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178 articles for “receptors”
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Recombinant Lactobacillus helveticus PJ4-Down Regulates TLR4 Mediated Inflammatory Responses in Sucrose Induced Diabetic Rats: A Novel Therapeutic Approach
Abstract: High sucrose diet (HSD) is known to induce type 2 diabetes. Recombinant Lactobacillus helveticus PJ4 was constructed to express the InuJ gene under the xylose promoter resulting in the secretion of inulosucrase enzyme in gastrointestinal tract which polymerizes the fructose moiety of sucrose to inulin type fructans. L. helveticus (pSLP-InuJ-Vhb) transformant (LHI) was intragastrically administered to rats fed with HSD diet. The composition of fecal microbiota and short-chain fatty acids …
Published in Research and Reviews : A Journal of Immunology · Vol. 7, Issue 2, 2017 · pp. 44–65 Read article
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An Insight to Hyponatremia in Cirrhosis: Pathophysiology and Management Approaches
Abstract: Cirrhosis is considered by systemic and splanchnic vasodilation that principals to extreme nonosmotic excretion of vasopressin. Hyponatremia is a mutual electrolyte irregularity in progressive liver disease that outcomes from the diminished capability of the kidney to excrete solute-free water that principals to “dilutional” hyponatremia water retention uneven to the retaining of sodium. Hyponatremia is mutual in cirrhosis. It frequently happens in a progressive phase of the disease and is related …
Published in Research and Reviews : A Journal of Immunology · Vol. 10, Issue 3, 2020 · pp. 30–46 Read article
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COVID-19: Impact on Human Health
Abstract: Researchers are on the cutting edge of devising the best strategy to combat the SARS-CoV-2 pandemic by studying and exploring the pathogenesis, prevention, and treatment as the world continues to be plagued by an increasing number of confirmed COVID-19 cases. The primary method for detecting the virus is via antigen testing and more accurate molecular tests such as rt PCR using patient samples. The most prevalent treatments for COVID-19 infection …
Published in Research and Reviews : A Journal of Immunology · Vol. 12, Issue 1, 2022 · pp. 1–8 Read article
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RsaI polymorphisms of ER-β and Idiopathic Male Infertility
Abstract: Purpose: Study on association between estrogen receptor gene polymorphism and male infertility has been interested, but highly specific genetic markers have been reported to be variable according to regions and nations. Herein we studied to figure out whether ERβ gene1082 G>A polymorphism could influence on sperm indices or not.Method: We dealt with 100 Korean patients with idiopathic male infertility diagnosed at our university hospital as a study group and 127 …
Published in Research and Reviews: A Journal of Medicine · Vol. 12, Issue 3, 2022 · pp. 34–41 Read article
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An Overview on the Management cum Treatment of Nephropathy in Type-1 Diabetes Mellitus
Abstract: The motive of this review is to keep updated with the medical nonfictions, the projected early natural arrangement of diabetic nephropathy, the theories behind the root of its pathogenesis pathophysiology, diagnosis and its supervision. Type 1 diabetes is an autoimmune disease characterized by advanced destruction of pancreatic beta cells by genetic and environmental factors which primes to an absolute necessity of insulin for survival and conservation of health; while Diabetic …
Published in Research and Reviews : A Journal of Medical Science and Technology · Vol. 9, Issue 3, 2020 · pp. 19–38 Read article
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A Clinical Correlation Made Between Opioid-induced Hyperalgesia and Hyperkatifeia with Brain Alterations Induced by Long-term Prescription Opioid Use
Abstract: The goal of this article is to establish a correlation between the clinical manifestations of opioid-induced hyperalgesia and hyperkatifeia with the morphological and functional connectivity changes seen in the human brain that can be caused by long-term prescription opioid use. This will be accomplished by reviewing the imaging results found in a small but unique study that demonstrated morphological and functional connectivity changes in long-term prescription opioid users. The primary …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 2, Issue 2, 2012 · pp. 1–11 Read article
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Discovery of Curcumin: Miraculous Activity as Anticancer
