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9 articles for “precision toxicology”
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Toxicology 4.0: Integrating Artificial Intelligence, Big Data, Health Informatics, and Precision Analytics for Predictive Toxicity Assessment, Real-Time Toxicovigilance, and Personalized Patient Safety
Abstract: Background: Toxicology is undergoing a major transformation, increasingly described as Toxicology 4.0, driven by the integration of artificial intelligence (AI), big data analytics, health informatics, and precision analytics. Conventional toxicity testing is limited by high costs, lengthy timelines, and challenges in translating animal and low-throughput in vitro findings to humans. Aim and Objectives: To comprehensively evaluate the emerging role of Toxicology 4.0 in predictive toxicity assessment, real-time toxicovigilance, and personalized …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 Read article
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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A Comprehensive Review on Coumarin Derivatives
Abstract: Coumarins are naturally occurring compounds found in plants, fungi, and microorganisms with diverse bioactivities. They have antithrombotic, anti-inflammatory, antioxidant, antimicrobial, antiviral, anticancer, and neuroprotective properties. Extracting coumarins, using methods like maceration and microwave- assisted extraction, is crucial for their applications. However, safety and toxicology are important, especially in pharmaceuticals, cosmetics, and food additives. Consuming moderate amounts of coumarin-rich foods is generally safe, but excessive intake raises concerns about hepatotoxicity and …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 1, 2025 · pp. 72–80 Read article
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Nanomaterials and Their Effects on the Environment: Analyzing Widespread Use
Abstract: Due to the need and uses of nanoparticles in a wide variety of fields of human activity, including industry, agriculture, commerce, medical, and public health, there has been a significant uptick in interest in nanotechnology among the general populace. Because of the inevitability of environmental exposure to nanomaterials as a consequence of their increasing incorporation into our everyday lives, more and more focus is being placed on the study of …
Published in Journal of Polymer & Composites · Vol. 11, Issue 1, 2023 · pp. 97–103 Read article
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Engineered Polymer Composites for Non-Surgical Lip Posture Correction in Facial Paralysis
Abstract: Facial paralysis presents significant functional and aesthetic challenges, particularly through lip posture deficits such as drooping and drooling, often inadequately addressed by traditional surgical or drug-based interventions, especially in debilitated patients. This study explores the application of engineered polymer composites in a novel, non-surgical lip posture corrector designed to statically suspend and correct lip position without requiring surgical or dental support. The device utilizes a precisely formulated blend of polymethylmethacrylate …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 Read article
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A Comprehensive Review of Forensic Medicine: Its Evolution, Scope, Applications, and Future Directions
Abstract: Forensic medicine, a key junction of medical and law, has evolved substantially throughout the centuries, responding to scientific and technological advances. Forensic medicine, derived from the Latin term forensis, meaning “before the forum,” has evolved significantly over the centuries from rudimentary methods of determining the cause of death to a sophisticated and highly specialized medical discipline. Today, it encompasses a wide range of fields, including clinical forensic medicine, forensic pathology, …
Published in Research and Reviews: A Journal of Health Professions · Vol. 15, Issue 3, 2025 · pp. 18–28 Read article
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Development and validation of a method for simulataneous determination of tenovifir disoproxil fumarate emtriculabine and isonized in bulk and pharmaceutical dosage form using RP-HPLC with relevance to toxicological aspects
Abstract: Hence, proposed analytical methods are simple, novel, economical, rapid, sensitive, reproducible and accurate for the Simultaneous estimation of Tenofovir Disoproxil Fumarate, Emtricitabine and Isoniazid in Bulk and Phamaceutical dosage form by using RP- HPLC. This Method gives reliable assay results with short analysis time using mobile phase of Acetonitrile : 0.02M Potassium Dihydrogen Orthophosphate: water (pH 5.3) in the ratio of 60: 25: 15 respectively. Retention time was found to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 17–25 Read article
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Pharma Tech: Leveraging Software for Drug Development & Clinical Research
Abstract: The pharmaceutical sector is progressively adopting software solutions to enhance the drug development process and optimize clinical research results. Drug development is a time-consuming, expensive, and intricate process that traditionally requires extensive laboratory research, preclinical testing, and several stages of clinical trials. Software tools are revolutionizing these stages by improving efficiency, minimizing errors, and speeding up timelines. During preclinical testing, predictive software tools are used to model toxicological effects and …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 1, 2025 · pp. 11–19 Read article