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22 articles for “MDA”
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Inhibition of MDA-MB-231 Breast Cancer Cell Proliferation by Simple Diphenyl Chalcone and Its Chlorinated Derivatives
Abstract: The pharmacological activities of chalcones and their derivatives are well documented. Chalcones are an important class of natural products that occur in edible plants such as spices, tea, fruits and other vegetables. In vitro studies have shown that chalcones inhibit proliferation of breast cancer cells by inducing apoptosis and blocking cell cycle progression. Substituent effects, namely, adding electron-withdrawing substituents to the chalcone structural motif, and the extents to which those …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 2, 2012 · pp. 7–12 Read article
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Effect of Caffeic Acid on Glutathione Metabolism of MCF-7 and MDA MB-231 Breast Cancer Cells
Abstract: Increasing incidences of breast cancer at alarming rates with treatment strategies having an overall detrimental effect on the patients led to investigating the potential of phytochemicals as anti-tumorigenic agents. Caffeic acid, an antioxidant and anti-tumorigenic phytochemical, has been tested on MCF-7(hormone responsive) and MDA MB-231(hormone-independent) breast cancer cell lines. Alterations in the levels of intracellular glutathione (GSH) in both cell lines due to exposure to the drug are the primary …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 1, 2022 · pp. 14–22 Read article
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Land Use/Land Cover Assessment of Tamil Nadu Coast, India using Remote Sensing and GIS Techniques
Abstract: Land use/land cover (LULC) mapping and monitoring has a significant role for regional planning, environmental and resource management towards sustainable management. The present study has been carried out for assessment of land use/land cover change in coastal districts of Tamil Nadu and Puducherry during last three decades. The study illustrated an integrated approach of remote sensing and GIS techniques to assess dynamic land use/cover in the coastal zone and estimate …
Published in Journal of Remote Sensing & GIS · Vol. 8, Issue 2, 2017 · pp. 25–37 Read article
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Immunological Biomarkers and Epidemiological Evaluation of Lymphatic Filariasis Elimination Efforts in Osun State, Nigeria
Abstract: Lymphatic filariasis (LF) remains a neglected tropical disease affecting millions globally, despite extensive elimination efforts. While the interruption of transmission is a key goal, the long-term immunological effects on individuals with existing complications like elephantiasis remain poorly understood. This study assessed the current transmission status of LF and the haematological profiles of infected individuals across selected Local Government Areas (LGAs) in Osun State, Nigeria. A total of 7,388 individuals from …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 22–30 Read article
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A MODEL DRIVEN APPROCH FOR REQUIREMENTS ENGINEERING OF INDUSTRIAL AUTOMATION SYSTEM
Abstract: A model-driven approach to developing multiple, consistent user interfaces for your application. An Abstract UI (AUI) model constrained to dialogue flow maintains the fundamental similarities of different user interfaces.. In particular, we will consider how to customize the User Interface at his AUI level by deriving and customizing dialog structures that take into account the limitations imposed by the front-end platform or novice user. The generated user interface is integrated …
Published in Journal of Mechatronics and Automation · Vol. 9, Issue 3, 2022 · pp. 1–4 Read article
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Eugenol Prevents Sodium Nitrate-induced Altered Antioxidant Status of Spermatozoa: An In Vitro Study
Abstract: Background: High level of nitrate (NO3) induces oxidative stress which affects the male and female reproductive system. In this regard, there is a great concern for the prevention of NO3-induced oxidative stress in the reproductive system by using herbal products. Eugenol is one such natural product found in clove extracted from cloves (Syzygium aromaticum) and is known for its antioxidant, anti-nociceptive, anti-inflammatory, and anti-apoptotic properties. Aim and Objectives: The present …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 12, Issue 2, 2022 · pp. 1–8 Read article
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Lipid Peroxidation in Postoperative Cases of Breast Carcinoma (Grade III)
Abstract: Breast cancer represents significant problem in the world. Oxidative modification of lipids is catalyzed by reactive oxygen species (ROS) which is known as lipid peroxidation (LPO); this changes the fluidity, permeability of membrane, cellular metabolic functions and causes derangement. Malondialdehyde (MDA) is a major end product and an index of LPO which crosslinks DNA, protein and nucleotides on the same and opposite strands. There are reports that LPO increased in …
Published in Research and Reviews: A Journal of Health Professions · Vol. 8, Issue 1, 2018 · pp. 16–22 Read article
