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40 articles for “Liver Enzymes”
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Effects of Plasticizer DI-(2 Ethylhexyl) Phthalate on Liver Enzymes of Adult Male Albino Rats
Abstract: AbstractDi-(2 Ethylhexyl) Phthalate (DEHP) is a common plasticizer used to make the plastic products more flexible. It is quite harmful as tested on other animal models and is carcinogenic too. The liver is the major organ for detoxification in body and is therefore affected first due to intake of any toxicant. The liver enzymes are good parameter to assess any such hepatic damage. In the present study, the acute toxicity …
Published in Research & Reviews : Journal of Ecology · Vol. 6, Issue 2, 2017 · pp. 6–9 Read article
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A Clinical Study based Observation on Prevalence of Altered Liver Enzymes among Patients of Hepatobiliary Diseases Attending National Institute of Unani Medicine, India
Abstract: Background: Hepatobiliary disease is a major health problem responsible for millions of deaths annually. As reported, more than 40 million deaths occur annually in South-East Asia Region due to hepatobiliary diseases. This study was conducted as a clinical trial to assess the efficacy of Unani formulation, from which the data on prevalence of altered liver enzymes among patients of hepatobiliary diseases in which the study participants were collected and compiled …
Published in Research and Reviews: A Journal of Medicine · Vol. 11, Issue 1, 2021 · pp. 5–11 Read article
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Herbs with Hepatoprotective Properties
Abstract: Liver is a vital organ of our body. It is responsible for detoxifying the toxins from the body. Non-hepatitis cases contribute the most for liver diseases. Liver helps in making bile, storing iron, copper, and vitamin A, B and D. There are many liver diseases which include sluggishness of liver, acute viral, drug induced hepatitis and alcoholic liver disease. In order to keep liver healthy, fibre rich diet should be …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 5, Issue 2, 2018 · pp. 21–24 Read article
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Sodium benzoate induced reproductive and metabolic changes in Anabas testudineus (Bloch, 1792)
Abstract: AbstractSodium benzoate is an effective antimicrobial agent used as a food preservative, but recently gained attention as the chemical toxicant. The present study investigated sodium benzoate induced male reproductive toxicity and metabolic changes at100 mg/ L concentration in the freshwater fish, Anabas testudineus. Sodium benzoate did not alter the weight of fish but increased the secretion of mucous as the primary defensive mechanism. Reduction in the absolute and relative weights …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 10, Issue 1, 2020 · pp. 56–71 Read article
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Decompensated Liver Failure and Acute Renal Failure in a Patient with Chronic HBV,HCV, and HIV Infections
Abstract: This case study focuses on a 30-year-old male patient suffering from decompensated liver failure and acute renal failure, complicated by chronic hepatitis B (HBV), hepatitis C (HCV), and HIV/AIDS. Presenting with severe abdominal pain, nausea, and general weakness, the patient had a history of alcohol and intravenous drug use, leading to chronic liver disease and acute renal failure. Despite aggressive interventions, including intravenous antibiotics and fluid therapy, his condition worsened …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 17–23 Read article
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Endosulfan-Induced Hepatotoxicity and its Amelioration by Administration of Bamboo (Dendrocalamus Strictus) Seed Extract in Rats
Abstract: Endosulfan is an important hepatotoxic agent that generates free oxygen radicals in liver and the incidence of toxic injury to the liver tissue in relation to its widespread has been reported. Bamboo is rich in phenolic components which possess various bioactivities and bamboo seed extract was found to have antioxidative properties. Hence, the present study has been designed to assess the protective role of bamboo seed extract against endosulfan induced …
Published in Research and Reviews: A Journal of Toxicology · Vol. 4, Issue 1, 2014 · pp. 1–7 Read article
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Pharmacological evaluation of Hepatoprotective activity of Indian medicinal plants Cordia Myxa and Canscora diffusa on wistar albino rats
