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412 articles for “Gene targeting”
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Resolving Travelling Salesman Problem Using Modified Clustering Technique
Abstract: AbstractTravelling Salesman Problem (TSP) is a quotidian stumbling block in the field of Computer Science and operation research designed to seek out the shortest pathway amid the given targets viz. cities where each target is considered only once. Many solutions to this setback like Ant Colony Optimization. Brute-Force approach, Genetic Algorithm, Fruit Fly Optimization etc. are available in literature. The main objective of these solutions is to minimize the time …
Published in Research & Reviews: Discrete Mathematical Structures · Vol. 6, Issue 1, 2019 · pp. 22–31 Read article
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Exploring The Therapeutical Potential Of Pongamia Pinnata For Herpes Simplex Virus Type 1 (HSV-1)
Abstract: Objective: Pongamia pinnata (L.), commonly known as Indian beech or pongam tree, is a tropical plant renowned for its medicinal properties in traditional medicine systems. Extracts derived from various parts of Pongamia pinnata have demonstrated antimicrobial, anti-inflammatory, and immunomodulatory activities. Such attributes make it a compelling candidate for exploring its therapeutic potential against HSV infections. Thymidine kinase is the target protein mostly used in the treatment of HSV1 infections. In …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 15, Issue 1, 2025 · pp. 1–9 Read article
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A study on Antibiotic Resistance: An Analysis of Molecular Mechanisms and Therapeutic Implications
Abstract: Antibiotic resistance (AR) represents one of the most critical existential threats to global public health, rapidly eroding the efficacy of established antimicrobial therapies and portending a return to the pre-antibiotic era. This analysis explores the intricate molecular landscape defining this crisis, focusing specifically on the primary mechanisms of action (MoA) utilized by major antibiotic classes—including cell wall inhibitors, protein synthesis inhibitors, and nucleic acid synthesis inhibitors—and the corresponding, diverse mechanisms …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 9–21 Read article
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Exploring The Multitarget Pharmacological Mechanism of Diabex for T2dm by Combining Network Pharmacology and Molecular Docking Techniques
Abstract: Objective: Hyperglycemia brought on by an absolute or relative absence of insulin synthesis or action characterises a set of illnesses known as diabetes mellitus. Chronic hyperglycemia in diabetes mellitus has been linked to organ damage, heart, and blood vessels. The persistent metabolic condition Diabetes is a severe global issue with negative social, health, and economic effects. It is a type of metabolism disorder that interferes with food digestion in the …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 62–73 Read article
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CRISPR-Cas System: Next Generation Genome Editing Tool
Abstract: CRISPR-Cas system provides sequence specific adaptive immunity against phages and mobile genetic elements. Resistance is acquired following phage infection or plasmid uptake when short specific sequence is added into CRSIPR array. This complex guides cRNA to target complementary DNA fragments and target its degradation. CRISPR array is then transcribed and processed into cRNA which forms complex with cas protein. The ability of CRISPR-Cas system to induce site specific DNA breaks …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 2, 2016 · pp. 10–16 Read article
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Wiskott-Aldrich Syndrome: A Comprehensive Guide
Abstract: Wiskott-Aldrich Syndrome (WAS) is an uncommon genetic disorder inherited through the X chromosome, marked by a combination of immune system deficiencies, eczema, and low platelet counts. This syndrome primarily affects males, leading to significant morbidity and mortality due to recurrent infections, bleeding complications, and autoimmune diseases. Mutations in the WAS gene disrupt the production of the Wiskott-Aldrich Syndrome protein (WASp), crucial for the functioning of immune cells and platelet formation. …
Published in Research and Reviews : A Journal of Immunology · Vol. 14, Issue 2, 2024 · pp. 39–46 Read article
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Pharmacoinformatic Based Screening Of Phytocompound Epigallocatechin Gallate To Identify As A Potential Bcl-2 Inhibitor
