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465 articles for “Toxic effects”
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Kapikacchu (Mucuna pruriens): A Promising Indigenous Herbal Drug and Its Effect on Different Disease Conditions
Abstract: Mucuna pruriens is widely known as “velvet bean,” which originally belongs to eastern part of India and China where it is cultivated as vegetable crop. It has been shown that its seeds are potentially of substantial medicinal importance. Kapikacchu belongs to Fabaceae family and it is widely used for aphrodisiac purpose as well as for Parkinson disease. It has lots of pharmacological properties such as hypoglycemic activity, antioxidant activity, aphrodisiac …
Published in Research and Reviews: A Journal of Toxicology · Vol. 7, Issue 3, 2017 · pp. 1–5 Read article
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Optimizing the removal of Chromium from aqueous solution by adsorption using sugarcane bagasse
Abstract: In Ethiopian tannery and textile industries, chromium concentration before treatment ranges from 1000 ppm to 5000 ppm. From this concentration about 95 % of chromium exists in the form of Cr (III), which was toxic when its concentration exceeded 5 ppm and oxidized in to Cr (VI). This chromium was disposed to environment with effluent in the form of chromium III and chromium VI was highly toxic to humans, animals …
Published in Journal of Water Pollution & Purification Research · Vol. 6, Issue 2, 2019 · pp. 22–36 Read article
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Targeting Dystrophin Restoration and Neuroprotection in Duchenne Muscular Dystrophy: Insights from Withania somnifera
Abstract: Duchenne muscular dystrophy is a genetic disorder. This disease affects men more common than women. Main objective of the present study was to identify the naturally active phytocompounds from Withania somnifera (Ashwagandha). Ashwagandha has a great value in the field of Ayurveda and Indian medicine and is used for treating muscular and neurological disorders. Toxicity prediction, molecular docking, statistical information, drug illness prediction, and Absorption, distribution, metabolism, excretion, and toxicity …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 15, Issue 2, 2024 · pp. 64–84 Read article
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Nanomaterials and Their Effects on the Environment: Analyzing Widespread Use
Abstract: Due to the need and uses of nanoparticles in a wide variety of fields of human activity, including industry, agriculture, commerce, medical, and public health, there has been a significant uptick in interest in nanotechnology among the general populace. Because of the inevitability of environmental exposure to nanomaterials as a consequence of their increasing incorporation into our everyday lives, more and more focus is being placed on the study of …
Published in Journal of Polymer & Composites · Vol. 11, Issue 1, 2023 · pp. 97–103 Read article
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Assessment of Diuretic Activity of Hydroalcoholic Extract of Matricaria Chamomilla (Linn.) and Its Phytochemical Analysis with Emphasis on Toxicology
Abstract: While the traditional medicines are derived from medicinal plants, minerals and organic matter, the herbal drugs are prepared from medicinal plants only. This current research work will be very beneficial in figuring out the Matricaria chamomilla leaves extract diuretic effect by determining the ions and electrolyte excreted by the animals using ion selective channel inhibition. The phytochemical screening results revealed that the after which it was observed whether the alkaloids …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 1, 2024 · pp. 1–10 Read article
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Study of Nickel Toxicity and Recovery in Freshwater Major Carp Catla catla
Abstract: The present work was carried out to examine the hazardous effects of chronic intoxication of nickel ions in Catla catla, a fresh water major carp. Fingerlings were exposed to sublethal concentrations of nickel sulphate solution (5 ppm and 10 ppm) for 21 days and histotoxicity in liver, brain and intestine was studied periodically. Normal architecture of hepatocytes was disrupted. The histopathological manifestations observed in the liver were congestion of hepatocytes, …
Published in Research and Reviews: A Journal of Toxicology · Vol. 1, Issue 1-3, 2011 · pp. 63–73 Read article
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Desk Research on Pollutants for Ecofriendly Environmental Researchers
Abstract: Substances of foreign origin called pollutants, play a main part in alarming health hazards. The essentiality of water is being used without considering the dreadful contaminants. Arsenic, the most potential and dreadful element, is always ignored whenever there is a need for the purification of water for drinking. Rehabilitation of any affected area in view of health issues is highly mandatory as per the international provisions of Environmental legislation. In …
