Search
40 articles for “Transdermal”
-
Recent Advances & Prospects of Transferosomes for Transdermal Delivery: Trends in Drug Delivery
Abstract: There have been several non-invasive administrations that have emerged recently to replace conventional needle injections. With its minimal rejection rate, remarkable ease of administration, and remarkable patient comfort and perseverance, the transdermal drug delivery system (TDDS) is the most attractive of them all. The skincare industry, which includes cosmetics, may also find use for TDDS in addition to the pharmaceutical industry. As this strategy mainly entails local drug administration, it …
Published in Trends in Drug Delivery · Vol. 11, Issue 3, 2024 · pp. 01–21 Read article
-
Analysis of Transdermal Patches: A Surgical Perspective
Abstract: In addressing the challenges associated with oral drug administration, the introduction of a transdermal drug delivery system has proven to be a valuable alternative. This system involves the application of a transdermal patch onto the skin, facilitating the controlled release of a specific medication through the skin and into the bloodstream. The primary objective is to enhance the healing process of the affected area of the body. Notably, the transdermal …
Published in Research and Reviews : Journal of Surgery · Vol. 12, Issue 3, 2023 · pp. 10–13 Read article
-
Formulation Development of Meloxicam Loaded Transdermal Patches and Their Evaluation
Abstract: The current studies aim the Formulation and development of transdermal patches of Meloxicam. Meloxicam is a Non- Steroidal Anti-inflammatory Drug. Transdermal patches show better patient compliance over conventional dosage forms because of their longer time of operation resulting in a reduction in less frequent dosing. Six batches of transdermal patches were prepared using different concentrations of hydroxyl propyl methyl cellulose, ethyl cellulose, and polyvinyl pyrrolidone to increase the physical properties …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 8, Issue 1, 2023 · pp. 12–22 Read article
-
A Novel Liquid Crystal Drug Delivery for Transdermal Application
Abstract: The present study was aimed at the formulation of liquid crystals of acyclovir that will be incorporated into a transdermal patch. Liquid crystals serve as drug carrier and have a good penetration-enhancer property, due to the extensive similarity of these colloidal systems with the intercellular lipids in the stratum corneum. The liquid crystals were prepared using tween 80 as emulsifier, cetosteryl alcohol as emulsion stabilizer and double-distilled water. Liquid crystals …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 28–37 Read article
-
Transethosomes: Rising Technology for Enhancing Transdermal Delivery of Drugs
Abstract: The skin has a total surface area of around 1.8 m2 and serves as the human body's interface with the outside world. The transdermal method of medication delivery has sparked a lot of interest in pharmaceutical research since it eliminates a lot of the issues that come with the oral route. Despite the fact that the skin, especially the stratum corneum, is a barrier to most medication absorption, it does …
Published in Trends in Drug Delivery · Vol. 8, Issue 3, 2023 · pp. 57–63 Read article
-
Evaluation of Polysaccharide-Based Membranes for Transdermal Drug Delivery in Chronic Pain Management
Abstract: In order to improve treatment effectiveness and patient compliance, chronic pain management is still a major challenge in modern healthcare, requiring creative medication delivery methods. The potential of polysaccharide-based membranes for transdermal drug delivery is assessed in this work, with particular attention to chitosan, alginate, and hydroxypropyl methylcellulose (HPMC). Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were two characterization techniques used to assess the membranes' physical and chemical …
Published in International Journal of Membranes · Vol. 1, Issue 2, 2024 · pp. 28–38 Read article
-
Formulation and Evaluation of Transdermal Patch to Enhance Treatment of Alopecia
Abstract: The improvement of novel topical sedate conveyance frameworks has picked up noteworthy consideration due to their potential in upgrading the helpful viability and persistent compliance whereas minimizing systemic side impacts. This thinks about centers on the definition and assessment of transdermal patches planned to discharge allicin, the essential naturally dynamic compound determined from garlic (Allium sativum) extricate. Allicin is eminent for its wide range of pharmacological properties, counting antimicrobial, anti-inflammatory, …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 20–33 Read article
