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40 articles for “method development and validation”
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Photochemically Assisted LC–MS Method Development and Validation for Stability-Indicating Determination of Glasdegib in Rat Plasma
Abstract: A simple, precise, and cost-effective LC–MS method was successfully developed for the determination of Glasdegib in rat plasma. The method optimization was carried out by systematically varying key chromatographic parameters, including flow rate, injection volume, analyte concentration, and mobile phase composition, to achieve optimal sensitivity and resolution. A C18 Hypersil BDS column (150 mm × 4.6 mm, 3.5 µm particle size) was used for chromatographic separation, offering effective peak shape …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 4, Issue 1, 2026 · pp. 11–20 Read article
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Development and Validation of a Robust RP-HPLC Method for Rufinamide Quantification in Pharmaceutical Dosage Forms
Abstract: The creation and validation of a simple, precise, and targeted reverse phase high-performance liquid chromatographic (RP-HPLC) approach allowed for the quantification of rufinamide in pharmaceutical dosage forms. With a mobile phase of methanol and water (50:50, v/v), the technique used a gradient mode Symmetry Qualisil gold C18 column (4.6 x 150mm, 5 μm). For the detection method, a flow rate of 1 mL/min was employed at 220 nm. During a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 25–32 Read article
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Multi-phase Flow Simulation Using Computational Fluid Dynamics
Abstract: Computational fluid dynamics (CFD)-based multi-phase flow simulation is a fast developing topic with broad applications in many scientific fields and industry. An extensive account of current developments, difficulties, and uses in multi-phase flow simulations is given in this review paper. Important modeling strategies, numerical methods, validation procedures, and new developments in CFD-based multi-phase flow analysis are covered. This paper is to contribute to the ongoing development and use of CFD …
Published in International Journal of Machine Systems and Manufacturing Technology · Vol. 1, Issue 2, 2023 · pp. 28–34 Read article
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Optimizing Antibiotic Analysis: A Comprehensive Guide to HPLC Process of Assessment and Quantification
Abstract: The history and uses of chromatography are thoroughly covered in this work, with an emphasis on the use of High-Pressure Liquid Chromatography (HPLC) in pharmaceutical analysis. Since its discovery by Russian botanist Mikhail Tswett in the 19th century, chromatography has undergone tremendous developments that have given rise to a variety of chromatography types and applications. The story follows the evolution historically, emphasizing Tswett's groundbreaking breakthrough in plant color classification and …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 27–44 Read article
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Evaluate the Impact of a First Aid Module on the Knowledge and Skills Related to First Aid Management Among Nursing Students at Gian Sagar College of Nursing, Ramnagar, Rajpura, Punjab
Abstract: Introduction: First aid refers to the immediate and temporary care provided to individuals who are injured, ill, or wounded before professional medical assistance becomes available. Since accidents can occur unexpectedly, having fundamental first aid knowledge is invaluable. It enables individuals to deliver prompt, lifesaving assistance and prevent complications until expert care arrives. Training nursing students in first aid is particularly important, as it equips them to preserve life, prevent further …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 3, Issue 2, 2025 · pp. 42–55 Read article
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Literature Review and Research Gaps in Power Quality Enhancement: From Conventional Methods to Intelligent Solutions
Abstract: Power quality (PQ) has become a critical concern in modern electrical power systems due to the rapid integration of renewable energy sources, proliferation of power electronic devices, and increasing sensitivity of loads. This paper presents a comprehensive literature review and research gap analysis of power quality enhancement techniques, ranging from conventional approaches to emerging intelligent solutions. Traditional methods, including passive filters, capacitor banks, and synchronous condensers, have been widely employed …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 4, Issue 1, 2026 · pp. 38–80 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Electromagnetic Propulsion Train for Future Transportation
Abstract: The Electromagnetic Propulsion Train project focuses on the development and analysis of a prototype system that achieves linear motion through the application of controlled electromagnetic forces. Unlike conventional railway systems that rely primarily on mechanical drive mechanisms such as wheels, axles, and traction motors, this project explores an alternative propulsion approach based on electromagnetic interaction. In this system, a sequence of electromagnets is strategically positioned along the track to generate …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 3, Issue 2, 2025 · pp. 25–31 Read article
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Computational Approaches to Understanding Cellular Signaling Pathways
Abstract: Cellular signaling pathways are fundamental in regulating vital processes, such as cell growth, differentiation, and apoptosis. The intricate and interconnected nature of these signaling networks requires sophisticated methods for their analysis. Computational approaches, including mathematical modeling, network analysis, and machine learning, have revolutionized the way researchers analyze and simulate cellular signaling. This article provides a comprehensive overview of computational strategies employed to model signaling pathways, with a focus on integrating …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 8–13 Read article
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DFT/Data Guided Predictive Modelling of Absorption Maxima in the OLED Rubrene Derivatives
Abstract: This study investigates the optical properties of rubrene derivatives to develop an accurate predictive model for absorption maxima using computational chemistry and chemoinformatic techniques. We benchmarked various quantum chemical methods, identifying that the M06-2X/aug-cc-pVDZ method in dichloromethane (DCM) provided the strongest correlation with experimental data. Key molecular descriptors such as band gap, ionization potential, and electrophilicity index were calculated and analyzed using principal component analysis (PCA) to identify significant factors …
Published in International Journal of Cheminformatics · Vol. 4, Issue 1, 2026 · pp. 41–56 Read article
