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1363 articles for “Pre-clinical”
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Polysaccharide-Based Composite Materials for Hemostatic Applications in Trauma Care
Abstract: Uncontrolled hemorrhage remains one of the leading causes of preventable trauma-related mortality worldwide, highlighting the urgent need for rapid, effective, and biocompatible hemostatic materials. Polysaccharide-based composite biomaterials have emerged as promising candidates owing to their excellent biocompatibility, biodegradability, and intrinsic hemostatic properties. Natural polysaccharides, including chitosan, alginate, cellulose derivatives, starch, and hyaluronic acid, are increasingly combined with synthetic polymers, bioactive ceramics, metallic nanoparticles, and other functional additives to enhance mechanical …
Published in Journal of Polymer & Composites · Vol. 14, Issue 5, 2026 Read article
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Monostotic Fibrous Dysplasia: Facial Swellings A Diagnostic Conundrum
Abstract: Asymmetrical swelling of the mandible in children may pose a significant diagnostic dilemma. The differential diagnosis ranges from traumatic, infectious, and metabolic processes to benign and malignant tumors that may present with similar clinical and radiological features, making an accurate diagnosis quite difficult. This is an illustrative case involving an 11-year-old girl who initially presented with tumefaction of the mandible and after several investigations and referrals were diagnosed as Monostotic …
Published in Research and Reviews: A Journal of Dentistry · Vol. 2, Issue 1-3, 2011 · pp. 45–49 Read article
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Combining Unstructured and Structured Clinical Data in a Hybrid Transformer Model to Enhance Cardiovascular Analytics and Clinical Decision- Making
Abstract: Since cardiovascular disease (CVD) continues to be a major global cause of morbidity and mortality, early and accurate risk prediction is essential for prompt intervention and individualized treatment. This study introduces a new hybrid transformer-based model that combines unstructured clinical narratives, structured data, and customized lifestyle characteristics. A comprehensive understanding of disease progression is made possible by the model's ability to capture contextual, temporal, and patient- specific insights through the …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 1, 2026 · pp. 30–37 Read article
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Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
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A brief survey on Alternative and Complementary Medicine with special reference to safety, toxins and toxicological concerns
Abstract: Alternative and Complementary Medicine (ACM) is a wide range of healthcare practices that may be used within or alongside conventional medicine, and many of these practices are rapidly becoming accepted and integrated into the modern healthcare system. In addition to traditional medicine systems (e.g. Ayurveda, Unani Medicine, Traditional Chinese Medicine, and Homeopathy), ACM includes practices that utilize natural remedies including herbal medicine, phytotherapy, naturopathy, acupuncture, yoga, and meditation. While these …
Published in International Journal of Toxins and Toxics · Vol. 3, Issue 1, 2026 · pp. 30–45 Read article
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An Overview of 98 Cases of Idiopathic Granulomatous Mastitis
Abstract: Background: Granulomatous mastitis is an uncommon, benign, chronic inflammatory condition of breast of uncertain etiology. The clinical features mimic tuberculosis and breast cancer that leads to diagnostic and therapeutic dilemma. Its optimal management is still unclear with high recurrence rate. Purpose: The purpose of this study is to present the clinico-pathological features of patients with Granulomatous mastitis and our experience with the medical and surgical treatment of these patients. Methods: …
Published in Research and Reviews : Journal of Surgery · Vol. 7, Issue 1, 2018 · pp. 5–9 Read article
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A Comprehensive Review of Machine Learning and Explainable AI Techniques for Disease Prediction Systems
Abstract: Large amounts of diverse medical data have been produced because of the quick development of digital healthcare systems, offering substantial chances to use machine learning methods for clinical decision support and illness prediction. By identifying intricate patterns in clinical data, machine learning-based models have shown great promise in early disease detection, risk assessment, and personalised healthcare. However, issues with transparency, interpretability, and reliability have been brought up by the growing …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 4, Issue 1, 2026 · pp. 20–28 Read article
