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62 articles for “Molecular Diagnosis”
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Molecular Diagnosis of Rifampicin Antibiotic Resistance in Mycobacterium Avium Subspecies Paratuberculosis Isolated from Sheep Clinical Samples
Abstract: The present study was conducted to identify parts of the rpoB gene in MAP of Indian sheep isolates. The rpoB gene (Beta sub unit of RNA polymerase) is involved in conferring the rifampicin antibiotic resistance in MAP bacteria. The resistance is due to the presence of mutations in the 81 bp variable region of the rpoB gene including C1367T and T1442C mutations identified by several workers. The study was further …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 12, Issue 3, 2022 · pp. 35–56 Read article
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Review on Advanced Molecular Diagnostic Tools and Their Applications
Abstract: Although the diagnosis of diseases is still primarily based on conventional methods (staining, culture, biochemical analysis), a series of advanced molecular diagnostic tools are increasingly introduced and incorporated in the workflow of clinical laboratories worldwide. These tools, such as polymerase chain reaction, northern blotting, restriction length polymorphism, flow cytometry, southern blotting, fluorescent in situ hybridization, agarose gel electrophoresis and pyrosequencing that are based on either the properties of nucleic acids …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 3, Issue 3, 2013 · pp. 21–33 Read article
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Curvularia spp. and Curvularia Infections: A Comprehensive Review
Abstract: Curvularia spp., dematiaceous (melanin-pigmented) fungi in the family Pleosporaceae, emerge as opportunistic pathogens that cause phaeohyphomycosis, allergic fungal rhinosinusitis, and keratitis. This review dissects their pathogenesis via melanized cell walls, conferring tissue invasion, protease secretion, and immune evasion in immunocompromised hosts. Clinical manifestations span cutaneous (70%), sinopulmonary (20%), disseminated (5-10%), and CNS forms, mimicking aspergillosis or mucormycosis. Laboratory diagnosis hinges on histopathology (irregular septate hyphae, 3-8 µm, brown on Fontana-Masson), …
Published in International Journal of Fungi · Vol. 3, Issue 2, 2026 Read article
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Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 07–22 Read article
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Magnetic ZnxFe2–xO3 Nanoparticles Enhanced Nanobiosensor Integrated with MOSFETs for Efficient Detections of Biomolecules and Cancerous Cells
Abstract: The human brain is mostly responsible for intelligence and consciousness. An artificial equivalence of this action is nanobiosensor, which is used in artificial intelligence. The need for nanodiagnostics platforms for detecting diseases at the genetic, molecular, and cellular level has triggered the development of nanobiosensors integrated with MOSFETs. This device enables simple, inexpensive rapid tests, accurate imaging methods, and accurate molecular diagnosis at point-of-care (POC). This device is seen as …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 3, 2024 · pp. 33–44 Read article
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A Comprehensive Review: Personalized Treatment Strategies in Stable Ischemic Heart Disease
Abstract: Stable Ischemic Heart Disease (SIHD) is one of the leading cardiovascular disorders associated with high morbidity and mortality worldwide. Since early symptoms such as chest pain, fatigue, and shortness of breath are often non-specific and difficult to recognize, diagnosis becomes challenging, and many cases remain undetected until advanced stages or complications occur. Traditional diagnosis depends heavily on clinical evaluation, electrocardiography, stress testing, and imaging techniques. The development of improved treatment …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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Global Polio Eradication: Opportunities and Challenges
Abstract: Poliomyelitis (polio) is a disease of public health importance that occurs mainly in children. In a small percent of infected children, the virus invades central nervous system that could result in paralysis. Now, the global eradication of polio is considered to be in the final stage. By 2002, three World Health Organization (WHO) regions (the Americas, Western Pacific and European regions) had been certified as polio-free. Since the start of …
Published in Research and Reviews : A Journal of Immunology · Vol. 4, Issue 1, 2014 · pp. 8–12 Read article
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Advances in Diagnostic Techniques in Veterinary Medicine
Abstract: Diagnostic techniques play a crucial role in veterinary medicine for accurate disease identification, treatment planning, and monitoring of animal health. This review article explores the latest advancements in diagnostic tools and technologies used in veterinary medicine, focusing on imaging modalities, molecular diagnostics, and point-of-care testing. The first section discusses the advancements in imaging modalities, including digital radiography, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography. These technologies have revolutionized …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 12, Issue 1, 2023 · pp. 1–4 Read article
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An Overview on Nuclear Imaging Scans (Diagnostic Nuclear Medicine) in Breast Cancer Diagnosis
Abstract: Nuclear medicine has major role in clinical oncology specially in tumor imaging. Under this, specific organs are evaluating or to detect presence of tumor in entire body. Nuclear medicine used to evaluate the extent of tumor at initial stage. Molecular imaging helps doctor to diagnose the accuracy of cancer. This study represents the types of nuclear medicine scan and molecular imaging in breast cancer diagnosis.Keywords: breast cancer, nuclear imaging scan, …
Published in Journal of Nuclear Engineering & Technology · Vol. 8, Issue 3, 2018 · pp. 12–17 Read article
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Understanding Leukemogenesis: Challenges and Advancements in Diagnostic Approaches
