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28 articles for “Solid Dispersion”
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Solubility Enhancement Technique for Verapamil by Solid Dispersion Method
Abstract: By creating a solid dispersion, this study aimed to address the limitations of the traditional solid dosage form of verapamil, including its low bioavailability and restricted clinical efficacy. In order to alter the drug's release and improve its solubility, verapamil solid dispersion was created using the Solvent Evaporation Method and Fusion Method. The physical state of the solid dispersed verapamil was determined using saturation solubility testing and dissolution studies. Verapamil …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 94–99 Read article
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Development and Characterization of a Solid Dispersion of an Anti-Diabetic Drug Using Pectin as a Natural Polymer
Abstract: Aim: The current study sought to improve the solubility and oral bioavailability of gliclazide by creating solid dispersions and oral dispersible tablets (ODTs) with enhanced physicochemical characteristics and maintained antidiabetic action. Methods: Preformulation studies were conducted to evaluate the physicochemical properties of gliclazide, including physical appearance, melting point, solubility, and partition coefficient. Solid dispersions were prepared using hydrophilic carriers-pectin and PVP K30, and subsequently characterized by Fourier Transform Infrared Spectroscopy …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
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Polymer Composite-Assisted Crystal Engineering for Drug Synthesis and Property Control through Solid Solutions and Co-Crystals
Abstract: The long-standing problem of low aqueous solubility, which affects about 90% of all new drug molecules under development, requires an immediate need for alternative approaches apart from the usual practice of crystallization. Polymer-composite-assisted crystal engineering is a novel technique for overcoming the aforementioned problem. This involves the addition of accepted pharmaceutical polymers, such as HPMC, PVP, PEG, and Eudragit copolymers in a single process, which can promote nucleation, stabilize the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 172–189 Read article
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Recent Advances in Delivering Strategies of Domperidone Challenges and Opportunities
Abstract: Domperidone (DMP), a potent gastroprokinetic and antiemetic drug, exhibits poor aqueous solubility and limited oral bioavailability. Therefore, to develop oral preparations with optimized oral bioavailability, the pharmacokinetic parameters of DMP need to be controlled. The present review aimed to discuss the physicochemical characteristics of DMP causing its unfavorable oral delivery, to explore the viable oral formulation approaches, and to propose some recent formulation approaches that can mitigate the above mentioned …
Published in Trends in Drug Delivery · Vol. 8, Issue 2, 2023 · pp. 13–24 Read article
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Advances in Solubility Enhancement Strategies for Poorly Water-soluble Drugs: A Comprehensive Review
Abstract: Solubility enhancement holds significant importance in the field of pharmaceutical research as it aims to augment the solubility and bioavailability of drugs that possess low solubility. Poorly soluble drugs pose a considerable challenge in drug development due to their tendency to display inadequate absorption, bioavailability, and therapeutic efficacy. The advancement of solubility enhancement techniques encompasses a wide range of approaches, including physical and chemical methods, as well as innovative technologies …
Published in International Journal of Vaccines · Vol. 1, Issue 1, 2024 · pp. 01–09 Read article
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Fast Dissolving Oral Thin Films: A Review
Abstract: Fast-dissolving oral thin films (FDOFs) represent a significant advancement in drug delivery technology, offering advantages over traditional solid dosage forms, especially for patients with swallowing difficulties. FDOFs dissolve rapidly in the mouth, releasing the active ingredient without the need for water or chewing. They have picked up ubiquity due to their comfort, taste veiling capabilities, and progressed persistent compliance. Ideal drugs for FDOFs should possess characteristics such as solubility, stability, …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 11, Issue 1, 2024 · pp. 24–31 Read article
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Pharmaceutical Syrup Formulation Enhancing Bioavaibility and Patient Compliance
