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43 articles for “Toxicology”
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Toxicology-Focused Development and Validation of an RP-HPLC Technique for Quantifying Bempefoic Acid and Rosuvastatin in a Fixed-Dose Combination
Abstract: A straightforward, precise method was developed to simultaneously assess Bempedoic acid and Rosuvastatin in both bulk and tablet forms. Utilizing a DIKMA Spursil C18 column (4.6 mm x 250 mm, 3.0 μm), chromatography was conducted with a mobile phase comprising 30% phosphate buffer and 70% acetonitrile, flowing at 1 ml/min. Operating at ambient temperature, the optimized wavelength for detection was set at 240 nm, revealing retention times of 4.418 min …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 1–9 Read article
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A brief survey on Alternative and Complementary Medicine with special reference to safety, toxins and toxicological concerns
Abstract: Alternative and Complementary Medicine (ACM) is a wide range of healthcare practices that may be used within or alongside conventional medicine, and many of these practices are rapidly becoming accepted and integrated into the modern healthcare system. In addition to traditional medicine systems (e.g. Ayurveda, Unani Medicine, Traditional Chinese Medicine, and Homeopathy), ACM includes practices that utilize natural remedies including herbal medicine, phytotherapy, naturopathy, acupuncture, yoga, and meditation. While these …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 30–45 Read article
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Comprehensive Insights into Toxicology: Mechanisms, Applications, and Modern Developments
Abstract: Toxicology, the study of the harmful effects of substances on living organisms, has become increasingly vital in today's world due to industrial growth, agricultural advancements, and heightened exposure to environmental and chemical toxins. This article examines the foundations of toxicology, exploring its definitions, core principles, and mechanisms of action. It also delves into specialized branches such as forensic, environmental, and medical toxicology, highlighting the differences between toxicants, toxins, and poisons, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 1, 2025 · pp. 31–37 Read article
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A Study on AI-Enhanced Environmental Toxicology: Sensor-Driven Predictive Framework
Abstract: Traditional environmental toxicology relies heavily on labor-intensive, often retrospective, sampling and analysis, limiting our understanding of dynamic pollutant behaviors and their real-time impact on ecosystems and human health. This study presents a novel, integrated framework leveraging advanced sensor networks and artificial intelligence (AI) to revolutionize the monitoring, assessment, and predictive modeling of environmental contaminants. We deployed a sophisticated array of multi-parameter sensors (e.g., electrochemical, optical, biosensors for heavy metals, organic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 Read article
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Review of Nutraceuticals and Dietary Supplements in Toxicology
Abstract: This article explores the expanding role of dietary supplements and nutraceuticals in toxicology. Although they are widely consumed, there is little proof that using supplements or nutraceuticals can improve health in people who are eating a healthy diet. However, some of these products can be extremely toxic. Moreover, very few people tell their doctors they take supplements. Therefore, there is a high chance of negative drug-supplement interactions. An outline of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 08–17 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Phytochemical, Pharmacological and Toxicological Studies of Solanum americanum: A Systemic Review
Abstract: Solanum americanum, a plant widely used in folk medicine, has recently gained attention in the scientific community due to its diverse therapeutic potential. The bioactive compounds found in different plant parts, such as alkaloids, flavonoids, and tannins, have significant medicinal effects. These compounds exhibit several pharmacological properties, such as antimicrobial, anti-inflammatory, anticancer, and antioxidant effects. However, despite these medicinal benefits, some compounds show significant toxicity to the human body if …
Published in Research & Reviews : Journal of Herbal Science · Vol. 14, Issue 2, 2025 · pp. 52–62 Read article
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Mycotoxins in Grains: Toxicological Impact, Detection Strategies, and Public Health Implications
Abstract: Many types of fungi create mycotoxins, which contaminate cereal grains like wheat, maize, rice, and barley. Even at low doses, aflatoxins, ochratoxins, fumonisins, and deoxynivalenol are harmful to humans and animals. This study covers mycotoxin occurrence, detection, toxicological consequences, and public health concerns in grain-based food systems. Advanced analytical methods, like LC–MS, ELISA, and biosensors, are discussed for their sensitivity and routine monitoring applications. Experimental and epidemiological studies analyze chronic …
Published in Research and Reviews: A Journal of Toxicology · Vol. 15, Issue 3, 2025 · pp. 8–18 Read article
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Development and validation of a method for simulataneous determination of tenovifir disoproxil fumarate emtriculabine and isonized in bulk and pharmaceutical dosage form using RP-HPLC with relevance to toxicological aspects
Abstract: Hence, proposed analytical methods are simple, novel, economical, rapid, sensitive, reproducible and accurate for the Simultaneous estimation of Tenofovir Disoproxil Fumarate, Emtricitabine and Isoniazid in Bulk and Phamaceutical dosage form by using RP- HPLC. This Method gives reliable assay results with short analysis time using mobile phase of Acetonitrile : 0.02M Potassium Dihydrogen Orthophosphate: water (pH 5.3) in the ratio of 60: 25: 15 respectively. Retention time was found to …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 17–25 Read article
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Vyanga, Present-Day Challenge: Insights from Toxicological Standpoint
Abstract: The condition of Vyanga can have significant repercussions, as facial disfigurement not only impacts an individual's psychological and social well- being but also hampers their overall contribution to society. This can result in reduced productivity, impaired social functioning, and diminished self-esteem. In classical Ayurvedic texts, Vyanga is categorized under Kshudrarogas, representing minor disorders with straightforward causes and symptoms. However, in certain instances, these conditions can lead to noticeable cosmetic impairments, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 11–16 Read article
