer. The sample was chromatographed using a C18 column (150x4.6mm, 5u) with a mobile phase composed of Acetonitrile and Ortho phosphoric acid in a 45:55 ratio, flowing through the column at a rate of 1ml/min. The detection wavelength for Quercetin, Kaempferol, and Piperine was set at …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 1–9 Read article
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Herbal Extract-Infused Biopolymers as Sustainable Film Formers in Skin and Hair Care Products
Abstract: Herbal extracts are becoming increasingly popular in cosmetic formulations. Due to increasing customer demand for natural, sustainable products. This review explores the potential of herbal extract-infused biopolymers as innovative film-formers in skin and hair care applications. Biopolymers, derived from natural sources, offer excellent biocompatibility, biodegradability, and functionality, making them suitable for enhancing the performance of cosmetic products. This article examines various herbal extracts that can be synergistically combined with biopolymers …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 1–12 Read article