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51 articles for “network biology”
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Introduction to Biological Networks and their Contributions to Systems Biology
Abstract: Biological networks provide a conceptual framework to represent and analyze the intricate interconnections among the numerous components that make up living systems. This review paper elucidates the foundational principles of networks and their diverse applications in systems biology, highlighting their crucial role in understanding the inherent complexity of biological processes. Utilizing graph theory, these networks represent entities like genes, proteins, and metabolites as nodes, with their interactions depicted as edges. …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 2, Issue 1, 2024 · pp. 53–70 Read article
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Integrative Network Biology Analysis of GSE6011 Uncovers Molecular Signatures in Duchenne Muscular Dystrophy
Abstract: Duchenne muscular dystrophy (DMD) is a rare, severe neuromuscular disorder demonstrated by progressive skeletal muscle deterioration and premature mortality. Despite advances in supportive care, no definitive cure exists, highlighting the need to explore novel molecular targets. The current study aimed to uncover key dysregulated genes and molecular pathways in DMD through a dataset-specific network biology approach. Publicly available microarray data (GSE6011) from DMD quadriceps muscle biopsies of 22 patients and …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 3, 2025 · pp. 36–48 Read article
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Unveiling Nature’s Potential: In Silico Exploration and Identification of Herbal Remedies for Major Depressive Disorder Through Molecular Interaction Studies
Abstract: Major depressive disorder (MDD), a globally discussed mental health condition, has drawn significant attention because of its unique and intricate nature. This is marked by the enduring presence of negative emotions stemming from a lack of interest, diminished self-esteem, and excessive rumination. Despite the widespread availability of various antidepressant medications, their effectiveness is hindered by low response rates, prolonged treatment durations, and the prevalence of side effects, such as headaches, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 54–62 Read article
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Application of Resource Allocation Similarity Based Link Prediction in Wireless Networks
Abstract: Link prediction in wireless networks plays a crucial role in predicting missing connections within multiplex networks. This study focuses on the utilization of similarity-based link prediction methods in wireless networks. These methods assume that the likelihood of linkage between nodes is determined by their similarity, based on shared features. Several similarity measures, such as Common Neighbors (CN), Preferential Attachment (PA), Adamic-Adar (AA), and Resource Allocation (RA) indices, are commonly employed …
Published in International Journal of Wireless Security and Networks · Vol. 1, Issue 2, 2023 · pp. 37–42 Read article
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Hybrid Approach for Community Detection Using Deep Learning Techniques
Abstract: Community detection in complex networks is a fundamental problem with applications across diverse domains, ranging from social networks to biological systems and beyond. Traditional methods based on graph theory have been widely used for identifying communities within networks. However, the intricate and evolving nature of modern networks demands more sophisticated approaches. This research work proposes a hybrid approach that combines the strengths of deep learning techniques with traditional community detection …
Published in Recent Trends in Electronics Communication Systems · Vol. 11, Issue 3, 2024 · pp. 18–26 Read article
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Navigating the Depths of Cancer Stem Cells: Unraveling Resistance Mechanisms and Emerging Therapeutic Strategies
Abstract: In the past few decades, comprehensive evidence has convincingly established the presence of cancer stem cells (CSCs) as a minor subset within tumors, contributing to an unusually elevated level of cellular diversity within the malignancy. CSCs are functionally identified by their capacity for self-renewal and differentiation, frequently influenced by signals from their surrounding microenvironment. The interconnected transcriptional, post-transcriptional, metabolic, and epigenetic regulatory networks govern the biological characteristics of CSCs. CSCs …
Published in Recent Trends in Infectious Diseases · Vol. 1, Issue 2, 2024 · pp. 14–18 Read article
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Graphene–Perovskite Hybrid Opto-Electronic Modulators for Ultra-Low Power Optical Communication
Abstract: This paper proposes a novel self-adaptive neuromorphic opto-electronic transceiver architecture designed to enhance the intelligence, adaptability, and efficiency of next-generation optical communication networks. The proposed system integrates neuromorphic computing principles with photonic signal processing to enable real-time learning, dynamic resource allocation, and autonomous compensation of channel impairments such as dispersion, nonlinearities, and noise. Unlike conventional transceivers, the developed model employs spiking neural networks embedded within opto-electronic circuits to mimic biological …
