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19 articles for “cytotoxic agents.”
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Paraquat Poisoning: - A Harmful Pesticide Dangerous to Human Being’s For Oral Ingestion
Abstract: Paraquat is a toxic chemical that is widely used as herbicide chemical product which related for agriculture purpose but some people intake oral paraquat poison with might be both accidental or intentional ingestion which leads to severe and often toxicity. It is an herbicide commonly used in India that has lethal consequences even on minimal consumption. The person who consumed paraquat has rate of mortality is high and there is …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 14, Issue 3, 2023 · pp. 21–25 Read article
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Chemotherapy: Side Effect and Management
Abstract: Cytotoxic drugs are therapeutic agents intended for but not constrained to, the treatment of cancer. These drugs are kenned to be highly toxic to cells, mainly through their action on cell reproduction. Cytotoxic drugs are increasingly being utilized in a variety of health care settings, laboratories and veterinary clinics for the treatment of cancer and other medical conditions such as rheumatoid arthritis, multiple sclerosis are autoimmune disorders. Cytotoxic drugs are …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 30–40 Read article
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Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications
Abstract: A well established strategy is to introduce a biologically relevant organic molecule in coordination sphere of transition metal complexes to increase the selectivity and biocompatibility. Phenylacetic acid (PAA), an organic molecule with a phenyl functional group and a carboxylic acid functional group, is a phenylalanine that is generated from the naturally occurring auxin, which is extensively present in plants. The most promising outcomes in the battle against cancer and microbes …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 68–78 Read article
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A REVIEW: P-GLYCOPROTEIN AND ITS ROLE IN CANCER
Abstract: Abstract The review is done on how P-glycoprotein recognizes various substrates and plays a key role in cancer. Chemotherapy is used for cancer treatment but multidrug resistance of cancerous cell is the major obstacle in therapy and also an important aspect which causes failure in the treatment by effluxion of a xenobiotic on the plasma membrane. In humans, P-glycoprotein is important transmembrane transporter. It is located on the apical surface …
Published in Trends in Drug Delivery · Vol. 7, Issue 2, 2020 · pp. 26–34 Read article
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Review on Textile Antimicrobial activity imparting by silver follow a line of investigation
Abstract: The present review aims to analyze the potential use of silver to propose innovative medical textile materials and their antimicrobial possession research. The paper provides data on the interest to use these silver particles to functionalize on the textile substrate and details the main applications of textile finishing. Further, the present work focuses on the coating of silver particles through electrospinning method. At length, it analyzes the improvement of the …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 12, Issue 1, 2021 · pp. 9–19 Read article
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In vitro Cytotoxicity of 17-Oxo-5-androsten-3β-yl esters against Liver, Neuroblastoma and Colon Cancer Cell Lines
Abstract: A tumor is abnormal growth of body tissue and steroidal derivatives represent a distinct class of antineoplastic agents. Positioning of the oxo group on the parental steroid skeleton has significant effect on the antineoplastic activity profile of the compounds. Recent work from our laboratory has also demonstrated the effectiveness of 17-oxo-5-androsten-3β-yl ester derivatives as potential antiproliferative agents and 5-alpha reductase inhibitors. The current study was undertaken to investigate the cytotoxicity …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 3, 2016 · pp. 23–27 Read article
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Mechanism of Action of Essential Oils and their Major Components
Abstract: The essential oil of lemongrass, palm rosa and eucalyptus were found to be good antimicrobial agents. To a large extent the results suggest their potential use as chemotherapeutic agents, food preserving agents, and disinfectants. However before considering these compounds as chemotherapeutic agents against human/animal diseases, it is important to study their cytotoxic and mutagenic effects. Studies were then carried to investigate the probable mechanism by which these compounds act against …
Published in Research & Reviews : Journal of Botany · pp. 33–43 Read article
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Excoecaria agallocha Extract from Leaves Encounters Antifungal, Antibacterial, and Cytotoxic Activity – In Vitro Studies
Abstract: Mangroves contain a wide range of bioactive substances, certain of and these have been used as solutions for a variation of conditions for thousands of years. Excoecaria agallocha leaf application components have been extracted in the presence of organic solvents along with water-based with a Soxhlet apparatus and antibacterial research properties employing diffusion agar well assays towards nine different kinds of culture infectious agents, six clinical trials isolated compounds, as …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 2, 2025 · pp. 1–7 Read article
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Phytochemical Screening and Biological Activity of Pomegranate Extracts
Abstract: Pomegranates are renowned for their abundance of bioactive compounds that exhibit potent antioxidant, anti-inflammatory, and antimicrobial properties, making them a subject of growing interest in natural medicine. This study aimed to compare the biological activities of ethanolic extracts derived from different parts of the pomegranate plant—specifically, the bark, peel, and leaves. A comprehensive investigation was conducted to evaluate their phytochemical composition and assess their antimicrobial, antioxidant, and anticancer properties. The …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 2, 2025 · pp. 64–79 Read article
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Marine Fungi – An Expandable Source for Production of Novel Bioactive Metabolites: A Comprehensive Review
