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111 articles for “path discovery”
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A Survey of Various Route Selection Strategies for Mobile Ad-Hoc Networks
Abstract: Mobile Ad-hoc Networks (MANETs) have a dynamic topology due to the mobile nature of portable devices. Because of high mobility of mobile devices in MANETs, a frequent path failure occurs when a node changes its position in the network. Due to path failure, packet loss occurs in the network. Packet loss is responsible for information lost and retransmission in the network. To minimize packet loss in the network, there should …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 2, Issue 1, 2015 · pp. 17–23 Read article
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Pathways in Drug Discovery and Development: From Molecular Targets to Market Approval
Abstract: A complicated, multidisciplinary, and resource-intensive process, the discovery and development of new pharmacological drugs is essential to the advancement of contemporary medicine. Finding and optimising lead chemicals comes after a disease-relevant biological target has been identified and validated. Through preclinical research in animal models, these leads are thoroughly assessed for toxicity, pharmacokinetics, safety, and efficacy. Clinical trials, which are carried out in several stages to evaluate safety, efficacy, ideal dosage, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 01–04 Read article
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Unveiling the Silent Threat: The Escalation and Defence Against Antibiotic Resistance
Abstract: The global challenge of antibiotic resistance presents a significant risk to public health, driven by multifaceted factors worldwide. This issue, akin to the impacts of climate change, requires concerted efforts at national and international levels to mitigate its consequences. Antibiotics have revolutionized modern medicine, enabling critical interventions like surgeries, transplants, and cancer treatments. However, without global collaboration, we face significant setbacks across medical, social, and economic domains. Initiatives to address …
Published in International Journal of Antibiotics · Vol. 2, Issue 2, 2025 · pp. 1–26 Read article
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In Silico Drug Designing of Breast Cancer in Homo sapiens
Abstract: Breast cancer is a severe health concern in India, with the highest mortality rate among women. It is brought on by uncontrolled cell division and has the potential to spread to other body regions. As a transcription factor, interactions with estrogen receptor (ER) alpha are primarily responsible for malignant tumors through regulating the transcription of numerous genes. Because most of the medications now used to treat breast cancer have significant …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 2, 2022 · pp. 12–27 Read article
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Molecular Pharmacokinetics and Structural Docking of Phenolic Acids for Targeting NF-κB Pathway Components in Inflammation and Fibrosis: A Computational Approach Toward Therapeutic Discovery
Abstract: Inflammation and Fibrosis are critical pathological processes associated with various chronic diseases, often mediated by the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. This study investigates the therapeutic potential of phenolic acids as modulators of the NF-κB pathway, aiming to identify novel ligands that can effectively interact with key components of this signaling cascade. A comprehensive computational approach was employed, utilizing molecular docking, pharmacological screening, and post-docking …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 14–31 Read article
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Review on Computer-Aided Drug Design in RAS Inhibitor Discovery
Abstract: This review explores the utilization of computer-aided drug design (CADD) methodologies in the discovery of inhibitors targeting the RAS pathway, a pivotal signaling cascade implicated in various cancers. Through an extensive examination of computational tools, methodologies, challenges, and recent advancements, this review aims to provide insights into the role of CADD in accelerating RAS inhibitor discovery. The discovery of effective inhibitors targeting the RAS pathway is of paramount importance in …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 3, 2024 · pp. 7–14 Read article
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A Study on accelerating threat of Emerging Infectious Diseases (EIDs) and imperative for a proactive, interdisciplinary Global Health Security Framework
Abstract: Emerging Infectious Diseases (EIDs) represent one of the most critical and persistent threats to global health security in the 21st century. Driven primarily by the synergy of unprecedented human encroachment into wild habitats, climate change-induced ecological disruption, accelerated international travel, and antimicrobial resistance, the frequency and severity of zoonotic spillover events are rapidly increasing. Traditional, reactive public health measures—focused on containment after an emergence—have repeatedly proven insufficient, leading to catastrophic …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 8–21 Read article
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An Energy Efficient Routing Algorithm for FiWi Access Network
Abstract: AbstractFiber wireless access network is a promising access network due to the provision of higher bandwidth, flexibility, and ubiquity. One of the main challenges for a FiWi access network is to minimize energy consumption. In this network, there are many concerns like ONU placement, ONU sleep mechanisms, power saving mechanisms, etc., which are accountable for achieving energy efficiency. Routing is another aspect at the front end of the network, which …
Published in Journal of Communication Engineering & Systems · Vol. 7, Issue 2, 2017 · pp. 1–13 Read article
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Drug Discovery and Development: An Overview from the Regulatory Prospective
Abstract: The improvement of medication from an underlying plan to its entrance into the market is an extreme process which can take around 5–10 years and cost $1.7 billion. The thought for another advancement can originate from an assortment of sources which incorporate the flow necessities of the market, new rising infections, good clinical research, business part, and so on. Once an objective for revelation has been picked, the pharmaceutical businesses …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 1, 2019 · pp. 1–9 Read article
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Revolutionizing oncology - role of artificial intelligence in early cancer detection and diagnostic advances-A comprehensive review
Abstract: Oncology has experienced a remarkable transformation with the adoption of artificial intelligence (AI), which has greatly enhanced cancer detection and diagnosis. As one of the leading causes of death worldwide, cancer highlights the importance of early detection in improving patient outcomes and survival rates. AI’s ability to analyze vast and complex datasets has enabled groundbreaking innovations in imaging, pathology, biomarker discovery, and predictive analytics. This review highlights key AI-driven advancements …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 1, 2025 · pp. 18–22 Read article
