Search
138 articles for “single cell”
-
Single-Cell Genomics and its Impact on Understanding Cellular Heterogeneity
Abstract: Single-cell genomics has transformed how we study the differences between individual cells, helping scientists uncover the detailed variety within tissues that traditional methods could not reveal. Traditional methods, such as RNA sequencing, average gene expression across many cells, thereby missing subtle yet important cellular variations. Single-cell technologies, such as single-cell RNA sequencing (scRNA-seq), DNA sequencing, and epigenomics, allow researchers to study individual cells in extraordinary detail like never before. This …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 1, 2025 · pp. 1–5 Read article
-
Single-Cell Proteomics approach for the development of Climate-resilient crops
Abstract: Over a last few years Single cell RNA sequencing technique has been growing at a faster pace but still the technique is unable to reveal the complexity and diversity of a cell. This void in the knowledge has led scientists to go for Single cell Proteomics. As proteins are the major work-horses of a cell they could better explain the unsolved cellular mysteries. Further the advancement in the mass spectrometry …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 11, Issue 3, 2021 · pp. 5–9 Read article
-
Scope of Single cell Genomics: Bioinformatics Review
Abstract: To study the Expression profile of genes and its regulations in single cell resolutions is one of the major factor to improvise the current therapeutic options. Bulk RNA sequencing has been discussed by many groups before, better understanding over analysis methods with standard best practice guidelines were demonstrated extensively in past 2 decades. The single cell resolution of RNA expression data analysis has many varieties of software in open source …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 9, Issue 1, 2022 · pp. 43–51 Read article
-
Comparative Evaluation of Genotoxicity in Peripheral Blood Mononuclear Cells in Oral Precancer and Cancer Patients Using Single Cell Gel Electrophoresis
Abstract: In the present study the comet assay was performed in peripheral mononuclear cells to evaluate DNA damage among tobacco chewers and smokers. The assay provides a quick, accurate and sensitive way to detect various forms of DNA damage in individual cells. The study comprises 50 oral cancer patients, 12 oral submucous fibrosis patients and 10 healthy controls. The length of the comet tail was used to determine the level of …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 11, Issue 2, 2022 · pp. 26–34 Read article
-
Capacity and BER Performance Analysis of Single Cell Massive MIMO with Various Precoding Techniques
Abstract: AbstractMassive Multi Input Multi Output (MIMO) is one of the promising technologies which will facilitate the 5th generation wireless communication system (5G) in the near future. It also goes by other names such as, large MIMO, hyper MIMO, full-dimension MIMO and ARGOS. In this technology the Base Station is incorporated with a large number of transmitting antennas (e.g., Hundreds, thousands). A large number of antenna help to focus the energy …
Published in Journal of Communication Engineering & Systems · Vol. 6, Issue 1, 2016 · pp. 1–14 Read article
-
Saccharomyces exiguus Single Cell Protein Synthesis in Ethanol
Abstract: At present, foods of animal and vegetable origin have two fundamental aspects of resolving the nutritional value for human and animal consumption. As well as the cost of agricultural production with the necessary inputs in a sustainability scheme. Consequently, there are other strategies for the generation of nutritional quality protein for consumption, such as the so-called protein of unicellular origin “single cell protein” (SCP), Saccharomyces exiguus is a precise example …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 1, 2023 · pp. 22–27 Read article
-
Evaluation of Gamma Radiation Induced DNA Damage in Bombyx mori, using Single Cell Gel Electrophoresis (Comet Assay)
Abstract: Bombyx mori (B. mori) is the model insect used in the present study, which is commercially important compared to other Lepidopterans. Eggs of late embryonic stage (7 day old) of B. mori were exposed to different doses of gamma radiation to study the extent of DNA damage using comet assay which is a rapid technique to study the genotoxic effects. Test samples were exposed to varied doses of radiation (100, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
-
The Intersection of Bioinformatics and Cellular Function in Disease Modeling
Abstract: The integration of bioinformatics and cellular biology has revolutionized our understanding of disease mechanisms, offering unprecedented opportunities to model complex biological systems. Bioinformatics is an interdisciplinary field that merges biology, computer science, and statistics, offering advanced tools to analyze vast biological datasets. Cellular functions, including gene expression, protein interactions, and metabolic pathways, form the foundation of physiological and pathological states. Disruptions in these processes can result in diseases like cancer, …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
-
Clone-Specific Drug Delivery Systems: Targeted Approaches and Future Clinical Applications
Abstract: Clone-specific drug delivery systems represent a transformative frontier in personalized medicine, addressing the longstanding challenge of clonal heterogeneity within diseases such as cancer, infectious diseases, and autoimmune disorders. Traditional drug delivery platforms often fail to discriminate between pathogenic and healthy cells, leading to systemic toxicity and reduced therapeutic efficacy. In contrast, clone-specific systems aim to selectively target and eliminate disease-driving cellular clones based on unique molecular signatures, thereby improving treatment …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 12, Issue 2, 2025 · pp. 21–29 Read article
-
Precision in Progress: The Crucial Nexus of Instrumentation and Measurement in Biotechnology Advancements
