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245 articles for “sequencing”
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Harnessing Deep Learning to Explore Microbial Community Structure and Carbon Storage Capacity in Mangrove Ecosystems: A Framework for Computationally
Abstract: Mangrove ecosystems represent one of the most efficient natural carbon sinks on Earth, functioning as critical blue carbon habitats that sustain diverse microbial communities responsible for biogeochemical cycling and long-term carbon storage. Despite their global ecological significance, accurately quantifying and predicting carbon sequestration in mangrove systems remains challenging due to the complex interactions between microbial diversity, sediment chemistry, and environmental drivers. This study presents a comprehensive and sustainable artificial intelligence …
Published in Research and Reviews : Journal of Computational Biology · Vol. 15, Issue 1, 2026 · pp. 41–49 Read article
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High-Velocity Impact Response of CFRP and Hybrid Composites: A Comprehensive Review on Ballistic Resistance and Damage Mechanisms
Abstract: This review consolidates recent advances in the study of high-velocity impact response of carbon fiber reinforced polymer and hybrid composites. Carbon fiber reinforced polymer composites are widely applied in aerospace, automotive, and defense due to their high strength-to-weight ratio, stiffness, and durability. However, their susceptibility to impact damage such as delamination, matrix cracking, and fiber breakage limits their performance under dynamic loading. To overcome these challenges, researchers have explored reinforcement …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 100–122 Read article
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Free Vibration Analysis of Circular Perforated Laminated Plates
Abstract: This study investigates the free vibration characteristics of circular perforated laminated composite plates. A finite element model is created to analyze the effects of perforation patterns, hole sizes, and laminate configurations on the natural frequencies and mode shapes of these structures. The model incorporates shear deformation theory and accounts for the anisotropic nature of composite materials. Parametric studies were held to examine how varying perforation geometries, including hole diameter, spacing, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 281–296 Read article
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Pharmacoepigenomics of Replication Timing: How Anti- Cancer Drugs Reshape Chromatin Domains and Mutational Landscapes.
Abstract: DNA replication timing serves as a fundamental epigenetic feature that organizes genome function during the cell cycle (3), while anti-cancer drugs profoundly alter this process to disrupt tumor growth(4). These agents target chromatin architecture, shifting replication domains and reshaping mutational patterns critical for cancer evolution (1,5). DNA replication timing (RT) domains serve as dynamic epigenetic organizers, partitioning the genome into early- and late-replicating regions that correlate with chromatin states, gene …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Integrative Structural-Functional Genomics of Fc and Fab: Precision Models for Monoclonal Antibody Stability and Anti-Aggregation Engineering
Abstract: Monoclonal antibodies (mAbs) represent the cornerstone of biotherapeutics, yet aggregation propensity compromises up to 50% of candidates during development, driven by Fab hypervariability and Fc vulnerabilities.(1,2) This review integrates functional genomics from OAS (4B+ sequences)(5) and structural databases (SAbDab: 10K+ structures)(6) with machine learning models achieving R=0.97 for SAP prediction.(11) We dissect biophysical mechanisms, benchmark predictive tools (DeepSP, ESM2), and engineering strategies (YTE, FW mutations) that enhance Tm by 5-10°C …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 1, 2026 Read article
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Thermo-Mechanical Vibration Analysis of Simply Supported Laminated and Flat Plates Under Harmonic Loading
Abstract: This paper delves into a numerical exploration of the vibration characteristics and frequency response of two types of plates: a simply supported rectangular laminated plate and a simply supported flat plate. These plates are subjected to concentrated harmonic forces within a thermal environment. The determination of the critical buckling temperature guides the assessment of thermal load effects. Analytical formulations, incorporating first-order shear deformation theory (FSDT) to consider shear deformation and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 2, 2026 · pp. 1519–1530 Read article
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Dynamic Response Analysis of Isotropic and Orthotropic Rectangular Plates under Clamped-Free Conditions
Abstract: This study explores Theoretical and numerical tools of determining the free vibration properties of isotropic and fiber-reinforced composite rectangular plates. The effect of anisotropy of materials on the dynamic response of the plates is compared between the Aluminium plates and the glass-epoxy laminates. The model used in the study is a three-dimensional finite element model that is designed using a combination of SolidWorks and ANSYS workflow. Clamped-free boundary conditions are …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 258–274 Read article
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Genomic Characterization of Emerging Arboviruses in Rural India