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Triple Action of Dandrovep to Treat Dandruff
Abstract: Dandruff is a typical scalp condition in which small pieces of dry skin flake off of the scalp. In the event that you have dull hair or you're wearing dark colors, it may be the pieces in once hair or on your shoulders. Dandruff may likewise make your scalp tingle. Numerous individuals trust that dandruff is brought about by poor cleanliness; however, this isn't valid. Albeit rare shampooing can make …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 6, Issue 1, 2019 · pp. 24–26 Read article
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Computational Approaches to Understanding Cellular Signaling Pathways
Abstract: Cellular signaling pathways are fundamental in regulating vital processes, such as cell growth, differentiation, and apoptosis. The intricate and interconnected nature of these signaling networks requires sophisticated methods for their analysis. Computational approaches, including mathematical modeling, network analysis, and machine learning, have revolutionized the way researchers analyze and simulate cellular signaling. This article provides a comprehensive overview of computational strategies employed to model signaling pathways, with a focus on integrating …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 8–13 Read article
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AI-Driven Multi-Objective Optimization of Conductive Polymer Composites for High-Performance Flexible Electronics
Abstract: The development of conductive polymer composites (CPCs) is critical for advancing flexible and wearable electronic technologies. However, the conventional trial-and-error approach to material formulation is time-consuming and often inefficient due to the high-dimensional nature of the design space. This study introduces a novel AI-driven framework that integrates machine learning (ML) with multi-objective optimization to accelerate the discovery of high-performance CPCs. A dataset of 1,000 experimentally reported formulations was compiled, capturing …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 734–745 Read article
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Reverse Pharmacology: A Gateway to Validation of Efficacy of Natural Drugs
Abstract: In spite of significant advances in genomics, proteomics, metabolomics and combinatorial chemistry in the present times, reverse pharmacology (RP) has led to deviation of drug discovery and development from its regular or normal process or path. RP is a trans-disciplinary path which reverses the drug discovery and development process from lab-clinic to clinic-lab. Natural products (NPs) of Unani medicine or traditional system of medicine (TSM) provide vast potential for novel …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 9, Issue 3, 2020 · pp. 48–53 Read article
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A Review on the Clinical and Pathological Significance of Prorenin Receptor [(P)RR]
Abstract: The (pro)renin receptor (P)RR discovery, which is a novel constituent of Renin Angiotensin-Aldosteron System (RAS) has brought renin and (pro)renin back into spotlight. The (P)RR binds both renin and its inactive precursor (pro)renin, this binding triggers a cascade of intracellular signalling that eventually leads to upregulation of the expression of profibrotic genes, potentially leading to pathogenesis of cardiac and renal fibrosis, growth and remodelling. Clinically, it is also seen that …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 2, 2015 · pp. 11–17 Read article
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Exploring the Dynamics of Eye Fluid: Lymphatics, Aqueous Humor, and Intraocular Pressure
Abstract: Lymphatic vessels are essential for regulating interstitial fluid balance, facilitating immune cell transport, supporting lipid absorption, and playing significant roles in tumor development and metastasis. Recent findings have expanded their recognized functions, particularly in pathological contexts. One notable discovery is the involvement of lymphatics in draining aqueous humor from the eye, a process closely linked to the regulation of intraocular pressure (IOP) and its implications for glaucoma progression. This review …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 2, 2025 · pp. 31–44 Read article
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Fuzzy Based Clustering Algorithm Rebroadcast with Ant Colony Based Cluster Head Selection for Minimizing the Routing Overhead in Mobile Ad-Hoc Networks
Abstract: Mobile Ad-hoc Networks (MANET) are built with no sort of management, rendering the quality of servicedespite the routing overhead. With MANET, mobile hosts cannot interact with other hosts in a single hop.In the case of multi-hop, packets transmitted by the source host get relayed with the help of multipleintermediate hosts prior to its arrival at the destination host. Owing to the node movement in MANETs,path outages and route discoveries happen …
Published in Journal of Mobile Computing, Communications & Mobile Networks · Vol. 8, Issue 2, 2021 · pp. 12–27 Read article
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Analysis for Respiratory Transmittable Diseases via Mass Spectrometry
Abstract: Microbial identification in clinical diagnostic laboratories has mainly relied on conventional phenotypic and gene sequencing identification techniques. The development of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) devices has revolutionized the repetitive identification of microorganisms in clinical microbiology laboratories by introducing an easy, rapid, high throughput, low-cost, and effective identification technique. This technology has been modified to the restraint of clinical diagnostic laboratories and has likely to replace …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 7, Issue 1, 2017 · pp. 26–30 Read article
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Magnetic ZnxFe2–xO3 Nanoparticles Enhanced Nanobiosensor Integrated with MOSFETs for Efficient Detections of Biomolecules and Cancerous Cells
Abstract: The human brain is mostly responsible for intelligence and consciousness. An artificial equivalence of this action is nanobiosensor, which is used in artificial intelligence. The need for nanodiagnostics platforms for detecting diseases at the genetic, molecular, and cellular level has triggered the development of nanobiosensors integrated with MOSFETs. This device enables simple, inexpensive rapid tests, accurate imaging methods, and accurate molecular diagnosis at point-of-care (POC). This device is seen as …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 3, 2024 · pp. 33–44 Read article
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CB₁ Reverse Agonists: A Cheminformatic and Patent Landscape Study
Abstract: The endocannabinoid system plays a crucial role in numerous physiological functions, making cannabinoid receptor 1 (CB1) an attractive target for therapeutic development. This review provides a systematic analysis of patent filings from 2019 to 2023 that focus on small-molecule CB1 reverse agonists. It begins with an overview of the endocannabinoid system, highlighting CB1’s involvement in energy balance, pain regulation, and neuroinflammatory processes The main section of the review examines fifteen …
Published in International Journal of Cheminformatics · Vol. 3, Issue 2, 2025 · pp. 33–36 Read article