Published in International Journal of Environmental Noise and Pollution Control · Vol. 2, Issue 2, 2024 · pp. 14–27 Read article
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Extraction of Copper from Electronic Waste (E-Waste): A Review
Abstract: The issue of electronic waste, or e-waste, is indeed a significant global concern with far-reaching environmental and health implications. As technology continues to advance and become more integrated into our daily lives, the disposal of obsolete or broken electronic devices has become a pressing issue. This waste not only contains valuable metals but also toxic substances, posing significant challenges for disposal and management. Improper disposal of e-waste is a significant …
Published in Journal of Materials & Metallurgical Engineering · Vol. 14, Issue 1, 2024 · pp. 14–27 Read article
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Bioremediation of Crude Oil Polluted Ecosystem Using Mixed Microbial Population on Polluted Areas
Abstract: Bioremediation utilizes the capability of microorganism to degrade all toxic wastes. This emerging technology is a promising method for the effective treatment of contaminated soil and water. This work investigates the possible methods to enhance the rate of natural bioremediation of hydrocarbons in a more effective, efficient, economical and environmentally friendly way. The bioremediation processes in this research was applied to a crude oil polluted ecosystem with a high level …
Published in Journal of Energy, Environment & Carbon Credits · Vol. 6, Issue 1, 2016 · pp. 16–24 Read article
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Use of Nitrates and Sulphates as Hydrogen Sink in Reducing Enteric Methane Production
Abstract: AbstractMethane (CH4) and other gases like carbon dioxide (CO2), nitrous oxide (N2O), are green house gases (GHGs) that aggravates the effects of solar and thermal radiation on surface and atmospheric temperature. CH4 is the second largest GHG having 21 times more heat generation potential than CO2. Global livestock agriculture was responsible for 18% of the anthropogenic GHG emissions annually. CH4 production in the rumen accounts for 2–12 % loss of …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 5, Issue 2, 2016 · pp. 5–8 Read article
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TOXICOLOGY: Present-Day Difficulties for Investigating Safety Science and Target Safety Evaluation of Major Human Hepatocytes
Abstract: Preclinical toxicology has developed into a more thorough understanding of toxicity pathways from its descriptive beginnings. Technological developments have made it possible to forecast safety occurrences, mitigate adverse effects, and create safety biomarkers. Because they are able to self-renew and specialize into different types of human body cells, stem cells are currently being employed for in vitro toxicological applications. However, as compared to primary human hepatocytes, stem cell-derived HLCs perform …
Published in Research and Reviews: A Journal of Toxicology · Vol. 14, Issue 3, 2024 · pp. 31–40 Read article
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Brine Shrimp Cytotoxicity was not Warrant for Teratogenicity: Comparative Analysis of Seaweed Methanolic Extracts Collected from Tamil Nadu Coastal Region on Brine Shrimp and Zebra Fish Embryos
Abstract: Brine shrimps have been served as valuable toxicological model systems. Besides, they are being used as preliminary models to identify the effective bioactive drug candidates against different diseases including cancer in recent decades. In the present study, we comparatively analyzed twenty-eight seaweed methanolic extracts for their cytotoxicity and teratogenicity using brine shrimp nauplii and zebra fish embryos (ZFEs). All of the seaweed extracts killed brine shrimps, but, only, Ulva lactuca …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 8, Issue 2, 2018 · pp. 24–32 Read article
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Exploring Nutool (Irrigation) as A Treatment Method in Ilaj Bit Tad-Beer (Regimenal Therapy)
Abstract: The Unani system of medicine employs four primary modes of treatment: Illaj bil ghiza (dietotherapy), Illaj bil Dawa (pharmacotherapy), Illaj bit tadbeer (Regimenal therapy), and Illaj bil yad (surgery). Illaj bit Tadbeer encompasses a range of regimenal interventions, including Hijamah (cupping), Irsal alaq (leeching), Fasd (venesection), Dalak (massage), Nutool (irrigation), Qay (Emesis), Idrar-i-Bawl (Diuresis), Tariq (Diaphoresis), Munzij and Mu'shil therapy (Concoction and purgation), Bukhoor (medicated steam), kayy (cauterization), Huqna (enema), …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 11, Issue 1, 2024 · pp. 1–6 Read article
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An Overview of Gene Therapy
