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9 articles for “LC-MS”
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HPLC and Tandem MS Device for the Recognition of Emtricitabine and Tenofovir Alafenamide in K2EDTA Human Plasma Utilizing Emtricitabine 15ND2 Tenofovir D5 as an IS
Abstract: Developed very impressionable, discriminating, and exact extreme-efficiency liquid chromatographytandem bulk spectrometry form for measurement of Emtricitabine and Tenofovir Alafenamide in human plasma. Emtricitabine15ND2 Tenofovir D5 was used as a within the standard (IS). The samples were divided on Phenomenex Kinetex C18 5 μm 100A, 100*4.6 mm procession utilizing Acetonitrile: 0.2% formic acid, 60:40 V/V as movable state, the retention period of Emtricitabine: 1.36 minutes (±0.5 minutes), Emtricitabine 15ND2: 1.36 minutes …
Published in Research and Reviews: A Journal of Toxicology Read article
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A Systematic Review of Impurity Profiling and Stability Studies in Pharmaceutical Drug Substances
Abstract: Ensuring the safety, efficacy, and quality of pharmaceutical goods is essential in the Indian pharmaceutical market, which is a global centre for generic drugs. Stability studies and impurity profiling are two fundamental activities that ensure this quality during the whole lifespan of a medicine. The effect of environmental variables such as temperature, humidity, and light on the quality of a drug substance over time is demonstrated by stability studies. The …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 81–88 Read article
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Milk Allergy: Significance, Detection and Management
Abstract: Milk allergy is a significant public health issue, particularly among infants and young children, with prevalence rates between 2 and 6% in early childhood, declining to 0.1–0.5% in adulthood. It is an immune-mediated adverse reaction to milk proteins, primarily involving immunoglobulin E (IgE)-mediated responses. Symptoms range from gastrointestinal distress and respiratory complications to severe anaphylaxis. The etiology of milk allergy involves genetic predisposition, environmental factors, an immature immune system, and …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 14, Issue 1, 2025 · pp. 15–19 Read article
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A Comprehensive Review of Analytical Method – Development and Method Validation of Digoxin Tablets
Abstract: The main objective of this review is to give an outline of the method development and validation process of digoxin, and this review covers the different types of spectroscopic and chromatographic techniques, such as HPLC, UHPLC-Tandem mass spectroscopy, TLC, and LC-MS. A novel method for the determination of digoxin in biological samples has been developed and validated, focusing on improving sensitivity, specificity, and reproducibility. The method was validated in terms …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 1, 2025 · pp. 47–58 Read article
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Evaluation of the Formation, Concentration, and Mitigation of Heterocyclic Amines in Selected Nigerian Proteinaceous Delicacies
Abstract: This study characterised the kinetics and concentration profiles of six HCA congeners — 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-Amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx), 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ), 1-Methyl-9H-pyrido[3,4-b]indole (harman), and 9H-pyrido[3,4-b]indole (norharman) — in six Nigerian food preparations (grilling of popular delicacies — including suya, kilishi, asun, and smoked catfish (eja aro)) using validated liquid chromatography–tandem mass spectrometry (LC-MS/MS) under three cooking modalities (charcoal grilling, pan-frying, oven-roasting). The inhibitory potential of five natural marinade formulations — …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 15, Issue 2, 2026 · pp. 1–11 Read article
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Recent Advancements and Comprehensive Review on Hyphenated Techniques
Abstract: Hyphenated techniques represent a powerful class of analytical methods that combine two or more established techniques – typically a separation method with a spectroscopic detection technique – to achieve enhanced analytical performance. First introduced by Hirschfeld in 1980, the term “hyphenation” refers to the online coupling of such methods, enabling more precise, sensitive, and comprehensive analysis of complex samples. These techniques exploit the strengths of individual methods while overcoming their …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 37–50 Read article
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Recent Advances in Transition Metal Complexes with Phenyl Acetic Acid and Pseudo Halogen: Synthesis, Characterization and Applications
Abstract: A well established strategy is to introduce a biologically relevant organic molecule in coordination sphere of transition metal complexes to increase the selectivity and biocompatibility. Phenylacetic acid (PAA), an organic molecule with a phenyl functional group and a carboxylic acid functional group, is a phenylalanine that is generated from the naturally occurring auxin, which is extensively present in plants. The most promising outcomes in the battle against cancer and microbes …
Published in Journal of Polymer & Composites · Vol. 12, Issue 6, 2024 · pp. 68–78 Read article
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Reimagining Solid Waste Management in India: A case of Circular approach in C&D Waste Management
Abstract: Construction and demolition (C&D) waste, which accounts for an estimated 150–500 MT yearly and about 10–20% of the nation's total municipal solid waste (MSW) generation, is a significant management challenge for India. Accelerated urbanization, population increase, infrastructural expansion, and urban redevelopment initiatives are the main causes of this quickly expanding waste stream. Much of this waste is disposed of through uncontrolled dumping, encroachment on low-lying areas, and overcrowded landfills in …
Published in Journal of Construction Engineering, Technology & Management · Vol. 16, Issue 1, 2026 · pp. 1–10 Read article
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Chemical Profile and Toxicity of Fresh and Dry leaves of the Essential Oils of Vetiveria zizanioides (L.) Nash. From Southwest Nigeria
Abstract: The fresh and dry leaves of Vetiveria zizanioides (L.) Nash (Gramineae) plant was collected, air dried and authenticated at the University of Ibadan Herbarium with voucher number: UIH-23237. The plant's dried, fresh leaves were hydro distilled in a Clevenger device to extract the essential oils. The oils were characterized by Gas Chromatography-Mass Spectrometry (GC – MS) while the toxicity of the essential oils was tested using brine shrimps’ lethality assay. …
Published in Recent Trends in Cosmetics · Vol. 1, Issue 1, 2024 · pp. 44–49 Read article