All articles
363 articles
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Marine-Derived Pharmaceuticals: Unlocking the Ocean's Potential for Human Health
Abstract: The ocean, covering 70% of the Earth’s surface, is a rich source of unique bioactive compounds with potential therapeutic applications. This review aims to highlight the significance of marine-derived pharmaceuticals in human health, focusing on clinically approved and commercially available medications. The review covers various marine-derived compounds, their structural features, modes of action, and applications in treating diseases, such as cancer, diabetes, and neurodegenerative disorders. The review identifies several marine-derived …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 1–12 Read article
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Ethnopharmacological Insights: Uncovering Plant-Based Neuroprotective Treatments for Neurodegenerative Disorders
Abstract: The development of plant-based therapies for neurodegenerative diseases holds significant promise due to the therapeutic potential of natural compounds, such as Laurus nobilis, Aronia melanocarpa, and celastrol. This review identifies critical literature gaps in the current research, including inconsistent extraction methods, lack of clinical trials, insufficient documentation of long-term effects, limited mechanistic insights, and poor bioavailability. Addressing these gaps through standardization, rigorous clinical trials, advanced delivery systems, and comprehensive ethnopharmacological …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 13–18 Read article
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Innovative strategies in capsule formulation from concept to market
Abstract: Innovative strategies in capsule formulation have revolutionized drug delivery and nutraceutical development, offering advanced solutions from initial concept to market release. This report explores the transformative techniques at each stage of capsule formulation, detailing novel approaches in ingredient selection, encapsulation technology, and manufacturing processes. By leveraging advancements in artificial intelligence, encapsulation methods, such as liposomal and nanoparticle technologies, and materials science, formulators can optimize the bioavailability, stability, and targeted delivery …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 1–8 Read article
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Pharmacokinetics and Pharmacodynamics Studies of Chia Seed Derived Compounds; A Review
Abstract: Chia seeds (Salvia hispanica L.) have been historically valued by ancient civilizations and are increasingly being recognized for their powerful nutritional and therapeutic properties. Rich in omega-3 fatty acids, polyphenols, fiber, and essential minerals, chia seeds are gaining attention for their potential health benefits. This review examines the pharmacokinetics and pharmacodynamics of chia seed-derived compounds, with emphasis on their absorption, distribution, metabolism, and elimination processes, as well as their biological …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article
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Review: The Future of Over-the-Counter (OTC) Medications
Abstract: According to Medicine, India's over-the-counter drug market is growing .The country's economy is expanding.The Indian pharmaceutical industry has experienced rapid growth in the last decade significant changes in the quality of business. The company actively promotes its products in the market; North Americans focus on finding cures for minor ailments compared to Europeans who rely on village pharmacists to treat minor ailments. Only the promotion and dissemination of public education …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 105–112 Read article
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Assessing the Clinical Efficacy and Safety of Semaglutide: A Comprehensive Study
Abstract: Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), has emerged as a versatile therapeutic agent with significant potential in managing a range of diseases. Extensive research has demonstrated its efficacy in treating obesity, type 1 and type 2 diabetes, and even neurodegenerative disorders like Parkinson’s disease. This comprehensive review examines the principal outcomes derived from clinical trials that incorporate semaglutide alongside other GLP-1 agonists, with particular emphasis on the mechanisms underlying …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 96–104 Read article
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Comparative Efficacy and Safety of Safinamide and Rasagiline in the Treatment of Parkinson’s Disease: A Meta-Analysis and Systematic Review
Abstract: Background: Recent studies have suggested Rasagiline and Safinamide monotherapy as potential management options for Parkinson’s disease. Parkinson’s disease, a neurological disorder characterized by tremors and movement difficulties, necessitates treatments aimed at managing clinical symptoms. Levodopa remains the primary effective treatment for Parkinson’s disease symptoms; however, its long-term use often leads to motor complications in many patients. Additional therapeutic drugs, such as dopamine agonists and monoamine oxidase B inhibitors, including Safinamide …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 74–91 Read article
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Dasatinib Induced Pulmonary Hypertension
Abstract: Dasatinib (Das) is a second-generation tyrosine kinase inhibitor that is used in the treatment of chronic myelogenous leukemia (CML) in patients who are resistant or intolerant to imatinib, as well as in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) patients. Dasatinib-induced pulmonary arterial hypertension (PAH) is a known but rare adverse effect of dasatinib and is grouped under Group-1 PAH. The mechanism of PAH development is not fully known, but …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 92–95 Read article
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Strategies in the Battle against Recurrent UTIs: A Brief Overview
Abstract: Recurrent urinary tract infections (UTIs) present a serious medical issue, and such conditions can disappoint those affected. They are uncomfortable, but a difficulty arises because treating such conditions with antibiotics comes with the risk of antibiotic overuse. This summary will evaluate the measures incorporated in treating frequent UTIs in the contemporary world. These measures include taking antibiotics regularly to prevent infections and alternatives to antibiotics such as probiotics, cranberry extract, …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 68–73 Read article
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Implementing Blockchain to Enhance Security in the Pharmaceutical Industry and Combat Drug Counterfeiting
Abstract: Drug counterfeiting has emerged as a critical threat to public health, as it has enabled inferior and counterfeit drugs to flood many markets around the world thereby eroding trust in healthcare systems and patient safety. This paper seeks to address the glaring need for adequate security safeguards to curb the circulation of counterfeit drugs by proposing a blockchain model designed specifically for the pharmaceutical industries. In general, the idea of …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 1, 2025 · pp. 33–46 Read article
