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30 articles for “Mycobacterium tuberculosis”
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First Insights into Whole Genome Sequencing of the Mycobacterium tuberculosis Complex: Molecular Diversity and Drug Susceptibility Patterns in Senegal
Abstract: Background: We conducted a bibliographic analysis of the Mycobacterium tuberculosis complex (MTBC) in sub-Saharan Africa, which included the analysis of 8,139 genomic sequences from 34 of the 49 sub-Saharan African countries. Notably, only one complete sequence from Senegal was identified, which had been generated in the United States. Our primary objective was to utilize whole genome sequencing (WGS) to detect resistance in anti-tuberculous strains of the MTBC in Senegal. This …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 · pp. 1–14 Read article
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Decoding the Mycobacterium tuberculosis–Macrophage Interplay: From Immune Defense to Pathogen Persistence
Abstract: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb) and has been responsible for over one billion deaths worldwide over the past two centuries, remaining a major global health challenge despite advances in diagnosis and treatment. The barriers that make tuberculosis difficult to treat and eliminate are inextricably tied to its intracellular habitat. However, a research gap lies in understanding the molecular mechanisms of its survival and …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 Read article
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In-Silico Repurposing of Antipsychotic Drugs Against Novel Protein Targets in Multidrug-Resistant Mycobacterium tuberculosis
Abstract: Multidrug-resistant TB is a growing worldwide health concern, particularly in high-burden areas. Resistance to frontline drugs like isoniazid and rifampicin is caused by mutations in key Mycobacterium tuberculosis proteins. Given the difficulty of developing new antibiotics, medication repurposing offers a good alternative. The potential use of molecular docking to target resistance-associated TB proteins with FDA-approved antipsychotic drugs is investigated in this work. Three proteins were selected: InhA (PDB ID: 5W07), …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 1, 2026 · pp. 49–63 Read article
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Pathogenesis, Treatment and Molecular Mechanisms for Development of Multidrug-resistant (MDR) TB as well as Identification of MDR Mycobacterium Tuberculosis
Abstract: Normal 0 false false false EN-US X-NONE X-NONE Tuberculosis (TB) is a medical, social, and economic disaster of huge magnitude in the world. Prevalence of TB has increased due to poverty, population growth, migration and a high number of TB cases in HIV positive individuals. High prevalence rate of M. tuberculosis strains with multidrug resistance (MDR) is a serious problem as global emergency. Strains of M. tuberculosis resistant to both …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 1, 2013 · pp. 16–38 Read article
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Colorimetric Redox Indicator assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region
Abstract: Tuberculosis (TB) has affected humans since antiquity. The burden of TB particularly with multi-drug-resistance (MDR) is increasing worldwide and has become a major public health concern. This study aims to perform Colorimetric Redox Indicator (CRI) assay for rapid detection of multidrug-resistant Mycobacterium tuberculosis in South Gujarat region. Total 234 samples were collected from South Gujarat region and were subjected for microscopy examination, culturing on Lowenstein-Jensen (LJ) medium and drug susceptibility …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 8, Issue 3, 2018 · pp. 65–70 Read article
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3D-QSAR and Molecular Docking Studies of Triazol-Cycloalkanol Derivatives Used as Potent 3-Dehydroquinase II Inhibitors Against Mycobacterium tuberculosis
Abstract: Tuberculosis is a life threatening infectious disease caused by gram positive bacteria mycobacterium tuberculosis. Emergence of drug resistance, multi drug resistance and extensively drug resistance strain of mycobacterium make the situation more worst. It increases the mortality rate of tuberculosis patient, time duration and cost of treatment. Various inhibitors and drug molecules are designed to combat this fatal disease. Enzymes of shikimate pathway are responsible for production of essential amino …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 5, Issue 3, 2015 · pp. 18–28 Read article
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In Silico Drug Design for Mycobacterium tuberculosis and Development of Host–Pathogen Interaction Network and Molecular Docking Procedures
Abstract: Objective: A leading cause of illness is the contagious disease tuberculosis (TB), this infection with Mycobacterium tuberculosis complex (MTBC) particularly M. tuberculosis and M. africanum, is what causes tuberculosis. Diverse receptor proteins (mycobacterial proteins) with various 3D structures and functions were evaluated to access the multi-domain antimycobacterial action of ligands. The specific receptor proteins PDB ID: 3PTY, PDB ID: 4OW8, PDB ID: 5KWA, and PDB ID: 3ZXR, were opted for …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 1–19 Read article
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GeneXpert MTB/RIF Assay (PCR Mycobacterium Tuberculosis): A Revolution in Management of Tuberculosis
Abstract: Background: Workup of pulmonary tuberculosis depends upon sputum microscopy. Sputum microscopy is less sensitive, human resource dependent and time consuming. Sometimes, it lead us to a delay in the diagnosis and may result in the spread of the disease. This seriously disturbs TB control program. There is a need for a more sensitive method. Similarly, early detection of rifampicin resistance is also of utmost importance to prevent MDR strains from …
Published in Research and Reviews : A Journal of Immunology · Vol. 8, Issue 2, 2018 · pp. 8–12 Read article
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AI in Healthcare: Drug Delivery in Tuberculosis
Abstract: Tuberculosis (TB) , mainly caused by Mycobacterium tuberculosis, remains a major global health burden, accounting for millions of new infections and deaths each year. Although progress has been made in diagnosis and treatment, the growing threat of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB makes disease control increasingly difficult. Conventional diagnostic approaches such as chest X-rays, sputum smear microscopy, and culture methods continue to play an important role, but they …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 9–17 Read article
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In silico Molecular Docking Analysis of Stephania glabra phytocompounds Targeting Thymidylate Kinase for potential Antituberculosis Activity
