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33 articles for “Lead optimization”
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Unveiling the Role of Lead Molecules in CADD: A Systematic Review
Abstract: The word "medicate plan" alludes to the objective creation of modern drugs. Arbitrary screening of engineered compounds, engineered of organically dynamic compounds based on actually happening drugs, amalgamation of basic analogs of actually happening lead particles, and usage of the bioisosteric hypothesis are a few of the strategies that have been utilized. As a result, the most recent drift in medicate plan is to either completely enhance a lead or …
Published in International Journal of Membranes · Vol. 1, Issue 1, 2024 · pp. 37–43 Read article
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A Review of Drug Design Techniques Assisted by Computers to Combat Diabetes
Abstract: Diabetes mellitus is a global health concern characterized by chronic hyperglycemia and associated complications. The creation of innovative medicines with enhanced efficacy and safety profiles continues to be a top focus, notwithstanding improvements in treatment. A useful method in drug development, computer-aided drug design (CADD) makes it easier to identify possible therapeutic candidates and optimise lead molecules. An extensive synopsis of CADD tactics used in the fight against diabetes is …
Published in Emerging Trends in Personalized Medicines · Vol. 2, Issue 1, 2025 · pp. 1–10 Read article
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Bone Fracture: Understanding, Therapies, and Rehabilitation
Abstract: Bone fractures are common injuries that can significantly impact an individual's quality of life. This article presents a comprehensive examination of bone fractures, encompassing their origins, categorization, and potential ramifications. This review of literature explores various therapeutic approaches and rehabilitation strategies employed in the management of bone fractures. Surgical interventions, non-surgical treatments, and rehabilitation techniques are discussed, highlighting their effectiveness in promoting healing, restoring function, and preventing complications. The article …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 1, Issue 1, 2024 · pp. 24–28 Read article
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An Extensive Analysis of Computer-Aided Drug Design for Novel Psychotropic and Neurological Substances
Abstract: A comprehensive review of the use of computer-aided drug design (CADD) in the creation of innovative neurologic and neuropsychiatric medications is given in this article. It discusses the challenges in traditional drug discovery approaches and highlights the role of computational methods in accelerating the identification and optimization of drug candidates targeting psychiatric and neurological disorders. The method of finding new drugs has been completely transformed by Computer-Aided Drug Design (CADD), …
Published in International Journal of Brain Sciences · Vol. 1, Issue 2, 2024 · pp. 19–27 Read article
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A Review on Anesthetic Drug Discovery with Computer Aided Drug Design
Abstract: In contemporary medicine, anaesthesia is essential for enabling surgical procedures, pain control, and patient comfort. Finding and creating safe and efficient anaesthetics is crucial to enhancing patient outcomes and developing the medical field. In this review, we provide a comprehensive overview of anesthetic drug discovery with a focus on the integration of computer-aided drug design (CADD) methodologies. Beginning with an exploration of anesthesia mechanisms and targets, we delve into the …
Published in International Journal of Antibiotics Read article
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The Role of Optimism in Reducing Psychological Distress Amongst Women in Urban Areas
Abstract: This paper aims to explore the role of optimism in reducing psychological distress among women living in urban areas. Psychological distress, encompassing anxiety, depression, and chronic stress, has become increasingly prevalent due to the fast-paced and demanding nature of urban life. Women, in particular, face unique stressors including work-life imbalances, financial pressures, safety concerns, and societal expectations, which contribute significantly to elevated levels of mental strain. Finding healthy coping strategies …
Published in International Journal of Trends in Humanities · Vol. 2, Issue 2, 2025 Read article
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Advancements in Humanoid Robot Locomotion: A Review of Control Strategies and Kinematic Models
Abstract: Humanoid robot locomotion has significantly improved over the past few decades, driven by improvements in control strategies and kinematic models. Researchers aim to develop robots that can walk, run, and navigate complex terrains with efficiency and stability. This review explores recent developments in humanoid locomotion, highlighting control strategies such as model predictive control, reinforcement learning, and central pattern generators. Additionally, it examines kinematic models, including inverted pendulum models and zero …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 3, Issue 1, 2025 · pp. 24–30 Read article