Abstract: Pharmaceutical syrup formulations are crucial for drug delivery, especially in pediatric and geriatric populations. However, challenges, such as bioavailability, stability, and patient compliance due to factors, like taste and viscosity, must be addressed. Strategies to enhance bioavailability include solubility enhancers, nanoparticle systems, and advanced techniques like solid dispersions and emulsions. Palatability plays a critical role in patient compliance, with flavoring agents, sweeteners, and texture modifications improving acceptability. Innovations, like controlled-release …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 1–6 Read article
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Review on Sustained Released Matrix Tablet
Abstract: Pharmaceuticals often use sustained release dose forms to prolong the therapeutic agent’s presence in the bloodstream and maintain a consistent plasma profile. The matrix governs the drug’s release rate. Hydroxypropyl methyl cellulose, a release retardant, is a key excipient in formulations due to its ability to promote sustained release. Techniques that include wet granulation, direct compression, or the dispersion of solid particles within a porous matrix, integrating polymers, like polymethyl …
Published in Trends in Drug Delivery · Vol. 12, Issue 2, 2025 · pp. 60–69 Read article
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Formulation of Wonderful base pomegranate shampoo and evaluation of it
Abstract: The current study objective was to create and assess a herbal shampoo using natural ingredients that prioritized both efficacy and safty. The extracts of pomegranate (the active ingredient), curry leaves, hibiscus leaves, Fenugreek seeds and reetha were combined in varying amounts to make the shampoo. As ancient times, people are used herbal shampoos, which are cosmetic preparations made with traditional ayurvedic herbs, to clean their hair, scalp, and to beautify …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 23–36 Read article
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An Insightful Study on SMEDDS Challenges and Potential Strategies
Abstract: Self-microemulsifying drug delivery systems (SMEDDS) have gained attention as an effective approach to enhance the bioavailability of poorly water-soluble drugs. They are innovative lipid-based formulations designed to enhance the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs. The development of SMEDDS involves systematic selection of components based on solubility and emulsification efficiency, followed by optimization of ratios using pseudo-ternary phase diagrams. The resulting formulations are evaluated for droplet size, …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 311–334 Read article
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Squeeze Casting of Hybrid Aluminum Matrix Composites: A Critical Review of Process Optimization, Reinforcement Strategies, and Performance Outcomes
Abstract: Increasing demand for lightweight, performance-oriented components in automotive, aerospace, and defense industries has driven advancements in squeeze casting, a hybrid technique merging forging and die-casting advantages to produce near-net-shape aluminum matrix composites (AMCs) with superior mechanical-tribological properties. This review critically examines the interplay of process parameters (e.g., squeeze pressure: 70–150 MPa, melt temperature: 650–800°C), reinforcement characteristics (volume fraction ≤10%, particle size: 10–71µm), and interfacial engineering strategies (flux-assisted bonding, ultrasonic dispersion) …
Published in Journal of Materials & Metallurgical Engineering · Vol. 15, Issue 2, 2025 · pp. 52–60 Read article
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IoT-Based Smart Waste Tracking & System for Monitoring
Abstract: In an era of rapid urban growth—driven by continued population growth and greater waste dispersion due to unregulated disposal practices by all citizens—a major challenge is emerging in the effective management of solid waste in urban environments. This project proposes a solution to this challenge: a Smart Waste Tracking & System for Monitoring. In this system, every household is provided with an RFID card, which they must use each time …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 4, Issue 2, 2026 Read article
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Performance Analysis of Graphene Reinforced Sug-ar-Alcohol Based PCM for Thermal Energy Storage System
Abstract: The thermal-conductivity of the Phase Change Materials (PCMs) of thermal heat storage systems is improved by distributing nano-particles in the basic PCM for a faster rate of heat transfer. During the charging and discharging procedures, the heat transfer properties of the newly created Sugar-Alcohol based PCM dispersed with 1.0 wt% graphene nanoparticles in a shell and helical tube storage tank were examined. The helical tube configuration caused the melting and …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 133–147 Read article
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Heat Transfer Performance of ZnO- Ethylene Glycol- Water Nanofluid Using Thermal Lens Technique
