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92 articles for “metabolic enzymes”
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Alteration in Metabolic Enzymes of Albino Rats under Cadmium Stress and their Modulation by Mentha Piperita
Abstract: Cadmium is a heavy metal posing severe risks to human health without any physiological function in the human body. Cadmium is found regularly in soil, rocks and ores, thus natural exposure is an important aspect, but increasing industrial application has put it in the category of bio-hazardous metals. Anticorrosive agents, stabilizer in PVC products, colour pigments, neutron-absorber in nuclear power plants, the fabrication of nickel-cadmium batteries and Phosphate fertilizers carry …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 3, 2013 · pp. 1–4 Read article
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Growth and Nitrogen (N) Metabolizing Enzymes of Mesophilic and Psychrophilic Heterocystous Cyanobacteria—In Response to Temperature Regimes
Abstract: The increased NR & NiR activity, GS and nitrogenase activities at 25°C and 35°C in psychrophilic and mesophilic organisms indicates that the Arctic isolate is a psychrotolerant as it shows increased enzyme levels than its original temperature in which we isolated the organism though biomass was greater at 3°C. The biomass and enzyme data indicates cyanobacteria are the initiators of primary colonization in polar and alpine environments and are responsible …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 8, Issue 3, 2018 · pp. 31–43 Read article
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Sodium benzoate induced reproductive and metabolic changes in Anabas testudineus (Bloch, 1792)
Abstract: AbstractSodium benzoate is an effective antimicrobial agent used as a food preservative, but recently gained attention as the chemical toxicant. The present study investigated sodium benzoate induced male reproductive toxicity and metabolic changes at100 mg/ L concentration in the freshwater fish, Anabas testudineus. Sodium benzoate did not alter the weight of fish but increased the secretion of mucous as the primary defensive mechanism. Reduction in the absolute and relative weights …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 10, Issue 1, 2020 · pp. 56–71 Read article
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Review on Histological and Functional Effect of Alcohol on Liver and Kidney
Abstract: Alcohol consumption represents the third largest risk factor for disease burden in most countries of the world. The purpose of this review is to give a comprehensive report of the existing data on the potential adverse effects of alcohol on liver and kidney toxicity. We used 82 different published materials for the compilation of this review article. The Google search engine was used for accessing published materials from databases like …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 7, Issue 2, 2018 · pp. 49–62 Read article
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Molecular Mechanisms of Drug Metabolism in Anesthesia: A Pharmacogenomic Perspective
Abstract: Pharmacogenomics studies how a person’s genetic profile affects their reaction to drugs, which is vital in anesthesia. Anesthetic pharmacology depends significantly on drug metabolism, which involves complex biochemical processes that manage the absorption, distribution, metabolism, and excretion (ADME) of anesthetic drugs. The cytochrome P450 (CYP) enzyme family plays a critical role in the metabolism of various anesthetic drugs, with genetic polymorphisms leading to inter-individual variability in drug responses. Specific CYP …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 90–95 Read article
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Living with Glucose-6-Phosphate Dehydrogenase Deficiency
Abstract: Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) is an X-linked recessive hereditary disease characterized by abnormally low levels of glucose-6-phosphate dehydrogenase, a metabolic enzyme involved in the pentose phosphate pathway, especially important in red blood cell metabolism. G6PD deficiency is the most common human enzyme defect. Individuals with this disease may exhibit non-immune hemolytic anemia in response to a number of causes, most commonly infection or exposure to certain medications or fava …
Published in Journal of Nursing Science & Practice · Vol. 6, Issue 1, 2016 · pp. 23–30 Read article
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Analysis of Proximate Composition, Nutritional Contents and Enzymatic Activities of a Local Variety of Betel Leaf from Bangladesh
Abstract: AbstractBetel leaf is a medicinal herb that is commonly used as chewing food item to almost all classes of people in Bangladesh. In the present study, a local variety of betel leaf, Dudhswar, was investigated for analyzing the levels of proximate compositions, vitamins, minerals and carbohydrate metabolizing enzymatic activities. At mature stage, moisture, ash and fiber contents of the betel leaf were 85.40%, 3.15% and 2.11%, respectively. Moisture content decreased …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 10, Issue 3, 2021 · pp. 21–30 Read article
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Biochemical Changes in Chickpea (Cicer arietinum L.) Plants Induced by Flooding
Abstract: Flooding is a significant environmental stressor that affects the growth, development, and productivity of chickpea (Cicer arietinum L.), a crucial pulse crop grown worldwide, especially in India. This study investigates the biochemical changes in chickpea plants subjected to prolonged and sudden flooding. Key parameters analyzed include carbohydrate metabolism, protein content, chlorophyll levels, amylase activity, and proline accumulation. Results show that flooding significantly reduces total sugar content in leaves, stems, and …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–9 Read article
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Antidiabetic and Antioxidant Activity of Leaves of Aegiceras corniculatum (L.) Blanco (Black Mangrove): An in vitro and in vivo Study
Abstract: AbstractPurpose: Aegiceras corniculatum (L.) Blanco, commonly known as Black Mangrove, is a species of shrub or tree mangrove with a distributed Indian mangrove forest and traditionally used to treat diabetes and other health ailments. Aim: The objective of this work was to enlighten the function of Indian mangrove variety of A. corniculatum leaves on carbohydrates blemishing reactions through diabetes using in vitro and in vivo methods. Methods: The aqueous leaves …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 23–31 Read article
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Bioenhancer to Boost Herbal Drug Efficacy
