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9 articles for “Coloumb Blockade”
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Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article
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Modelling and Electrical Characterization of Single Electron Transistor
Abstract: A nano-electronic device with low power consumption, high performance, and quantum effects is the single electron transistor (SET). It's used in charge sensor applications, infrared radiation detectors, and spectroscopy. However, it faces limitations in lithography, co-tunneling effect, low gain, high output impedance, and background charges. Therefore, prior simulation is needed to optimize SET's work function and understanding physics concepts. A master equation approach is used to propose a new model …
Published in Journal of Semiconductor Devices and Circuits · Vol. 10, Issue 3, 2024 · pp. 19–25 Read article
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Optimizing Anesthesia for Major Surgery: The Role of Sequential Combined Spinal-Epidural Technique
Abstract: The Combined Spinal Epidural (CSE) approach has been widely employed over the last decade because it achieves rapid onset and substantial blockage while also allowing for the modification or prolongation of the block. Background: Sequential spinal-epidural anesthesia (SSEA) combines the rapid onset and dense blockade of spinal anesthesia with the prolonged duration and adjustable analgesia of epidural anesthesia. This technique is particularly beneficial in major surgeries requiring prolonged operative time …
Published in Research and Reviews : Journal of Surgery · Vol. 14, Issue 2, 2025 · pp. 12–18 Read article
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Pharmacogenomics in Anesthesia: Case Studies and Clinical Applications for Personalized Care
Abstract: Pharmacogenomics, the study of how genetic variability influences individual responses to medications, is transforming anesthetic practice by enabling personalized care. This case study collection explores the integration of pharmacogenomic insights into anesthesia management, highlighting its impact on safety, efficacy, and patient outcomes. Adverse reactions to anesthetics often arise from genetic polymorphisms that alter drug metabolism or sensitivity. For instance, patients with RYR1 mutations are susceptible to malignant hyperthermia (MH) when …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 15, Issue 2, 2025 · pp. 85–91 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
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Continuous Thoracic Epidural Infusion: A Comparative Study of Fentanyl and Ropivacaine V/S Fentanyl and Bupivacaine in Upper Abdominal Surgery for Postoperative Analgesia
Abstract: To measure and compare the efficacy of analgesia with the both techniques with measurement of changes in hemodynamics, respiratory rate, and SPO2 with the two techniques and to compare their side effects and evaluate the patient’s satisfaction. The random selection of patients was allocated in two groups. Each group consist of 25ASA group I–II patients. Infusion was given at the rate of 0.1 ml/kg/h. Group RF: continuous thoracic epidural infusion …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 3, Issue 2, 2014 · pp. 1–10 Read article
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Comparative Study of Analgesic Effect of Intrathecal Magnesium Sulphate, Clonidine and Dexmedetomidine as an Adjunct to Intrathecal Bupivacaine in Spinal Anesthesia for Lower Limb Orthopaedic Surgeries
Abstract: This prospective double blind, randomized controlled trial study was undertaken to compare the onset and duration of analgesia with the intrathecal bupivacaine and its combination with either clonidine or magnesium sulphate or dexmedetomidine, to establish the ideal combination of drug with least side effects. The study included 80 patients between age group 20–60 years of ASA grade I & II, scheduled for orthopaedic lower limb surgery. Patients were randomly assigned …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 3, Issue 3, 2014 · pp. 13–18 Read article
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Polypyrrole-Based Conductive Polymer-Gated Single Electron Transistor with Deep Neural Network Assistance for Biomedical Energy Harvesting and Charge Detection
Abstract: The increasing demand for intelligent biomedical monitoring systems has accelerated research into ultra-low-power sensing technologies capable of operating with high sensitivity and minimal energy consumption. Conductive polymers have attracted considerable attention for biomedical and nanoelectronic applications due to their tunable electrical properties, biocompatibility, and environmental stability. Among them, Polypyrrole (PPy) is a promising functional polymer that can enhance charge transport and electrostatic coupling in nanoscale devices. In this work, a …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 Read article