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Assessment of Diuretic Activity of Hydroalcoholic Extract of Matricaria Chamomilla (Linn.) and Its Phytochemical Analysis with Emphasis on Toxicology
Abstract: While the traditional medicines are derived from medicinal plants, minerals and organic matter, the herbal drugs are prepared from medicinal plants only. This current research work will be very beneficial in figuring out the Matricaria chamomilla leaves extract diuretic effect by determining the ions and electrolyte excreted by the animals using ion selective channel inhibition. The phytochemical screening results revealed that the after which it was observed whether the alkaloids …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 1–10 Read article
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Oligomenorrhea: An Overview in Toxicology
Abstract: In the contemporary era characterized by a swift and cutthroat environment, numerous gynecological issues are on the rise owing to sedentary lifestyles, improper dietary patterns, and other factors. The interaction between physical and mental health significantly affects the menstrual cycle. According to data, a staggering 80% of women grappling with irregular menstrual cycles find themselves in the grips of Oligomenorrhea, constituting 19.3% of this demographic. In today’s fast-paced and competitive …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 45–51 Read article
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Toxicological Optimization and Assessment of Buccal Films Containing Felodipine Co-crystals to Enhance Bioavailability
Abstract: The preformulation study of felodipine was carried out and it was found that the drug is poorly water soluble. The co-crystals were prepared using three different co-formers sorbitol, ascorbic acid and oxalic acid. The solublity enhancement was observed in combination with sorbitol compared to other co-formers used. The characterization of co crystals was performed like PXRD, FTIR, SEM Analysis. XRD results indicates the amorphous form of the drug. The co-crystals …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 2, 2024 · pp. 10–29 Read article
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Hakim Ismail Jurjani (1042–1137 AD): Life, Works, and Medical Legacy
Abstract: Hakim Ismail Jurjani, also known as Seyyed Isma’il Jorjani, was among the most distinguished physicians and scholars of medieval Persian medicine whose contributions significantly influenced the development of Greco-Arab and Unani medical traditions. His monumental encyclopedia, Zakhīra Khwārazmshāhī (Treasure of the Khwarazm Shah), is regarded as one of the greatest medical compilations of the Islamic Golden Age and represents a landmark in the evolution of Persian scientific literature. Unlike earlier …
Published in Research and Reviews : A Journal of Ayurvedic Science, Yoga and Naturopathy · Vol. 13, Issue 2, 2026 Read article
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A Comprehensive Review on the Role of Antacids in the Management of Stomach Disorders
Abstract: Antacids are among the most widely used over-the-counter medications for the symptomatic management of acid-related gastrointestinal disorders, including dyspepsia, gastroesophageal reflux disease (GERD), gastritis, and peptic ulcer disease. These agents provide rapid relief by neutralizing gastric hydrochloric acid, thereby increasing intragastric pH and reducing mucosal irritation. In addition to their therapeutic benefits, the long-term and excessive use of antacids may be associated with adverse effects and toxicological concerns, including electrolyte …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 2, 2026 Read article
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The Alarming Impact of Microplastics on the Reproductive System of Fish
Abstract: Environmental contaminants that are biologically active significantly affect ecosystems, animals, and human health. Plastic pollution has drawn international attention for its detrimental effect on the environment and biodiversity health. The aquatic ecology of our planet is full of microplastics. Regular, extensive use of nonbiodegradable polymers required several years for them to break down. Over the course of those years, it discharged tiny particles of 100 nm or less. Due to …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 13, Issue 2, 2024 · pp. 8–13 Read article
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Computational Exploration of Bhrijraj-derived Phytochemicals as Potential Anti-inflammatory Agents: A Molecular Docking Study with Cyclooxygenase-II Complex
Abstract: The molecular docking analysis was meticulously conducted using state-of-the-art computational tools, notably Chimera and Python. These tools were employed to unravel the complex interactions between the identified phytochemicals from Bhrijraj and the target protein, COX-II. The 3D structures of the phytochemicals were prepared with precision using ChemSketch, ensuring accuracy in the subsequent molecular docking simulations. This rigorous approach enhances the reliability and validity of the findings. This research aims to …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 31–37 Read article
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Effects of the Embryonic Bisphenol an Exposure on The Postnatal Development, Learning and Memory of Rat Offspring: Fundamental Study
Abstract: We studied the morphologic changes in some organs and changes of learning and memory of the rat offspring after the embryonic bisphenol A exposure. Background: Bisphenol A, widely used as polycarbonate plastics material to manufacture food packaging, toys, glasses, computers, kitchen utensils and medical instruments, is one of the most common endocrine-disrupting chemicals. It is demonstrated that bisphenol A may be mingled with foodstuff and beverage from package and receptacle. …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 58–63 Read article
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Origin and Development of Forensic Science and Branches of Forensic Science
Abstract: Forensic science is like the Sherlock Holmes of the real world, blending scientific expertise, legal acumen, and investigative prowess to crack cases and bring justice to the forefront. It’s essentially the art of using scientific methods to untangle the mysteries of crimes and legal disputes. Picture this: a team of experts delving into the minutiae of evidence – from DNA samples to fingerprints, from chemical analyses to digital footprints – …
Published in OmniScience: A Multi-disciplinary Journal · Vol. 15, Issue 1, 2025 · pp. 19–27 Read article