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Status of Dengue in Different Regions of Southern Bengal
Abstract: Introduction: Dengue is an endemic disease affecting various parts of the world, including India. At present, it isone of the major global health problems that need an immediate attention. The aim of our study was to determine the sero-prevalance and clinic-epidemiological data of dengue in few districts of Southern Bengal.Methodology: A total of 11,846 cases of either sex or age groups were included, followed by a detailed clinical and physical …
Published in Research and Reviews: A Journal of Health Professions · Vol. 11, Issue 1, 2021 · pp. 11–19 Read article
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Vaccine Candidates and Animal Models for Kala-Azar
Abstract: Kala-azar or Visceral Leishmaniasis (VL) is a serious human disease in tropical regions and rapidly emerging as an opportunistic infection in HIV patients. The available treatment against VL is associated with toxicity and drug resistance. Even though the development of vaccines against VL is received limited attention. The only successful immunization strategy in humans has been leishmanization, which is based on the development of durable immunity after recovery from infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 5, Issue 1, 2015 · pp. 29–35 Read article
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Lactoferrin Nanoparticles as Therapeutic Agent for Infectious Diseases
Abstract: Lactoferrin (Lf) is a mammalian cationic iron-binding glycoprotein, present in many mammalian excretions and supporting newborn growth to food and pharmaceutical applications. It possesses antibacterial, antimicrobial, antiviral and antiparasitic activity thus, making it an important part of the host defense system. This review focusses on recent therapeutic advances of the natural bioactive protein Lf and its use as a potential treatment agent. Nanoparticles have been tremendously used for several clinical …
Published in Research and Reviews : Journal of Dairy Science and Technology · Vol. 7, Issue 3, 2018 · pp. 37–40 Read article
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Kisunla (Donanemab): A Novel Breakthrough Illuminating a Path to Better Alzheimer’s Outcomes
Abstract: Background: Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by cognitive decline, memory loss, and loss of independence. Despite decades of extensive research, disease-modifying treatments have been limited in success. Recent therapeutic advancements have led to the development of monoclonal antibodies targeting amyloid-beta (Aβ) plaques, particularly the pyroglutamate-modified variant, a key pathological hallmark of AD. Objectives: This review aims to explore the therapeutic potential of Donanemab (Kisunla), a novel …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 15, Issue 3, 2025 · pp. 37–45 Read article
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Canine Pseudopregnancy: A Review
Abstract: Canine pseudopregnancy is a normal physiological syndrome that occurs in female dogs in their diestrual phase of estrous cycle. It simulates the peri and post-whelping signs that includes nesting, increase in weight and enlargement of mammary gland, lactation and mothering behavior on toys, shoes, puppies of other bitches. Decreased levels of progesterone, meanwhile raised levels of prolactin predispose the bitches to pseudopregnancy. It is a self-limiting clinical condition; however, anti-prolactin …
Published in Research and Reviews : Journal of Veterinary Science and Technology · Vol. 7, Issue 1, 2018 · pp. 7–11 Read article
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Computational Biomodeling: Transforming Drug Design with Advanced Simulations
Abstract: Computational biomodeling has emerged as a transformative approach in the field of drug discovery, significantly enhancing the efficiency and precision of identifying and optimizing potential drug candidates. This article explores the various computational techniques utilized in drug design, including molecular docking, molecular dynamics (MD) simulations, free energy calculations, and virtual screening, and examines how these methods collectively contribute to the drug development process. The integration of these advanced simulations allows …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 3, 2024 · pp. 24–29 Read article
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Artificial Intelligence based Point of Care Device in Advanced Medical Diagnostic Techniques
Abstract: Application of Point-of-Care Testing (POCT) at medical sites provides instant diagnostic results that help doctors make quick decisions for patient care. The traditional point-of-care testing equipment faces restrictions because they test single parameters and experience calibration problems in addition to inefficient data management systems. POCT technology benefits from the integration of Artificial Intelligence (AI) which creates a novel system to solve current operational limitations. The presented study introduces an intelligent …
