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140 articles for “computational validation”
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Bio-Inspired FGPCs for Biomedical and Structural Applications
Abstract: Bio-inspired functionally graded polymer composites (FGPCs) represent a new class of smart materials that use gradient material distributions to enhance mechanical and biological properties, mimicking natural systems like bones, shells, and plant stems. FGPCs exhibit smooth gradient distributions across interfaces, which improves biocompatibility and reduces the risk of failure under complex loading and environmental conditions. In this study, bio-inspired FGPCs were designed, fabricated, and validated using a combined experimental and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 456–481 Read article
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3D Printing of Polymer-Based Functionally Graded Materials: Recent Developments and Challenges
Abstract: Additive manufacturing (AM), specifically 3D printing, has become a useful technique for fabricating functionally graded materials (FGMs) because it can facilitate the spatial distribution of materials. Polymer FGMs (P-FGMs) have gained a great deal of interest due to their lightweight, customizable, multifunctional properties. In comparison to conventional fabrication, 3D printing allows better control of composition and microstructure, which results in materials with controlled mechanical, thermal, and biological properties. This review …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 338–347 Read article
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Chemical Reactor Design and Analysis: A Review
Abstract: Chemical reactors play a critical role in industries such as oil and gas, chemical processing, and power generation, where they operate under extreme pressure and handle highly toxic, compressible fluids. The growing need for alternative energy sources has led to an increased demand for vessels capable of withstanding high pressure and temperature, especially in the chemical and petroleum industries. Recent innovations in chemical reactor technology have concentrated on creating new …
Published in Recent Trends in Fluid Mechanics · Vol. 12, Issue 2, 2025 · pp. 49–59 Read article
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Genomic Selection for Grain Yield in Wheat Using Machine Learning on DArT Molecular Markers: A Comparative Evaluation Across Multi-Environment Trials
Abstract: Genomic selection (GS) predicts complex quantitative traits directly from genome-wide molecular markers, bypassing the need for extensive phenotypic trials and accelerating plant breeding cycles. We conducted a comparative evaluation of seven regression approaches — ridge regression (the machine-learning equivalent of RR-BLUP), Lasso, Elastic Net, Partial Least Squares, linear Support Vector Regression, Random Forest, and Gradient Boosting — for predicting grain yield from 1,279 Diversity Array Technology (DArT) molecular markers genotyped …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
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A Review on Kaempferol Eye Drops for the Glaucoma Treatment
Abstract: One of the main causes of permanent blindness, glaucoma is defined by gradual damage to the optic nerve, mostly brought on by oxidative stress, neuroinflammation, and high intraocular pressure (IOP). The investigation of herbal alternatives is necessary since current synthetic therapies, such as beta-blockers and prostaglandin analogs, frequently result in ocular discomfort, systemic toxicity, and poor patient compliance. Clitoria ternatea contains kaempferol, a bioactive flavonoid that has shown anti-inflammatory, antioxidant, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 110–121 Read article
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Multi-Objective Optimization of Polymer-Based Functionally Graded Composites for Lightweight Structures
Abstract: Functionally graded composites (FGCs) improve lightweight structural performance by allowing material properties to change smoothly across a component. Polymer-based FGCs (P-FGCs), in particular, are gaining prominence in aerospace, automotive, and biomedical industries due to their excellent strength-to-weight ratio, tunability, and ease of processing. However, optimizing these materials for lightweight structural applications requires addressing conflicting design objectives, such as maximizing stiffness while minimizing weight or enhancing thermal resistance while maintaining manufacturability. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 961–973 Read article
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Exploring the Therapeutic Potential of Phytochemicals in Aloe Barbadensis Miller Through Molecular Docking for Ulcerative Colitis Management
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation of the colon, often associated with immune dysregulation and oxidative stress. Natural compounds have gained significant attention as alternative therapeutic agents due to their efficacy and minimal side effects. Quercetin, a flavonoid abundantly found in Allium cepa (onion), has demonstrated potent anti-inflammatory and antioxidant properties. This study employs an in silico approach to evaluate the therapeutic potential …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 13, Issue 1, 2026 · pp. 06–12 Read article