Published in Trends in Opto-electro & Optical Communication · Vol. 16, Issue 1, 2026 · pp. 41–52 Read article
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Neuromorphic Spiking Neural Networks and Event-Driven Hardware: Architectures, Learning Paradigms, and Experimental Realizations
Abstract: With the current computational boom the research community is seeking for more sustainable energy efficient i.e. biologically inspired models of conventional Artificial Neural Networks (ANNs). Spiking Neural Networks (SNNs) known as the third generation of neural network models, provide a revolutionary approach by mimicking the asynchronized event-driven and temporally accurate signaling of the mammalian brain. Whereas conventional deep learning models operate with real-valued activations and dense matrix multiplications, SNNs use …
Published in Current Trends in Signal Processing · Vol. 16, Issue 2, 2026 Read article
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Monoclonal Antibodies in Next Generation Animal Nutrition: Mapping Nutrient Immune Interaction Networks in Livestock Systems
Abstract: Sustainable livestock production is increasingly constrained by disease pressure, antimicrobial resistance, and declining feed efficiency under intensifying environmental stressors. Conventional nutritional strategies, while essential, remain insufficient to precisely regulate immune function and metabolic resilience. This review explores the emerging role of Monoclonal antibodies as advanced biologics in next generation animal nutrition, with a focus on mapping nutrient immune interaction networks in livestock systems. It synthesizes current knowledge on how nutrients …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Predictive Modeling of Polymer Composites for Medical Implants Using Artificial Intelligence Techniques
Abstract: The use of polymers in biomaterials was now key to designing the next generation of medical implants, which need to be strong and also compatible with living tissue. Tests for biocompatibility, such as those done in the laboratory and by doing experiments on animals, require much time and many resources, so the need for computer-based approaches becomes clear. An artificial intelligence approach was provided in this study to determine how …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 665–692 Read article
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Recent Developments in Structural Genomics: Uncovering Cellular Functions
Abstract: Structural genomics has become a groundbreaking field for understanding cellular functions by revealing the three-dimensional structures of proteins and other biomolecules. This field combines advanced methods like X-ray crystallography, nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and computational modeling to explore the molecular structure and behavior of cellular components. Recent advances have significantly accelerated the pace of structure determination, bolstered by high-throughput methods and artificial intelligence tools like AlphaFold. These developments …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 30–35 Read article
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Physics-Informed Generative and Tensor-Based Framework for DNA Sequence Simulation and Genomic Structure Discovery
Abstract: In this paper, we explore the intersection of artificial intelligence (AI) and mathematical physics to propose advanced methods for DNA sequence generation and analysis. Specifically, we investigate how physics-informed Generative Adversarial Networks (GANs) and tensor network representations can be harnessed to restructure DNA for applications in genetic science. The proposed methodology offers a unique integration of concepts of thermodynamic modeling with innovative GAN architecture in order to allow the creation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Myco-Engineering Systems: Harnessing Fungal Networks for Carbon Sequestration and Sustainable Ecosystem Restoration
Abstract: Fungal organisms play a foundational role in global ecosystem stability, particularly through their contributions to nutrient cycling, soil regeneration, and carbon sequestration. Recent scientific advances have highlighted the potential of fungal mycelial networks as natural bioengineered systems capable of supporting sustainable environmental restoration. This paper introduces the concept of Myco-Engineering Systems, an interdisciplinary framework that integrates fungal biology, environmental science, and artificial intelligence (AI) to enhance carbon capture and ecosystem …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 16, Issue 2, 2026 Read article
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Identification of Hub Genes and Enriched Gene Ontology & Pathways in Idiopathic Pulmonary Fibrosis Through Bioinformatics Approaches
