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1953 articles for “phosphoinositol-3-kinase pathway” (ranking capped at the first 2,000 matches — narrow the search to see the rest)
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Digital Frontiers in Life Sciences: The Transformative Role of Computing in Modern Biology
Abstract: The integration of computers in the biological sciences has revolutionized research and experimentation, facilitating advancements in areas such as genomics, bioinformatics, systems biology, and ecological modeling. The ability to process vast amounts of biological data efficiently has transformed how scientists study complex biological systems and phenomena. Computational tools enable the analysis of DNA sequences, protein structures, metabolic pathways, and ecological dynamics, which were previously beyond the reach of traditional laboratory …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 4, Issue 1, 2026 Read article
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Polymeric Ion-Exchange Complexes of Carbomer for Taste Masking and Enhanced Drug Bioavailability: A Physicochemical and In Vivo Study
Abstract: Famotidine (FAM) was recognized as a crystalline powder that varies in color from white to pale yellow and possesses an extremely bitter flavor. This study aimed to conceal the unpleasant flavor of FAM through employing unconventional ion-exchange resins sourced from Carbomer polymer Evaluation (Carbopol 974P). We used FTIR, DSC, and XRD to look at the drug-resin combination in its hard form to learn more about its physical and chemical properties. …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 727–740 Read article
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Comparative Study on Oro Dispersible Tablets of Candesartan Cilexetil Formulated with Natural and Synthetic Disintegrants
Abstract: Candesartan cilexetil, a BCS class II drug with low aqueous solubility and poor bioavailability (15%), poses challenges for oral delivery. To address this limitation, the present study focuses on polymer-based inclusion complexation and composite formulation strategies to enhance solubility and dissolution behavior. The drug was incorporated into β-cyclodextrin (β-CD), a cyclic oligosaccharide polymer, by the kneading method in different drug-to-carrier ratios. Among these, the 1:1 molar ratio complex exhibited the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 687–695 Read article
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Experimental Analysis of Glass Fiber Composite on Low Velocity Impacts
Abstract: This research specifically deals with determining the retained tensile strength after loading Glass Fiber Reinforced Polymer (GFRP) composites following low-velocity impact. The purpose is to determine the degree to which these impacts affect the structural performance and mechanical integrity of GFRP materials. Experimental tests were conducted on glass fiber composite specimens in order to observe variation in tensile strength upon impact. The results indicated significant tensile strength reduction in impact …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 789–796 Read article
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Cancer Chemotherapy-Induced Cachexia: Bridging Mechanisms, Management, and Future Therapies
Abstract: Involuntary weight loss, skeletal muscle atrophy, adipose tissue depletion, anorexia, and systemic inflammation are all symptoms of chemotherapy-induced cachexia, a complex illness. Although it is common, it remains poorly understood and is often referred to as an "orphan disease." This study covers the epidemiology, pathophysiology, clinical symptoms, diagnosis, treatment, and emerging treatment options for chemotherapy-induced cachexia. To comprehend the causes, clinical results, and therapeutic approaches, a literature-based synthesis of recent …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 1, 2026 · pp. 17–26 Read article
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Interaction of Mosquito’s hppd Enzyme with Lansoprazole Sulfide A New Hope to Tackle the Mosquito Menace – an in-Silico Study
Abstract: Tyrosine detoxification is an important physiological process that helps blood-feeding insects, such as mosquitoes that transmit Plasmodium parasites causing malaria, digest their blood meals. An enzyme known as 4-hydroxyphenylpyruvate dioxygenase (HPPD), which is part of the tyrosine detoxification pathway, helps in removing excess tyrosine in a high-protein blood meal. Excess tyrosine can be lethal to the insects, and hence, the role of HPPD enzyme is very critical. Inhibitors of HPPD …
Published in International Journal of Insects · Vol. 3, Issue 1, 2026 · pp. 1–11 Read article
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Bayesian Optimization–Driven Operating Parameter Tuning for Maximizing Methane Yield in Anaerobic Digestion
Abstract: To achieve maximum methane production in an anaerobic digestion (AD) process, a combination of various operational parameters must be tuned nonlinearly in the digestion ecosystem. The conventional trial and error optimization methods are slow, resource consuming, and in most instances, cannot model the intricate parameter interaction in biogas production. The current work introduces a Bayesian Optimization-based model to optimize the set of conditions to maximize the level of methane produced …