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Exprimental Study on the Protective Action of rhGM-CSF for Acute Lung Injury
Abstract: Anti-cancer agents and radiation therapies result in various complications on respiratory systems like interstitial pneumonia, acute lung damage, bacterial pneumonia and pneumomycosis in clinical oncology. Recently it is being interested in variable rolls of GM-CSF to protect the lungs. We infuse the ethyl alcohol and lipopolysaccharide (LPS) to damage lung orally, and then inject GM-CSF subcutaneously at the same time and then observe the changes of lung tissue. As a …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 8, Issue 3, 2019 · pp. 4–8 Read article
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Influence of Reptin on acute pancreatitis model of the rat
Abstract: Background and Aim: In acute pancreatitis, hyperproduction of inflammatory mediators, including inflammatory cytokines, exacerbation of tissue injury due to microcirculatory disturbances, secondary activation of inflammatory cells in distant organs, and the cascade are the pathogenic basis of pancreatitis severity. Therefore, inhibition of pancreatic enzyme activity, blocking production, and preventing the activation of inflammatory cells is a practical way to prevent the development of severe acute pancreatitis and multiorgan failure. In …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 11, Issue 2, 2022 · pp. 36–40 Read article
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Protective Effect of Chloroform Extract of Cyperus Rotundus against DNBS Induced Inflammatory Bowel Disease in Rats
Abstract: The present study was designed to evaluate the effects of Cyperus rotundus on DNBS (Dinitrobenzene sulfonic acid) induced IBD in experimental rats. The experimental protocol (Protocol No. 9012 dated 26th Dec 2009) was approved by Institutional Animal Ethical Committee of Anand Pharmacy College. Colitis was induced with DNBS (180 mg/kg in 50% ethanol) intracolonically in animals on the 11th day of the study. Animals were fasted for 24 h prior …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 3, 2014 · pp. 24–32 Read article
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Effect of Salicylic Acid on Biochemical Traits in Two Cultivars of Soybean under Salt Stress
Abstract: AbstractSoybean is considered to be moderately salt sensitive species and is affected by salinity condition in terms of growth and yield. Among the abiotic stress, salinity is one of the serious agricultural problems worldwide which reduces field production. Foliar feeding of plants can effectively improve plant growth and productivity and is known to be more effective than soil application. Salicylic acid (SA) is a naturally occurring plant growth regulator which …
Published in Research & Reviews : Journal of Botany · Vol. 5, Issue 2, 2016 · pp. 9–18 Read article
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Mechanistic Studies on Aziridinyl-Benzoquinones in Cultured Tumour Cells
Abstract: This study compares the anti-tumour effects of NQO1 activated drug RH1 (2, 5-diaziridinyl-3 - hydoxymethyl-6-methyl-1, 4-benzoquinone) with a lipophilic ester derivative Es5 on the isogenic cell lines MDA 468 and MDA 468 NQO1 which differs only in expression of wtNQO1. A 39- fold enhancement of growth inhibitory activity was seen in NQO1 expressing cells compared the NQO1 null cells for the Es5 compared to the 25- fold increase seen for …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 2, 2023 · pp. 37–45 Read article
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Anti-ulcer Properties of Methanol Extract and its Solvent Fractions of Stem Bark of Lannea acida on Indomethacin Induced Gastric Ulcer in Albino Rats
Abstract: Lannea acida is use in Nigeria for the treatment of Peptic ulcers. The methanol and its solvent fractions (hexane, ethylacetate and butanol) of the stem bark of Lannea acida were evaluated for antiulcerogenic activity using indomethacin model. The anti-ulcerogenic mechanisms of the plant using the model employed in this study were done by estimation of Superoxide dismutase (SOD), Glutathione (GSH), Catalase (CAT), Vitamins A, C and E, and Malondialdehyde (MDA). …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 11, Issue 3, 2023 · pp. 20–35 Read article
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Extant Roofing Pattern and Early Decay of Residential Buildings in Port Harcourt Municipality, Rivers State
Abstract: The design and construction pattern of roofs in the tropical environment like Port Harcourt Municipality, Rivers State is a major factor that determined how functional and the life span of building components and materials. In recent time residential building components and materials had been observed to decay earlier than expected due the existing roofing pattern. This study is aimed at assessing the extant roofing pattern and identified factors responsible for …
Published in International Journal of Environmental Planning and Development Architecture · Vol. 3, Issue 2, 2025 · pp. 16–24 Read article
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Is Beating Heart Coronary Artery Bypass Graft Surgery Associated with Lesser Oxidative Stress and Inflammatory Response?