Abstract: Objectives: The B-cell lymphoma-2 (Bcl-2) is a protein that is particularly though to be involved in preventing apoptosis. Bcl-2 family members also essential for cancer survival, and its over expression has been linked to tumor genesis, development and resistance to anticancer treatments. The Bcl-2 family of members that inhibit apoptosis is a promising target for the creation of anticancer drugs. Methods: The study was based on computational approach using different …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 1–13 Read article
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Green Renewable Synthesis of Iron Oxide Nanoparticles Embedded in a Polymer-Enzyme Composite for Wastewater Treatment in Hail, Saudi Arabia
Abstract: Effective wastewater treatment through green and sustainable approach is one of the primaries concerning issue of the Kingdom of Saudi Arabia (KSA) to resolve water scarcity. KSA has witnessed massive industrial development over the last four decades alongwith majorly generate wastewater pollution. Therefore, sustainable wastewater treatment is among primary research goal of KSA and current study is also targeted in this direction. Henceforth, The objective of the present study is …
Published in Journal of Polymer & Composites · Vol. 13, Issue 6, 2025 · pp. 297–305 Read article
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The Intersection of Bioinformatics and Cellular Function in Disease Modeling
Abstract: The integration of bioinformatics and cellular biology has revolutionized our understanding of disease mechanisms, offering unprecedented opportunities to model complex biological systems. Bioinformatics is an interdisciplinary field that merges biology, computer science, and statistics, offering advanced tools to analyze vast biological datasets. Cellular functions, including gene expression, protein interactions, and metabolic pathways, form the foundation of physiological and pathological states. Disruptions in these processes can result in diseases like cancer, …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 2, Issue 2, 2024 · pp. 1–7 Read article
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Computational Screening of Vitex negundo Compounds for Potential Arthritis Therapies in India
Abstract: Objective: Arthritis is a pervasive medical condition that manifests as inflammation and discomfort within the joints. As of September 2021, arthritis has affected an estimated 180 million people in India, making it a substantial public health concern with a considerable impact on individuals' quality of life and healthcare systems. Therefore, using molecular docking, drug-likeness prediction, and ADME analysis, an effort was made to identify natural compounds from Vitex negundo, which …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 01–18 Read article
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Superoxide Dismutase: An Emerging Target for Human Therapeutic
Abstract: Superoxide dismutases (SODs) represent a very essential antioxidant guard beside oxidative stress in the body. The enzyme does something as an excellent restorative mediator next to reactive oxygen species (ROSs)-mediated multiple sicknesses. The current review portrays the curative property of SOD in diverse physiological and pathological circumstances such as cancer, inflammatory diseases, gene mutation, cardio therapy, aging, neurodegenerative diseases, and diabetes. However, the enzyme has positive boundaries in experimental applications. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 9, Issue 1, 2019 · pp. 165–172 Read article
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Exploring Pharmacological Mechanism Of Pteridines And Its Derivatives Against Neurodegenerative Disorders Using Network Pharmacology And Molecular Docking Techniques
Abstract: Objectives: Pteridines have been identified via various research and shown therapeutic efficacy in Neurodegenerative disorders(ND) preclinical models. In the current study, a network pharmacology technique was applied to determine the underlying mechanism of the pteridines' protective effects on ND. Network pharmacology was utilised in order to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 1–13 Read article
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Investigating mosquito innate immune defence mechanism towards malaria vaccine development
Abstract: Mosquito-borne diseases weigh heavily on public health across the globe. The mosquito’s innate immune system certainly decides whether malaria parasites survive inside the vector, and that sighted it as a logical place to discover new vaccine ideas. In this review, we examine how Anopheles mosquitoes defend themselves against Plasmodium parasites and how those defenses could be turned into tools for malaria control. We focus on three layers of immunity: antimicrobial …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 50–54 Read article