Abstract: Two plants (Cordia myxa and Canscora diffusa), which were claimed to possess hepatoprotective activity, were selected. The Selected plants were authenticated by an expert botanist. In the current study, herbal extraction involving solvents of decreasing polarity (petroleum ether, ethyl acetate, and hydroalcoholic) was used to extract bioactive compounds from the plants of Cordia Myxa and Canscora diffusa in polyherbal preparations. A phytochemical evaluation was performed, including an acute toxicity study …
Published in International Journal of Tropical Medicines · Vol. 2, Issue 1, 2025 · pp. 31–44 Read article
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Toxicological and Pharmacological Effect of Khadirarista in Animal Model
Abstract: AbstractThe objective of this study is to investigate the toxicological and pharmacological aspects of the popular Ayurvedic preparation Khadirarista (KDR). Khadirarista was administered orally to male albino rat. After 46 days of treatment period, animals were fasted for 18 h after the last administration. Biochemical studies including; total protein, serum albumin, blood urea nitrogen, bilirubin, creatinine, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were conducted. Triglyceride and creatinine levels were …
Published in Journal of AYUSH: Ayurveda, Yoga, Unani, Siddha and Homeopathy · Vol. 2, Issue 2, 2013 · pp. 61–67 Read article
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SGOT (Serum Glutamic Oxaloacetic Transaminase)—Its Role (A Review Article)
Abstract: Aspartate transaminase (AST) is an important liver enzyme which catalyses reversible transfer of an alpha amino group between aspartate and glutamate. It has an important role in amino acid metabolism. AST is predominantly found in the liver, skeletal muscle, kidneys, brain and red blood cells. AST is measured as a part of diagnostic liver function test, but AST reflects pathology in organs other than liver. Elevation in AST is found …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 9, Issue 3, 2019 · pp. 1–5 Read article
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A Case Report of Advanced Periampullary Carcinoma: Palliative Chemotherapy Following Whipple’s Surgery
Abstract: This case report delves into the complex management of a 60-year-old female patient diagnosed with Stage 4 periampullary carcinoma, encompassing the pancreatic head. Presenting with difficulty in eating, diagnostic investigations, including ERCP, confirmed the diagnosis, leading to Whipple's surgery. Postoperatively, liver metastasis was identified, prompting palliative intervention through stenting and the initiation of a GEMOX chemotherapy regimen. The patient responded favorably to the initial chemotherapy cycle, leading to a planned …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 1, 2024 · pp. 1–6 Read article
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Seroprevalence of Hepatitis E Virus and Serum Level of Serum Aspartate Transaminase (AST) and Alkaline Phosphatase (ALP) Among Jaundice Patients in Kathmandu Valley, Nepal
Abstract: Hepatitis E is an acute disease caused by hepatitis E virus that usually manifest as acute jaundice. It is a waterborne infection and occurs sporadically or as epidemic outbreaks. Hepatitis E virus (HEV) is a positive-stranded RNA virus with a 7.2 kb genome with three open reading frames In this study we report the seroprevalence of HEV in different categories of jaundice patients along with their elevation of serum bilirubin, …
Published in Research and Reviews: A Journal of Medicine · Vol. 4, Issue 3, 2014 · pp. 37–42 Read article
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Hepatoprotective Efficiency of Nigella sativa L. Extract on D-Galactosamine Induced Toxicity
Abstract: The Protective role of Nigella Sativa L. alcoholic extract (NSE) was investigated on D-Galactosamine (DGalN) induced hepatotoxicity in rats. Twenty four adult wistar albino rats were divided into four groups viz Control, D-Galatosamine induced hepatotoxicity, Nigella sativa alcoholic extract and Nigella Sativa alcoholic extract pretreatment prior to the administration of D-Galactosamine. After treatment, the rats were sacrificed, blood and liver samples were collected for determination of Serum Aspartate transaminase (AST), …
Published in Research and Reviews: A Journal of Toxicology · Vol. 1, Issue 1-3, 2011 · pp. 39–44 Read article
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Sub-acute Toxicity of β-cyfluthrin in Hepatic Tissue and its Amelioration through Punica granatum in Swiss albino mice
Abstract: β-cyfluthrin, member of synthetic pyrethroid pesticide Type II is broadly used multipurpose insecticide. Widespread and indiscriminate use of β-cyfluthrin leads to environmental contamination and toxicity towards nontarget mammalian systems. The present study was undertaken to examine toxic manifestation of β-cyfluthrin in hepatic tissue of Swiss albino mice and also evaluate possible mitigative potential of pomegranate juice (PJ) in combating pesticide induced hepato-toxicity. Animals were divided into five groups namely, control, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 3, 2020 · pp. 41–52 Read article