Published in International Journal of Energy and Thermal Applications · Vol. 4, Issue 1, 2026 · pp. 1–8 Read article
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OBD-II Big Data–Driven ML and AI-Based Virtual Sensing for Fuel Economy, Component Health, and Carbon Intelligence
Abstract: The rapid growth of connected vehicles has led to the large-scale availability of high-frequency On-Board Diagnostics II (OBD-II) data; however, much of this data remains underutilised, as existing studies and commercial systems typically address fuel economy, maintenance, or emissions in isolation or rely on additional physical sensors. Such fragmented and sensor-dependent approaches limit scalability and increase system cost, particularly in high-volume and resource-constrained vehicle markets. To address this gap, this …
Published in Journal of Automobile Engineering and Applications · Vol. 13, Issue 1, 2026 · pp. 39–50 Read article
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Polymer Electrolyte Films Doped with Nanofillers ZnO: Electrochemical and Optical Investigations
Abstract: The electrochemical and optical characteristics of polymer composite electrolyte films doped with zinc oxide (ZnO) nanofillers are thoroughly examined in this work. Because of its superior film-forming capacity, flexibility, and ionic transport properties, poly(vinyl alcohol) (PVA) mixed with potassium iodide (KI) is used as the host polymer electrolyte. To investigate their effects on ionic conductivity, dielectric behavior, and optical transmission, ZnO nanoparticles are synthesized and added to the PVA–KI matrix …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 320–332 Read article
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A Gamified Digital Platform for Sustainable Farming Practices: Simulation, Statistical Analysis, and Water Resource Management Implications
Abstract: Sustainable farming practices play a critical role in enhancing agricultural water use efficiency, conserving limited water resources, and ensuring long-term food security under increasing environmental and climatic pressures. Despite their importance, farmer participation in conventional agricultural extension and training programs remains limited due to low engagement and a lack of sustained motivation. To address this challenge, this study proposes a gamified digital decision-support platform aimed at promoting sustainable agricultural and …
Published in Journal of Water Resource Engineering and Management · Vol. 13, Issue 1, 2026 · pp. 13–24 Read article
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An Empirical Analysis of Cost, Time, and Quality Relationships Using Correlation and Regression Techniques
Abstract: Cost, time, and quality have been recognized as the three key dimensions that determine construction project performance and are commonly represented through the "Project Management Triangle." However, despite their theoretical linkage, there is limited empirical evidence to quantify the nature of their relationships, particularly within developing construction markets. This paper seeks to contribute to addressing this shortfall by investigating the specific influence of cost and schedule variations upon quality outcomes …
Published in Journal of Construction Engineering, Technology & Management · Vol. 16, Issue 1, 2026 · pp. 52–60 Read article
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A Shear Strength Reduction Method for an Open Pit Slope Stability Analysis Based on Finite Element Method
Abstract: Slope stability assessment of open pit mines is critically important, since it forms part of the overall productivity and safety management strategy of the mines. The aim of this work is to investigate the overall stability conditions of three (3) open pits in Gold Fields Limited, Tarkwa Ghana. Field and laboratory investigations were conducted as well as empirical methods. Finite Element Analysis (FEA) in Rocscience was carried out using the …
Published in Journal of Geotechnical Engineering · Vol. 13, Issue 1, 2026 · pp. 1–24 Read article
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Evaluation of CI Engine Performance and Emissions Using WB10CNT90: A CNT-Reinforced Biodiesel Blend Approach and its Marketing Prospects for sustainable fuel Commercialization
Abstract: The experimental and analytical evaluation of the WB10CNT90 blend—a combination of 10% waste biodiesel derived from Madhuca longifolia, 90% conventional diesel, and 100 ppm Multi-Walled Carbon Nanotubes (MWCNTs)—demonstrates its potential as an efficient and eco-friendly alternative to conventional diesel. The Brake Thermal Efficiency (BTE) of the engine increased by approximately 15%, indicating enhanced energy conversion efficiency during combustion. Simultaneously, the Brake Specific Fuel Consumption (BSFC) showed a reduction of nearly …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 741–759 Read article
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Performance and Emission Profiles Enhancement of CI Engine with Aluminium Oxide-Reinforced Polymeric Composite in Biodiesel Blends