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Impact of Self-Help Groups (SHGs) on Sustainable Livelihood Development in Rural Uttarakhand: A Study on the Influence of DAY-NRLM in Income Generation and Community Empowerment
Abstract: Self-Help Groups (SHGs) have emerged as a vital mechanism for fostering sustainable livelihoods in Uttarakhand, a region challenged by poverty, migration, and unemployment. This study examines the role of SHGs in expanding livelihood programs and empowering members, particularly in income generation, while highlighting the importance of group-based approaches for vulnerable communities like small farmers and craftsmen. Data collection for the study involved a questionnaire targeting 288 respondents across 100 SHGs …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 14, Issue 2, 2025 · pp. 46–54 Read article
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In Silico Exploration of Podophyllum Hexandrum-Derived Phytocompounds as Potential Therapeutics Against Small Cell Lung Cancer (SCLC): A Molecular Docking Approach
Abstract: Small Cell Lung Cancer (SCLC) is a fast-growing and aggressive type of lung cancer that spreads quickly strongly associated with smoking. It is characterized by symptoms, such as persistent cough, breathing difficulties, or hoarseness, though it can sometimes be asymptomatic which makes early detection challenging. The tumor suppressor gene TP53 is critical in regulating the cell cycle and preventing uncontrolled cell division. Mutations in TP53 result in the loss of …
Published in International Journal of Molecular Biotechnological Research · Vol. 3, Issue 1, 2025 · pp. 1–11 Read article
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Virulence Factors in pathogens :mechanisms of infection & disease progression
Abstract: Pathogens, like bacteria, viruses, fungi, and parasites, have evolved specialized tools – known as virulence factors – that help them infect hosts, escape the immune system, and cause disease. These factors play a key role in determining how severe an infection becomes, how quickly it spreads, and how the body responds. Some pathogens use adhesins to stick to host cells, while others produce toxins that damage tissues or disrupt normal …
Published in International Journal of Pathogens · Vol. 2, Issue 1, 2025 · pp. 6–11 Read article
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Immune Dysregulation and Cytokine Circuitry in Genital Endometriosis: Mechanistic Insights and Next-Generation Immunotherapeutic Strategies
Abstract: Genital endometriosis is increasingly recognized as an immune-mediated inflammatory disorder driven by complex interactions between dysregulated immune cells, cytokine hubs, and microbiome-derived modulators. This review introduces a novel “immune–cytokine circuitry” framework that unifies innate and adaptive immune abnormalities with key cytokine loops sustaining chronic inflammation, angiogenesis, neuroinflammation, and immune tolerance. Within this circuitry, macrophage polarization, dendritic cell immaturity, NK-cell anergy, Treg expansion, Th17 amplification, and B-cell–mediated autoimmunity converge to establish …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 06–16 Read article
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Emerging Engineered Nanoweapons for Tumors
Abstract: Cancer is a type of disease characterized by abnormal growth of cells which tend to proliferate in uncontrolled manner. It occurs at molecular level when genes undergo genetic alterations. The malignant growth of tumor cells results in non-functioning of the concerned organ. Over the years, cancer targeting technique has greatly improved by new approaches based on nanotechnology. Nanotechnology is helpful in development of new therapies against cancer. Nanotechnology is a …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 2, 2012 · pp. 1–6 Read article
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Therapeutic Effect of PEGylated Phytosomes Loaded with Herbal Drugs for Treating Paediatric Leukaemia
Abstract: To treat pediatric leukemia, this study evaluated a co-encapsulated pegylated phytosome system based on herbal anti-cancer medications. In this study, herbal drug-soy lecithin complex-loaded phytosomes were prepared as drug carriers to overcome the limitations of natural drugs like poor absorption, low oral bioavailability, poor aqueous solubility, and so on. This is a targeted nano-drug delivery that enhances the absorption and bioavailability of the herbal drug used. In this study, herbal …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 24, Issue 3, 2022 · pp. 48–69 Read article
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In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article