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132 articles for “toxicity test.”
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Role of Models in Predicting Toxicity Criteria against Arsenic Toxicity Test Exposed to Therapon Jarbua (Forsskal, 1775)
Abstract: Prediction of safe concentration, no-effect concentration for reduced animal usage in chronic toxicity test was attempted as well as to create a toxicity criteria limit for arsenic using Therapon jarbua in static renewal acute toxicity test. The LC50 value derived was 3.95 (3.43–4.58) mg/L arsenic. The derived LC50 was applied for prediction of safe concentration leading to a value of 39.5 µg/L. The raw survival and mortality data was fed …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 3, Issue 3, 2013 · pp. 22–28 Read article
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Mercury-induced Biochemical Changes in Perna viridis Exposed in Chronic Toxicity Test
Abstract: In the present study, the Asian green mussel, Perna viridis, was exposed to 50, 75, 113, 160 and 253 µg/L Hg concentrations under chronic toxicity for the assessment of biochemical biomarkers. Higher levels of glutathione S-transferase (GST), reduced glutathione (GSH), lipid peroxidation (LPO) and lower levels of protein, catalase (CAT) and acetylcholinesterase (AchE) were found. The values were found to be significant at P < 0.01. This study suggests that …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 15–22 Read article
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New Distribution Record of Five Species of Xylaria from Tripura, Northeast India
Abstract: The present study deals with new distribution record of five Xylaria species from Tripura, North-east India. Out of total five species, X. obovata, X. nigripes, X. multiplex and X. hypoxylon were not reported from entire Northeast India. Present findings revealed a potential check list of Xylaria of the region. It was observed that Xylaria species prefer to grow on dead decaying wooden logs situated on the moist deciduous forest floor. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 8, Issue 1, 2018 · pp. 1–10 Read article
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Toxic Potential of Carbaryl on Reproductive and Fertility Parameter in Male Wister Albino Rats
Abstract: This study aims to evaluate the adverse effect of carbaryl on reproductive system of male Wister albino rats. Adult male Wister albino rats were orally administered with 50, 100 and 150 mg/kg body weight of carbaryl for 90 days. Animals from each group were sacrificed after the study period. Sperm count, sperm motility, antioxidant assay (SOD, CAT, LPO, and protein carbonyl), Hormones assay histological analysis and fertility parameters were performed …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 2, 2015 · pp. 1–6 Read article
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Biochemical Biomarkers as a Tool in Chromium Induced Toxicity to Green Tiger Prawn, Penaeus semisulcatus (De-Haan, 1844)
Abstract: Estuarine ecosystem and its biodiversity are at higher risk due to coastal contamination by heavy metals and conservation of biodiversity can be accomplished by utilizing biomarkers of pollutant at different exposure levels. In the present study, chronic toxicity test was conducted to evaluate the antioxidants and enzymes as the possible biomarkers in Green Tiger Prawn, Penaeus semisulcatus. The chronic endpoint value (MATC), no-observed effect concentration (NOEC), and low-observed effective concentration …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 4, Issue 2, 2014 · pp. 1–12 Read article
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The Acute Toxicological Effects of Paraquat on Male Reproductive Hormones (Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone) of Intoxicated Rats
Abstract: Paraquat (PQ) a contact herbicide widely used to control weeds in agricultural, recreational, or industrial sites has been linked in various studies as a contributory agent to high male infertility in regions of most use. The current study investigated the acute toxicity effect of PQ administered intraperitoneal (ip.) on reproductive hormones; luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (Te) of male rats. 24 rats, grouped four per group …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 3, 2015 · pp. 13–16 Read article
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Evaluation of Marine Waste Water And Aromatic Hydrocarbons Toxicity Using A Battery of Assays
Abstract: Abstract The aim of this study is to evaluate the toxic effects of marine wastewater and representative aromatic hydrocarbons using a battery of assays. The methods employed for the toxicological evaluation involve physic-chemical analysis of the marine wastewater, toxi-chromo test using mutant E coli and sub-chronic animal toxicity testing with emphasis on body weight determination, biochemical indices and histopathological examination. The results showed that Nembe water side wastewater sample contain …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 2, 2020 · pp. 1–13 Read article