Abstract: The marine environment, representing the largest and most extreme biome on Earth, serves as an unparalleled reservoir of biodiversity. Within this vast ecosystem, marine fungi have emerged as a prolific source of structurally diverse and pharmacologically active secondary metabolites. Dwelling in habitats characterized by extreme high salinity, high hydrostatic pressure, and low temperatures, these microorganisms have evolved unique biochemical and metabolic pathways to synthesize novel compounds, including pyrrole-imidazole alkaloids, cyclic …
Published in International Journal of Fungi · Vol. 3, Issue 1, 2026 · pp. 30–37 Read article
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Herbal Immuno-modulators- Pros and Cons
Abstract: Recently, there has been a greater global focus on plant research, and a ton of data has accumulated to show the enormous potential of the medicinal plants used in various traditional systems. In actual practise, the majority of immunostimulants and immunosuppressants are cytotoxic medications with substantial side effects. In treating immune-related disorders, there is growing interest in using herbal medicines as multi-component agents to modulate the complex immune system and …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 10, Issue 3, 2023 · pp. 22–29 Read article
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Graphene Oxide: A Potential Drug Carrier for Cancer Therapy—Review
Abstract: Graphene oxide (GO) is a single or few layer’s sheet derived from graphite using strong oxidizing agents. Graphene oxide possesses outstanding aqueous processability, amphiphilicity, functionalizability, surface enhanced area and fluorescence ability. Hydrophilicity is an important property for mixing the material with ceramic or polymer matrixes while trying to improve their electrical and mechanical properties. Acquiring a promising application in the biomedical area, graphene molecules undergo complex interactions with the biological …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 8, Issue 3, 2017 · pp. 21–31 Read article
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Formation of hygiene and cosmetic wipes using herbal formulation
Abstract: Increase in the awareness among the consumers against the health and hygiene products has increase the demand of nonwovens. There is huge increase in hygiene products in the recent COVID-19 pandemics. The hygiene products help the control the moisture as well as acts as a good disinfectant against the pathogens present on the skin. In the present study wet wipes formulations are being done using herbal formulations. Xanthum gum is …
Published in Research and Reviews: A Journal of Toxicology · Vol. 11, Issue 3, 2024 · pp. 1–8 Read article
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Comprehensive Review of Kojic Acid and Its Derivatives: Biological Activities, Safety, and Therapeutic Potential in Depigmentation
Abstract: There are several uses for kojic acid in human medicine, particularly in depigmentation. Additionally, derivatives of it are suggested to enhance efficacy, avoid side effects, and stop chemical degradation. With an eye toward human use and an attempt to clarify the action mechanisms, the goal of this study was to review the most recent scientific literature regarding the biological activities and safety information of kojic acid or its derivatives. During …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 45–53 Read article
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Histological Effects of the Antibiotic Gentamicin on the Ovarian Tissue of Female White Laboratory Rats
Abstract: This study aimed to evaluate the histological alterations induced by Gentamicin in the ovarian tissue of white laboratory rats. A total of 12 adult female rats were used and randomly divided into two groups, with each group consisting of six animals. The experimental group received Gentamicin at a dose of 120 mg/kg body weight administered as an injection once daily, while the control group received an equivalent volume of normal …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 1–8 Read article
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Arsenic as a Cause of Cancer
Abstract: Inorganic Arsenic (iAs) is a pervasive and ubiquitous environmental toxin that has created world-wide human health problems. Populations exposed to high concentrations of arsenic-contaminated drinking water suffer serious health consequences ranging from acute toxicities to development of malignancies, including alarming cancer incidence and death rates. Epidemiologic studies have shown a relationship between chronic arsenic exposure and disease of the skin, lung, urinary bladder, and conceivably liver, kidney, and prostate in …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 5, Issue 3, 2016 · pp. 8–21 Read article
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Anticancer and Antioxidant Property of Bunium bulbocastanum Fruits Various Fractions
Abstract: Bunium bulbocastanum (family Apiaceae) fruits are normally used as a culinary spice for years. Since antioxidant property has a significant role in preventing oxidative stress, which has been demonstrated to be a major cause in the pathogenesis of cancer, the present study was aimed to evaluate the in vitro antioxidant and cytotoxic effect of Bunium bulbocastanum fruit extracts. Standard in vitro antioxidant assays such as reducing power, super oxide scavenging, …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 3, Issue 1, 2016 · pp. 9–13 Read article
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Cancer Treatment by Radionuclide Therapy
Abstract: Recently, pretargeted nuclear imaging and radiotherapy have gained tremendous attention for diagnosis and treatment of cancer with nanomedicines. Radionuclide therapy (RNT) is one of the rapidly growing fields of nuclear medicine which works on the mechanism of delivery of cytotoxic levels of radiation to the disease sites, sparing the normal cells. RNT targets diseases at the cellular level rather than on a topographic anatomical level when compared to conventional external …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 2, 2018 · pp. 4–7 Read article
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A Review on Nano-emulsion for Delivery of Anti-cancer Drugs
Abstract: Cancer disease is characterized by abnormal cell growth. Malignant growth treatments have progressed significantly, yet there is a requirement for development in particularity and feeling of dread toward foundational harmfulness. Nanotechnology is the reconciliation of nanoscience into medication by the utilization of nanoparticles. The appearance of nanoscience in disease conclusion and treatment will assist clinicians with better surveying and oversee patients and further develop the medical care framework and administrations …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 7–13 Read article