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A Review on the Regulatory Study for Implementation of Schedule-M Amendments in Pharmaceutical Industries in India
Abstract: A major regulatory change in pharmaceutical manufacturing industry in India is the introduction of the updated Schedule M (2023–2024). The aims to compliance the country's Good Manufacturing Practices (GMP) with international quality standards. The review evaluates the Schedule M amendments implementation strategies, industrial impact and regulatory relevance. Legislative texts, official notices, WHO GMP reports, ICH guidelines, guidance documents of CDSCO and peer-reviewed literature were all explored as part of the …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 13, Issue 2, 2026 Read article
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InSilico Analysis and Homology Modeling of Tetrahydroprotoberberine Oxide involved in the Berberine Biosynthesis
Abstract: Objective: Berberine, a bioactive compound found in various plant species, exhibits diverse pharmacological properties with potential applications in pharmaceutical research. The biosynthesis of berberine involves several enzymatic steps, with (S)-tetrahydroprotoberberine oxidase playing a pivotal role. This study aimed to elucidate the structural and functional characteristics of (S)-tetrahydroprotoberberine oxidase to better understand its role in berberine biosynthesis and its potential biotechnological applications. Methods: Using bioinformatics tools and computational methods, the physicochemical …
Published in Emerging Trends in Metabolites · Vol. 1, Issue 1, 2024 · pp. 7–26 Read article
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A Factorial Investigation of Hyperparameter Tuning Strategies for Lasso- Based Genomic Prediction
Abstract: In an earlier comparative study of machine-learning methods for genomic prediction of wheat grain yield, we reported a counter-intuitive result: automated nested-cross-validation tuning of the Lasso regularization penalty reduced mean predictive ability relative to a fixed, arbitrarily chosen penalty (mean Pearson r falling from 0.408 to 0.349 across four environments), the opposite of the expected effect of hyperparameter tuning. We hypothesized two possible explanations at the time — high-variance penalty …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 2, 2026 Read article
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Design and Optimization of Radial Turbines for Waste Heat Recovery Applications
Abstract: Waste heat recovery (WHR) offers a compelling way to improve sustainability and energy efficiency in several different industrial sectors. In waste heat recovery (WHR) systems, radial turbines are essential because they capture waste heat and transform it into useful mechanical or electrical energy. A thorough summary of the design and optimization concepts guiding radial turbines for WHR applications is given in this review article. After outlining the basic concepts of …
Published in International Journal of Mechanical Dynamics and Systems Analysis · Vol. 1, Issue 2, 2023 · pp. 52–58 Read article
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The Electromagnetic Transients in Compensated High Voltage Power Lines
Abstract: This paper addresses the simulation of the transients developed in high voltage lines, which are initiated by lightning discharges. The analysis allows for compensated and uncompensated lines. Both the individual and simultaneous series inductive and shunt capacitive compensation types can be dealt with. The sizes and locations of the compensating elements are included in the analysis. Numerous studies on the transient concentrated stresses across these elements and the related protection …
Published in International Journal of Electrical Power and Machine Systems · Vol. 1, Issue 2, 2023 · pp. 1–8 Read article
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Electromagnetic Transients in Compensated Power Lines- Revisited: New Approach and Case Studies
Abstract: This paper addresses the simulation of the electromagnetic transients developed in high voltage power lines, which are initiated by lightning discharges. The analysis can handle both individual and simultaneous series inductive and shunt capacitive compensation types. The sizes and locations of the compensating elements are included in the analysis. The derived Laplace s-domain mathematical model applies the concept of the ABCD transmission constants representing equivalent two-port networks. The resulting currents …
Published in International Journal of Electrical and Communication Engineering Technology · Vol. 2, Issue 1, 2024 · pp. 19–26 Read article
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Novel Laplace-domain Approach to the Electromagnetic Transients in Compensated High Voltage Power Lines