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Anti-hyperglycemia Effects of Plant Secondary Metabolites Towards PKA/CREB Pathway Activation in Diabesity
Abstract: Objective: Diabesity, the amalgamation of diabetes and obesity, presents a significant global health challenge. This research carefully examines how plant secondary metabolites influence glucose regulation in diabetes using the PKA/CREB pathway, paying particular attention to diabesity—the combination of diabetes and obesity. Understanding the complex ways in which these metabolites affect metabolic health will help to identify new treatment approaches for managing diabetes and its associated problems. By conducting a thorough …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 33–50 Read article
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Chemiluminescence: Recent Developments and Photochemical Applications in Analytical Chemistry
Abstract: Chemiluminescence (CL) is the observable production of electromagnetic radiation from a chemical reaction, typically in the form of ultraviolet, visible, or infrared light. According to subjective yield, CL has either been directly emitted from electronically excited intermediate products, or it has been supported by another molecule to emit CL. Since the 1950s, CL has been supported as a valid analytical tool, with the descriptive issued scope being limited to content …
Published in International Journal of Photochemistry and Photochemical Research · Vol. 2, Issue 1, 2024 · pp. 20–25 Read article
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Machine Learning Assisted Timing Violation Prediction in Sub-7nm VLSI Physical Design
Abstract: The continuous scaling of semiconductor technology into the sub-7nm regime has introduced significant challenges in timing closure due to process variability, interconnect delay, power density, and manufacturing uncertainties. Conventional static timing analysis techniques often require extensive computational resources and iterative optimization cycles, resulting in increased design complexity and longer turnaround time. This research proposes a Machine Learning Assisted Timing Violation Prediction framework for sub-7nm VLSI physical design to improve early-stage …
Published in International Journal of VLSI Circuit Design & Technology · Vol. 4, Issue 1, 2026 Read article
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Evaluating an ai-supported experiential learning intervention: a quasi-experimental study of the joyful saturday model for student engagement and holistic development
Abstract: Student disengagement, declining academic motivation, and passive classroom participation remain major challenges in modern higher education systems. Traditional lecture-based teaching methods often fail to accommodate diverse learning styles and do not sufficiently promote active participation or collaborative learning. To address these challenges, the present study evaluates the effectiveness of Joyful Saturday, a structured experiential learning initiative designed to improve student engagement, motivation, and holistic development through interactive academic activities supported …
Published in International Journal of Behavioral Sciences · Vol. 3, Issue 1, 2026 · pp. 79–88 Read article
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Optimization of Process Parameters for AISI 304 Using Micro-EDM Drilling Process Through Response Surface Method
Abstract: The increasing demand for micro-parts in high-tech products, such as micro-electromechanical systems (MEMS) applications and micro-electronic devices, has driven significant advancements in micromachining technologies. Among the various micromachining processes, the fabrication of accurate microholes and pins is critical for the performance and reliability of miniature components. Micro-hole drilling plays a vital role by enabling the production of deep holes with excellent straightness, roundness, and surface quality. It is widely used …
Published in International Journal of Manufacturing and Production Engineering · Vol. 3, Issue 1, 2025 · pp. 37–47 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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A Review of Drug Design Techniques Assisted by Computers to Combat Diabetes
Abstract: Diabetes mellitus is a global health concern characterized by chronic hyperglycemia and associated complications. The creation of innovative medicines with enhanced efficacy and safety profiles continues to be a top focus, notwithstanding improvements in treatment. A useful method in drug development, computer-aided drug design (CADD) makes it easier to identify possible therapeutic candidates and optimise lead molecules. An extensive synopsis of CADD tactics used in the fight against diabetes is …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
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Design and Analysis of Thermoelectric Dc boost converter
Abstract: In today’s consumer-oriented market, researchers are increasingly focusing on harvesting energy from ambient and renewable sources to enable sustainable power generation and reduce dependency on conventional energy resources such as batteries and fossil-fuel-based electricity. The rapid growth of portable electronics, wireless sensor networks, and Internet of Things (IoT) devices has created a significant demand for low-power, long-life, and maintenance-free energy solutions. In many practical situations, frequent battery replacement is difficult, …
Published in International Journal of Electro-Mechanics and Material Behaviour · Vol. 4, Issue 1, 2026 · pp. 1–10 Read article
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Multilingual Education and Language Policy in a Globalized World: Toward Inclusive and Equitable Learning Systems
Abstract: Multilingual education involves teaching and learning in two or more languages, promoting linguistic diversity and enhancing educational outcomes. It acknowledges learners’ native languages and integrates them with dominant or global languages to foster inclusivity and cognitive development. Multilingual education (MLE) serves as a critical framework for promoting inclusivity and equity within increasingly globalized and culturally diverse classrooms. This paper explores the role of MLE and the influence of language policies …
Published in International Journal of Education Sciences · Vol. 3, Issue 1, 2026 · pp. 64–74 Read article
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Analyzing the Sheet Metal Extrusion Process Using Finite Element Analysis
Abstract: A wide range of sheet metal forming techniques has been developed to make it easier to produce intricate 3D objects. However, the knowledge still isn't sufficient. The sheet metal extrusion method was examined in this research as one of the common sheet-bulk metal manufacturing technologies. Consideration of the flow-stress curve's impact across a broad range of plastic strain and ductile damage played a pivotal role in constructing a realistic finite …
Published in International Journal of Fracture Mechanics and Damage Science · Vol. 1, Issue 1, 2023 · pp. 13–25 Read article