Abstract: Bioenhancers are natural substances that significantly improve the absorption, bioavailability, and therapeutic efficacy of drugs when co-administered, without showing notable pharmacological activity of their own. In herbal medicine, the concept of bioenhancement has received growing attention as many phytoconstituents exhibit low oral bioavailability due to poor solubility, limited permeability, and extensive first-pass metabolism. The traditional Ayurvedic system first introduced this concept through the discovery of Piperine, the active alkaloid from …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 · pp. 01–13 Read article
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Bacilli: The Keystone Biocontrol Agents Eradicating Phytopathogens
Abstract: As a result of the niches provided by plants to microbes, multitude of interactions occurred some of which are detrimental to the plants, including pathogenicity which results in diseased plants caused by harmful microbial community inhabiting a plant. Studies have shown that pesticides are applied to control the disease-causing microbes, but the adverse effects of the pesticides have necessitated the need for biocontrol agents that are eco-friendly. In this article, …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 13, Issue 1, 2023 · pp. 22–32 Read article
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Role of Plant-based Natural Products in the Treatment of Type 2 Diabetes
Abstract: Diabetes mellitus is caused by the elevation of blood sugar levels and has become a serious health concern worldwide with the number of cases steadily increasing annually. Due to the increased side effects and costs associated with the use of conventional drugs, alternative treatment methods that use natural compounds from medicinal plants have been researched. This review summarizes the recent advances and discoveries of plant based natural compounds used for …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 12, Issue 2, 2021 · pp. 1–14 Read article
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Mirabilis Jalapa Flower Extract as Natural Food Dye and Green Cellular Delivery of Nanoparticles
Abstract: Use of artificial colouring agents in sweets and packed food has become a common scenario now a day, which pose serious consequences in consumers especially children. Various studies around the globe reported the serious health hazards of artificial food dyes which include organ damage of liver, kidney and lungs thereby affecting metabolic enzymes, serum creatine and urea levels and brain damage resulting in neurotoxicity and even behavioural deficits in children. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 2, 2023 · pp. 27–34 Read article
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Role of Carboxylesterases in Xenobiotic Metabolism and Detoxification: Insights for Cheminformatics Approaches
Abstract: Xenobiotics, which include a wide range of environmental pollutants, food additives, drugs, and carcinogens, are foreign chemical entities that enter the human body and may accumulate, leading to toxic effects. Phase I and phase II metabolic responses are among the detoxification procedures that are necessary to lessen these negative consequences. This review highlights the pivotal role of carboxylesterases (CES), enzymes involved in the hydrolysis of ester, amide, and thioester bonds …
Published in International Journal of Cheminformatics · Vol. 2, Issue 2, 2024 · pp. 9–17 Read article
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Interaction of Bioactive Component of Aframomum melegueta on Molecular Docking
Abstract: Computational mimicry of the structure of large complexes created by di- and poly-interaction of molecules has been termed molecular docking. The purpose of molecular docking is the prediction of the three-dimensional structures of interest, this is due to that docking only produces plausible candidate structures. The docking was carried out between the bioactive compounds against 5α-reductase, 3β-hydroxy-steroid dehydrogenase, and 17β-hydroxy-steroid dehydrogenase of returned binding energy, BE (kcal/mol) between -5.9 and …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 2, Issue 1, 2024 · pp. 51–60 Read article
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Geological Nutrient Sourcing of Potassium and Phosphorus in Agricultural Crops
Abstract: Potassium and phosphorus can be considered as important nutrients and are being supplied as ingredients in the fertilizers. In presence of potassium, the crop yields, shelf life, disease resistance and plant growth are improved. The mineral fertilizers have enhanced the crop yields and they are expected to segregate spatially. Due to the utilization of the mineral fertilizers, there was intensification of crops and they have helped humans to consume healthy …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 9, Issue 2, 2020 · pp. 24–28 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications
Abstract: A well established strategy is to introduce a biologically relevant organic molecule in coordination sphere of transition metal complexes to increase the selectivity and biocompatibility. Phenylacetic acid (PAA), an organic molecule with a phenyl functional group and a carboxylic acid functional group, is a phenylalanine that is generated from the naturally occurring auxin, which is extensively present in plants. The most promising outcomes in the battle against cancer and microbes …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 68–78 Read article
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Role of Raman Spectrometry in Understanding Structure, Function, and Position of Lipids in a Cell
Abstract: Recent researches focus on the functional aspects of lipids as they equally perform with proteins and enzymes in metabolisms and other biological processes. Lipids are fatty substances soluble only in alcohol and ethers but insoluble in water or other polar solvents. The Raman Spectrometry is a proven technique used for the proper understanding of the structure, function and position of lipids in a cell. The lipid study can be done …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 4, Issue 1, 2014 · pp. 19–30 Read article
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Metabolic Reprogramming in Carcinogenesis: An Overview
Abstract: Metabolic reprogramming is a crucial mechanism via which cells modify their metabolic pathways to adjust to changes in the environment and maintain growth, survival, and function. This phenomenon is of utmost importance in a wide range of physiological and pathological situations, specifically in cancer, immunological responses, and stem cell biology. In cancer, metabolic reprogramming facilitates fast cell growth and survival, as demonstrated by the Warburg effect, where cancer cells prioritize …
Published in Research and Reviews: A Journal of Medicine · Vol. 14, Issue 2, 2024 · pp. 32–38 Read article