Search
11 articles for “Linkers”
-
Monoclonal antibodies in targeted cancer therapy advances, resistance mechanisms, and next-gen formats (Bispesifics, ADCs)
Abstract: Breast cancer is one of the leading causes of cancer-related morbidity and death worldwide, which emphasizes the need for more effective and focused treatment strategies. antibody-mediated drug delivery techniques. Specifically, antibody–drug conjugates (ADCs) have emerged as a potential approach that combines the specificity of monoclonal antibodies with the potent cytotoxicity of anticancer drugs. By selectively targeting tumor-associated antigens, ADCs enhance drug accumulation within cancer cells while minimizing systemic toxicity associated …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 2, 2026 Read article
-
Assessing the Knowledge and Attitudes of Eligible Couples Regarding Small Family Norm in a Selected Rural Area of Gwalior
Abstract: This study aimed to determine the level of knowledge and attitude of eligible couples toward permanent family planning methods in a selected rural area of the district. The research method was an evaluation. Sixty couples were chosen at random who met the inclusion and exclusion criteria. The primary purpose of this research is to evaluate the level of understanding and satisfaction with permanent family planning methods among eligible couples in …
Published in International Journal of Community Health Nursing And Practices · Vol. 1, Issue 2, 2023 Read article
-
Bioconjugates and Biohybrid Polymers: Intricate Cellular Integration Methods and Sophisticated Biofunctionalization Techniques for Tailored Properties in Medical Contexts
Abstract: Bioconjugates are made when biological molecules are covalently linked to manufactured polymers. They can be used in many ways for imaging, diagnosis, and specific drug delivery. Getting perfect cellular fusion is very important for how well they work. Biomolecules can be attached to polymer scaffolds in a controlled way using techniques like click chemistry and site-specific conjugation. This makes sure that the molecules connect optimally with their biological targets. Using …
Published in Journal of Polymer & Composites · Vol. 12, Issue 3, 2024 · pp. 227–243 Read article
-
Gelatin-EiO2 (Ei = Si/Ti/Zr) Based Mesoporous Nano-hybrids: Synthesis and Characterization
Abstract: The hybrid materials are mostly prepared by combining the organic or bio-organic part to the inorganic building blocks and are used in many applications. Gelatin as one of the main component of hybrid materials is an attractive option. It is biodegradable; biocompatible; non-toxic; bio-adhesive and contains many active groups such as –NH2, –COOH, in the biopolymer backbone makes these hybrid materials important in various technological applications. The synthesis of a …
Published in Journal of Materials & Metallurgical Engineering · Vol. 14, Issue 3, 2024 · pp. 30–58 Read article
-
Study of the Properties and Destructibility of the Native and Cross-Linked Potato Starch-Filled Polymer Composites for Food Packaging Applications
Abstract: Plastic is a vital component of modern life, commonly used in daily food packaging for its convenience and durability. Plastic marketing bags are manufactured from low-density polythene (LDPE) which causes ecological inconvenience as most of the plastic components are stored in waste and underground conditions for an elongated time. Plastic is a synthetic or semi-synthetic material that does not decompose naturally, and its primary drawback is its environmental impact, prompting …
Published in Journal of Nanoscience, NanoEngineering & Applications · Vol. 14, Issue 3, 2024 · pp. 12–23 Read article
-
Inclusion of Silver Ions into Modified Cellulosic Fabrics for Durable and Improved Antibacterial Activity
Abstract: Silver ions were added to β-cyclodextrin-grafted organic cotton to create antibacterial fabrics that are more effective and long-lasting. In the presence of sodium hypophosphite, citric acid was used as a cross-linker to graft β-cyclodextrin onto the fabric, cementing the structure for ten minutes at 150°C. The presence of silver ions on the grafted fabric was verified by UV-visible and FTIR spectral studies of β-cyclodextrin, β-cyclodextrin-grafted fabric, ungrafted fabric, silver ions, …
Published in Journal of Thin Films, Coating Science Technology & Application · Vol. 11, Issue 3, 2024 · pp. 39–52 Read article
-
Polymer Chemistry in Nutraceutical Composites: Exploring Natural Polymers and Binding Systems in a Bamboo-Enhanced Formulation
Abstract: Polymer chemistry underpins the development of advanced nutraceutical composites, blending natural polymers with functional ingredients for health benefits. This study examines a novel nutraceutical formulation comprising ragi (16.39 g/100g), wheat (12.29 g/100g), soybean (12.29 g/100g), buffalo milk (16.39 g/100g), buffalo butter (4.13 g/100g), bamboo extract (0.90 g/100g), and auxiliary components (37.61 g/100g, including fats, sugars, and proteins). Natural polymers—proteins from soybean and milk, polysaccharides from ragi and wheat—form a macromolecular …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 878–884 Read article
-
Conversion of PET waste bottles into a useful catalyst
Abstract: Metal-organic frameworks (MOF) are composed of metal ions and organic linkers and have many application fields. Most of MOFs are synthesized by solvothermal method and in this method we mainly use DMF solvent.This paper proposed the synthesis method of MOF UiO-66 which is more eco-friendly than conventional method using harmful DMF solvent. In this method we use the PET waste bottles, which causes a lot of environmental problems in all …
Published in Journal of Catalyst & Catalysis · Vol. 12, Issue 3, 2025 · pp. 11–17 Read article
-
Carboxymethyl Cellulose-Based Spray-Dried Microspheres: Recent Advances and Applications in Targeted Drug Delivery Systems
Abstract: Microspheres are spherical particles ranging from 1 to 1000 μm, made from natural or synthetic polymers and inorganic materials. Their structure allows precise drug delivery, improving targeted release and minimizing off-target effects. Natural polymers such as starch, chitosan, and alginate are favored for their biodegradability, adhesion, and compatibility, enhancing mucosal interaction and residence time. Microspheres are widely used in site-specific drug delivery, gene therapy, and vaccine administration, improving immunogenicity, extending …
Published in Journal of Polymer & Composites · Vol. 13, Issue 5, 2025 · pp. 251–268 Read article
-
Rheological Studies of a Cross-Linked Polymer Gel System
Abstract: The petroleum accumulations are found associated with water and it is rarely obtained without accompanying water production. Water production is a major technical, environmental, and economic challenge associated with oil and gas extraction. Rheological findings are of fundamental importance for the development, manufacture and processing of innumerable products. Polymeric gels exhibit a wide range of rheological properties and they are stable both mechanically and thermally in most cases thus are …
Published in Journal of Petroleum Engineering & Technology · Vol. 16, Issue 2, 2026 · pp. 13–26 Read article
-
Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article