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47 articles for “albino rats”
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Phytochemical Screening, Proximate Analysis and Acute Toxicity Study of Ethanolic Extract of Launaea taraxacifolia on Visceral Organs of Albino Rats
Abstract: Despite increase in the acceptance of herbs for the treatment of certain diseases, there are limited information on the effectiveness, safety and toxicity of herbs. In this study, proximate analysis, phytochemical screening and acute toxicity studies on the herbal recipe, Launaea taraxacifolia were carried out. Constituents of Launaea taraxacifolia were extracted using ethanol. Phytochemical screening and proximate analysis were carried out on the extract. Fifteen (15) albino rats, divided into …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 3, 2014 · pp. 1–8 Read article
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Cysticercosis in a Wistar Albino Rat
Abstract: The present study was conducted to know the cause for multiple cysts in the liver of laboratory rat used for experimental purpose in research work. A male Wistar albino rat about 22 weeks of age showed the presence of numerous cysts in liver. The cyst along with normal liver tissue was collected in 10% of formalin and processed for histopathology. Gross examination of liver showed white to yellowish cyst of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 6, Issue 2, 2017 · pp. 23–25 Read article
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Toxic Potential of Carbaryl on Reproductive and Fertility Parameter in Male Wister Albino Rats
Abstract: This study aims to evaluate the adverse effect of carbaryl on reproductive system of male Wister albino rats. Adult male Wister albino rats were orally administered with 50, 100 and 150 mg/kg body weight of carbaryl for 90 days. Animals from each group were sacrificed after the study period. Sperm count, sperm motility, antioxidant assay (SOD, CAT, LPO, and protein carbonyl), Hormones assay histological analysis and fertility parameters were performed …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 2, 2015 · pp. 1–6 Read article
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Anti-Ulcer Activity of Methanolic Extract of Mucuna Pruriens Seed on Indomethacin Induced Ulcers in Albino Rats
Abstract: The present study was intended to investigate and evaluate the antiulcer activity of the methanol seed extract of Mucuna pruriens using indomethacin induced ulcer in albino rats and to determine its link between oxidant or antioxidant parameter. The extract of Mucuna pruriens was tested on indomethacin induced gastric ulcer in albino rats. The antiulcer activity of high dose (400 mg/kg) and low dose (200 mg/kg) of ethanolic extract of Mucuna …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 5, Issue 2, 2015 · pp. 1–8 Read article
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Effects of Plasticizer DI-(2 Ethylhexyl) Phthalate on Liver Enzymes of Adult Male Albino Rats
Abstract: AbstractDi-(2 Ethylhexyl) Phthalate (DEHP) is a common plasticizer used to make the plastic products more flexible. It is quite harmful as tested on other animal models and is carcinogenic too. The liver is the major organ for detoxification in body and is therefore affected first due to intake of any toxicant. The liver enzymes are good parameter to assess any such hepatic damage. In the present study, the acute toxicity …
Published in Research & Reviews : Journal of Ecology · Vol. 6, Issue 2, 2017 · pp. 6–9 Read article
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Antidiarrheal Activity of Leucaena Leucocephala in Castor Oil Induced Diarrhea in Albino Rats
Abstract: The purpose of the present study was to evaluate scientifically the anti-diarrheal effects of different extracts of leaves of Leucaena leucocephala. Different extracts of Leucaena leucocephala like petroleum ether, chloroform, and ethyl acetate were studied against castor oil induced diarrhea model in albino rats. The weight of the fecal matter induced by castor oil induced diarrhea was recorded as the chief parameter. Standard drug loperamide (1 mg/kg, i.p.) showed highly …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 7, Issue 1, 2020 · pp. 8–12 Read article
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Brain GST Inhibition, An Additional Mode of Action Following Beta-Cyfluthrin Intoxication in Albino Rat