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CRISPR, Recombinant DNA, and LAMP-Based Platforms for Monkeypox: Emerging Tools for Diagnosis and Therapeutic Development
Abstract: Monkeypox, a zoonotic viral infection caused by the Monkeypox virus of the Orthopoxvirus genus, has recurred as a worldwide public health concern after recent outbreaks outside of its classical endemic areas in Central and West Africa. The resurgence has demanded a thorough reassessment of its epidemiology, mode of transmission, and clinical presentation. In light of these challenges, recombinant DNA technology (rDNA) has emerged as a candidate for developing vaccines, diagnostics, …
Published in International Journal of Virus Studies · Vol. 3, Issue 1, 2026 · pp. 7–28 Read article
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Controlled Drug Delivery of Furosemides Using Floating Tablet System
Abstract: The development of gastroretentive drug delivery systems (GRDDS) has gained interest, particularly for drugs like furosemide with narrow absorption windows in the upper gastrointestinal (GI) tract. Furosemide, a commonly used diuretic, faces challenges due to limited bioavailability and rapid elimination, requiring frequent dosing and affecting patient compliance. This review highlights the formulation and evaluation of floating furosemide tablets as an effective strategy to enhance therapeutic efficacy. Floating tablets allow prolonged …
Published in International Journal of Membranes · Vol. 2, Issue 1, 2025 · pp. 23–31 Read article
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Physiotherapeutic Strategies to Enhance Throwing Accuracy in Cricket Players
Abstract: Background: Throwing accuracy is a crucial skill for cricket players, impacting both individual performance and team success. Physiotherapeutic strategies can enhance throwing mechanics, strength, and flexibility, leading to improved accuracy. Objectives: This study aims to outline effective physiotherapeutic interventions that optimize throwing accuracy in cricket players. Methods: A comprehensive review of current literature and practices was conducted with 3 articles found through PubMed, Google Scholar & Research Gate year range …
Published in International Journal of Orthopedic Nursing and Practices · Vol. 2, Issue 2, 2024 · pp. 30–34 Read article
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Yoga and Neural Health: Enhancing Brain Function Through Postural Alignment
Abstract: Correct posture significantly influences neural function and brain health by ensuring optimal alignment of the spine and nervous system. Poor posture disrupts neural communication, impairs blood flow, and affects cerebrospinal fluid (CSF) circulation, leading to adverse effects on cognitive performance, emotional regulation, and overall brain health. This study examines the physiological connection between posture and neural health, emphasizing its impact on cognitive function, mood, and neuroplasticity. Using a mixed-methods approach, …
Published in Recent Trends in Sports · Vol. 2, Issue 1, 2025 · pp. 24–28 Read article
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A review on Skin care and renewal with a beauty mask
Abstract: An important part of aesthetics is skin health. For this purpose, researchers and skincare experts continuously develop innovative materials and advanced techniques. To maintain optimal skin health, facial cosmetics keep skin moisturized and help to eliminate sebum from the skin. Using cosmetics that are appropriate for the kind of skin on the face leads to good skin. Therefore, in this study, we developed a natural face pack using readily available …
Published in Recent Trends in Cosmetics · Vol. 2, Issue 1, 2025 · pp. 1–7 Read article
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Optimizing the Work Environment for Interior Designers: Enhancing Creativity, Collaboration, and Well-being in Design Studios and Beyond
Abstract: In the field of interior design, the conventional office setup is no longer adequate to unleash the full creative potential of designers. This paper advocates for environments that go beyond the basic provisions of a laptop and chair, emphasizing the necessity of spaces that truly ignite creativity. By delving into the unique requirements of interior designers, this research underscores the critical importance of environments that engage the senses and facilitate …
Published in International Journal of Atmosphere · Vol. 1, Issue 1, 2024 · pp. 1–14 Read article
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Evaluating the Role of Pharmacists in Managing Antibiotic Use and Combating Multi-Drug Resistance in Hospital Settings
