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12 articles for “Epigenetic changes”
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Environmental Pollutants and Biodiversity Loss: Analyzing the Role of Persistent Organic Pollutants in Ecosystem Decline
Abstract: Persistent Organic Pollutants (POPs) significantly impact biodiversity, with various factors influencing their effects on species and ecosystems. Species in poor body condition, like carnivores and predators, are more vulnerable to POPs due to weakened immune systems and reduced detoxification abilities. Dietary habits also affect the accumulation of POPs, as chemicals biomagnify up the food chain. Carnivores accumulate higher concentrations, leading to reproductive failures, hormonal imbalances, and death, while herbivores face …
Published in International Journal of Toxins and Toxics · Vol. 2, Issue 1, 2025 · pp. 9–20 Read article
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Multifactorial Diseases Becoming the Epigenetic Factor for the Genz
Abstract: This comprehensive paper investigates the complex interplay between multifactorial diseases, particularly obesity and cardiovascular disease (CVD), and their relationship with epigenetic mechanisms, highlighting the transgenerational implications of these interactions. The multifaceted nature of obesity and CVD, involving genetic predisposition, environmental influences, and epigenetic modifications, underscores the intricate pathways contributing to disease susceptibility and progression. Drawing upon a synthesis of diverse research findings, the paper elucidates the critical role of genetic …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 2, Issue 1, 2024 · pp. 16–22 Read article
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Colostrum-Driven Epigenetic Programming in Dairy Cows: A Pathway to Optimal Reproductive Health
Abstract: Colostrum is a vital nutritional source for neonatal calves, providing immune support and essential growth factors. Recent research suggests that colostrum’s impact extends beyond immediate immunological protection, influencing long-term reproductive health through epigenetic modifications. In dairy heifers, early-life exposure to high-quality colostrum may program the developing reproductive system, affecting ovarian function, uterine health, and overall fertility. The components of colostrum, including hormones, growth factors, and bioactive peptides, can induce epigenetic …
Published in Emerging Trends in Metabolites · Vol. 2, Issue 1, 2025 · pp. 35–51 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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Role of Epigenetic Mechanisms in Lung Fibrosis: Therapeutic Opportunities and Challenges
Abstract: Lung fibrosis poses a serious risk to one's health since it might result in respiratory failure due to an abnormal accumulation of fibrotic tissue in the lungs. Epigenetic mechanisms, such as histone changes, DNA methylation, and non-coding RNAs, closely control gene expression patterns and cellular processes associated with lung fibrosis. Anomalies in DNA methylation patterns connected to changes in gene expression profiles and disturbances in fibrotic signalling pathways are potential …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 13, Issue 2, 2024 · pp. 9–20 Read article
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Progression in multi-omics and immunological research on host-parasite interactions: Transcriptomics, proteomics, genomics, metabolomics, and immune responses
Abstract: The interaction occuring between hosts and parasites is a quick and multi step-complex biological process that tries to influence disease outcomes. In recent years, multi-omics approaches, such as transcriptomics, proteomics, genomics, metabolomics, and immunological studies, have gathered substantial eye in dissecting these interactions at a microscopic level. These techniques enable a vast understanding of the molecular structures involved in parasitic infections and host defense mechanisms. This article reviews the advancements …
Published in Recent Trends in Infectious Diseases · Vol. 2, Issue 1, 2025 Read article
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REVIEW OF PHARMACOEPIGENETICS: BRIDGING EPIGENETICS AND PERSONALIZED MEDICINE
Abstract: Pharmacoepigenetics is an emerging field that explores how alterations in gene expression, independent of DNA sequence changes, influence individual responses to drugs. Unlike pharmacogenetics, which focuses primarily on genetic variation, pharmacoepigenetics integrates genetic, environmental, and lifestyle factors to explain interindividual differences in drug efficacy, toxicity, and resistance. Key epigenetic mechanisms including DNA methylation, histone modifications, non-coding RNAs, and RNA methylation play critical roles in regulating drug metabolism and therapeutic outcomes. …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Drug Resistance in Targeted Cancer Treatment: Clinical Difficulties, Molecular Mechanisms, and Emerging Strategies
Abstract: Targeted cancer therapy, which selectively inhibits the molecular mechanisms responsible for tumor growth and development, has revolutionized modern oncology. Targeted therapies have lower systemic toxicity and better therapeutic efficacy when compared to traditional chemotherapy. However, the emergence of medication resistance often limits the long-term efficacy of these treatments, ultimately resulting in treatment failure and disease progression. Drug resistance develops through a number of intricate biological processes and can be innate …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 17, Issue 1, 2026 · pp. 130–138 Read article
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Paternal Pre-Pubertal Smoking: Small RNAs, Lasting Marks, and the Hidden Legacy of Early Exposure
Abstract: While the negative effects of maternal smoking during pregnancy are well-established, the lasting and transgenerational impact of paternal pre-pubertal smoking remains a critical, underexplored area. Emerging evidence in sperm epigenetics suggests that cigarette exposure during early male development may create persistent molecular imprints that can affect the health of future offspring. This phenomenon is rooted in the fact that heredity extends beyond the DNA sequence. Sperm carry a complex epigenetic …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 1, 2026 · pp. 1–5 Read article
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Trauma- Its Transgenerational Inheritance and Associated Nuances in Perinatal Care: A Systematic Review
Abstract: The research is a systematic review of the existing clinical and animal studies pertaining to effects of trauma on immediate offsprings and its transgenerational inheritance. The research also summarises the current statistical data on perinatal care globally with special emphasis on India as a developing nation and the current strategies, government policies and international recommendations on maternal and child health as put forward in the Sustainable development goal 2030 by …
Published in International Journal of Children · Vol. 1, Issue 1, 2024 · pp. 37–45 Read article
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Biopolymer Degradation and Structure–Property Relationships in Ageing: A Polymer Science Perspective
Abstract: Ageing, as viewed from the polymer sciences perspective, is perceived as the gradual modification of the structure-property-function interrelationship of biopolymers such as proteins, polysaccharides, nucleic acids and their molecular aggregates. Such changes include structural organization, mechanical behavior, physicochemical stability and functional effectiveness. Ageing is an inevitable multifactorial polymeric process. Due to the growing aging population globally, more age-associated complications emerge, which are correlated with the molecular degeneration of biopolymeric complexes. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 479–489 Read article
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An Approach towards in Management of Chronic Kidney Disease
Abstract: The current international guidelines define and classify the chronic kidney disease (CKD) as decreased kidney function shown by decreased glomerular filtration rate (GFR). Glomerular filtration rate of 60 ml/min/1.73 m 2 for at least 3 months is a marker for kidney damage. The underlying causes for chronic kidney disease are proteinuria and hypertension. It is the main cause of CKD in many high-, middle- and low-income countries. In different countries, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 12, Issue 1, 2025 · pp. 9–15 Read article