-
Formulation and Evaluation of Transdermal Drug Delivery of Piroxicam
Abstract: The aim of the present study was to formulate transdermal films loaded with Piroxicam (PX). Transdermal films were prepared by using sodium alginate (SA) and xanthan gum (XG) as biopolymers by varying the blend ratios viz., 10:0, 8:2, 6:4, 4:6 and 2:8 (w/w %) through solution casting method. The drug loaded membranes were evaluated for thickness, tensile behaviours, and content uniformity. In-vitro diffusion was determined by Franz diffusion cell. Piroxicam …
Published in Trends in Drug Delivery · Vol. 1, Issue 2, 2014 · pp. 8–13 Read article
-
Microneedles: A New Concept for Transdermal Drug Delivery
Abstract: Transdermal delivery keeps a promising carrier in the transport of drugs which get direct access across the skin deep into the systemic circulation. Advantages of transdermal drug delivery system include improved patient compliance, less dose of biologicals, avoidance of gastric irritation as well as the elimination of the first-pass metabolism. Microneedles can be used to improve transdermal drug delivery for some drugs. In this study, we focus on methods of …
Published in Trends in Drug Delivery · Vol. 6, Issue 3, 2019 · pp. 22–29 Read article
-
Recent Advances and Technologies in Transdermal Drug Delivery System
Abstract: Transdermal drug delivery system is usually well liked by patients and second in terms of preference after oral route. The global market for transdermal system is expected to rise in near future. Skin is considered to be the major barrier in transdermal delivery. However, few technologies and advances such as radiofrequency, ultrasound, electroporation, iontophoresis, and microneedle have been identified to overcome these barriers. Systems or devices that incorporate these technologies …
Published in Trends in Drug Delivery · Vol. 3, Issue 1, 2016 · pp. 38–45 Read article
-
A Study To Assess The Effect Of Transdermal Oxygen Therapy On Pressure Ulcer Healing Among Bedridden Patients
Abstract: Background of the study: Pressure ulcers are localized injuries to the skin and or to the underlying tissue that mostly occur on bony prominence from pressure, or pressure in combination with shear and or friction. Objectives: To assess pre- post and compare the pre and post interventional pressure ulcer healing in experimental and control group. Methodology: A pre- post control group design among 30 bedridden patients those having pressure ulcers …
Published in Trends in Drug Delivery · Vol. 10, Issue 3, 2023 · pp. 16–23 Read article
-
Microsponges: A Novel Approach for Transdermal Delivery of Tolnaftate
Abstract: The present study was aimed at preparing tolnaftate-loaded microsponges and incorporating them into a topical formulation. Microsponge delivery system was chosen as it can increase the concentration of the drug on the superficial layer of the skin. Microsponges were prepared by quasi-emulsion technique. The studies like drug entrapment efficiency showed that the drug was completely entrapped within the pores of the microsponges. The microsponges were incorporated into the optimized carbopol …
Published in Trends in Drug Delivery · Vol. 2, Issue 2, 2015 · pp. 38–46 Read article
-
Polymer Chemistry in Sustained-Release Herbal Composites: Designing a Stable Euphorbia tithymaloides Topical System with Phospholipid and Polymer Matrices
Abstract: Polymer chemistry enables the stabilization and sustained release of herbal actives, critical for topical therapeutic applications. This study explores a novel process for preparing a stable, sustained-release topical composition of Euphorbia tithymaloides, leveraging polymer-based systems. Ethanolic extract (50 mg) of the plant, rich in unstable sugar moieties (e.g., D-ribose) and sterols (e.g., stigmasterol), is encapsulated within a phospholipid matrix of phosphatidylcholine (50–100 mg) and cholesterol (50–100 mg). This lipid-polymer complex, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 165–171 Read article
-
Microneedles: A Modern Breakthrough in Drug Delivery Systems
