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189 articles for “ADME”
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Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
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Pharmacophore mapping, 3D QSAR, docking, and ADME prediction studies of novel Benzothiazinone derivatives
Abstract: Background Tuberculosis is a major public health concern worldwide which is caused by Mycobacterium tuberculosis. DprE1 (Decaprenyl Phosphoryl Ribose 2’- Epimerase) is the most challenging target for development of novel anti- tubercular agents because it is a small protein and located into cytoplasmic membrane. So, novel anti-TB drugs did not bound effectively with it. DprE1 catalyzes the oxidation of the 2’ hydroxyl group of DPR (Decaprenyl Phosphoryl D- Ribose) …
Published in International Journal of Antibiotics · Vol. 1, Issue 1, 2024 · pp. 59–82 Read article
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Streamlining Hostel Management: An Innovative Online System for Efficient Administration
Abstract: This article presents a hostel administration system built with XAMPP, which integrates Apache, MySQL, PHP, and Perl into a user-friendly package, in response to the tourism industry's increasing demand for improved management. The system is made to make handling check-ins and check-outs, billing, and room assignment easier, among other hostel management duties. The Hostel Management Framework is an online program designed to oversee various operations in a hostel. This concept …
Published in International Journal of Electronics Automation · Vol. 2, Issue 2, 2024 · pp. 26–33 Read article
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Molecular Docking Study: Targeting mycobacterium leprae ML2640 Protein Using Active Compounds from Coscinium fenestratum
Abstract: Objectives: Leprosy is an infectious disease in skin, peripheral nerve and mucosa of upper airway. Around 70% of this infection is caused by Mycobacterium leprae, which was discovered during1873. Multi drug therapy is used for the treatment, still multiple drug resistance and reactions has been reported among patients. Hence, this work focused on identifying bioactive compounds from Coscinium fenestratum that can target mycobacterium leprae ML2640 protein by in-silico approach. Method: …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 2, 2023 · pp. 21–33 Read article
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Effect of Nebulization With 3% Hypertonic Saline for Airway Clearance on Mechanically Ventilated Patients Admitted in ICUs of Pt. B.D. Sharma, PGIMS, Rohtak
Abstract: Background of the Study: The ability to breathe artificially prolongs life in many situations. Patients requiring mechanical breathing in the intensive care unit are more likely to have complications and even death due to a variety of interconnected causes. As a result, it became critical to rapidly ventilate in the safest and most efficient manner available. Intubated patients have benefited from nebulized suctioning, as it improves lung clearance and decreases …
Published in International Journal of Emergency and Trauma Nursing and Practices · Vol. 1, Issue 2, 2023 · pp. 20–27 Read article
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A Study to Assess the Effectiveness of Cradle Hold Position on the Gratification During Breastfeeding Among Postnatal Mothers Admitted at Selected Maternity Hospitals in South Bangalore, Karnataka
Abstract: This study aims to assess the effectiveness of the cradle hold position on the satisfaction experienced during breastfeeding among postnatal mothers admitted at selected maternity hospitals in south Bangalore, Karnataka. The cradle hold position is a commonly used breastfeeding technique where the mother supports the baby's head with one hand and holds the baby's body with the other arm, bringing the baby's mouth to the breast. The level of satisfaction …
Published in International Journal of Women's Health Nursing And Practices · Vol. 2, Issue 1, 2024 · pp. 30–36 Read article
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Exploring DHCP Protocol Administration: A Packet Tracer Simulation Study
Abstract: The following functions of DHCP are included to lessen network administration: TCP/IP setting that is automated and centralized. the capability of centrally defining TCP/IP setups. the use of DHCP options to allocate a complete range of additional TCP/IP configuration values. DHCP runs at the application layer of the TCP/IP stack. Although this essay will concentrate on Windows NT, another advantage of DHCP is that it is compatible with a wide …
Published in International Journal of Radio Frequency Innovations · Vol. 1, Issue 2, 2023 · pp. 1–11 Read article
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A Comparative Analysis of Factors Contributing to Relapse in Alcohol and Opioid Dependence Among Patients Admitted to Selected Hospitals in Ludhiana, Punjab.