Abstract: Leukaemia development, or leukemogenesis, is a multifactorial process driven by a complex interplay of environmental, genetic, and epigenetic factors. Despite substantial advancements in technology and medicine, which have enhanced our understanding of the contributing factors, early and accurate diagnosis remains a major challenge due to the overlapping clinical features shared by the various leukaemia subtypes. This study explores the molecular and cellular mechanisms underlying leukemogenesis, while also addressing the difficulties …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 1, 2025 · pp. 11–22 Read article
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Canine Ehrlichiosis and Its Diagnostic Techniques: Review
Abstract: Canine monocytic ehrlichiosis, caused by Ehrlichia canis is one of the important immuno-suppressive infectious vector-borne diseases of dogs. Importantly, canine ehrlichiosis can be caused by different Ehrlichia species, which are intracellular rickettsial organisms belonging to the order Rickettsiales and included in the family Rickettsiaceae. Ehrlichias are the obligate intracellular organisms that affects the host immunologic response. It is typically a disease of leukocyte and platelet manifested by an acute reduction …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 1, 2020 · pp. 1–11 Read article
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Malaria Diagnosis through Conventional Methods: A Comprehensive Review
Abstract: The incidence of drug-resistant parasite strains is rising, there is an apparent increase in the number of cases of malaria worldwide, and in a small number of cases and there has been a dramatic rise in international migration and travel. Over 1 million people die from malaria every year; 90% of these deaths are in African children, who live in tropical and subtropical regions. Although there are now efficient techniques …
Published in International Journal of Pathogens · Vol. 1, Issue 2, 2024 · pp. 8–14 Read article
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A Study of Optical Sensor in Clinical applications
Abstract: The escalating demand for precise, real-time, and minimally invasive diagnostic and monitoring tools in clinical practice has propelled the development of sophisticated sensor technologies. Among these, optical sensors have emerged as a cornerstone, leveraging the interaction of light with biological matter to translate molecular or cellular events into quantifiable signals. Their inherent advantages – including high sensitivity, specificity, rapid response times, non-ionizing nature, and potential for miniaturization – make them …
Published in International Journal of Optical Innovations & Research · Vol. 3, Issue 2, 2025 · pp. 1–7 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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Advances in Lung Cancer Detection and Diagnosis: An Integrative Approach Using Computational Chemistry, Statistics, Bioinformatics, Artificial Intelligence, and Machine Learning
Abstract: Lung cancer is still one of the most common and lethal cancers globally, accounting for more than a million deaths each year. Prompt detection is important, and imaging techniques like chest X-rays, MRIs, PETs, CTs, and molecular imaging have become important tools. But still, even though all these techniques do not provide an accurate classification of the lesion, they have led to the development of computer-based high-resolution image analysis. Computer …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 13, Issue 2, 2026 Read article
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Occupational Infections and Preventive Measures: An Update
Abstract: There are many infections which are closely associated with certain occupations, whereby the workers are put at a higher risk of being contracted with certain infections in the work setup. Occupational hazards are classified as being either physical (high temperature or pressure) or chemical (organic solvents and chemicals) or biological (virus, bacteria, fungi) hazard. Sometimes the prevalent occupation-associated life-style results in higher risk of exposure to the infections. These hazards …
Published in Research and Reviews: A Journal of Medicine · Vol. 1, Issue 1, 2011 Read article
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An Overview on the Management cum Treatment of Nephropathy in Type-1 Diabetes Mellitus
Abstract: The motive of this review is to keep updated with the medical nonfictions, the projected early natural arrangement of diabetic nephropathy, the theories behind the root of its pathogenesis pathophysiology, diagnosis and its supervision. Type 1 diabetes is an autoimmune disease characterized by advanced destruction of pancreatic beta cells by genetic and environmental factors which primes to an absolute necessity of insulin for survival and conservation of health; while Diabetic …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 3, 2020 · pp. 19–38 Read article
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Liquid Biopsy in Solid Tumor: An Ultimate Source for Molecular Landscaping, Biomarker Discovery and Clinical Management
Abstract: Presently, work in the liquid biopsy field showed a great prospect utility in the diagnosis and stratification of cancer patients and furthermore personify an adaptive method for monitoring treatment response when compared to the tissue biopsy approach. Analysis of cell free DNA (cfDNA), circulating tumor cells (CTCs) and exosomes, all conjointly referred to as “liquid biopsies,” are not only a modality to monitor treatment efficacy, disease progression, and emerging therapy …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 8, Issue 3, 2019 · pp. 25–36 Read article
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Beyond Conventional Membranes: Advanced Functional Platforms for Precision Healthcare and Biomedical Applications
Abstract: Traditional membrane technologies have historically been used as passive separation barriers in filtration, purification, and biomedical applications. Recent progress in nanotechnology, biomaterials, bioengineering, and surface modification has revolutionised membranes into dynamic, intelligent, and multifunctional platforms that can sense, regulate, and engage with biological systems. These sophisticated functional membranes provide unparalleled prospects for precision medicine by facilitating targeted drug administration, bio sensing, tissue restoration, organ assistance, diagnostic uses, and individualised therapy …
Published in International Journal of Membranes · Vol. 3, Issue 2, 2026 Read article
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article