Abstract: Microneedles (MNs) represent a revolutionary and transformative advancement in the realm of transdermal drug delivery systems, which are designed to facilitate the administration of therapeutic agents through the skin. These exceptionally small, micron-scale needles penetrate the stratum corneum, thereby enabling the direct delivery of pharmacological agents into the underlying dermis or the upper epidermis, consequently enhancing bioavailability while simultaneously circumventing the detrimental effects of first-pass metabolism and the degradation that …
Published in Trends in Drug Delivery · Vol. 12, Issue 3, 2025 · pp. 01–07 Read article
-
Development of an Innovative Nanotransdermal Formulation Utilizing an Optimal Combination of Acyclovir and Omeprazole to Improve Antiviral Efficacy
Abstract: The study effectively created nanogel formulations of Acyclovir and Omeprazole using the solvent diffusion technique. Among the various formulations (F1–F9), F9 was identified as the most suitable for gel preparation based on its pH evaluation. Drug content analysis, performed using UV-spectroscopy, confirmed the homogeneity of the prepared nanogels, which appeared opaque, free of lumps, particles, or aggregates. The spreadability assessment of F9 demonstrated excellent spreadability, while viscosity values for all …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 1, 2024 · pp. 19–35 Read article
-
Biodegradable and Natural Fiber-Reinforced Polymer Composites for Advanced Controlled Drug Delivery Systems
Abstract: Polymer-gel forms have gained popularity in medicine as means of medication delivery over the skin. This is so since they enable medications pass the skin more readily. These products allow medicine to be administered without surgery and provide continuous active ingredient supply. They are excellent for long-term therapy for managing conditions that keep resurfacing. From tiny synthetic ones to huge biological ones, polymer gels can store a wide spectrum of …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 271–284 Read article
-
Design Approach based Formulation of Deformable Liposomes and their In vitro Skin Permeation
Abstract: Leukemia is the common cause of disease and its worldwide incidence is increasing. Cytarabine pyrimidine nucleoside analogs most widely used for the treatment of leukemia, but the major obstacles to existing treatments are adverse effect and poor patient’s compliances. To provide sustained drug release with minimum side effects and to develop more patients affable formulation, the authors investigated the transdermal delivery of cytarabine through deformable liposomes. The present work demonstrated …
Published in Trends in Drug Delivery · Vol. 4, Issue 3, 2017 · pp. 14–25 Read article
-
Cosmetic Topical Formulations: Design Strategies, Skin Interaction Mechanisms, Clinical–Cosmetic Applications, and Emerging Trends
Abstract: Cosmetic topical products are central to modern skin care, as they deliver active ingredients directly to the skin surface and upper layers to improve appearance, texture, and function. By acting locally on the epidermis and adnexal structures, these preparations help manage dryness, photoaging, pigmentation, acne, and sensitive-skin conditions while minimizing systemic exposure. A wide range of dosage forms—creams, lotions, gels, ointments, serums, sprays, and transdermal-inspired cosmetic patches—are engineered to modulate …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 1, 2026 · pp. 39–47 Read article
-
A Novel Approach of Protein Peptide Drug Delivery System
Abstract: Protein and peptides perform vital functions in body and are essential for life. They show various roles as therapeutic agents in treatment of cancer and diabetes. Various routes are available for the delivery of proteins and peptides such as oral route, transdermal route, pulmonary route, parenteral route, ocular route, nasal route, buccal route. However physicochemical properties of protein and peptides make them challenging for exogenous administration, especially in oral administration. …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 7, Issue 2, 2020 · pp. 44–59 Read article
-
Formulation and Evaluation of Hybrid Polymer Films using Metformin as Model Drug
Abstract: The present work was to formulate transdermal films which can produce a constant and prolonged release of drug using Chitosan and polyethylene oxide. In the present study high molecular weight Chitosan (300 K) and Polyethylene oxide (600 K) were used.initially, pre-formulation studies were performed to check the solubility of drug and polymers. A suitable method was developed for the estimation of absorption maxima of the drug by UV double beam …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 5, Issue 1, 2018 · pp. 1–15 Read article