Abstract: Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant remodeling of lung tissue and excessive extracellular matrix deposition, ultimately leading to respiratory failure. Despite ongoing research, the molecular mechanisms underlying IPF remain incompletely understood. This research aims to uncover differentially expressed genes (DEGs) and related biological pathways through an integrated analysis of microarray data. Two publicly available datasets, GSE110147 and GSE53845, were obtained from the Gene …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 1, 2026 · pp. 1–13 Read article
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Oceanmind Systems: AI-Driven Marine Life Intelligence for Climate Prediction and Ocean Ecosystem Stability
Abstract: Oceans regulate global climate systems, support biodiversity, and serve as critical carbon sinks, yet they remain under-monitored relative to their ecological importance. Traditional oceanographic methods rely heavily on satellite sensing, buoy networks, and periodic marine surveys, which often fail to capture real-time biological dynamics at micro-ecosystem levels. This paper introduces OceanMind Systems, an artificial intelligence (AI)-driven marine intelligence framework that integrates marine life behavior, oceanographic data, and computational modeling to …
Published in International Journal of Marine Life · Vol. 3, Issue 2, 2026 Read article
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The Rise of Fractional Calculus: Novel Applications in Engineering and Biological Systems
Abstract: Fractional calculus (FC) is an advanced mathematical framework that generalizes the classical concepts of differentiation and integration to non-integer, or fractional, orders. This extension of traditional calculus allows for the modeling of complex dynamic systems that exhibit behavior not easily captured by integer-order differential equations. Over the last few decades, fractional calculus has seen a rapid rise in popularity, particularly in applied mathematics, engineering, and biological sciences, due to its …
Published in Recent Trends in Mathematics · Vol. 1, Issue 2, 2024 · pp. 7–11 Read article
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Harnessing Bacteria for Next-Generation Data Storage Technologies – A Review
Abstract: The exponential increase in global digital information has created a pressing need for storage technologies that are more durable, compact, and sustainable than conventional electronic media. While hard drives, solid-state drives, and cloud-based systems have transformed information management, they face severe limitations related to storage density, energy consumption, maintenance costs, and long-term preservation. Researchers have, therefore, begun exploring biological systems as alternative information storage platforms. Among these, bacteria have emerged …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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A Neuromorphic-Inspired, Low-Power VLSI Architecture for Edge AI in IoT Sensor Nodes
Abstract: As the proliferation of Internet of Things (IoT) devices continues to rise, there is an increasing demand for real-time, energy-efficient artificial intelligence (AI) processing directly at the network edge. Traditional edge AI accelerators, often based on deep learning models like convolutional neural networks (CNNs), struggle to meet the ultra-low-power requirements of battery-constrained IoT sensor nodes. In response to this challenge, this study introduces a neuromorphic-inspired, low-power very- large-scale integration (VLSI) …
Published in Journal of Microelectronics and Solid State Devices · Vol. 12, Issue 2, 2025 · pp. 41–47 Read article
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Exploring the Role of MAPK3 in Major Depressive Disorder: Molecular Docking, Dynamics, and Binding Free Energy Analysis of Natural Compounds as Alternatives to Conventional Drugs
Abstract: Major Depressive Disorder (MDD) is a prevalent neuropsychiatric disorder with limited treatment efficacy and significant side effects associated with conventional antidepressants. Recent studies have highlighted the role of mitogen-activated protein kinase 3 (MAPK3) in the mechanisms underlying MDD, positioning it as a potential target for the development of novel therapeutic drugs. In this study, we employed various computational approaches to explore natural compounds as viable alternatives to synthetic antidepressants. Researchers …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 3, Issue 2, 2025 · pp. 53–68 Read article
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Environmental Impact Assessment of Ocean Energy Converters Using Quantum Machine Learning
Abstract: The accelerating deployment of ocean energy converters (OECs) across tidal, wave, osmotic, and thermal domains necessitates rigorous, data-intensive environmental impact assessment (EIA) frameworks capable of modelling multi-stressor marine ecosystems in real time. Classical machine learning approaches, while operationally mature, encounter scalability bottlenecks and feature correlation limitations when applied to the high-dimensional, non-linear datasets characteristic of offshore monitoring networks. This paper presents a comprehensive quantum machine learning (QML) framework for the …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 16, Issue 1, 2026 · pp. 22–31 Read article