Published in International Journal of Biomedical Innovations and Engineering · Vol. 3, Issue 2, 2025 Read article
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A review on the effects of Indian medicinal spices on age related molecular and cellular pathways in light of geriatric muscle loss
Abstract: Biological aging is an enigmatic and progressive process, which can be affected by various mechanisms - genetic alteration, deregulated nutrient sensing, proteostasis, cellular degeneration and stem cell dysfunctioning. Indian spices are an underexplored repository of phytoactives with a medicinal potential. Especially spices like cumin (Cuminum-cyminum) and fennel seeds (Foeniculum vulgare) are central to the Indian diet as well as a part of numerous traditional recipes and formulations with medicinal implications. …
Published in Research & Reviews : Journal of Food Science & Technology · Vol. 12, Issue 3, 2024 · pp. 1–10 Read article
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Using Artificial Intelligence for The Design of Polymeric Drug Delivery Systems
Abstract: AI is cost effective and time efficient process. Artificial intelligence is a method which uses high speed calculation, the improvement regarding algorithm along with collection about biological and chemical features in pharmaceutical exploration and development .Present day because continuous progress towards machine learning (ML),Artificial intelligence an effective statistics analysing technology might have been broadly utilized in drug design .In pharmaceutical exploration and research employ of AI in target identification, compound …
Published in Journal of Polymer & Composites · Vol. 13, Issue 1, 2025 · pp. 1018–1027 Read article
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Cancer Chemotherapy-Induced Cachexia: Bridging Mechanisms, Management, and Future Therapies
Abstract: Involuntary weight loss, skeletal muscle atrophy, adipose tissue depletion, anorexia, and systemic inflammation are all symptoms of chemotherapy-induced cachexia, a complex illness. Although it is common, it remains poorly understood and is often referred to as an "orphan disease." This study covers the epidemiology, pathophysiology, clinical symptoms, diagnosis, treatment, and emerging treatment options for chemotherapy-induced cachexia. To comprehend the causes, clinical results, and therapeutic approaches, a literature-based synthesis of recent …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 17–26 Read article
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Bacteriophages- A New Frontier in Medicine
Abstract: Bacteriophages, or phages, are viruses that specifically target and infect bacteria, offering an innovative alternative to traditional antibiotic treatments, especially in the face of rising antibiotic resistance. The resurgence of phage therapy has been driven by the increasing prevalence of multidrug-resistant bacterial strains and the slowdown in the development of new antibiotics. Phages, unlike antibiotics, target specific bacterial strains, reducing the impact on the natural microbiota and potentially offering a …
Published in International Journal of Virus Studies · Vol. 1, Issue 2, 2024 · pp. 31–35 Read article
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Flaxseed and Diabetes Management: A Comprehensive Review of Recent Studies and Potential Mechanisms
Abstract: Diabetes mellitus, a condition characterized by chronic hyperglycemia, has become a significant global health challenge, leading to substantial morbidity and mortality rates. Dietary techniques are crucial for the effective control of diabetes, including both pharmaceutical and non-pharmacological therapies. Flaxseed (Linum usitatissimum) is one of the functional foods that has attracted a lot of interest because of its abundance of bioactive components, including lignans, dietary fiber, and alpha-linolenic acid (ALA). The …
Published in International Journal of Nutritions · Vol. 2, Issue 1, 2025 · pp. 24–32 Read article
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Botanical Blockade: Phytochemical Targeting Of Nf-Κb in Cancer Therapy
Abstract: The control of inflammation, corpuscle survival, proliferation, and allowed response are all influenced by the acute archetypal agent NF-κB. Its abnormal activity is typically seen in a range of malignancies, where it aids in bump advancement, metastasis, and treatment waste. The function of NF-κB in scar analysis is discussed in this product, along with significant phytochemicals that seem to be interested in targeting this pathway, based on recent investigation. It …
Published in Research & Reviews: A Journal of Pharmacognosy · Vol. 12, Issue 1, 2025 · pp. 13–21 Read article