Abstract: Cardiac operations using cardiopulmonary bypass have been associated with systemic inflammatory response, increased levels of circulating adhesion molecules, and oxidative stress. This study aims to assess various responses in patients undergoing coronary artery bypass grafting (CABG) with or without Cardiopulmonary bypass (CPB) with respect to time after surgery. Sixty consecutive patients undergoing CABG either by on-pump or off-pump technique were studied. Serum levels of tumor necrosis factor- (TNF- -6 (IL-6), …
Published in Research and Reviews : A Journal of Immunology · Vol. 1, Issue 1-3, 2011 · pp. 16–26 Read article
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Arsenic Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Arsenic (As) is a metalloid listed in group Va of the periodic chart. It exists in nature in the oxidation states +V (arsenate), +III (arsenite), 0 (arsenic) and −III (arsine). In the aqueous environment inorganic arsenic appears commonly in the oxidation states +V and +III as arsenous acid (As (III)), arsenic acid (As (V)), and their salts. Chronic and acute exposures of arsenic leads to cancer, cardiovascular disease (hypertension and …
Published in Research and Reviews: A Journal of Toxicology · Vol. 2, Issue 2, 2012 · pp. 16–37 Read article
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Molecular Mechanism of Fluoride Induced Oxidative Stress and Its Possible Reversal by Chelation Therapy
Abstract: Fluorine (Fl) a member of the halogen family is the most electronegative and reactive of all the elements of the Periodic table. Chronic and acute exposures of fluoride leads to cardiovascular disease (hypertension and atherosclerosis), neurological disorders, gastrointestinal disturbances, liver disease, renal disease, reproductive effects, other health disorders and also affects the antioxidant system in the body. Furthermore, reactive oxygen species (ROS)-mediated oxidative damage is a common malady in fluoride …
Published in Research and Reviews: A Journal of Toxicology · Vol. 3, Issue 2, 2013 · pp. 7–34 Read article
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Anti-Ulcer Activity of Ethanolic Extract of Sesamum indicum Seed on Indomethacin-Induced Ulcer Model and Its Antioxidant Property in Gastro-Protection
Abstract: The present study was intended to investigate and evaluate the antiulcer activity of the ethanol seed extract of Sesamum indicum Linn. using Indomethacin Induced Ulcer in Albino rats and to determine its link between oxidant or antioxidant parameter. The extract of Seamum indicum Linn. was tested on indomethacin induced gastric ulcer in Albino rats. The antiulcer activity of high dose (400 mg/kg) and low dose (200 mg/kg) of ethanolic extract …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 5, Issue 2, 2015 · pp. 18–25 Read article
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‘Betazen’ Herbal Formulation, Ameliorates Experimentally Induced Metabolic Disturbances in Insulin Resistant Rats
Abstract: The present study was designed to evaluate anti-diabetic activity of ayurvedic formulation ‘Betazen’ in experimentally induced insulin resistant rats. Wistar rats were being rendered insulin resistant by administration of dexamethasone (2 μg/day s.c), along with high fat-high sugar (HFHS) diet (i.e. vanaspati ghee and fructose enriched) for 42 days. Animals with fasting blood glucose levels (BGL) of more than 150 mg/dl were selected, divided into different groups and administered 2.7 …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 6, Issue 2, 2016 · pp. 13–23 Read article
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Anti-Ulcer Activity of Methanolic Extract of Mucuna Pruriens Seed on Indomethacin Induced Ulcers in Albino Rats
Abstract: The present study was intended to investigate and evaluate the antiulcer activity of the methanol seed extract of Mucuna pruriens using indomethacin induced ulcer in albino rats and to determine its link between oxidant or antioxidant parameter. The extract of Mucuna pruriens was tested on indomethacin induced gastric ulcer in albino rats. The antiulcer activity of high dose (400 mg/kg) and low dose (200 mg/kg) of ethanolic extract of Mucuna …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 5, Issue 2, 2015 · pp. 1–8 Read article