Abstract: AbstractCancer is the second most life-threatening disease and one of the main public health problems worldwide now a day. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin is an active ingredient of the Curcuma longa plant, has received great attention over …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 9, Issue 2, 2020 · pp. 29–38 Read article
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Relation of Thyroid Profile in Gall Stone Disease Patients
Abstract: Introduction: Gallstone disease is a very common gastro-intestinal disorder which is present worldwide. They may form because of many different disorders and the basis for it is impaired metabolism of cholesterol, bilirubin and bile acid and is characterized by formation of stones in hepatic or common bile duct or gall bladder. There has been a discussion, regard to the relation of thyroid disorders and gallstone disease, there are several explanations …
Published in Research and Reviews : Journal of Surgery · Vol. 6, Issue 2, 2017 · pp. 8–12 Read article
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Induction of G1 Phase Cell Cycle Arrest and Apoptosis in Breast Cancer MCF-7 Cells by Sulphonamide Derivative CID-6861424
Abstract: Breast cancer is most frequently detected and leading cause of cancer death in women worldwide. 80% of the breast cancer are estrogen receptor positive and the presently available drugs are ineffective either due to intrinsic resistance or due to acquired resistance. Sulfonamide compounds are a class of compounds showing activities like, antibacterial, antiviral including antitumor. In the present study we have investigated the anti-cancerous activity of sulfonamide derivative CID-6861424 on …
Published in Research and Reviews: A Journal of Toxicology · Vol. 9, Issue 2, 2019 · pp. 1–17 Read article
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Description of Amraz-E-Gosh (Ear Diseases) in Unani and Modern Perspective: A Review
Abstract: The human ear is tremendously complex and amazingly designed organ meant primarily for hearing and balancing the body. In Unani terminology, it is known as Uzuemudarikfaslat (distance receptor organ). In classical Unani literature, diseases of the ear are well described and are called as Amraze Gosh like Tarash (impaired hearing), Waqr and Samum (deafness), Wajauluzn (ear ache), Tanin-o-Dawi (tinnitus), Siqle Sama’at (reduced hearing), Hikkatuluzn (itching in ear) Sansanahat (ringing of …
Published in Research & Reviews : A Journal of Unani, Siddha and Homeopathy · Vol. 4, Issue 1, 2017 · pp. 31–38 Read article
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Anticancer, Bioactive, & Therapeutic Applications of Cannabinoids
Abstract: Cannabinoids, a complex class of lipophilic compounds found in Cannabis sativa L., are attracting significant clinical interest for their multifaceted therapeutic potential, particularly within oncology. This review provides a comprehensive synthesis of contemporary knowledge detailing the distinct anti-cancer properties of phytocannabinoids (such as δ-tetrahydrocannabinol and cannabidiol), endogenous endocannabinoids, and synthetic analogues. Accumulating evidence from robust in vitro and in vivo oncological models demonstrates that these compounds aggressively suppress tumor progression …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 15, Issue 2, 2026 · pp. 17–30 Read article
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Recent Advances in Nanotechnology-Assisted Liquid Crystal Biosensors for Sensitive and Naked-Eye Detection of Antibiotics
Abstract: The widespread use of antibiotics in healthcare, veterinary medicine, agriculture, and aquaculture has resulted in increasing levels of antibiotic residues in food products and environmental samples, posing significant risks to human health and contributing to antimicrobial resistance. Conventional analytical methods, including high-performance liquid chromatography (HPLC), liquid chromatography–mass spectrometry (LC–MS), enzyme-linked immunosorbent assay (ELISA), and electrochemical techniques, offer excellent sensitivity but require sophisticated instrumentation, skilled personnel, and extensive sample preparation. In …
Published in International Journal of Crystalline Materials · Vol. 3, Issue 2, 2026 Read article
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Evaluation of Anti-inflammatory Activity of Zornia gibbosa Span (Samyojaki)
Abstract: 93% of wild medicinal plants used for making Ayurvedic medicines in the country are endangered. Hence the usage of drugs which are common and abundantly available should be encouraged to control the extensive overuse of few classical drugs. An Ayurveda states that every drug possesses medicinal property, so it’s our prime duty to scrutinise those drugs which are abundantly available & cost-effective for their medicinal value. The herb Zornia gibbosa …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 1, 2014 · pp. 5–8 Read article
