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302 articles for “analytical methods”
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A Review of Analytical Method Development and Validation of Amiodarone Pharmaceutical Dosage Form
Abstract: The review provides an in-depth analysis of the analytical method development and validation process for amiodarone tablets. Method validation is crucial in the pharmaceutical industry for ensuring the quality and efficacy of tablets, as it ensures the accuracy, precision, and reliability of analytical techniques used in drug testing. It is a prerequisite for method development, adhering to good manufacturing practices, and optimizing processes. This review aims to consolidate and analyse …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 59–71 Read article
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A Comprehensive Review of Analytical Method – Development and Method Validation of Digoxin Tablets
Abstract: The main objective of this review is to give an outline of the method development and validation process of digoxin, and this review covers the different types of spectroscopic and chromatographic techniques, such as HPLC, UHPLC-Tandem mass spectroscopy, TLC, and LC-MS. A novel method for the determination of digoxin in biological samples has been developed and validated, focusing on improving sensitivity, specificity, and reproducibility. The method was validated in terms …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 47–58 Read article
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Analytical Method Development and Validation of Simultaneous Estimation of Natural Active Constituents Andrographolide and Piperine by UV Method.
Abstract: A simple, accurate, precise, and robust UV-Visible spectrophotometric method was developed and validated for the simultaneous estimation of Andrographolide and Piperine in bulk and combined pharmaceutical dosage forms. Preformulation studies confirmed favorable physicochemical properties for both drugs, including acceptable solubility profiles, melting points, pH values, and partition coefficients. The method development involved determination of λmax values at 224 nm for Andrographolide and 288 nm for Piperine using ethanol as solvent. …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 3, 2025 · pp. 33–41 Read article
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From Differential Equations to Data Science: A Survey on Analytical Methods in Contemporary Problems
Abstract: The integration of differential equations and data science methods represents a dynamic and evolving approach to solving contemporary challenges across a wide range of disciplines, including engineering, physics, biology, economics, and finance. Differential equations have long served as fundamental tools for modeling continuous systems and processes, offering powerful insights into the behavior of natural and man-made phenomena. For example, they describe how heat diffuses through materials, how populations grow in …
Published in Recent Trends in Mathematics · Vol. 2, Issue 2, 2025 · pp. 1–6 Read article
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RP-HPLC Analytical Method Development and Validation for Quantitative Estimation of Metoclopramide Hydrochloride in Solid Oral Formulations
Abstract: RP-HPLC technique formulated for the numerical assessment of Metoclopramide Hydrochloride in tablet formulation has been confirmed for reliability. A C18 column facilitated the chromatographic separation using a mobile phase comprising 60:40 (v/v) potassium dihydrogen phosphate buffer: meth anol mixture. Such method was used to detect, where the retained time was 6.78 minutes and Metoclo pramide Hydrochloride produced a clear peaked at 273 nm. Results were in agreement with ICH Q2 …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 07–15 Read article
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Analytical Method Development and Validation for Simultaneous Estimation of Paracetamol and Piroxicam by UV Method
Abstract: A new establishment and validation of a simple, precise, accurate and cost effective UV-Visible spectrophotometric method was developed to estimate both Paracetamol and Piroxicam simultaneously in conjoined pharmaceutical dosage forms. This technique was founded on simultaneous equation method of absorbances recorded at 252.0 nm and 282.0 nm of Paracetamol and Piroxicam in methanol respectively and an isosbestic point could be observed at 265.0 nm. It showed very good linearity over …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 14–21 Read article
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Analyzing The Mechanisms of Polymerization and The Related Kinetic Pathways Using Refined Analytical Methods.
Abstract: In numerous sectors, polymeric materials play a crucial role, yet effectiveness is largely determined by their molecular structure and the processing parameters utilized. This investigation presents an integrative approach aimed at delineating the connections between polymer structure, properties, and processing through sophisticated characterization methods. With the implementation of small angle X Ray Scattering (SAXS),NMR(Nuclear magnetic resonance( spectroscopy) FM(Atomic Force Microscopy) and rheological analysis, we analyze the complex interplay between molecular …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 86–94 Read article
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Comprehensive Overview of Analytical Chemistry: Principles, Techniques, and Method Validation
Abstract: Analytical chemistry constitutes a vital discipline within the realm of scientific inquiry, facilitating the identification and measurement of components present in diverse substances and mixtures. This paper delineates the principles, methodologies, and applications of analytical chemistry, focusing on spectroscopy and chromatography techniques. Spectroscopy, including UV-Visible spectroscopy, elucidates molecular properties by analysing the absorption of electromagnetic radiation, while chromatography enables the separation of compound mixtures based on differential affinities to stationary …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 1, 2024 · pp. 14–21 Read article
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Optimizing Antibiotic Analysis: A Comprehensive Guide to HPLC Process of Assessment and Quantification
Abstract: The history and uses of chromatography are thoroughly covered in this work, with an emphasis on the use of High-Pressure Liquid Chromatography (HPLC) in pharmaceutical analysis. Since its discovery by Russian botanist Mikhail Tswett in the 19th century, chromatography has undergone tremendous developments that have given rise to a variety of chromatography types and applications. The story follows the evolution historically, emphasizing Tswett's groundbreaking breakthrough in plant color classification and …
Published in International Journal of Antibiotics · Vol. 1, Issue 2, 2024 · pp. 27–44 Read article
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A Systematic Review of Method Development and Validation for Ramipril Analysis Using Hplc in Cardiovascular Research
Abstract: The field of analytical chemistry encompasses a variety of methods that are crucial in determining the chemical composition of different substances. UV-visible spectroscopy and high-performance liquid chromatography (HPLC) are two widely utilized methods that are the subject of this article. UV-visible spectroscopy uses the Beer-Lambert law to quantify light absorption, which can provide information about the concentration of absorbing species. The method is based on how light and matter interact, …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 15, Issue 2, 2024 · pp. 37–44 Read article