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Biochemical Estimation of Allaxon Induced Hyperglycemia in Rats Treated with Polyherbal Preparation of Two of Indian Medicinal Plants Cordia Myxa and Canscora Diffusa
Abstract: A systematic study was conducted on extracts of Cordia myxa and Canscora diffusa to evaluate their qualitative chemical composition, phytochemical content, and antidiabetic activity. Then the Poly herbal extract is prepared with the selected plant powders, subjected to acute-toxicity studies for dose fixation. The herbal extracts formulation was prepared taking three selected dosages. The preparations are evaluated for anti-diabetic activity using Steptozotocine and Alloxan induced diabetic models in rats. The …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 52–60 Read article
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Development of a Blockchain-Based System for Drug Counterfeiting and Traceability in the Pharmaceutical Supply Chain
Abstract: Counterfeit drugs present a major risk to public health and pose a substantial threat to the pharmaceutical industry, leading to severe economic losses and risking patient lives. Ensuring the safety and authenticity of the pharmaceutical supply chain is critical to addressing this issue. This study presents a novel approach for enhancing the security and authenticity of the pharmaceutical supply chain through the integration of blockchain technology, decentralized storage, and artificial …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 99–114 Read article
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An Assessment of Nutritional Status among Students of Government Primary Schools in Semi-Urban areas of Chitradurga region
Abstract: Understanding children's nutritional status is crucial for enhancing future generations' quality of life, as evidenced by the elevated prevalence of stunting (36.2%), wasting (26%), and underweight (35.2%) in Karnataka according to the National Family Health Survey. This study aimed to assess the nutritional status, dietary habits, socio-economic conditions, and demographic profiles of students in Government primary schools in the semi-urban Chitradurga region. Using a validated questionnaire, data from 441 students …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 61–67 Read article
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Challenges and Opportunities in the African Pharmaceutical Industry
Abstract: Background: The pharmaceutical industry in Africa has significant potential for growth; however, it is overwhelmed with grappling challenges. Nonetheless, these challenges can create a window of opportunities for innovation. This article provides an in-depth analysis of the profound challenges and opportunities in the continents pharmaceutical industry. Methods: Using data collected from published literature, reports and gray literature was used to conduct a narrative review. Using data collected from various publications …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 3, 2024 · pp. 88–98 Read article
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Review on Computer-Aided Drug Design in RAS Inhibitor Discovery
Abstract: This review explores the utilization of computer-aided drug design (CADD) methodologies in the discovery of inhibitors targeting the RAS pathway, a pivotal signaling cascade implicated in various cancers. Through an extensive examination of computational tools, methodologies, challenges, and recent advancements, this review aims to provide insights into the role of CADD in accelerating RAS inhibitor discovery. The discovery of effective inhibitors targeting the RAS pathway is of paramount importance in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 7–14 Read article
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Recent Trends in Ocular Drug Delivery: Challenges and Approaches
Abstract: Drug topically regulation can be accessed most easily in the eye. When given topically as eye drops, medication ocular bioavailability is quite low. Drug entry into specific ocular locations is complicated by the complex anatomy and physiology of the human eye. Research has long been interested in the topical administration of successful treatments. To provide a suitable ocular penetration and extend the duration of drug residence is their challenging task. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 22–38 Read article
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Sphagneticola trilobata: A Green Treasure of Phytochemical Constituents and Medicinal Values
Abstract: Sphagneticola trilobata originally from the Caribbean, Mexico, and Central America, and is a plant of the Asteraceae family, tribe Heliantheae, that is now found growing across the Neotropics. The plant profile, key components, chemical test, and pharmacological actions of S. trilobata are all included in this review. The main constituents of the plant were limonene, bicyclogermacrene, α-humulene, α-pinene, α-phellandrene, and germacrene D, camphene, sabinene, 10-nor-calamenen-10-one, γ-amorphene. Which shows pharmacological active …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 15–21 Read article
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RP-HPLC method for simultaneous determination of Drospirenone and Ethinylestradiol in Bulk and their Pharmaceutical dosage form
Abstract: Oral contraceptive is used to prevent the pregnancy which is contain hormones to block the release of eggs from the ovaries. Most of them contain estrogen and progesterone. Nowadays, usage of hormonal contraceptive is sharply enhancing; around 100 million of women worldwide are taking these drugs. With this drug fertility rate can be supressed as long as they want or plan their activity along with these drugs provide efficacy, reliability, …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 46–67 Read article
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Artificial Intelligence in Drug Repurposing: A Short Impact Assessment
Abstract: Artificial intelligence (AI) in pharmaceutical repurposing has become a game-changing tool that opens new avenues for the application of new drugs that have already been approved. Traditional drug discovery is a lengthy and expensive process, whereas AI can rapidly analyze vast datasets of biological, chemical, and clinical information to predict drug-disease interactions. AI-driven techniques, such as machine learning, natural language processing, and deep learning, enable the identification of potential repurposing …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 42–45 Read article
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The Clinical Landscape of Wogonin: Advancing Targeted Treatments for Chronic Diseases
Abstract: The traditional Chinese medicinal herb Scutellaria baicalensis Georgi, commonly known as Chinese skullcap or Huang-Qin, has long been used to treat a variety of conditions, including cancer, viral infections, and seizures. Its pharmacological effects are largely attributed to the high concentration of flavones, particularly wogonoside, and its aglycone derivative, wogonin. Among the bioactive compounds found in S. baicalensis, wogonin has garnered the most scientific attention due to its potent therapeutic …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 46–52 Read article