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311 articles for “detection limit”
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A Comprehensive Review of Analytical Method – Development and Method Validation of Digoxin Tablets
Abstract: The main objective of this review is to give an outline of the method development and validation process of digoxin, and this review covers the different types of spectroscopic and chromatographic techniques, such as HPLC, UHPLC-Tandem mass spectroscopy, TLC, and LC-MS. A novel method for the determination of digoxin in biological samples has been developed and validated, focusing on improving sensitivity, specificity, and reproducibility. The method was validated in terms …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 47–58 Read article
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RP-HPLC method for simultaneous determination of Drospirenone and Ethinylestradiol in Bulk and their Pharmaceutical dosage form
Abstract: Oral contraceptive is used to prevent the pregnancy which is contain hormones to block the release of eggs from the ovaries. Most of them contain estrogen and progesterone. Nowadays, usage of hormonal contraceptive is sharply enhancing; around 100 million of women worldwide are taking these drugs. With this drug fertility rate can be supressed as long as they want or plan their activity along with these drugs provide efficacy, reliability, …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 46–67 Read article
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Advancements in Analytical Techniques and Validation Methods for Pharmaceutical Tablet Formulations Using HPTLC
Abstract: High Performance Thin Layer Chromatography (HPTLC) is a versatile analytical technique which has been effectively used for pharmaceutical quality control and cost effectively, rapidly, and high throughput analyzed tablet formulations. HPTLC is different from traditional chromatographic methods as multi sample analysis is possible in one run with low consumption of solvent, which are principles of green analytical chemistry. But existing HPTLC is limited in sensitivity, resolution and reproducibility and these …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 3, 2026 Read article
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Enhanced Sensitivity Iontronic Pressure Sensor Gauge Using Laser-Created Micro-Pyramid Structures for Wide Linear Range
Abstract: The achievement of high sensitivity, ultrahigh pressure resolution, and great linearity across a wide pressure range under huge pressure preloads remains a challenge despite the substantial development of flexible capacitive pressure sensors. Here we offer an ultrathin ionic layer-integrated microstructure creation process that is configurable. At 1700 kPa, the sensor's linear range sensitivity is 33.7 kPa-1; at 2000 kPa, the pressure resolution is 0.00725%, and the detection limit is 0.36 …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 107–118 Read article
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Artificial intelligence-integrated nanobiotechnology for precision medicine, smart diagnostics, and sustainable environmental applications
Abstract: Background: Nanobiotechnology integrates nanoscale materials with biological systems, enabling breakthroughs in drug delivery, biosensing, and environmental monitoring. However, the complexity of biological interactions and the vast parameter space of nano‑bio interfaces limit conventional design. Artificial intelligence (AI) offers powerful tools for modelling, predicting, and optimising these systems.Objective: This review provides a systematic, STM‑compliant overview of AI‑integrated nanobiotechnology across three domains: precision medicine (AI‑optimised nanocarriers, personalised therapeutics), smart diagnostics (AI‑powered nano‑biosensors, …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 28, Issue 2, 2025 Read article
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A Sensitive SPE-ECD-GLC Procedure for Analyzing Simazine Quantitatively in Food Products
Abstract: Short and simple solid-phase extraction (SPE) method interfacing and hyphenating gas liquid chromatographic-electron capture detection (GLC-ECD) method has been developed for the qualification and quantification of simazine in some daily used agro products. United States Pharmacopeia G-42 gas chromatography stationary phase with ZB-35a, HTb Inferno-cZ (Zebron, Za) capillary column with an enlarged and extended temperature range of –60° to 400°C and electron capture detector was selected correlating some chemical, physical …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 20–27 Read article
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Integrated Microfluidic Platform for Accelerated Catalytic Analysis: Enhancing Sensitivity and Efficiency