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Analgesic Activity and Acute Toxicity Study of Zornia gibbosa Span (Samyojaki) in Mice
Abstract: The herb Zornia gibbosa Span is a member of fabaceae family and commonly known as Nellujollusoppu/Haradahacchaga in Udupi district of Karnataka. The drug is widely used in the treatment of fracture by folklore practitioners to pacify pain and inflammation. In fracture the pain is generated by multiple nociceptors presence in response to discontinuity of periosteum and endosteum during trauma. So in order to justify the folklore claims, pharmacological analysis of …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 4, Issue 1, 2014 · pp. 1–4 Read article
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Altitude Related Variation of Antioxidant Properties of Tea Leaf (Camellia sinensis)
Abstract: Places, in the high altitude are subject to higher UV radiation as compared to places of low altitude, provided they bear the same latitudinal location. Here, in this investigation, the oxidative stress and associated cell protection in tea plants growing in Mysore (12°30′ N 76°65′ E, 770 m) and Ooty (Dodabeta – 11°4090′ N, 76°6966′ E, 2623 m) has been studied. The UV radiation varies in these two places – …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 4, Issue 2, 2014 · pp. 1–6 Read article
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching Hospital
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article
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3D-QSAR Studies, Molecular Docking and Adme Property Prediction of Mannosyl Triazoles Used as Potent Antiadhesives of Uropathogenic E. coli
Abstract: Urinary tract infections (UTIs) are among the most common infectious diseases, accounting for almost five million cases annually and causing considerable morbidity and mortality. Escherichia coli is a commensal inhabitant of the mammalian large intestine and the most common cause of UTIs in humans. Increasing incidence of antibiotic-resistant E. coli causing up to 95% of these infections, calls for additional therapeutic considerations. In this study, 3D-quantitative structure-activity relationship (3D-QSAR) analysis …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 6, Issue 1, 2016 · pp. 26–33 Read article
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Morinda citrifolia Leaf Induced Leukemia Cells Apoptosis and Produced Synergistic Effects with Zerumbone
Abstract: Leukemia is the most common cancer among children and the 7th most common cancer worldwide. The vegetable Morinda citrifolia leaves was investigated and compared with Zerumbone (a known anti-leukemia compound) separately and in combination, for their apoptotic effects on murine myelomonocytic leukaemia cell line (WEHI-3B). Zerumbone, a sesquiterpene from Zingiber zerumbet was anti-cancer via suppressing free radical generation, inflammation, cancer cell proliferation, metastasis, anti-apoptosis, NF-κβ, Iκβα kinase activation and invasion. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 3, 2016 · pp. 24–32 Read article
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Heat Transfer Enhancement in Solar Parabolic Trough Collectors Design Using C-shape, V-shape, and Reverse L-shape Roughness
Abstract: Solar energy can be collected and used in a large variety of ways including: passive daylighting,heating liquids and gasses, or generating electricity. Additionally, many energy sources such as wind,biomass, hydroelectricity, and even fossil fuels originate from the energy provided by the sun.Parabolic solar concentration systems are state-of-the-art or mature technology. Parabolic-troughsolar concentrating systems are parabolic-shaped collectors made of reflecting materials. Thecollectors reflect incident solar radiation onto its focal line toward …
Published in Journal of Refrigeration, Air conditioning, Heating and ventilation · Vol. 8, Issue 1, 2021 · pp. 26–41 Read article
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The Role of Quercetin, Curcumin, Eugenol, and Andrographolide in COVID-19 Treatment: A Review of Their Mechanisms of Action and Clinical Efficacy
Abstract: The world has recently experienced the covid diseases. It became the global worry with no remedy initially. Later, different antiviral medications in the form of injections and nasal sprays began to be employed. Many studies have been conducted to determine the antiviral effects of phytochemical substances. The corona virus's spike protein interacts with the ACE2 receptors on the alveoli's surface to enter the cell. After that, the polyprotein is transformed …
Published in Research and Reviews : A Journal of Biotechnology · Vol. 13, Issue 1, 2023 · pp. 27–38 Read article