Abstract: The aim of the study was to reveal the neurotoxic effect of an orally administered beta-cyfluthrin, a type-II pyrethroid in albino rats on the basis of activity of brain GST (Glutathione-s-transferase), AChE (acetylcholinesterase) and of total proteins level at different doses 35.48 and 5.06, 2.53, 1.68, 1.27 mg/kg body weight, for acute (1 day) and sub-acute (7, 14, 21 and 28 days) treatments respectively. Results reveal that beta-cyfluthrin administration inhibits …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 3, 2014 · pp. 30–36 Read article
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The Effect of Vitamin C on the Reproductive Functions of Paraquat Intoxicated Male Albino Rats (Rattus norvegicus)
Abstract: Paraquat (PQ) is a bipyridylium herbicide applied around trees in Orchids and between crop rows to control broad-leaved and grassy weeds. Its oxidation results in the formation of superoxides and supernitrite species which causes damage to cellular components. Studies have implicated PQ as one of the pesticides that contributes to the reduction in male reproductive functions in humans and animals during exposure. This study, therefore, determined the antioxidant effect vitamin …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 3, 2014 · pp. 9–29 Read article
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Possible Histological Changes in the pancreas of Female Albino Rats for Prolonged Administration of Aspartame
Abstract: Aspartame sweetener was noted to be inducing histopathological changes on the pancreatic tissue of female albino rats so this study defined the aims and objectives properly. Biometry did use materials from the animal facility of the Department of Biology College of Science, University of Kufa. The study was carried out over the duration of two months where thirty male rats aged between 15 to 20 weeks with body weight of …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 15–21 Read article
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Toxic Effects and Ld50 Study of Ethanolic Leaf Extract of Nerium oleander Against Albino Rats
Abstract: Nerium oleander, kaner in hindi is a medium sized ornamental shrub plant. It is found worldwide and categorized in apocynaceae family. It has dark green, leathery, thick and lanceolate leaves which are arranged opposite or in whorls of three to five. It can tolerate drought and high temperature. Because of its shrubby nature it is grown along the highways to protect drivers from the high beam light of the vehicles …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 11, Issue 3, 2022 · pp. 42–45 Read article
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Alteration in Metabolic Enzymes of Albino Rats under Cadmium Stress and their Modulation by Mentha Piperita
Abstract: Cadmium is a heavy metal posing severe risks to human health without any physiological function in the human body. Cadmium is found regularly in soil, rocks and ores, thus natural exposure is an important aspect, but increasing industrial application has put it in the category of bio-hazardous metals. Anticorrosive agents, stabilizer in PVC products, colour pigments, neutron-absorber in nuclear power plants, the fabrication of nickel-cadmium batteries and Phosphate fertilizers carry …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 3, 2013 · pp. 1–4 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article
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Improvement of Motor and Sensory–Motor Behaviors after the Human Amniotic Epithelial Cells Transplantation in 6-OHDA Lesioned Corpus Striatum of Wistar Albino Rats
Abstract: Deficits in apomorphine-induced rotation and rotarod in rat have been proposed as a nondrug-induced model of the akinesia associated with the Parkinson’s disease. In the present study, we examined the disabilities in the rotarod and apomorphine-induced rotations have been observed after the 6-hydroxydopamine-induced denervation in the striatum. These impaired activities have reversed after the Human Amniotic Epithelial (HAE) cells transplantation during long-term observation. The neuronal densities and diameter were reduced …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 4, Issue 2, 2014 · pp. 34–45 Read article
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Anti-ulcer Properties of Methanol Extract and its Solvent Fractions of Stem Bark of Lannea acida on Indomethacin Induced Gastric Ulcer in Albino Rats
Abstract: Lannea acida is use in Nigeria for the treatment of Peptic ulcers. The methanol and its solvent fractions (hexane, ethylacetate and butanol) of the stem bark of Lannea acida were evaluated for antiulcerogenic activity using indomethacin model. The anti-ulcerogenic mechanisms of the plant using the model employed in this study were done by estimation of Superoxide dismutase (SOD), Glutathione (GSH), Catalase (CAT), Vitamins A, C and E, and Malondialdehyde (MDA). …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 3, 2023 · pp. 20–35 Read article
