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6 articles for “Parkinson’s and Alzheimer’s disorders”
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Integrating Network Pharmacology and Molecular Docking to Assess Rutin’s Pharmacological Properties
Abstract: Objectives: In the present research, the network pharmacology process was applied to determine the underlying mechanism of the pharmacological properties of Rutin. Network pharmacology was utilized to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The identification of diverse drug-target interactions using network pharmacology may be utilized to discover novel medications for difficult conditions like …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 20–33 Read article
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In vivo Modulatory Effect of Clerodendrum Splendens (Glory Blossom) in Aluminum Induced Alzheimer Diseases and Lonchocarpus Sericeus in Rotenone Induced Parkinson’s Disease on Na+/K+ Atpase (Sodium Pump) in the Cerebral Tissues of Male Albino Wister Rats
Abstract: Elegant research has shown that plants are useful for both curative and preventive purpose on the humans populous. Prevalent among diseases associated with humans are neurological diseases which affect a large sector of the population especially the elderly. The most common neurological diseases are Parkinson and Alzheimer disease which affect a large sector of the brain and also cause an imbalance in brain electrolyte. Among such electrolytic mechanisms of the …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 1, Issue 2, 2023 · pp. 31–36 Read article
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Aquatic Ecosystems: A Review on Prospecting of Anticancer Molecules from Fungi & Other Microbes
Abstract: Marine biota; namely, actinomycetes, bacteria, fungi, microalgae, green algae, oceanic weeds, mangroves, and other extremophiles constitute about 90% of the oceanic biomass. The organisms are taxonomically diverse, biologically productive/active, and biochemically unique. These unique biochemiques may act as a great source for the discovery of new bioactive molecules, including anticancer drugs. The marines produce medicinally potent biochemicals; namely, sulfated saccharides, polyphenols, and, sterols. Only a few of these alkaloids have …
Published in International Journal of Fungi · Vol. 1, Issue 2, 2024 · pp. 1–22 Read article
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A Comprehensive Review on Neturaceuticals in Alzheimer's and Neurodegenerative Disease an Cognitive Enhancement
Abstract: Neurodegenerative diseases, including Alzheimers disease (AD), Parkinsons disease (PD), and related cognitive disorders, represent a significant and growing public health challenge, particularly in aging populations. Despite advances in pharmacological treatments, therapeutic options for cognitive decline and neurodegeneration remain limited. Recent interest has shifted towards nutraceuticals— bioactive compounds derived from food or natural sources—as promising adjuncts or alternatives in the management of these conditions. This review examines how nutraceuticals can help …
Published in International Journal of Brain Sciences · Vol. 2, Issue 1, 2025 · pp. 1–9 Read article
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Neurodegeneration and Cognitive Decline: Causes, Consequences, and Treatment Approaches
Abstract: Neurodegenerative diseases gradually destroy nerve cells, often leading to fatal outcomes. The phrase includes a wide range of clinical problems, such as a variety of Neurological conditions include movement disorders, like Parkinson’s disease (PD) and progressive cognitive impairments, with Alzheimer’s disease (AD) being the most common among them. A loss of neurones and synaptic connections, typically in later life, is a prevalent feature of Usually, the onset and development of …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 3, Issue 1, 2025 · pp. 47–59 Read article
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Non-Enzymatic Glycation in Alzheimer’s and Parkinson’s Disease: A Molecular Approach to Pathology and Recent Advances
Abstract: Non-enzymatic glycation, a biochemical process by which reducing sugars spontaneously bind to proteins, leads to the formation of advanced glycation end-products (AGEs), which have emerged as critical contributors to the pathogenesis of several neurodegenerative diseases, particularly Alzheimer’s disease (AD) and Parkinson’s disease (PD). The accumulation of AGEs can significantly alter protein structure, stability, and function, triggering a cascade of detrimental effects, including increased oxidative stress, heightened neuroinflammation, and the promotion …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 36–41 Read article