Search
15 articles for “Direct compression method”
-
Zolmitriptan Mouth Dissolving Tablets: Development of Formulas and Invitro Evaluation
Abstract: Pharma Burst ODT super disintegrants were used in different concentrations to manufacture Zolmitriptan fast dissolving tablets by a direct compression method. With a 28° angle of repose, there is good flow. The densities for bulk and tapped materials are 0.410 (g/ml) and 0.500 (g/ml), respectively. The compressibility index and Hausner ratio have values of 19.05 and 1.24, correspondingly. According to IP standard, weight variation test results range from 121.4 mg …
Published in Emerging Trends in Personalized Medicines · Vol. 1, Issue 2, 2024 · pp. 1–15 Read article
-
Application of Natural and Synthetic Polymer-Based Disintegrants in the Design of Fast Dissolving Cefuroxime Axetil Tablet Composites
Abstract: The current paper examines how natural and synthetic polymer-based disintegrants can be used to design fast-soluble types of tablet composites. A model drug was chosen and tablets were prepared by the direct compression method using different polymeric excipients, such as guar gum, locust bean gum, sodium starch glycolate (SSG) and cross povidone. Eight formulations were prepared and tested on the basis of critical material and performance characteristics including thickness, hardness, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1348–1360 Read article
-
Rapid-On-Tongue Delivery: A Review of ODT Technologies, Taste Masking and Compliance
Abstract: Orodispersible Tablets (ODTs), another name for Fast Dissolving Drug Delivery Systems (FDDS), are innovative drugs that dissolve in the mouth rapidly without requiring water. These will be especially helpful for kids, the elderly, and others who have difficulty swallowing ordinary tablets or capsules. Superdisintegrants are used in these pills to break down quickly in the mouth, while flavorings or sweeteners are used to cover up any harsh or unpleasant taste. …
Published in Trends in Drug Delivery · Vol. 13, Issue 1, 2026 · pp. 01–08 Read article
-
Development and Optimization of Orally Disintegrating Tablets (ODTs) Containing Standardized Curcumin Extract for Enhanced Bioavailability and Patient Compliance
Abstract: This research centers on creating and perfecting orally disintegrating tablets with standardized curcumin extract to both increase its bioavailability and promote better patient adherence. Although curcumin has numerous therapeutic applications. It remains clinically ineffective due to its poor aqueous solubility and bioavailability constraints. The development of orally disintegrating tablets involved direct compression with various levels of superdisintegrants including sodium starch glycolate and cross povidone to address existing challenges. Research teams …
Published in Research & Reviews: A Journal of Drug Formulation, Development and Production · Vol. 12, Issue 3, 2025 · pp. 1–06 Read article
-
Advancements in Engine Oil Durability, Performance, and Diagnostics
Abstract: The depletion of fossil fuels and environmental concerns have driven the search for alternative fuels and enhanced lubricants. This article explores advancements in machine oil durability, focusing on vegetable oil modifications, synthetic lubricants, and diagnostic methods for marine engine oils. A study comparing Karanja oil blends with mineral diesel in direct injection compression ignition engines revealed comparable wear characteristics and reduced metallic debris for Karanja oil-fueled engines. Investigations on synthetic …
Published in Journal of Petroleum Engineering & Technology · Vol. 14, Issue 3, 2024 · pp. 39–45 Read article
-
Design and Assessment of Fixed Dose Combination Containing Fenofibrate and Pravastatin Sodium in Tablet Formulation: A Bioinformatics Approach
Abstract: The aim of this is study is to formulate and evaluate fixed dose combination of Fenofibrate and Pravastatin sodium in tablet dosage for the treatment of Dyslipidemia. For the formulation and optimization of fenofibrate layer, two factor three level factorial design was used as experimental design for optimization with a minimum of nine run. All the nine trial (F1–F9) has been formulated according to the experimental design by wet granulation …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 11, Issue 1, 2024 · pp. 1–20 Read article
-
Deep Plate: A Deep Learning Approach to Recipe Generation from Food Images
Abstract: In the deep learning era, image understanding is advancing in sophistication, encompassing both semantic interpretation and the generation of meaningful image descriptions. To achieve this, deep neural networks must undergo specific cross-model training; these networks must be both simple enough to handle a wide range of inputs and complex enough to encode the fine contextual information associated with the image. An appropriate example of the previously described picture comprehension problem …
Published in Journal of Operating Systems Development & Trends · Vol. 11, Issue 2, 2024 · pp. 15–22 Read article
-
An Investigative Study on Cache-Oblivious Data Structures
Abstract: Cache-oblivious data structures and data management systems have emerged as critical components in modern computing environments, aiming to optimize memory access patterns across different levels of the memory hierarchy without explicit knowledge of cache sizes or configurations. This study presents an overview of cache-oblivious techniques, including adaptive data structures, compression, parallel processing, and security considerations. The workexplores future directions in cache-oblivious systems, such as non-volatile memory support, graph processing, edge …
Published in International Journal of Data Structure Studies · Vol. 1, Issue 2, 2023 · pp. 33–37 Read article
-
Deep Learning Enhanced Compressive Sensing for Wireless IoT Data Optimization and Weather Monitoring.