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Review on Histological Effect of Lead on Liver and Kidney
Abstract: Our environment can be polluted by environmental toxins which are chemicals and other materials produced largely from industry and its products. There are large numbers of environmental toxicants which are potentially harmful to health. These large numbers of environmental toxicants can be divided into three major categories (heavy metals, air pollutants, and pesticides) and they are commonly studied environmental toxicants. Environmental toxins can be entered into the body by various …
Published in Research and Reviews: A Journal of Toxicology · Vol. 10, Issue 1, 2020 · pp. 8–29 Read article
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Influence of Methanolic Extractives of Prepupal Stages of Black Soldier, Hermetia Illucens L. (Diptera: Stratiomyidae) on the Biochemical Parameters of Serum and Liver in the DMBA Induced Toxicity in Norwegian Rat, Rattus Norvegicus (L)
Abstract: The larvae of Black soldier fly (BSF), Hermetia illucens L., are reducing the environmental pollution through utilization of organic waste for their development on organic wastes and converting the organic waste into protein and fat rich biomass. Health promoting potentials of black soldier fly derived proteins as ingredient of diet appears to be crucial need of modern days. In present attempt, forty Norwegian Rats were utilized as experimental animals. The …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 12, Issue 3, 2021 · pp. 1–19 Read article
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Utilization of the Sibininto treat the DMBA Induced Hepatotoxicity and Free-Radical Damage in Norwegian Rat, Rattus norvegicus (L).
Abstract: DMBA is abbreviated form of the 7,12-Dimethylbenz[a]anthracene. It is working as immuno-suppressor. It also serves as a tumor initiator. It allows for a greatly accelerated rate of growth of tumor and making many cancer studies possible. The plant, Silybum marianum (L) yields pharmacologically active compound named as silbinin. The silbinin deserve documented antioxidant activity. The purpose of this study was to assess this silbinin for protective influence in DMBA induced …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 11, Issue 1, 2020 · pp. 26–36 Read article
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Antidiabetic and Antioxidant Activity of Leaves of Aegiceras corniculatum (L.) Blanco (Black Mangrove): An in vitro and in vivo Study
Abstract: AbstractPurpose: Aegiceras corniculatum (L.) Blanco, commonly known as Black Mangrove, is a species of shrub or tree mangrove with a distributed Indian mangrove forest and traditionally used to treat diabetes and other health ailments. Aim: The objective of this work was to enlighten the function of Indian mangrove variety of A. corniculatum leaves on carbohydrates blemishing reactions through diabetes using in vitro and in vivo methods. Methods: The aqueous leaves …
Published in Research & Reviews : Journal of Herbal Science · Vol. 7, Issue 1, 2018 · pp. 23–31 Read article
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Buccal Drug Delivery System: A Review
Abstract: The occurrence of interfacial molecular attracting force into the surface of biologically known substrates and naturally or synthetically occurring polymer, that in turn permits the polymer to cling to the biologically known surfaces for a prolonged length of time, is known as bio adhesion. Bio adhesive polymerizing system has employed into creation of goods for a variety of biomedical applicability, including surgical glue and denture adhesive, for a long time. …
Published in Trends in Drug Delivery · Vol. 9, Issue 2, 2022 · pp. 16–27 Read article
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Toxicity of Alpha-Cypermethrin on Fish
Abstract: Alpha-cypermethrin is a type II synthetic pyrethroid. Synthetic pyrethroids are used extensively for the control of insect pest and public health purpose. A fresh water fish was exposed to lethal concentration and sub lethal concentration of alpha-cypermethrin, respectively to observe the enzyme activity in functionally two different tissues—gills and liver. The present article focusses on non-target organism in fresh water environment and critically evaluates the toxicity of these pyrethroids in …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 10, Issue 2, 2021 · pp. 33–38 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article