Abstract: Tuberculosis (TB) is an infectious disease caused by the bacteria Mycobacterium tuberculosis. It mainly affects the lungs and spreads through the air when a person with active TB in their lungs coughs, sneezes, or spits. This study investigates several bioactive compounds derived from plants to forecast how effective plant-based ligands will be at preventing tuberculosis. The purpose of the study was to use computational techniques to assess the effectiveness of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 2, 2025 · pp. 25–37 Read article
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Pathogenesis and Treatment of Tuberculosis (T.B) Disease
Abstract: Tuberculosis (TB) is an infectious illness spread through the air that is caused by organisms from the Mycobacterium tuberculosis complex. M. tuberculosis is a lung infection in primary stage, but it can infect any area of the body. M. tuberculosis infection can progress from latent TB infection, in which the bacteria are isolated within granulomas, to infectious infection, in which the patient develops symptoms such as cough, fever, night sweats, …
Published in Research and Reviews : A Journal of Immunology · Vol. 11, Issue 3, 2021 · pp. 42–48 Read article
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Cartridge-Based Nucleic Acid Amplification for Rapid Tuberculosis Diagnosis
Abstract: In terms of public health, tuberculosis continues to have a significant impact on people's lives. The process of determining the underlying cause of a sickness or condition in a patient is known as clinical diagnosis. It entails the use of numerous diagnostic methods, including physical examinations, laboratory testing, and imaging procedures for medical purposes. Smear microscopy, which are frequently utilized, have poor sensitivity and lengthy turnaround times, respectively. An innovative, …
Published in International Journal of Pathogens · Vol. 1, Issue 1, 2024 · pp. 43–48 Read article
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Drug-Resistant TB—Problem and Management: a Review
Abstract: Tuberculosis (TB) is one of the oldest diseases known to affect humans. TB is a major cause of death worldwide. The bacteria Mycobacterium tuberculosis is the causative agent of TB. It usually affects the lungs and causes pulmonary TB. The intestine, meninges, bones, joints, lymph glands, skin and other tissues of the body are also affected. TB caused by drug-susceptible strains is curable in virtually all the cases after proper …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 6, Issue 3, 2019 · pp. 30–34 Read article
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Standard Diagnostic Procedure for Tuberculosis: A Review
Abstract: Normal 0 false false false EN-US X-NONE NE Despite continuous effort in monitoring and treatment of tuberculosis, the disease remains a major public health issue. Rapid diagnosis and appropriate therapies become the first priorities in controlling the growing epidemics. The bedside decision on the initiation of anti-tuberculous drug therapy are based on epidemiologic, clinical, radiolographic, and/or histological findings, which can generally be supported by a rapid microbiologic test, commonly a …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 3, Issue 3, 2013 · pp. 34–40 Read article
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A Potential Role of Ayurvedic Treatment in Tuberculosis
Abstract: According to the World Health Organization (WHO), tuberculosis (TB) is one of the top tencauses of death worldwide and verified as a global health problem. The main reason of globalhealth problem is generally the tremendous burden of disease. In the estimated survey of TB in2016, 10.4 million people suffered with TB and 1.7 million died with this disease. After a longperiod of neglect some new interventions are developed by various …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 10, Issue 1, 2019 · pp. 1–10 Read article
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A Narrative Review on Tuberculosis Disease Transmission, Treatment, Prevention, Emergency Care, and Vaccine Allocation in Second Highest Populated Country (India)
Abstract: Tuberculosis, an airborne illness caused by Mycobacterium tuberculosis, is a highly contagious disease primarily impacting the lungs, though it can also affect other body parts, excluding hair and nails. There are two main types of tuberculosis: pulmonary tuberculosis (PTB), which targets the lungs, and extrapulmonary tuberculosis (EPTB), which involves other areas such as lymph nodes, bones, joints, and the nervous system. The theme for World Tuberculosis Day in 2024 is …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 2, Issue 1, 2024 · pp. 7–13 Read article
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Disseminated Tuberculosis in an Infant: A Case Report
Abstract: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Even though tuberculosis among pregnant woman is not uncommon, documented cases of congenital tuberculosis are rare. It is because placenta forms a protective barrier against the invasion of foetus by the organism. Although rare, congenital tuberculosis should be distinguished from more frequent acquired neonatal tuberculosis. Diagnosis of neonatal tuberculosis is difficult as sputum is generally not available for examination. Gastric aspirate …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 3, Issue 3, 2013 · pp. 5–7 Read article
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Computer-Aided Drug Design on Tuberculosis
Abstract: Currently, India's Directly Observed Treatment Short Course (DOTS) program is the world's largest and fastest-growing initiative for treating medical patients, second only in terms of population coverage. The main obstacles to TB control in India are inadequate primary healthcare in rural regions of many states, unregulated private treatments resulting in extensive misuse of first- and second-line TB medications, the spread of HIV, a lack of political commitment, and, most importantly, …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 22–31 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Understanding the Impact: Adult BCG Vaccination in the Fight Against Tuberculosis
Abstract: Tuberculosis (TB) remains a big global health challenge, with significant mortality rates, especially in developing nations. India holds most TB cases throughout the globe. As HIV rates, multidrug-resistant tuberculosis (MDR-TB), and extensively drug-resistant tuberculosis (XDR-TB) continue to increase, the situation is deteriorating. These all come in the way of the End TB epidemic campaign by the World Health Organization (WHO) by 2030. Immunology and vaccinology represent critical fronts in TB …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 3, 2024 · pp. 1–6 Read article