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The Ames Test in Twenty-first Century
Abstract: Since the 19th century, industrial development has increased exposure to mutagens and possible carcinogens. In order to avoid these health risks, several techniques have been developed to recognize genotoxins. In the 1970s, Dr. Bruce Ames and colleagues, studying the histidine operon of Salmonella typhimurium, observed that histidine (−) auxotroph mutants were reverted to histidine (+) upon exposure to a mutagen. The researchers further observed that known carcinogens were mutagenic to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 1, 2012 · pp. 23–37 Read article
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Exploring the Dynamic Mechanical Analysis and Biocompatibility of Compression-Molded PMMA for Biomaterial Applications
Abstract: Metals such as titanium, cobalt, and magnesium are commonly used as biomaterials. However, their use can lead to tissue reactions due to the formation of foreign bodies which may cause blood cancer. Researchers have addressed this issue by substituting biomaterials with polymethyl methacrylate materials (PMMA). The PMMA material being studied is produced using the compression molding technique. This article examines the mechanical properties and biotoxicity of PMMA. These materials have …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 482–499 Read article
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Toxicological Evaluation Of Two Nigerian Refinery Effluents Using Natural Biomonitors
Abstract: Abstract The present study aimed to evaluate the toxic effects of two Nigerian refineries’ effluents using natural bio-monitors. Standard physicochemical analysis, toxi-chromo test using mutant E. coli and sub-chronic animal toxicity testing with emphasis on tissue heavy metal accumulation, biochemical parameters and histopathology, were adopted during the study. The physicochemical results revealed that the two effluent samples are highly polluted although PH sample was more polluted than the Warri sample. …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 2, 2020 · pp. 22–31 Read article
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Validation of Tropical Artificial Soil by Ecotoxicological Assessment of the Effect of Potash on Eisenia fetida
Abstract: AbstractEcotoxicity tests provide a direct measure for the effects of chemicals to earthworms and help to establish adverse ecological effects. The research methodology recommended by the Organisation for Economic Co-operation and Development (OECD) Guideline for testing of chemicals no. 207 meets the most criteria expected for ecotoxicological testing except the testing condition and the organic matter. The guideline was initially developed by temperate countries like Europe and North America, thus …
Published in Research & Reviews : Journal of Ecology · Vol. 2, Issue 2, 2013 · pp. 15–23 Read article
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Effects of Plasticizer DI-(2 Ethylhexyl) Phthalate on Liver Enzymes of Adult Male Albino Rats
Abstract: AbstractDi-(2 Ethylhexyl) Phthalate (DEHP) is a common plasticizer used to make the plastic products more flexible. It is quite harmful as tested on other animal models and is carcinogenic too. The liver is the major organ for detoxification in body and is therefore affected first due to intake of any toxicant. The liver enzymes are good parameter to assess any such hepatic damage. In the present study, the acute toxicity …
Published in Research & Reviews : Journal of Ecology · Vol. 6, Issue 2, 2017 · pp. 6–9 Read article
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Toxicology 4.0: Integrating Artificial Intelligence, Big Data, Health Informatics, and Precision Analytics for Predictive Toxicity Assessment, Real-Time Toxicovigilance, and Personalized Patient Safety
Abstract: Background: Toxicology is undergoing a major transformation, increasingly described as Toxicology 4.0, driven by the integration of artificial intelligence (AI), big data analytics, health informatics, and precision analytics. Conventional toxicity testing is limited by high costs, lengthy timelines, and challenges in translating animal and low-throughput in vitro findings to humans. Aim and Objectives: To comprehensively evaluate the emerging role of Toxicology 4.0 in predictive toxicity assessment, real-time toxicovigilance, and personalized …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 Read article
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Ascorbic Acid Indicates Positive Role in Detoxification Studied on the Fresh Water Fish, Channa Orientalis (Schneider)