Abstract: This comprehensive review examines the critical importance of instrumentation and measurement technologies in enabling advances across diverse domains of modern biotechnology. Detailed examples are provided demonstrating how analytical tools empower quantitative biology, drive discoveries, catalyze innovations, and provide solutions to global challenges. The historical evolution of bioanalytical techniques is traced, highlighting milestones that unleashed new capabilities. Current trends and future outlook are explored, underscoring the ongoing pivotal need for precision …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 11–19 Read article
-
Experimental investigation on impact resistance and energy absorption of multicell thin walled glass fibre reinforced polymer composite
Abstract: The objective of this study is to explore the behaviour of different types GFRP cell structures under dynamic load testing. In this study we have designed, fabricated, tested and analyzed specimens of different configurations (Cylindrical structure – 1 cell, 2 cell and 4 cell) using Glass Fibre Reinforced Polymer (GFRP). GFRP constituents are Glass fibre of 200 GSM with L-12 epoxy and K-6 hardener. Test specimens were manufactured by conventional …
Published in Journal of Polymer & Composites · Vol. 11, Issue 13, 2023 · pp. 85–95 Read article
-
Outcome of the Ayurvedic medication on a patient with Sickle cell anaemia – A single case study
Abstract: Sickle cell disease is caused by genetic modification of β-globin (HBB). The result of clinical syndromes is characterized by chronic hemolytic anemia and can be complicated by vaso-occlusion and vasculopathy which can lead to severe and chronic organ damage and premature death. A 17-year-old female patient was diagnosed with sickle cell anemia with symptoms of severe weakness, shortness of breath, loss of appetite, constipation, severe calf pain, chest pain, abdominal …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 11, Issue 3, 2022 · pp. 1–8 Read article
-
Design of Single Bitline Novel 5T SRAM Cell to Reduce The Power Dissipation Using Cadence
Abstract: Fast growing field of IC technology is persistently demanding for low power consumption and efficient solution. Most of the available SRAM designs are based on standard 6T SRAM cell in addition to other circuit and transistors count. A novel 5T CMOS SRAM is presented in this paper, for simultaneously minimizing power consumption and an improving process speed. The presented unique 5T SRAM cell employs single bitline for read/write function. Implementation …
Published in Journal of VLSI Design Tools and Technology · Vol. 6, Issue 1, 2016 · pp. 49–54 Read article
-
Review on Design and Experiment Analysis of Two Cell Stack Proton Exchange Membrane Fuel Cell
Abstract: Design and experimental analysis of two cell stack PEM fuel cell with curvilinear flow field plate is done for doing comparison with single cell PEM fuel cell with serpentine flow field pattern to see the changes in output based on design of flow field and by increasing the active area. Following review is specially done on two cell stack PEM fuel cell in which the active area is 25 cm2; …
Published in Journal of Catalyst & Catalysis · Vol. 3, Issue 1, 2016 · pp. 15–24 Read article
-
Stem Cell Therapy for Hemorrhagic Stroke: A Single Case Study Report
Abstract: Stroke is the leading cause of morbidity and mortality worldwide. Stem cell therapy holds a great promise where transplanted cells can migrate at the site of injury and trigger regeneration of neurons that can lead to functional improvement. The present study was carried out to evaluate the effect of autologous bone marrow and allogeneic cord blood stem cell transplantation in hemorrhagic stroke patients. In the present case report, autologous bone …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 22–26 Read article
-
Characterization of a Single-Ended Schmitt-Trigger based 9T SRAM Cell
Abstract: Data stability is a prime concern in submicron regime. This work presents a single-ended Schmitt- trigger (ST) based 9T static random-access memory (SRAM) cell. Proposed design provides enhanced read stability as it uses ST based inverters. Low power dissipation is achieved by employing just a single bit line. Simulation is carried out on gpdk 180nm CMOS technology on Cadence. Proposed design offers 1.36x improvement in read static noise margin (RSNM) …
Published in Journal of Microelectronics and Solid State Devices · Vol. 6, Issue 2, 2019 · pp. 26–31 Read article
-
A Cost-Effective Fast Cell Balancing Technique for Lithium- Ion Batteries using a Single DC–DC Converter with Direct Energy Transfer
Abstract: A novel quick lithium-ion battery balancing method with a single DC-DC converter for facilitating the direct energy transfer process in low and high voltage cells is introduced in this research work. Cost effectiveness in the design of the switch network is achieved by the use of relays in switching the cells. A control circuit including an MCU and a battery management IC is used for the sensing of cell voltages …
Published in Journal of Power Electronics and Power Systems · Vol. 16, Issue 2, 2026 · pp. 1–13 Read article
-
Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
-
Hybridization of Photovoltaic Panels and Thermoelectric Generators: Energy Efficiency Improvement
Abstract: Heat removal from PV panels has been revealed as a feasible and operational solution to reduce the temperature of the panel and increase energy efficiency. In this paper, the use of a thermoelectric generator (TEG) attached to the photovoltaic panel is proposed. A set of Peltier cells has been designed, built, and coupled to the rear side of a PV panel to remove the heat flow generated at the PV …
Published in Journal of Microwave Engineering and Technologies · Vol. 9, Issue 3, 2022 · pp. 29–46 Read article
-
Long non-coded RNA, cancer, immune cells, tumor micro-environment, immuno-oncology, immune escape, cancer-immune cycle, lncRNA signature
Abstract: Developing data from current research reveals fresh insights into the roles played by long non-coding RNAs (lncRNAs) in immuno-oncology. Long non-coding RNAs (lncRNAs) not only influence the aggressiveness of cancer cells but also play a crucial role in controlling different immune cells and stromal cells, which in turn changes the tumor micro-environment and impacts anti-tumor immunity. The significance of predictive indicators derived from long non-coding RNAs (lncRNAs) is underscored by …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 1, 2024 · pp. 7–26 Read article