Abstract: Antibiotic resistance is now one of the crucial health issues of the world, especially in hospitals where high usage of antimicrobials is increasing the rate at which multi-drug resistant (MDR) organisms appear. Misprescription, extended treatment, and over-use of broad spectrum antibiotics play a large role in the development of resistance resulting in the growth of morbidity, mortality and health care expenditure. This review analyses the essentiality of pharmacists in controlling …
Published in International Journal of Antibiotics · Vol. 3, Issue 2, 2026 · pp. 12–19 Read article
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Comparative Performance Study: Deterministic vs. Probabilistic Models in Retail Chains
Abstract: The finished goods, raw materials, and product stock that a business has on hand for sale are referred to as inventory. They enable the companies to achieve their sales levels and are a chance to cost control and decision making. It is a huge asset to a manufacturing firm. Inventory model permits forecasting of quantities of raw material, inventory and spare parts of the equipment to a very high level …
Published in Recent Trends in Mathematics · Vol. 2, Issue 1, 2025 · pp. 1–6 Read article
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Mitigation of Peak to Average Power Ratio in Orthogonal Frequency Division Multiplexing through SOP-PTS
Abstract: Orthogonal Frequency Division Multiplexing (OFDM) is a popular multicarrier modulation technology extensively employed in 4G wireless communication systems to transmit data over a dispersive channel. To address the Peak-to-Average Power Ratio (PAPR) issue in OFDM, a technique called Partial Transmit Sequence (PTS) is commonly utilized. The PTS method involves dividing the data block into non-overlapping sub-blocks and then combining them using phase factors to mitigate PAPR. However, the conventional PTS …
Published in International Journal of Radio Frequency Innovations · Vol. 1, Issue 1, 2024 · pp. 32–39 Read article
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The Role of Precision Agriculture in Enhancing Horticultural Crop Yields
Abstract: This article explores the quantification of lithium and mapping of mineral composition in crushed lithium ore utilizing two distinct calibration techniques with Laser-Induced Breakdown Spectroscopy (LIBS). Thirty samples from a pegmatite lithium deposit were analyzed, with representative mineral samples extracted, mixed with resin, and polished into disks. These disks underwent examination via an analyzer and an integrated mineral analyzer, facilitating mineral identification. The first calibration technique used empirical mineral chemistry …
Published in International Journal of Trends in Horticulture · Vol. 1, Issue 1, 2024 · pp. 18–23 Read article
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The Role of Artificial Intelligence in Enhancing Athlete Performance and Training Strategies
Abstract: Artificial Intelligence (AI) is transforming modern sports by improving athlete performance, training methods, and decision-making processes. The integration of AI technologies such as machine learning, data analytics, wearable sensors, and computer vision has enabled coaches and sports scientists to analyze large amounts of performance data with greater accuracy and efficiency. Athletes' physiological indicators, movement patterns, injury risks, and recuperation processes are all monitored by these technology. Training regimens can therefore …
Published in Recent Trends in Sports · Vol. 3, Issue 2, 2026 · pp. 1–7 Read article
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Mystery of Grass milk: A Deeper Dive into Quality, Quantity and Economics of Grass-milk in Dairy Cows
Abstract: Consumers perceive ‘grass-fed milk’ as healthier than conventional ones since grass-fed milk contains higher levels of beneficial fatty acids and lower levels of omega-6. The study highlights the nutritional benefits of feeding green grass, in terms of quality, quantity, and farm economics emphasizing its specific influence on the fatty acid profile of milk, including enrichment of omega-3 fatty acids and conjugated linoleic acids. It also delves into the environmental benefits …
Published in International Journal of Nutritions · Vol. 2, Issue 2, 2025 Read article
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Effect of Skin Barrier Damage on Absorption and Action of Cosmeceuticals
Abstract: The skin acts as a primary defensive barrier protecting the human body against environmental aggressors, microbial invasion, and chemical exposure. The integrity of the skin barrier, particularly the stratum corneum, plays a crucial role in regulating the permeation of substances applied topically. Cosmeceuticals, a hybrid category between cosmetics and pharmaceuticals, are designed to deliver biologically active ingredients into the skin to exert therapeutic or beneficial effects. However, the condition of …
Published in Recent Trends in Cosmetics · Vol. 3, Issue 2, 2026 · pp. 1–19 Read article