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Standardization and Diuretic Activity of Hydro-alcoholic Extract of Mukia maderaspatana Whole Plant in Experimental Rats
Abstract: In this present study, the purity of Mukia maderaspatana a Cucurbitaceae plant in powdered form was standardized by the common physico-chemical analysis like ash values, extractive values and moisture content. The results show that total ash, sulfated ash, water soluble ash and acid-insoluble ash of 21.5% w/w, 33% w/w, 10% w/w and 2.5% w/w respectively were up to standard. The water-soluble and alcohol-soluble extractive values were 8.5 and 3.2% w/w …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 4, Issue 2, 2013 · pp. 10–15 Read article
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In vivo Modulatory Effect of Clerodendrum Splendens (Glory Blossom) in Aluminum Induced Alzheimer Diseases and Lonchocarpus Sericeus in Rotenone Induced Parkinson’s Disease on Na+/K+ Atpase (Sodium Pump) in the Cerebral Tissues of Male Albino Wister Rats
Abstract: Elegant research has shown that plants are useful for both curative and preventive purpose on the humans populous. Prevalent among diseases associated with humans are neurological diseases which affect a large sector of the population especially the elderly. The most common neurological diseases are Parkinson and Alzheimer disease which affect a large sector of the brain and also cause an imbalance in brain electrolyte. Among such electrolytic mechanisms of the …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 31–36 Read article
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Effects of High Dose of Ethanolic Extract of Luffa cylindrica on Rat Uterus
Abstract: The objective of the present study was to investigate the various aspects of uterus and uterine histology in cyclic female albino rats to gain insights into the possible mechanism of antifertility effect of the ethanolic extract of Luffa cylindrica. High dose level (0.5 mg/ml) of ethanoloic leaf extract of Luffa cylindrica was administered to determine the effect of the extract on uterine histology of female albino rats. The high dose …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 1, 2012 · pp. 20–28 Read article
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Anti-Ulcer Activity of Ethanolic Extract of Sesamum indicum Seed on Indomethacin-Induced Ulcer Model and Its Antioxidant Property in Gastro-Protection
Abstract: The present study was intended to investigate and evaluate the antiulcer activity of the ethanol seed extract of Sesamum indicum Linn. using Indomethacin Induced Ulcer in Albino rats and to determine its link between oxidant or antioxidant parameter. The extract of Seamum indicum Linn. was tested on indomethacin induced gastric ulcer in Albino rats. The antiulcer activity of high dose (400 mg/kg) and low dose (200 mg/kg) of ethanolic extract …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 2, 2015 · pp. 18–25 Read article
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Hepatoprotective Efficiency of Nigella sativa L. Extract on D-Galactosamine Induced Toxicity
Abstract: The Protective role of Nigella Sativa L. alcoholic extract (NSE) was investigated on D-Galactosamine (DGalN) induced hepatotoxicity in rats. Twenty four adult wistar albino rats were divided into four groups viz Control, D-Galatosamine induced hepatotoxicity, Nigella sativa alcoholic extract and Nigella Sativa alcoholic extract pretreatment prior to the administration of D-Galactosamine. After treatment, the rats were sacrificed, blood and liver samples were collected for determination of Serum Aspartate transaminase (AST), …
Published in Research and Reviews: A Journal of Toxicology · Vol. 1, Issue 1-3, 2011 · pp. 39–44 Read article
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Antisteroidogenic Activity of Ethanol Extract of Andrographis paniculata in Female Rats
Abstract: Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 In the present study, the antisteroidogenic activity of the ethanolic extract of Andrographis paniculata leaf was investigated in female albino rats. The ethanolic extract-treated rats showed an alteration in the estrous cycle pattern when administered orally with the drug for 15 days. They exhibited a prolonged length of estrous cycle with significant increase in the proestrous and destroys stages compared with …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 1, Issue 3, 2011 · pp. 1–8 Read article