Abstract: This research explores the application of deep learning and compressive sensing in order to optimize data traffic in non-orthogonal multiple access (NOMA)-based wireless internet of things (IoT) networks and weather monitoring. Such a framework would be very effective and overcome pilot attacks and reconstruction losses for secure data transmission. In this regard, a strong communication model has been adopted based on power-domain NOMA for simultaneous wireless transmission by multiple IoT …
Published in International Journal of Satellite Remote Sensing · Vol. 2, Issue 2, 2024 · pp. 20–36 Read article
-
Development of Eco-friendly Glass Fiber Composites Embedded with Paddy Stubble for Sustainable Applications and Its Metallurgical Characterization
Abstract: The extreme rise in environmental challenges owing to agricultural activities, among which paddy stubble burning remains a huge concern. Burning about 15 million tons of paddy stubble leads to emissions discharge of various toxic pollutants and gases notably, nitrogen oxides, methane and carbon monoxide in large scale causing global air pollution and climate change. The study focuses on obtaining and preparing a paddy stubble powder and using it with glass …
Published in Journal of Polymer & Composites · Vol. 13, Issue 2, 2025 · pp. 640–648 Read article
-
Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article
-
Surface Level and Underwater Waste Removal System
Abstract: The paper introduces novel approach for surface and underwater waste collection, impact of water pollution can be devastating, affecting aquatic ecosystems, human health, and economies. Pollutants can harm aquatic plants and animals, disrupt ecosystems, and degrade water quality, making it unsafe for drinking, swimming, and other activities. Waterborne illnesses can also spread because of contaminated water, impacting groups of people who depend on tainted water supplies for hygiene and drinking. …
Published in Recent Trends in Fluid Mechanics · Vol. 11, Issue 2, 2024 · pp. 30–35 Read article
-
Improving Black Cotton Soil with Sodium Hydroxide and Fly Ash: An Assessment of Optimum Moisture Content, Dry Density, and California Bearing Ratio
Abstract: This study investigates the stabilization of Black Cotton Soil (BCS), an expansive clayey soil primarily composed of montmorillonite minerals, using sodium hydroxide (NaOH) and fly ash. Due to its high plasticity and significant volume changes with moisture, BCS is challenging for construction purposes. Adding NaOH and fly ash can potentially improve the soil's moisture tolerance, compressibility, and reduce its plasticity, making it more suitable for structural applications. The research evaluates …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 192–201 Read article
-
Comprehensive Study of Least Squares Estimation in Fast Fading MIMO-OFDM Systems
Abstract: MIMO-OFDM technology is now the foundation for modern wireless communication systems, allowing dramatic improvements in spectral efficiency, power efficiency, and transmission rate. On the other hand, the least accurate channel estimation is still a critical task, especially when they are in fast-fading environments. This study gives a comprehensive survey of LSE-based approaches and their applications on different fast-fading channel models for MIMO-OFDM systems. Techniques like Pilot Assisted Channel Estimation (PACE), …
Published in Journal of Microwave Engineering and Technologies · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
-
AI-Assisted Optimization of Supersonic Airfoil Shapes Using CFD Coupling
Abstract: This paper presents a novel framework for optimizing supersonic airfoil geometries through integrated artificial intelligence and computational fluid dynamics coupling. Traditional gradient-based optimization methods for high-speed aerodynamic shapes suffer from computational expense and convergence difficulties in non-convex design spaces. The proposed methodology employs a deep neural network surrogate model trained on high-fidelity Reynolds-Averaged Navier-Stokes solutions to approximate aerodynamic performance metrics across the design space. A hybrid particle swarm-genetic algorithm searches …
Published in Journal of Aerospace Engineering & Technology · Vol. 16, Issue 1, 2026 Read article