Abstract: This paper addresses the simulation of the electromagnetic transients developed in high voltage power lines, which are initiated by lightning discharges. The analysis can handle both individual and simultaneous series inductive and shunt capacitive compensation types. The sizes and locations of the compensating elements are included in the analysis. The derived Laplace s-domain mathematical model applies the concept of the ABCD transmission constants representing equivalent two-port networks. Applying the relations …
Published in International Journal of Electrical Machine Analysis and Design · Vol. 2, Issue 1, 2024 · pp. 15–21 Read article
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Electromagnetic Transients in Strongly Non-Uniform Overhead High Voltage Lines
Abstract: This paper addresses the electromagnetic transients in high strongly non-uniform overhead voltage lines. For their simulation, a novel Laplace-domain approach has been introduced. The voltage and current patterns in terms of location and complex frequency are determined by a set of simultaneous algebraic and partial differential equations. To solve them numerically, an effective Mathematica code is proposed. By contrasting the outcomes of their application to multiple case studies with those …
Published in Journal of Power Electronics and Power Systems · Vol. 15, Issue 1, 2025 · pp. 30–36 Read article
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Supply Chain Design Considering Social and Environmental Risks
Abstract: The aim of the research is to design a supply chain taking into account social and environmental risks. In this research, an attempt was made to present a model that, by considering variables close to the real world, simultaneously considers cost and sustainability issues for designing a meat supply chain network, including locating facilities, using technology in them, how products flow in the network, etc. In order to examine the …
Published in International Journal of Industrial and Product Design Engineering · Vol. 4, Issue 1, 2026 · pp. 35–43 Read article
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Computational Approaches to Understanding Cellular Signaling Pathways
Abstract: Cellular signaling pathways are fundamental in regulating vital processes, such as cell growth, differentiation, and apoptosis. The intricate and interconnected nature of these signaling networks requires sophisticated methods for their analysis. Computational approaches, including mathematical modeling, network analysis, and machine learning, have revolutionized the way researchers analyze and simulate cellular signaling. This article provides a comprehensive overview of computational strategies employed to model signaling pathways, with a focus on integrating …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 8–13 Read article
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A Systematic Review on Leukemia Detection and Classification Techniques Using Gene Expression
Abstract: Early diagnosis of genetic diseases is crucial for effective treatment, especially in the case of Leukemia, a type of blood cancer characterized by abnormal proliferation of white blood cells. This paper presents a systematic review of recent computational techniques for the detection and classification of Leukemia using gene expression data obtained from DNA microarray analysis. The study explores diverse methodologies including machine learning (ML), deep learning (DL), and bio-inspired algorithms …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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Framework-Based Optimization of Catalysis Efficiency through Reaction Pathway Engineering
Abstract: The rational design of heterogeneous catalysts through framework-based approaches has emerged as a transformative strategy for controlling reaction pathways and enhancing catalytic efficiency. This paper examines recent advances in the optimization of catalytic performance through engineered frameworks, including metal-organic frameworks (MOFs), zeolites, and related porous materials. By integrating computational methods with experimental validation, researchers have achieved unprecedented control overactive site architecture, reactant confinement, and elementary reaction steps. This work reviews …
Published in Emerging Trends in Chemical Engineering · Vol. 13, Issue 2, 2026 · pp. 88–99 Read article
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Numerical Investigation on Concrete Filled Steel Tube Composite Circular Columns Under General Loading
Abstract: Concrete-filled steel tube (CFST) composite columns are extensively utilized in civil engineering constructions because of their numerous structural advantages, such as superior seismic performance, high load- bearing capacity, fire resistance, remarkable ductility, and ability to absorb energy effectively, especially in areas prone to seismic activity. CFST columns are employed in tall buildings and bridges to enhance rigidity and increase bearing capacity, but their behavior can be affected by buckling. There …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 164–199 Read article