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1340 articles for “Target”
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Mystic Malignant Melanoma Modalities
Abstract: Melanoma is a highly aggressive form of cancer with four recognized subtypes. In about 90% of cases, melanoma is diagnosed as a primary tumor, without signs of spreading. If caught early, the survival rate is quite high, reaching around 94%. However, for metastatic melanoma, the survival rate drops significantly to about 40%. Diagnosing melanoma can be tricky, as it shares features with benign conditions like seborrheic keratosis, benign moles, blue …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 13, Issue 3, 2024 · pp. 1–10 Read article
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A Comprehensive Review: Emerging Nanotechnology in Cancer Drug Delivery
Abstract: Nanotechnology has become a groundbreaking strategy in cancer therapy, especially in drug delivery systems, offering improved treatment effectiveness while minimizing the adverse effects associated with traditional methods. This review presents an in-depth analysis of recent progress in nanotechnology for cancer drug delivery, emphasizing the design, mechanisms, and practical applications of nanoparticle-based systems. Nanoparticles, such as liposomes, dendrimers, and gold nanoparticles, offer unique advantages, including improved drug solubility, targeted delivery to …
Published in Nano Trends – A Journal of Nano Technology & Its Applications · Vol. 27, Issue 1, 2025 · pp. 24–33 Read article
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Harnessing the Power of Big Data for Personalized Marketing
Abstract: In today’s digital age, big data has revolutionized the way businesses engage with customers, driving a shift from traditional blanket marketing strategies to highly personalized campaigns. By examining large volumes of data gathered from various sources like social media, websites, and transaction records, companies can gain valuable insights into consumer behavior, preferences, and buying patterns. Personalized marketing leverages these insights into craft-tailored experiences that resonate with individual customers. For instance, …
Published in Current Trends in Information Technology · Vol. 15, Issue 1, 2025 · pp. 19–22 Read article
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Thermosensitive and pH-Responsive Polymers for Smart Drug Delivery Systems
Abstract: Sensitive to temperature and pH, polymers are becoming a fascinating new class of material suitable for application in drug delivery systems. These polymers can be utilised in controlled release of medications as they change form depending on temperature and acidity. Thermosensitive polymers vary their formation and breakdown behaviour with temperature variations. They are therefore perfect for delivering pharmaceuticals to individuals as heat may be utilised to activate the medications at …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 479–491 Read article
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Graphene-Polymer Nanocomposites for Drug Delivery Applications
Abstract: Graphene-polymer nanocomposites (GPNCs) have gained significant attention in drug delivery due to their exceptional physicochemical properties, including high surface area, mechanical strength, tunable functionality, and biocompatibility. These nanocomposites integrate graphene derivatives, such as graphene oxide (GO) and reduced graphene oxide (rGO), with biocompatible polymers to enhance drug loading efficiency, stability, and controlled release. Various natural (chitosan, alginate) and synthetic (PLGA, PEG, PCL) polymers are used to functionalize graphene, enabling targeted …
Published in Journal of Polymer & Composites · Vol. 13, Issue 4, 2025 · pp. 362–374 Read article
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Tiny Titans: The Promise of E-Nanorobots in the Fight Against Cancer
Abstract: Cancer, a disease characterized by uncontrolled cell growth, continues to be a leading cause of mortality worldwide. Despite advances in surgery, radiation, and chemotherapy, significant challenges remain in achieving targeted and effective treatments without harmful side effects. But what if we could deploy microscopic robots, engineered at the nanoscale, to precisely target and destroy cancerous cells while leaving healthy tissue untouched. The fascinating possibilities of e-nanorobots are driving extensive research …
Published in Journal of Advancements in Robotics · Vol. 12, Issue 2, 2025 · pp. 11–21 Read article
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Comprehensive Review of Adenoid Cystic Carcinoma: Pathogenesis, Diagnosis, and Emerging Therapeutic Approaches
Abstract: Adenoid cystic carcinoma (ACC)is an infrequent neoplasm, highly malignant, that develops mainly in the salivary glands with the potential to exist in any secretory glandular sites, including the lacrimal glands, breast, and respiratory tract. ACC usually has a benign initial course, but conversely, it is notoriously aggressive in behavior with high incidence of perineural invasion, local recurrence, and distant metastasis, mostly to the lungs. The tumor’s molecular features are characterized …
Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 1–17 Read article
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CRISPR-Cas9: Revolutionizing the Genetic Frontier
Abstract: The rapid development of CRISPR/CRISPR-associated enzyme (Cas) technology has enabled truly customised treatment of human genetic disorders, paving the way for recent developments in the field of gene therapy. Because CRISPR/Cas can accurately target and edit individual genes within a genome, it has established itself as a formidable tool for genetic manipulation. CRISPR/Cas9 technology allows for precise editing of specific DNA sequences in an organism's genome. This method uses three …
Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article
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A study on Antibiotic Resistance: An Analysis of Molecular Mechanisms and Therapeutic Implications
Abstract: Antibiotic resistance (AR) represents one of the most critical existential threats to global public health, rapidly eroding the efficacy of established antimicrobial therapies and portending a return to the pre-antibiotic era. This analysis explores the intricate molecular landscape defining this crisis, focusing specifically on the primary mechanisms of action (MoA) utilized by major antibiotic classes—including cell wall inhibitors, protein synthesis inhibitors, and nucleic acid synthesis inhibitors—and the corresponding, diverse mechanisms …
Published in International Journal of Antibiotics · Vol. 3, Issue 1, 2026 · pp. 9–21 Read article
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Immunological Mechanisms Underlying Autoimmune Disorders: Recent Advances and Therapeutic Implications
Abstract: A diverse range of illnesses known as autoimmune disorders are typified by dysregulated immune responses against self-antigens, which result in tissue damage and persistent inflammation. Understanding the genetic, epigenetic, and environmental variables that contribute to autoimmune pathogenesis has advanced significantly during the last ten years. Current disease models have been transformed by new understandings of immunological tolerance mechanisms such as the functions of regulatory T cells, cytokine networks, and the …
Published in Research and Reviews : A Journal of Immunology · Vol. 16, Issue 1, 2026 · pp. 21–25 Read article
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Non-Small Cell Lung Cancer: Types, Pathogenesis, Diagnosis, and Novel Therapeutic Strategies
Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, accounting for over 85% of all cases globally. It remains one of the primary causes of cancer-related death due to its rapid progression, few early symptoms, and late detection. The three main forms of non-small cell lung cancer (NSCLC) are adenocarcinoma, squamous cell carcinoma, and giant cell carcinoma; each has a unique histology, prognosis, and response to …
Published in Research and Reviews: A Journal of Pharmacology · Vol. 16, Issue 2, 2026 · pp. 07–22 Read article
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Review on Strengthening & Retrofitting of RCC & Masonry Bridge Structure with Analytical Modelling of Sensor Data for the Durability of Bridge Structure
Abstract: In later a long time, monstrous advancement in Structural Health Monitoring (SHM) of bridges makes a difference address the life span and unwavering quality of bridge structure at differentiating stages of their benefit life. This article gives a point-by-point understanding of bridge observing, and it centers on sensors utilized and all sorts of harm location (strain, Displacement, acceleration, and temperature) concurring to bridge nature (scour, suspender failure, disconnection of bolt …
Published in Trends in Transport Engineering and Applications · Vol. 9, Issue 3, 2022 · pp. 16–23 Read article
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Exploring Pharmacological Mechanism Of Pteridines And Its Derivatives Against Neurodegenerative Disorders Using Network Pharmacology And Molecular Docking Techniques
Abstract: Objectives: Pteridines have been identified via various research and shown therapeutic efficacy in Neurodegenerative disorders(ND) preclinical models. In the current study, a network pharmacology technique was applied to determine the underlying mechanism of the pteridines' protective effects on ND. Network pharmacology was utilised in order to reveal the interactions between medications and the targets of illnesses, and it is capable of completely articulating the complexity between diseases and medications. The …
Published in Research and Reviews : Journal of Computational Biology · Vol. 11, Issue 03, 2022 · pp. 1–13 Read article
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Pf Phosphatidylserine decarboxylase: Molecular modeling and inhibithors prediction
