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5 articles for “forced degradation”
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A Systematic Review of Impurity Profiling and Stability Studies in Pharmaceutical Drug Substances
Abstract: Ensuring the safety, efficacy, and quality of pharmaceutical goods is essential in the Indian pharmaceutical market, which is a global centre for generic drugs. Stability studies and impurity profiling are two fundamental activities that ensure this quality during the whole lifespan of a medicine. The effect of environmental variables such as temperature, humidity, and light on the quality of a drug substance over time is demonstrated by stability studies. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 81–88 Read article
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Stability-Indicating Rp-Hplc Development and Validation for the Estimation of Lercanidipine Hydrochloride Content in Tablet Dosage Form
Abstract: A sensitive, stability-revealing, and easy reverse-phase high-performance liquid chromatographic (RP-HPLC) technique was developed and rationalized to be in a position to determine Lercanidipine hydrochloride in ingested dosing preparations. It was separated by chromatography on a C 18 column using a mobile phase containing 10 mM potassium dihydrogen phosphate buffer and methanol (20:80, v/v; pH 4.0) at a flow rate of 1.0 mL/min and UV detected at 258 nm. The retention …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 17–26 Read article
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Simultaneous Determination And Stability Indicating Method For Telmisartan, Metoprolol Succinate And Cilnidipine In Tablet Dosage Form.
Abstract: There are several medicinal agents available for antihypertensive activity. Telmisartan, metoprolol and cilnidipine are among them. Quantitative and qualitative analysis plays a pivotal role in safeguarding patients. Here, the estimation of these drugs was performed by using the chromatographic technique RP-HPLC. It was conducted with Phosphate buffer (pH 3.5 ± 0.01): Methanol (50:50 v/v) mobile phase. The system was operated at 1 ml/min. Drug volume to the system was 20μl. …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 32–38 Read article
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Seismic-Resilient Structural Systems: Geotechnical Engineering
Abstract: Earthquakes represent one of the most destructive natural hazards, capable of causing severe structural damage, loss of life, and substantial economic disruption. Seismic waves propagating through the ground can induce excessive forces and deformations in buildings, often leading to partial or complete collapse. Statistical records indicate that thousands of earthquakes occur globally each year, including several major events that result in significant damage. Past earthquake disasters have repeatedly demonstrated that …
Published in Journal of Geotechnical Engineering · Vol. 13, Issue 1, 2026 · pp. 55–63 Read article
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Effect of Leading-Edge Roughness on the Aerodynamic Characteristics of the Wind Turbine blade
Abstract: Leading-Edge Roughness (LER) strongly dictates boundary layer transition and performance degradation on an airfoil operating at transitional Reynolds numbers, an aerodynamic regime where shear-layer stability mechanisms remain highly complex. The wind tunnel experiments were conducted to investigate the aerodynamic impacts of surface roughness applied over 25% of the chord of a NACA 0018 airfoil using two discrete roughness gradations. Surface roughness induces an early boundary layer trip, causing elevated section …
Published in Journal of Aerospace Engineering & Technology · Vol. 16, Issue 2, 2026 Read article