Abstract: Introduction: Substance abuse involves the dangerous or detrimental use of psychoactive substances, such as alcohol and illegal drugs. The use of these substances can result in dependence syndrome, which encompasses a range of behavioral, cognitive, and physiological effects that arise from ongoing substance use. Objectives: This study was carried out to examine the factors linked to relapse in alcohol and opioid dependence among patients admitted to selected hospitals in Ludhiana, …
Published in International Journal of Evidence Based Nursing And Practices · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Analysis of a New Approach to Admission Call Control
Abstract: This study presents a new method of managing call admission in wireless networks using a resource reservation technique. The system under study comprises a defined number of operating devices, standby units, and technicians assigned to repair failed devices. In this method, the failure and repair of devices are assumed to follow an exponential distribution. Whenever a device fails, a standby unit replaces it to maintain seamless functionality, and the failed …
Published in International Journal of Mobile Computing Technology · Vol. 3, Issue 2, 2025 · pp. 01–06 Read article
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A Retrospective Study to Assess the Incidence of Anaemia Among Pregnant Women Admitted in a Tertiary Care Centre, Jalandhar, Punjab
Abstract: Background: Anemia during pregnancy is a common and preventable condition that contributes significantly to adverse maternal and neonatal outcomes, including preterm delivery, low birth weight, and increased maternal morbidity. Despite the implementation of various national health programs in India, the burden of anemia among pregnant women remains high, particularly in rural regions. Objective: To assess the incidence and severity of anemia among pregnant women admitted to a tertiary care center …
Published in International Journal of Women's Health Nursing And Practices · Vol. 3, Issue 2, 2025 · pp. 38–42 Read article
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In Silico Analysis and Docking Study of the Active Phyto Compounds of Ginkgo Biloba Against Alzheimer's Amyloid-Beta Protein
Abstract: Objective: Alzheimer's disease, an age-related progressive neurological condition, arises due to the accumulation of amyloid-beta protein within the brain. In this study, an attempt was made to explore the potential of natural compounds derived from Ginkgo, known for their diverse medicinal properties, in the prevention of the disorder by employing molecular docking techniques, conducting drug-likeness prediction assessments, and performing ADME analysis. Methods: Amyloid beta protein was retrieved from the PDB …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 Read article
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A Structure-based Design Approach to Catharanthus roseus Phytoconstituents as Potential Inhibitors of B-Cell Lymphoma 6 Protein
Abstract: Objectives: Lymphoma is a cancerous disease. It develops into millions of people worldwide. Identify the naturally active compounds from Catharanthus roseus, they have multiple values in the medicinal field of Siddha, and Indian Ayurveda are used as a disease-preventing agent. Drug illness prediction, toxicity prediction, statistical information, molecular docking, as well as absorption, distribution, metabolism, and excretion (ADME) analysis are used to predict the fit ligand as a drug. Methods: …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 2, 2023 · pp. 14–34 Read article
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In Silico Docking Analysis to Identify Therapeutic Benzoic Acid Derivatives for Acute Myeloid Leukaemia
Abstract: Background: The study is anchored to initiate subjugation against modern cancer therapy for Acute Myeloid Leukaemia (AML) which involves natural therapeutics as an alternative therapy that would degrade the prospect of adverse side effects along with anti-cancer properties. Objectives: Collate the various characteristics of Giltertinib with natural benzoic acid derivative phytochemicals for a disquisition regarding their similarities and differences in the context of providing adverse side effects. Methods: ADME toxicity …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 50–63 Read article
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QSAR Modeling of a Novel Series of Methoxylated Chalcones as Antioxidant Agents Against Gram-Positive Bacteria Staphylococcus aureus