Abstract: In this study, we introduce a groundbreaking advancement in microfluidic technology tailored for catalytic and catalytic analysis. Our innovative microfluidic device integrates novel features aimed at augmenting sensitivity and accelerating analysis while ensuring reliability and user-friendliness. The hallmark of our device is the fusion of sample preparation and analysis functionalities within the microfluidic chip. By embedding sample preconcentration and purification modules, we achieve remarkable enhancements in sensitivity and detection limits. …
Published in Journal of Catalyst & Catalysis · Vol. 10, Issue 2, 2023 · pp. 51–27 Read article
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UV Method of Development and Validation of Olaparib
Abstract: An analytical method must be developed and validated in the discovery, development, and production of pharmaceuticals to ensure the identification, purity, potency, and performance of drug commodities. Quality control laboratories use official test protocols that emerge from the processes. A simple ultraviolet spectrophotometric approach was designed and validated using various characteristics, including linearity. Precision, reproducibility, accuracy, robustness, ruggedness, limit of detection, and limit of quantification are among the measuring criteria. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 20–27 Read article
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Stability-Indicating Rp-Hplc Development and Validation for the Estimation of Lercanidipine Hydrochloride Content in Tablet Dosage Form
Abstract: A sensitive, stability-revealing, and easy reverse-phase high-performance liquid chromatographic (RP-HPLC) technique was developed and rationalized to be in a position to determine Lercanidipine hydrochloride in ingested dosing preparations. It was separated by chromatography on a C 18 column using a mobile phase containing 10 mM potassium dihydrogen phosphate buffer and methanol (20:80, v/v; pH 4.0) at a flow rate of 1.0 mL/min and UV detected at 258 nm. The retention …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 1, 2026 · pp. 17–26 Read article
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Seasonal Variations of Air Quality Measures In Warri and Effurun, Delta State, Nigeria.
Abstract: Air quality in Urban Cities like Warri and Effurun has been deteriorating over time. The distribution levels of air pollutants in the Warri and Effurun environments may be related to both natural and man-made factors. In addition to evaluating the quality of rainwater with regard to pH, heavy metals (Fe, Pb, Cd, As, Hg, CU, Zn), and some anions (Cl-, NO3-, SO42-, CO32-), this project study aims to investigate, using …
Published in International Journal of Pollution: Prevention & Control · Vol. 2, Issue 1, 2024 · pp. 23–48 Read article
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Estimation of Alogliptin and Dapagliflozin in Synthetic Mixture by RP-HPLC Method
Abstract: The primary objective of the proposed research was to develop and validate analytical methods for the simultaneous quantification of Alogliptin and Dapagliflozin in a synthetic mixture. Alogliptin and Dapagliflozin are medications used for managing diabetes, with Alogliptin inhibiting the enzyme Dipeptidyl peptidase-4 and Dapagliflozin belonging to the class of sodium-glucose cotransporter 2 inhibitors. High-performance liquid chromatography method development was conducted using a C18 column (250 mmX4.6 mm, 5 μm particle …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 37–46 Read article
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HPTLC Method Development and Validation for Rabeprazole Sodium in Pharmaceutical Formulation
Abstract: Background: The most common medication for acid related disorders stands as Proton pump inhibitor (PPI) Rabeprazole Sodium. The pharmaceutical formulations require essential quality control of Rabeprazole Sodium through reliable analytical methods to maintain reliability. HPTLC provides a cost-effective rapid method for drug quantification compared to conventional HPLC methods so how HPTLC stands as an appropriate method for drug determination. Objective: The emphasis of this research project involves developing and validating …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 18–24 Read article
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An Overview on MOSFET based Sensor Design
Abstract: In the past two decades the MOSFET has transformed from a simple switch in digital logic to an analog powerhouse that can be cofabricated with the sensing material on a single chip. MetalOxideSemiconductor FieldEffect Transistors (MOSFETs) have silently become the beating heart of modern sensor platforms, translating the faint whispers of physical, chemical, and biological phenomena into robust electrical signatures. This abstract surveys the latest advances that have turned the …
Published in Journal of Microelectronics and Solid State Devices · Vol. 13, Issue 1, 2026 · pp. 20–26 Read article
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Thin Film Technology in Sensor Manufacturing – A Technical Discussion