Abstract: Plasmodium falciparum (P.f) is a protozoan parasite responsible for the most severe and deadly form of malaria. The resistance of Pf to last resort antimalarial drugs has been reported, there is an urgent need to identify new therapeutic candidates for drug development. Advancements in bioinformatics technologies provide potential cost and time-effective solutions for predicting therapeutic candidates. Phosphatidylserine decarboxylase (PSD) is a member of the lyase family (more specifically, the carboxy-lyases), …
Published in Research and Reviews : Journal of Computational Biology · Vol. 12, Issue 2, 2023 · pp. 60–78 Read article
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Study of Data Science in Online Behavioral Advertising
Abstract: The proliferation of the COVID-19 pandemic has led to a growing significance of social media in people's lives. Online activity in the digital domain has expanded considerably, showing a higher reliance on social media platforms for communication in both personal and professional situations. Coronavirus has a global impact on e-commerce and hence transformed the nature of business. Despite the COVID-19 issue and economic slowdown, the Indian e-commerce industry exhibited an …
Published in Journal of Open Source Developments · Vol. 10, Issue 3, 2023 · pp. 1–6 Read article
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New Wine in Old Wineskin: Progressive Development of Genomic Editing in Bombyx mori
Abstract: The Bombyx mori insect emerging from lepidopteran family is exploited as an important remunerative specie, vis-a-vis as a model organism for scientific findings. It is unequivocally a primal insect model in which genomic altering tool was used to establish a gene function in vitro. A significant milestone in Bombyx genetics is evidenced by contemporary advancement in germline transformation and whole-genome sequencing, producing genetically engineered silkworms (new wine in an old …
Published in Research & Reviews : Journal of Agricultural Science and Technology · Vol. 7, Issue 3, 2018 · pp. 17–25 Read article
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Network Pharmacological Studies in Biological Interactions of Thymoquinone
Abstract: Thymoquinone, a bioactive phytochemical compound belonging to the class of benzoquinones, is prominently present in the plant Nigella sativa. Despite its widespread use, the precise molecular mechanisms underlying its beneficial effects remain elusive. To address this gap, we employed network pharmacology to investigate the actions of Thymoquinone (TQ). Our methodology encompassed the utilization of diverse bioinformatic tools to scrutinize this molecule of interest comprehensively. Initially, we retrieved the chemical structure, …
Published in Research and Reviews : Journal of Crop science and Technology · Vol. 12, Issue 3, 2023 · pp. 18–25 Read article
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Design & Implementation of Radar for Air Defence Security & Surveillance System
Abstract: With increasing threat from different countries, India must develop a strong defensive barrier againstthem. The emerging technology in war ammunition makes us one of the most well-armed countries in the world.One of the most used weapons is missiles, which were extensively developed under the guidance of Dr. APJAbdul Kalam, the architect of IGMDP (Integrated Missile Development Program). Whatever may be thetechnology it is appreciated only when human loss is avoided. …
Published in Research & Reviews : Journal of Space Science & Technology · Vol. 12, Issue 3, 2023 · pp. 16–22 Read article
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A Review on RBC-Hitchhiking as a Novel Drug Delivery System
Abstract: Red Blood Cells (RBCs) are the human body's most abundant cells. Transferring oxygen to cells and body tissues is their main function. Owing to their unique biological properties, they are very useful for drug delivery. Due to their biocompatibility and known protection in transfusions, RBCs are especially attractive carriers. RBCs are biodegradable, possess very long circulation half-lives. The vast majority of drugs fail because they disperse across the body, landing …
Published in Trends in Drug Delivery · Vol. 8, Issue 1, 2023 · pp. 1–4 Read article
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Melanogenic Inhibitory Effects of Sesamum indicum Phytocompounds Towards CDK 2, c-KIT, and BRAF.
Abstract: Objective: Melanoma is thought to be the fifth most frequent cancer in the US population, despite cancer being the most common cause of death in the globe. BRAF, CDK2, and c-KIT proteins are regarded as potential therapeutic agents since mutations in these proteins are the primary cause of melanoma. For the investigation of their pharmacological properties and therapeutic activities against the target proteins, Sesamum indicum L. and its phytocompounds were …
Published in International Journal of Bioinformatics and Computational Biology · Vol. 1, Issue 3, 2023 · pp. 46–61 Read article