Abstract: Background: Chalcones are aromatic ketones belonging to the flavonoid family. They are plant-based compounds and are widely found in nature. For centuries, these bioactive molecules have been utilized in various traditional medicines for the treatment of several ailments. Chalcones have antibacterial, antiviral, antimalarial, antifungal, antioxidant, and antileishmanial properties. They are also used to treat inflammation and cancer. Chalcones act as angiogenesis inhibitors, an important factor in cancer progression and metastasis. …
Published in International Journal of Biochemistry and Biomolecule Research · Vol. 3, Issue 1, 2025 · pp. 28–34 Read article
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Care Sched: Doctor and Patient Appointment Management
Abstract: The medical appointment system is a web application that uses PHP, JavaScript, and CSS to improve the efficiency of booking medical appointments. It features two interfaces: an admin side where patients and doctors manage their appointments and a user side where they may handle an appointment and to view records, and manage their medicines. The web platform that the system makes available provides a convenient online experience from any internet-enabled …
Published in International Journal of Computer Science Languages · Vol. 3, Issue 1, 2025 · pp. 1–12 Read article
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Exploration of 5-Hydroxybowdichione Flavonoids As Inhibitors of Dengue Virus Ns5 RNA-Dependent RNA Polymerase Using Molecular Docking Approach
Abstract: Objectives: Human lives are now seriously threatened by dengue fever, which is brought on by the dengue virus (DENV). Aedes aegypti mosquitoes, which reproduce in still water, are the primary vectors of the arboviral virus known as dengue. It is well-recognized that phytochemicals have a high potential to eliminate bacterial, viral, and fungal infections in people. Thus, it demonstrates its inhibitory effects on the dengue virus. This study identifies some …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 1, Issue 1, 2023 · pp. 1–16 Read article
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An Automated System for Training and Placement Activities
Abstract: The training and placement cell constitutes a vital component of any institution, playing a pivotal role in molding the career trajectories of students. This system allows students, companies, and admins to log in for campus recruitment purposes. The primary aim of this project is to create a platform for the college’s placement cell, benefiting students, visiting companies, and the placement officer. The admin has access to student information, allowing for …
Published in International Journal of Mobile Computing Technology · Vol. 1, Issue 2, 2023 · pp. 31–37 Read article
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Using Multitarget Molecular Docking to Examine the Antiviral Potential of Clerodendrum Phlomidis against Measles
Abstract: Objective: Measles, a viral disease caused by a member of the Paramyxoviridae virus family, is highly contagious and characterized by a respiratory illness and a maculopapular rash on the skin. Children are the main victims of the illness. In the context of drug development, this study investigates the efficacy of phytocompounds derived from Clerodendrum phlomidis against the target protein of the measles virus. Methods: The 7SKS protein was retrieved from …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 2, 2023 · pp. 32–42 Read article
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Evaluating the Use of Antibiotic Prophylaxis in Surgical Procedures: A Study Conducted at a Tertiary Care Teaching Hospital in Southern India
Abstract: Background: Prophylactic antibiotics can reduce the frequency of postoperative wound infections. Well-designed trials have demonstrated that the appropriate administration of prophylactic antibiotics in surgeries can reduce postoperative infections to about one-half of the incidence in untreated patients. Objectives: To examine surgeon's adherence to the hospital's antibiotic policy by comparing and assessing the usage of antibiotics as prophylactic before surgery. Methods: A prospective observational study was carried out among inpatients in …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 2, Issue 2, 2024 · pp. 7–17 Read article
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Molecular Docking Evaluation of Cedrus deodara Secondary Metabolites as a Potent Anti-ovarian Cancer Agent
Abstract: Objective: According to the statistics for the year 2022 it was seen that cancer total cases is 14,61,427. After breast cancer, ovarian cancer is the second most frequent cancer among women. The estrogen receptor (PDB ID: 1X7E), progesterone receptor (PDB ID: 1A28), and Phosphoinositide 3-kinases (PDB ID: 4FJY) can be considered as target protein for ovarian cancer. The plant Cedrus deodara and its phytochemicals were chosen in this study to …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 77–93 Read article