Abstract: Thin‑film technology has become the cornerstone of modern sensor manufacturing, enabling the convergence of miniaturisation, multifunctionality, and cost‑effective mass production. This paper surveys the latest advances in deposition techniques—ranging from magnetron sputtering and chemical vapour deposition to atomic‑layer deposition (ALD) and ink‑jet‑printed sol‑gel processes—and examines how their unique material‑control capabilities translate into performance gains across the sensor spectrum (chemical, physical, and bio‑sensing). By integrating nanoscale thickness control (≤ 10 nm) …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 13, Issue 1, 2026 · pp. 47–57 Read article
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Levels of Some Essential and Non-Essential Metals in Selected Cereals Marketed at Holeta City, Ethiopia
Abstract: Cereals are the most commonly and widely used sources of food in Ethiopia; hence determining the nutrient contents has a vital importance for the health of consumers. In the present study, the concentration of metals (Na, K, Fe, Cu, Mn, Zn, Ni, Cd, Co, Pb, and Ag) were determined in three cereal types (maize, sorghum and barely) using FAAS and flame photometry. The optimized wet digestion involving both, concentrated HNO3 …
Published in Research and Reviews: A Journal of Toxicology · Vol. 6, Issue 3, 2016 · pp. 19–24 Read article
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Uranium and Heavy Metal Contamination of Sirhind Canal Water and Groundwater in the Malwa Belt of Punjab and its Mitigation Strategies
Abstract: Inductively coupled plasma mass spectroscopy (ICPMS) has been used to measure the Uranium and heavy metals content of the Sirhind canal water and ground water samples of adjoining villages of the collection points along the canal. The aim of this study is to propose mitigation strategies for Uranium in the groundwater of Malwa belt. The uranium and heavy metal content of the water samples collected at the five different locations …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 1, 2020 · pp. 34–41 Read article
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Polypyrrole-Based Conductive Polymer-Gated Single Electron Transistor with Deep Neural Network Assistance for Biomedical Energy Harvesting and Charge Detection
Abstract: The increasing demand for intelligent biomedical monitoring systems has accelerated research into ultra-low-power sensing technologies capable of operating with high sensitivity and minimal energy consumption. Conductive polymers have attracted considerable attention for biomedical and nanoelectronic applications due to their tunable electrical properties, biocompatibility, and environmental stability. Among them, Polypyrrole (PPy) is a promising functional polymer that can enhance charge transport and electrostatic coupling in nanoscale devices. In this work, a …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article
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Modern Trends in Tungsten(VI) Analysis: From Smart Organic Reagents to High-Sensitivity Spectrophotometry
Abstract: The present review focuses on the spectrophotometric determination of tungsten(VI) using a wide range of organic reagents and their derivatives. Organic ligands have gained considerable importance in analytical chemistry due to their strong ability to form stable and highly colored complexes with tungsten(VI), which enhances the sensitivity and selectivity of spectrophotometric analysis. Various chromogenic reagents reported in the literature for tungsten(VI) determination have been critically examined and compared on the …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 17, Issue 2, 2026 · pp. 19–29 Read article
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Lamivudine And Dolutegravir Simultaneous Dosage Forms Determined and Validated Using The RP-UPLC Method
Abstract: RP-UPLC has been used to produce a straightforward, precise, and accurate approach for the simultaneous estimation of dolutegravir and lamivudine in a pharmaceutical dose form. A HSS C18 column of 2.8 x 50 mm and featuring particles with a size of 1.6 μm was used to process the chromatogram. A mixture of 70:30 Buffer Na2HPO4 and methanol made up the mobile phase, which was pushed across the column at a …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 1, 2024 · pp. 5–13 Read article
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Enhancing LAN Security Using Machine Learning
Abstract: The modern Local Area Network (LAN) is a critical component of any organization's infrastructure, facilitating communication, resource sharing, and access to the wider internet. However, this connectivity also brings inherent security risks. Traditional security measures, relying on signature-based detection and rule-based systems, are increasingly struggling to keep pace with the evolving sophistication of cyberattacks. This is where Machine Learning (ML) offers a powerful alternative, enabling proactive threat detection and enhanced …
Published in International Journal of Wireless Security and Networks · Vol. 3, Issue 2, 2025 · pp. 07–16 Read article