Abstract: Arboviruses (arthropod-borne viruses) represent a rapidly evolving group of pathogens responsible for significant morbidity and mortality, particularly in tropical and subtropical regions. Rural India, characterized by dense vector populations, changing ecological patterns, and limited healthcare infrastructure, has become a hotspot for the emergence and re-emergence of arboviral diseases such as dengue, chikungunya, Japanese encephalitis, and more recently, Zika virus infections. Advances in genomic technologies, including next-generation sequencing (NGS), metagenomics, and …
Published in International Journal of Pathogens · Vol. 3, Issue 2, 2026 · pp. 1–8 Read article
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Differential Gene Expression Analysis of Human Atrial Fibroblasts Reveals Dysregulation of RNA Metabolism and Translational Machinery in Atrial Fibrillation
Abstract: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by extensive structural remodeling and the activation of atrial fibroblasts, which drive the progression of fibrosis. To identify the underlying transcriptomic alterations, we analyzed six human atrial fibroblast RNA-Seq datasets (three control and three AF) retrieved from the Sequence Read Archive. After performing rigorous quality control and adapter trimming, we aligned the reads to the GRCh38 human reference genome using a …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 2, 2026 · pp. 15–25 Read article
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Integrated DIPlib and OpenCV Framework for Precise Geometric Characterisation of Woven Fibre-Reinforced Polymer Composites
Abstract: The mechanical properties of woven fibre-reinforced polymer (FRP) composites stem entirely from the geometrical regularity inherent in their reinforcement structure. Changes in the size of the unit cell, fibre tow separation, weave angle, and fibre tow spacing will have an immediate effect on the stiffness and shear modulus of the material. In this paper, a combined machine vision system that incorporates both the OpenCV and DIPlib libraries is proposed for …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 158–171 Read article
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Structural Performance Evaluation of Circular Perforated Plates under Mechanical Loading
Abstract: Circular perforated plates are structurally critical components in aerospace, automotive, and marine sectors, where perforation-induced stress concentrations govern failure under mechanical loading. This study conducts a systematic finite element analysis of stress distribution, deformation, and interlaminar behavior in aluminum and glass-epoxy laminates ([−45/45/90/0]S and [−45/45/90/0]AS) under uniform transverse pressure with clamped-free boundary conditions. Four perforation configurations—no hole, central hole, single-series, and 25-hole grid—were evaluated using ANSYS Shell-181, verified against Kirchhoff–Love, …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 1–20 Read article
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Design and simulation of Solar Powered Automated Dual Rotor Mechanism for Sugarcane Harvesting
Abstract: Sugarcane being the vast cultivated cash crop of India’s agricultural economy has undoubtedly one of the most difficult harvesting processes. The existing mechanisms to harvest sugarcane are costly and are not affordable by rural based farmers. In this project a novel design mechanism is suggested that would serve the purpose of harvesting with least manpower, being cost effective and serving the purpose of cutting, stripping, sorting and loading of the …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 4, Issue 1, 2026 · pp. 18–26 Read article
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Pick and Place Drone using Primus X Flight Controller
Abstract: The development of an uncomplicated drone for pick-and-place tasks makes this project a superb beginner’s hands-on exercise. The drone is outfitted with an accelerometer, gyroscope, magnetometer, and barometric sensors which allows for controlled, stable flight. A Primus X flight controller powers the drone due to these features. The drone is sustained by a battery which drives four geared motor propellers. The gripper is designed in SolidWorks and cut using a …
Published in International Journal of Robotics and Automation in Mechanics · Vol. 4, Issue 1, 2026 · pp. 27–35 Read article
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Physio-Mechanical Experimental Characterization of Natural Fiber Polymer Composites for a Boat Hull
Abstract: Composite materials which will provide for improved mechanical properties – a focus there to develop light weight, more rugged, stronger ship hull materials. The various application of glass fibers reinforced composites can be seen in the marine applications, such as boat hull, but in case of failing badly, they are non-recyclable and poses the threat to health hazards for aquatic animals and human beings which is their significant disadvantage. MARPOL …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 58–67 Read article
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AI-Driven Pharmacogenomics and Precision Medicine: Future of Personalized Therapy
Abstract: Pharmacogenomics and artificial intelligence (AI) are emerging as important drivers of precision medicine, enabling healthcare systems to adopt individualized therapeutic approaches. Pharmacogenomics examines how genetic variations influence drug response, efficacy, metabolism, and toxicity, while AI provides advanced computational tools for analyzing complex genomic and clinical data. This review highlights the integration of AI-driven pharmacogenomics in personalized therapy and its potential to improve treatment outcomes. Machine learning, deep learning, natural language …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 · pp. 1–12 Read article
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Personalized Medicine: the impact of ferrofluids, clinical procedures, strategies, applications,challenges, current trends, and reseach opportunities.