Abstract: Nanofluids are engineered fluids used in advanced electronic systems for thermal management. Fluids with dispersed nanoparticles have exhibited remarkable thermal properties. Ethylene glycol (EG) and water mixtures are widely used in many industrial areas. This study investigates the synthesis and heat transfer performance of ZnO-EG, ZnO-water, and ZnO-EG-water nanofluids using a dual-beam thermal lens technique. ZnO is a widely used inorganic, UV-absorbing, multifunctional semiconducting material with applications in various fields …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 440–445 Read article
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Composite Fabrication by Stir-Cast for Al C355.0 With Particulates Hematite Reinforcements at Different Weight Percentages in Copper Chills with and Without Water Circulation for Mechanical and Fatigue Performance
Abstract: This study investigates the fabrication of aluminum matrix composites using the stir casting method to analyze the mechanical characterization and fatigue behavior of Al C355.0 composites reinforced with varying weight percentages of hematite particulates. The hematite content was systematically adjusted from 0 wt. % to 12 wt. % in 3 wt. % increments, with the presence of constituent elements confirmed through Energy Dispersive Spectroscopy (EDS). The incorporation of hematite reinforcement …
Published in Journal of Polymer & Composites · Vol. 13, Issue 3, 2025 · pp. 324–336 Read article
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Tensile and Microstructural Behaviour of Friction Stir Welded AL7050 Hybrid Composites Reinforced with Multani Mitti and Cow Dung Ash
Abstract: The study examines Al7050 aluminum alloy composites made by stir casting and bonded by friction stir welding (FSW), supplemented with environmentally friendly Multani Mitti (MM) and cow dung ash (CDA). The study assesses the effects of different hybrid reinforcement contents (0–8 vol%) on the microstructural properties, hardness, and tensile behavior of the base alloy and its FSW joints. Tensile testing reveals an initial decline at 2% reinforcement but a notable …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 78–89 Read article
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Smart Biopolymer–PCM Composite Modules with Embedded Wireless Thermal Sensing for Autonomous Energy Storage Applications
Abstract: The development of multifunctional polymer composite systems for intelligent thermal energy storage has gained significant attention due to the increasing demand for sustainable and autonomous thermal management technologies. In the present study, a wireless-integrated biopolymer–phase change material (PCM) composite module embedded with thermal feedback sensors was successfully fabricated and experimentally investigated for advanced thermal energy storage applications. Polylactic acid (PLA) was employed as the biodegradable polymer matrix, while paraffin wax …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 193–205 Read article
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Effects of Nano B4C Addition on the Solidification Behavior of Al-2219 Alloy Composites
Abstract: The inclusion of nano B4C particulates in Al-2219-Nano B4C alloy was investigated to understand their impact on hardness and wear characteristics. 500 nm-sized nano B4C particulates are used as reinforcements for structures in the Al2219 alloy matrix. The nanocomposites were fabricated using the two-stage liquid stir melt method with varying weight percentages (2, 4, 6, and 8 wt. %) of Nano B4C in the Al-2219 alloy matrix. Renewable energy dispersive …
Published in International Journal of Manufacturing and Production Engineering · Vol. 2, Issue 1, 2024 · pp. 31–38 Read article
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Enhancement of Mechanical Properties in Eutectic Al-Si Alloy Matrix Composites Reinforced with Kyanite and Graphite via Stir Casting
Abstract: The purpose of this work is to enhance the mechanical performance of a eutectic Al–Si alloy by incorporating hard ceramic (kyanite) and soft solid lubricant (graphite) reinforcements using a liquid-state stir casting route. Metal matrix composites were fabricated with kyanite contents of 2, 4, and 6 wt.% and a constant 2.5 wt.% graphite. Their microstructures and mechanical properties were systematically evaluated. The microstructure was examined using optical microscopy and energy …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 90–100 Read article
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Synthesis and Structural Characterization of Nanocrystalline CeO2 and Ce0.95Cu0.05O2 Solid Solution Catalysts: Properties and Applications
Abstract: The main study and the development of CeO2 and Cu-doped CeO2 nanocrystals containing transition- metal species are of crucial importance for understanding the preparation and fabrication of CeO2 and Cu-doped CeO2 nanoparticles by solution combustion technique to taken glycine as fuel. The structural properties of Ce1-xCuxO2 nanocrystals were examined by investigating the influence of cerium dioxide and Cu dopant ions. The CeO2 single-phase cubic system was successfully incorporated with Cu …
Published in Journal of Catalyst & Catalysis · Vol. 11, Issue 3, 2024 · pp. 29–38 Read article