Abstract: Aquatic animals provide useful data for toxicological evaluations. Ascorbic acid acts as a detoxifier reduces which toxicity of pesticides. In this present work Ascorbic acid indicates positive role in detoxification. The study was carried out on the fresh water fish, Channa orientalis (Schneider) These aquatic organisms are adaptive and convenient for laboratory experimentation for toxicity testing. The role of ascorbic acid on experimental fish, Channa orientalis is discussed in this …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 2, 2024 · pp. 6–9 Read article
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Role of Fluid Engineering in Biomedical and Healthcare Systems: A Comprehensive Review
Abstract: Fluid engineering — the study and application of fluid behavior, transport, and interaction — has become a cornerstone of modern biomedical and healthcare systems. This review synthesizes the multifaceted roles fluid engineering plays across diagnostics, therapeutics, biomedical devices, and physiological modeling. Micro-fluidics enables precise manipulation of microliter and nanoliter volumes, facilitating rapid point-of-care diagnostics, high-throughput screening, and the fabrication of uniform nano particles for targeted drug delivery. In cardiovascular medicine, …
Published in Trends in Mechanical Engineering & Technology · Vol. 16, Issue 1, 2026 · pp. 1–5 Read article
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In vitro and In vivo Trypanocidal Activity of Methanolic Extract of Lantana camara leaves on Trypanosoma brucei in Laboratory Mice
Abstract: In this study, the methanol extract of Lantana camara leaves were tested for their trypanocidal activity in vitro in a microtiter plate and in vivo using male laboratory mice. Five different concentrations 10mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50mg/ml of the extract were prepared and the time taken to immobilize the parasites were recorded. The in vitro results showed that the leave extract at concentrations of 50 mg/ml had …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 2, 2024 · pp. 32–41 Read article
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Biochemical Estimation of Allaxon Induced Hyperglycemia in Rats Treated with Polyherbal Preparation of Two of Indian Medicinal Plants Cordia Myxa and Canscora Diffusa
Abstract: A systematic study was conducted on extracts of Cordia myxa and Canscora diffusa to evaluate their qualitative chemical composition, phytochemical content, and antidiabetic activity. Then the Poly herbal extract is prepared with the selected plant powders, subjected to acute-toxicity studies for dose fixation. The herbal extracts formulation was prepared taking three selected dosages. The preparations are evaluated for anti-diabetic activity using Steptozotocine and Alloxan induced diabetic models in rats. The …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 14, Issue 3, 2024 · pp. 52–60 Read article
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Assay of the Antitrypanosomal Activity of Ziingiber Officinale Extract in Wister Rats
Abstract: This research investigated the antitrypanosomal effects of Zingiber officinale in rats infected with Trypanosoma brucei brucei. Twelve adult rats, 7 weeks old and of both sexes, were randomly divided into six groups (1 through 6), with each group consisting of two rats. All six groups (1–6) were intraperitoneally injected with 0.1 ml of blood containing 10⁶ Trypanosomes/ml. Groups 1–4 received daily intraperitoneal doses of the plant extract at concentrations of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 14, Issue 1, 2025 · pp. 32–37 Read article
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Nanotechnology-Based Cosmeceuticals for Anti-Aging and Skin Regeneration
Abstract: Nanotechnology has transformed the cosmetic industry of the cosmeceuticals by allowing the production of sophisticated delivery systems that improve the stability, penetration, bioavailability, and therapeutic efficacy of active ingredients in cosmetics. The present review identifies the value of nanotechnology-based cosmeceuticals in anti-aging and skin regeneration, with special focus on the recent developments in nanocarrier technologies and their use in dermatology. Many nanocarriers have exhibited great potentials in enhancing delivery of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 33–45 Read article
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The Effect of Vitamin C on the Reproductive Functions of Paraquat Intoxicated Male Albino Rats (Rattus norvegicus)
Abstract: Paraquat (PQ) is a bipyridylium herbicide applied around trees in Orchids and between crop rows to control broad-leaved and grassy weeds. Its oxidation results in the formation of superoxides and supernitrite species which causes damage to cellular components. Studies have implicated PQ as one of the pesticides that contributes to the reduction in male reproductive functions in humans and animals during exposure. This study, therefore, determined the antioxidant effect vitamin …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 3, 2014 · pp. 9–29 Read article