Abstract: Personalized medicine has shown progressive development and evolution in health care systems. It is considered as transformative emerging medicine encorporating advanced technologies including genomics, AI as thinking partner, and nanotechnology in a greater extent. The quest for painless injection, lesstoxicity, rapid cell separation, and gene sequencing make ferrofluid the focus of personalized medicine. Currently, magnetic nanoparicles and ferrofluides are becoming driving force of personalized medicine. However, contronlling and managing nanoscale …
Published in Emerging Trends in Personalized Medicines · Vol. 3, Issue 2, 2026 Read article
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Performance Evaluation of Kevlar-Sisal-S-Glass Hybrid Composites with Ceramic Fillers for Structural Applications
Abstract: This study examines the mechanical properties of hybrid composite laminates reinforced with Kevlar, sisal, and S-glass fibers, and incorporating ceramic fillers—silicon carbide (SiC) and aluminum oxide (Al2O3)—within an epoxy matrix. The hand lay-up method was utilized to produce the laminates, ensuring a uniform fiber stacking sequence and including 10% filler material. Two composite variations were synthesized: one incorporating SiC and the other Al₂O₃, and both underwent tensile, flexural, hardness, and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 3, 2026 · pp. 1308–1322 Read article
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Effect of Silicon Carbide Filler on Mechanical and Damping Behavior of Basalt/Stainless Steel Hybrid Laminated Composites
Abstract: This study consolidates three experimental investigations on hybrid laminated composites reinforced with basalt fibre, stainless steel (SS) wire mesh, and silicon carbide (SiC) filler using vacuum infusion moulding. Three laminates were fabricated with filler variations of 0%, 1.5%, and 3% by weight of matrix material, maintaining a stacking sequence of [0B/0W/45B/0W/0B/45W]s with a thickness of 4–5 mm. The first investigation focused on impact strength. Drop-weight impact testing revealed a steady …
Published in Journal of Polymer & Composites · Vol. 14, Issue 4, 2026 · pp. 367–385 Read article
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Harnessing Bacteria for Next-Generation Data Storage Technologies – A Review
Abstract: The exponential increase in global digital information has created a pressing need for storage technologies that are more durable, compact, and sustainable than conventional electronic media. While hard drives, solid-state drives, and cloud-based systems have transformed information management, they face severe limitations related to storage density, energy consumption, maintenance costs, and long-term preservation. Researchers have, therefore, begun exploring biological systems as alternative information storage platforms. Among these, bacteria have emerged …
Published in International Journal of Molecular Biotechnological Research · Vol. 4, Issue 2, 2026 Read article
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Toxicological Profiling and Safety Assessment of NASAT 2.0: A Conceptual Framework for Adaptive Nanoparticle Therapy in Rabies
Abstract: Rabies, caused by the highly neurotropic Rabies lyssavirus, remains one of the most enigmatic and universally lethal infectious diseases known to modern medicine. Once clinical symptoms manifest following successful neuroinvasion, the fatality rate approaches absolute certainty (approximately 99.9%), a staggering statistic that has remained largely unchallenged despite massive, concurrent advances in modern virology, critical care medicine, and cellular immunology. Current late-stage therapeutic protocols, most notably the widely debated Milwaukee Protocol, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 16, Issue 2, 2026 · pp. 1–19 Read article