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A Comprehensive Review of Metabolite
Abstract: Metabolites, tiny chemicals, are essential to physiology, signalling, and biological function. This extensive review classifies metabolites into primary and secondary categories by biological relevance. Alkaloids, flavonoids, and terpenoids contribute to ecological interactions and defence systems, while amino acids, nucleotides, and carbohydrates directly affect development and cellular function. The article examines metabolic pathways, mass spectrometry, NMR, and metabolomics, a growing field. Metabolites play a crucial role in various scientific and practical …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 2, 2025 Read article
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Advances in Analytical Chemistry Research Methodology: Trends and Applications
Abstract: Analytical chemistry is critical to scientific study because it allows for the accurate identification, measurement, and characterization of chemical compounds. Recent advances in methodology have improved accuracy, sensitivity, and efficiency, with techniques such as High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), Mass Spectrometry (MS), and Nuclear Magnetic Resonance (NMR) spectroscopy transforming analytical procedures. The combination of Artificial Intelligence (AI) and Machine Learning (ML) has enhanced data processing, pattern recognition, and …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 12, Issue 2, 2025 · pp. 10–18 Read article
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Gear-Related Stress Analysis and Comparison Between the Fem and Agma Standards
Abstract: In many different devices, gears enable the efficient transfer of motion and torque. They are an essential component of modern mechanical power transmission systems. It has been demonstrated that bending and surface contact stresses at the gear tooth are the primary causes of gear failure, despite their widespread use. Too much stress can lead to tooth wear, pitting, or breakage, which can ultimately reduce the operating life and reliability of …
Published in Trends in Mechanical Engineering & Technology · Vol. 15, Issue 3, 2025 · pp. 13–18 Read article
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A Comprehensive Exploration of Method Validation and Development in Pharmaceutical Analysis: Focus on Vortioxetine Analysis
Abstract: The pharmaceutical industry relies on rigorous method validation to ensure the accuracy, precision, and reliability of analytical techniques employed in drug testing and quality control. This comprehensive exploration delves into the validation parameters and guidelines essential for method validation, emphasizing accuracy, precision, linearity, detection and quantitation limits, specificity, range, robustness, and ruggedness. Validation plays a pivotal role in guaranteeing high-quality products, adhering to good manufacturing practices (GMP), and optimizing manufacturing …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 11, Issue 1, 2024 · pp. 46–52 Read article
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HPTLC Method Development and Validation for Rabeprazole Sodium in Pharmaceutical Formulation
Abstract: Background: The most common medication for acid related disorders stands as Proton pump inhibitor (PPI) Rabeprazole Sodium. The pharmaceutical formulations require essential quality control of Rabeprazole Sodium through reliable analytical methods to maintain reliability. HPTLC provides a cost-effective rapid method for drug quantification compared to conventional HPLC methods so how HPTLC stands as an appropriate method for drug determination. Objective: The emphasis of this research project involves developing and validating …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 2, 2025 · pp. 18–24 Read article
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An Analytical Review of Machine Learning Methodologies
Abstract: Machine Learning (ML) is a dynamic and rapidly developing area of computer science that enables the system to learn from data and improve its performance without clear programs. Rooted in statistical theory and computer algorithms, ML has become a major technology that progresses in artificial intelligence. It strengthens the detection of the recommendations and speech for extensive applications from autonomous vehicles and medical diagnoses. This paper has reviewed the basics …
Published in Recent Trends in Mathematics · Vol. 3, Issue 1, 2026 · pp. 13–21 Read article
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Recent Advancements and Comprehensive Review on Hyphenated Techniques
Abstract: Hyphenated techniques represent a powerful class of analytical methods that combine two or more established techniques – typically a separation method with a spectroscopic detection technique – to achieve enhanced analytical performance. First introduced by Hirschfeld in 1980, the term “hyphenation” refers to the online coupling of such methods, enabling more precise, sensitive, and comprehensive analysis of complex samples. These techniques exploit the strengths of individual methods while overcoming their …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 37–50 Read article
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UV Method of Development and Validation of Olaparib
Abstract: An analytical method must be developed and validated in the discovery, development, and production of pharmaceuticals to ensure the identification, purity, potency, and performance of drug commodities. Quality control laboratories use official test protocols that emerge from the processes. A simple ultraviolet spectrophotometric approach was designed and validated using various characteristics, including linearity. Precision, reproducibility, accuracy, robustness, ruggedness, limit of detection, and limit of quantification are among the measuring criteria. …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 20–27 Read article
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A Data-driven Approach to Sales Analysis
Abstract: Decisions made using data from digital sources are said to be data-driven when they are analysed and interpreted. Across many sectors, a data-driven approach is an effective technique for gaining insights, making wise choices, and guiding corporate strategy. This study covers the concept of data analytics in sales analysis of bakery and mess. It involves evaluating diverse types of information, including sales data, customer preferences, production costs, and supplier details. …
Published in Journal of Advanced Database Management & Systems · Vol. 11, Issue 1, 2024 · pp. 29–41 Read article
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Analytical Technique Optimization and ICH-Directed Verification of a Reverse Phase HPLC Approach for Quantification of Bupropion Hydrochloride
Abstract: This method was developed for retention time, peak resolution and baseline response using Bupropion Hydrochloride under optimized conditions as validation. The method resulted in two well separated, well defined peaks, a minor peak at 7.5 minutes 12 mV and a main peak at 11.52 minutes 150 mV. At the same time, the baseline has remained stable during the chromatographic run and the fluctuations of noise are very small (0.5 ± …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 2, 2025 · pp. 47–54 Read article