Abstract: Gene therapy is a revolutionary technique in medical science that seeks to cure or stop illnesses by means of introducing, altering, or quieting genes inside a patient's cells. Advancements in molecular biology, genetics, and biotechnology have propelled this field forward markedly changed over the last few decades. The underlying idea of gene therapy is to introduce genetic material into target cells via viral or non-viral vectors to rectify faulty genes, …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 89–105 Read article
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Progress in Pharmacological Potential of Thione Substituted 1,3,4-Thiadiazoles: A Review
Abstract: Heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. From the last decade, good research is going on the 1,3,4-thiadiazole ring, as a result of which, many research groups has developed novel clinically useful compounds. These compounds had shown its importance as anti-inflammatory, analgesic, antimicrobial, antitumor, antifungal, antimycobacterial, anticonvulsant, antidiabetic, antiviral agents etc. So far, the modifications of the 1,3,4-thiadiazole ring has proven highly effective way …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 3, Issue 2, 2012 · pp. 9–34 Read article
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Cytotoxic and Antigenotoxicity Activity of Hibiscus sabdariffa Extract Against Tobacco Smoke Extract in Allium cepa Cells
Abstract: The present study was objective to determine whether and to what extent Hibiscus sabdariffa (H. S) extract can reduced the genotoxic damage by Cigarette smoking extract on Allium cepa cells. For this purpose, we used onion bulbs were treated with %2 cigarette smoking extract for 12 h, then treated with concentrations 0.1, 0.01, 0.001 mg/ml of H.s extract for other 12 h; while negative control in water and positive control …
Published in Journal of Modern Chemistry & Chemical Technology · Vol. 14, Issue 2, 2023 · pp. 17–23 Read article
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Effect of Initial Temperature and Diameter of Ethanol Droplet on Evaporation Dynamics in Convective Air Medium
Abstract: Ethanol is a suitable biofuel as it has fewer toxic emissions and higher-octane numbers. For spray combustion applications, the gas phase motion must be considered while numerically investigating the fundamental aspects of droplet evaporation and combustion processes. Hence, we have numerically simulated the evaporation dynamics of an isolated spherically shaped ethanol droplet under a forced convective air environment in the absence of gravity. The momentum transfer between two phases is …
Published in Journal of Polymer & Composites · Vol. 11, Issue 14, 2023 Read article
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Exploring Type-II Diabetes Potential of Phyto-Derived Carbon Dots
Abstract: The integration of phytoconstituents with carbon dots (C-dots) presents a novel and sustainable approach to the development of nanotherapeutics for type 2 diabetes mellitus (T2DM). C-dots, zero-dimensional carbon-based nanomaterials, exhibit unique physicochemical properties including high fluorescence, tunable surface chemistry, biocompatibility, and low toxicity. Their ability to enhance the solubility, bioavailability, and targeted delivery of poorly soluble phytochemicals renders them highly suitable for biomedical applications. This study explores the synthesis of …
Published in Research and Reviews: A Journal of Pharmaceutical Science · Vol. 16, Issue 3, 2025 · pp. 08–25 Read article
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Pattern of Poisoning, Management and Antidote Availability in St. Paulo’s Specialized Hospital Addis Ababa, Ethiopia
Abstract: Poisoning is the contact with a substance that results in toxicity. It can be deliberate or accidental. Antidotes are substances opposing the harmful effect of poisons and are cornerstones in the management of poisoning. Availability of antidotes highly affects the effective poisoning management. To assess the poisoning management in relation to an antidote availability. A retrospective study was used to assess the practice of poisoning management and antidote availability in …
Published in Research and Reviews: A Journal of Toxicology · Vol. 5, Issue 3, 2015 · pp. 8–12 Read article
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Novel Nano Polymeric Lipid-Based Carriers for Emerging Pain Management of Rheumatoid Arthritis
Abstract: An inflammatory condition known as rheumatoid arthritis (RA) results in chronic joint inflammation, severe disability, and early death. RA is 3–5 times more common in women than in men, with a global frequency of roughly 0.3 percent–1%. The ultimate goal of RA treatment is to give symptomatic alleviation; there is no recognized cure for RA. NSAIDs are frequently used to treat RA, including indomethacin, diclofenac, ibuprofen, celecoxib, and specifies the …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 2, 2022 · pp. 30–38 Read article