Abstract: The integration of aluminium oxide (Al₂O₃) nanoparticles into B10 biodiesel blends offers a promising approach to improving engine performance and reducing harmful emissions. This study evaluates the effect of Al₂O₃ additives on Brake Thermal Efficiency (BTE), Brake Specific Fuel Consumption (BSFC), and exhaust emissions in a compression ignition engine. Experiments were conducted using calibrated instruments, and uncertainties were considered with a coverage factor of 1.66, yielding an overall error margin …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 775–788 Read article
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Polymeric Hybrid Systems Engineered with Multiple-Stage Energy Absorption for Temperature Control
Abstract: Polymer–composite based phase change systems offer an effective strategy for adaptive thermal management; however, most existing systems exhibit single-stage latent heat transitions, limiting their applicability in environments with fluctuating thermal loads. In this study, a thermoplastic polyurethane (TPU) polymer matrix was reinforced with two microencapsulated paraffin-based phase change materials (PCM-A and PCM-B) to achieve multi-level latent heat storage behavior. The fabricated TPU/PCM-A10–B20 polymer–composite demonstrated two distinct endothermic transitions at approximately …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 146–155 Read article
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Design and Analysis of Quantum Dot Solar Cell Using SCAPS-1D Software
Abstract: Compared to conventional solar cells, quantum dot solar cells (QDSCs) have drawn a lot of attention due to their hybrid structure, low production cost, and greater power conversion efficiency. Nevertheless, carrier recombination in the quasi-neutral region (QNR) continues to limit their performance. The electron transport layer (ETL) and hole transport layer (HTL) are two of the layers that are most important in determining the overall efficiency of the device. The …
Published in Journal of Alternate Energy Sources & Technologies · Vol. 17, Issue 1, 2026 · pp. 15–20 Read article
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Structure–Property–Performance Characteristics of Chlorella Vulgaris Lipid-Based Bio-Composites Modified with n-Pentanol
Abstract: The depletion of fossil fuel resources and increasingly stringent emission regulations have intensified the need for sustainable alternatives for compression ignition (CI) engines. Biodiesel derived from Chlorella vulgaris microalgae is a renewable, non-edible fuel; however, its higher viscosity and lower volatility can adversely affect engine performance. To address these limitations, higher alcohols such as n-pentanol can be employed as effective modifiers to improve fuel physicochemical properties while maintaining compatibility with …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1636–1648 Read article
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Sustainability and Mechanical Performance Evaluation of Cementitious Composites Reinforced with Waste Rubber Aggregates and Ground Granulated Blast Furnace Slag
Abstract: The development of environmentally responsible composite materials has gained global momentum with the shift toward circular and sustainable construction practices. In this work, the performance of cementitious composites that partially substitute natural fine and coarse aggregates with recycled rubber aggregates from end-of-life tires and Ground Granulated Blast Furnace Slag (GGBS) as an additional cementitious material is examined. A total of thirty composite mixes were formulated by varying GGBS (10–30%) and …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 1164–1180 Read article
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Development of a Durable Superhydrophobic EP/PDMS Coating Reinforced with Micro-CaCO₃ and Nano-ZnO for Enhanced Corrosion Protection and Multifunctional Performance on Carbon Steel
Abstract: Balancing exceptional multifunctional performance with mechanical robustness in micro-nano composite films remains a significant challenge for practical applications. In this work, a superhydrophobic coating reinforced with micro-CaCO₃ and nano-ZnO particles was fabricated through a versatile single-step brushing method. The optimized EP/PDMS@micro-CaCO₃/nano-ZnO coating achieved a water contact angle (WCA) of 173.54° ± 2.53° and a sliding angle (SA) of 1.50° ± 1.12°. Owing to its carefully engineered micro-nano hierarchical structure, the …
Published in Journal of Polymer & Composites · Vol. 14, Issue 1, 2026 · pp. 216–238 Read article
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Immunological Biomarkers and Epidemiological Evaluation of Lymphatic Filariasis Elimination Efforts in Osun State, Nigeria
Abstract: Lymphatic filariasis (LF) remains a neglected tropical disease affecting millions globally, despite extensive elimination efforts. While the interruption of transmission is a key goal, the long-term immunological effects on individuals with existing complications like elephantiasis remain poorly understood. This study assessed the current transmission status of LF and the haematological profiles of infected individuals across selected Local Government Areas (LGAs) in Osun State, Nigeria. A total of 7,388 individuals from …
Published in International Journal of Tropical Medicines · Vol. 3, Issue 1, 2026 · pp. 22–30 Read article